3,270
Views
113
CrossRef citations to date
0
Altmetric
Extra Views

The insulin receptor substrate (IRS) proteins

At the intersection of metabolism and cancer

Pages 1750-1756 | Published online: 01 Jun 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Camelia Papuc, Gheorghe V. Goran, Corina N. Predescu, Liliana Tudoreanu & Georgeta Ștefan. (2022) Plant polyphenols mechanisms of action on insulin resistance and against the loss of pancreatic beta cells. Critical Reviews in Food Science and Nutrition 62:2, pages 325-352.
Read now
Peng Huang, Shaomi Zhu, Xin Liang, Qinxiu Zhang, Xiaohong Luo, Chi Liu & Linjiang Song. (2021) Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives. Cancer Management and Research 13, pages 5317-5336.
Read now
Jinli Pei, Zhengpan Xiao, Ziyi Guo, Yechun Pei, Shuangshuang Wei, Hao Wu & Dayong Wang. (2020) Sustained Stimulation of β2AR Inhibits Insulin Signaling in H9C2 Cardiomyoblast Cells Through the PKA-Dependent Signaling Pathway. Diabetes, Metabolic Syndrome and Obesity 13, pages 3887-3898.
Read now
Izael S Costa, Amanda F Medeiros, Grasiela Piuvezam, Gidyenne C B S Medeiros, Bruna L L Maciel & Ana Heloneida A Morais. (2020) Insulin-Like Proteins in Plant Sources: A Systematic Review. Diabetes, Metabolic Syndrome and Obesity 13, pages 3421-3431.
Read now
Shulun Jiang, Di-an Fang & Dongpo Xu. (2020) Transcriptome analysis of Takifugu obscurus liver in response to acute retene exposure. Journal of Environmental Science and Health, Part A 55:10, pages 1188-1200.
Read now
Marc Rendell, Halis Kaan Akturk & Sri Harsha Tella. (2013) Glargine safety, diabetes and cancer. Expert Opinion on Drug Safety 12:2, pages 247-263.
Read now

Articles from other publishers (107)

Susan C. McKarns. (2023) A Review of Neuroreceptors for Clinical and Experimental Neuropharmacology in Central Nervous System Disorders. Current Reviews in Clinical and Experimental Pharmacology 18:3, pages 192-241.
Crossref
Mehnaz Ahmed, Tannishtha Biswas & Susmita Mondal. (2023) The strategic involvement of IRS in cancer progression. Biochemical and Biophysical Research Communications 680, pages 141-160.
Crossref
Xuelai Li, Wei Li, Shichang Zhang, Wen Sang, Yu Peng & Yao Zhao. (2023) RNA interference against the putative insulin receptor substrate gene IRS1 affects growth and development in the pest natural enemy Pardosa pseudoannulata . Pest Management Science.
Crossref
Samar M. Hammad & Maria F. Lopes-Virella. (2023) Circulating Sphingolipids in Insulin Resistance, Diabetes and Associated Complications. International Journal of Molecular Sciences 24:18, pages 14015.
Crossref
Hari Priya Vemana & Vikas V. Dukhande. (2023) The effect of hormones insulin and glucagon on ubiquitin modifications elucidated by proteomics in liver cells. Life Sciences 329, pages 121935.
Crossref
Hana Nůsková, Fabiola Garcia Cortizo, Lena Sophie Schwenker, Timo Sachsenheimer, Egor E. Diakonov, Marcel Tiebe, Martin Schneider, Jasmin Lohbeck, Carissa Reid, Annette Kopp-Schneider, Dominic Helm, Britta Brügger, Aubry K. Miller & Aurelio A. Teleman. (2023) Competition for cysteine acylation by C16:0 and C18:0 derived lipids is a global phenomenon in the proteome. Journal of Biological Chemistry 299:9, pages 105088.
Crossref
Hoau-Yan Wang, Zhe Pei, Kuo-Chieh Lee, Boris Nikolov, Tamara Doehner, John Puente, Nadav Friedmann & Lindsay H. Burns. (2023) Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer’s disease patient lymphocytes. Frontiers in Aging 4.
Crossref
Dariusz Szukiewicz. (2023) Molecular Mechanisms for the Vicious Cycle between Insulin Resistance and the Inflammatory Response in Obesity. International Journal of Molecular Sciences 24:12, pages 9818.
Crossref
Jeong Yoo, Jae Eun Park & Ji Sook Han. (2023) HMC Ameliorates Hyperglycemia via Acting PI3K/AKT Pathway and Improving FOXO1 Pathway in ob/ob Mice. Nutrients 15:9, pages 2023.
Crossref
Hallgeir Selven, Lill-Tove Rasmussen Busund, Sigve Andersen, Mona Irene Pedersen, Ana Paola Giometti Lombardi & Thomas Karsten Kilvaer. (2023) High Expression of IRS-1, RUNX3 and SMAD4 Are Positive Prognostic Factors in Stage I–III Colon Cancer. Cancers 15:5, pages 1448.
Crossref
David A. Bunsick, Jenna Matsukubo & Myron R. Szewczuk. (2023) Cannabinoids Transmogrify Cancer Metabolic Phenotype via Epigenetic Reprogramming and a Novel CBD Biased G Protein-Coupled Receptor Signaling Platform. Cancers 15:4, pages 1030.
Crossref
Xihong Zhang, Sidhant Varma & Douglas Yee. (2023) Suppression of Insulin Receptor Substrate 1 Inhibits Breast Cancer Growth In Vitro and in Female Athymic Mice. Endocrinology 164:3.
Crossref
Chandrani Chattopadhyay, Rajat Bhattacharya, Jason Roszik, Fatima S. Khan, Gabrielle A. Wells, Hugo Villanueva, Yong Qin, Rishav Bhattacharya, Sapna P. Patel & Elizabeth A. Grimm. (2022) Targeting IRS-1/2 in Uveal Melanoma Inhibits In Vitro Cell Growth, Survival and Migration, and In Vivo Tumor Growth. Cancers 14:24, pages 6247.
Crossref
Carlos Jiménez-Cortegana, Lourdes Hontecillas-Prieto, Daniel J. García-Domínguez, Fernando Zapata, Natalia Palazón-Carrión, María L. Sánchez-León, Malika Tami, Antonio Pérez-Pérez, Flora Sánchez-Jiménez, Teresa Vilariño-García, Luis de la Cruz-Merino & Víctor Sánchez-Margalet. (2022) Obesity and Risk for Lymphoma: Possible Role of Leptin. International Journal of Molecular Sciences 23:24, pages 15530.
Crossref
Marco Infante. 2022. Evolving Concepts in Insulin Resistance. Evolving Concepts in Insulin Resistance.
Hsi-Hsien Hsieh, Huiyu Yao, Yue Ma, Yuannyu Zhang, Xue Xiao, Helen Stephens, Naureen Wajahat, Stephen S. Chung, Lin Xu, Jian Xu, Raajit K. Rampal & Lily Jun-shen Huang. (2022) Epo-IGF1R cross talk expands stress-specific progenitors in regenerative erythropoiesis and myeloproliferative neoplasm. Blood 140:22, pages 2371-2384.
Crossref
Ji-Sun Lee, Michael W. Lero, Jose Mercado-Matos, Sha Zhu, Minjeong Jo, Claire E. Tocheny, Jennifer S. Morgan & Leslie M. Shaw. (2022) The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC. Cell Reports 41:10, pages 111759.
Crossref
Xue-Qing Geng, Li-Chao Pan, Hui-Qing Sun, Yuan-Yuan Ren & Zhen-Yuan Zhu. (2022) Structural characterization of a polysaccharide from Abelmoschus esculentus L. Moench (okra) and its hypoglycemic effect and mechanism on type 2 diabetes mellitus . Food & Function 13:23, pages 11973-11985.
Crossref
Ma Ting, Yu-e Miao, Feng-xiu Yu, Guang-cai Luo, Xin Xu, Li-xia Xiao, Guo-qing Zhang & Jin Chang. (2022) Correlation Study on the Expression of INSR, IRS-1, and PD-L1 in Nonsmall Cell Lung Cancer. Journal of Oncology 2022, pages 1-7.
Crossref
Jae-Eun Park & Ji-Sook Han. (2022) HM-Chromanone, a Major Homoisoflavonoid in Portulaca oleracea L., Improves Palmitate-Induced Insulin Resistance by Regulating Phosphorylation of IRS-1 Residues in L6 Skeletal Muscle Cells. Nutrients 14:18, pages 3815.
Crossref
Jia-Li Hu, Gulinazi Yierfulati, Lu-Lu Wang, Bing-Yi Yang, Qiao-Ying Lv & Xiao-Jun Chen. (2022) Identification of potential models for predicting progestin insensitivity in patients with endometrial atypical hyperplasia and endometrioid endometrial cancer based on ATAC-Seq and RNA-Seq integrated analysis. Frontiers in Genetics 13.
Crossref
Intan Sofia Omar, Amira Hajirah Abd Jamil, Noor Azmi Mat Adenan & Ivy Chung. (2022) MPA alters metabolic phenotype of endometrial cancer-associated fibroblasts from obese women via IRS2 signaling. PLOS ONE 17:7, pages e0270830.
Crossref
Hongru Li, Jinrui Zhang, Yan Shi, Guanfang Zhao, Haijiao Xu, Mingjun Cai, Jing Gao & Hongda Wang. (2022) Mechanism of INSR clustering with insulin activation and resistance revealed by super-resolution imaging. Nanoscale 14:20, pages 7747-7755.
Crossref
Adriana Monroy, Laura Gómez-Laguna, Carlos E. Aranda-Flores & Silvestre Alavez. 2022. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 2265 2282 .
Sandra Díaz del Moral, Maha Benaouicha, Ramón Muñoz-Chápuli & Rita Carmona. (2021) The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration. International Journal of Molecular Sciences 23:1, pages 234.
Crossref
Jirawat Riyaphan, Dinh-Chuong Pham, Max K. Leong & Ching-Feng Weng. (2021) In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes. Biomolecules 11:12, pages 1877.
Crossref
Qinghua Deng, Liyin Du, Yuming Zhang & Guowen Liu. (2021) NEFAs Influence the Inflammatory and Insulin Signaling Pathways Through TLR4 in Primary Calf Hepatocytes in vitro. Frontiers in Veterinary Science 8.
Crossref
Anna De Blasio, Antonella D’Anneo, Marianna Lauricella, Sonia Emanuele, Michela Giuliano, Giovanni Pratelli, Giuseppe Calvaruso & Daniela Carlisi. (2021) The Beneficial Effects of Essential Oils in Anti-Obesity Treatment. International Journal of Molecular Sciences 22:21, pages 11832.
Crossref
Adi Jacob Berger, Elinor Gigi, Lana Kupershmidt, Zohar Meir, Nancy Gavert, Yaara Zwang, Amir Prior, Shlomit Gilad, Uzi Harush, Izhak Haviv, Salomon M. Stemmer, Galia Blum, Emmanuelle Merquiol, Mariya Mardamshina, Sivan Kaminski Strauss, Gilgi Friedlander, Jair Bar, Iris Kamer, Yitzhak Reizel, Tamar Geiger, Yitzhak Pilpel, Yishai Levin, Amos Tanay, Baruch Barzel, Hadas Reuveni & Ravid Straussman. (2021) IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy. Nature Cancer 2:10, pages 1055-1070.
Crossref
Shuai Hao, Qiancheng Li, Yuanpu Liu, Fannian Li, Qi Yang, Jing Wang & Chengtao Wang. (2021) Insulin Receptor Substrate 1 Is Involved in the Phycocyanin-Mediated Antineoplastic Function of Non-Small Cell Lung Cancer Cells. Molecules 26:16, pages 4711.
Crossref
Vanessa Angonesi Zborowski, Suélen Osório Heck, Luiza Souza Marques, Nícolas Klummer Bastos & Cristina Wayne Nogueira. (2021) Memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and BDNF signaling pathways in prediabetic mice. Physiology & Behavior 237, pages 113346.
Crossref
Mayumi Nakahara, Homare Ito, John T Skinner, Qing Lin, Rasa Tamosiuniene, Mark R. Nicolls, Achsah Dorsey Keegan, Roger A. Johns & Kazuyo Yamaji-Kegan. (2021) The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions. American Journal of Physiology-Lung Cellular and Molecular Physiology.
Crossref
Yi-Fang Tu, Si-Tse Jiang, Chi-Wu Chiang, Li-Ching Chen & Chao-Ching Huang. (2021) Endothelial-specific insulin receptor substrate-1 overexpression worsens neonatal hypoxic-ischemic brain injury via mTOR-mediated tight junction disassembly. Cell Death Discovery 7:1.
Crossref
Mohammed H. Qusa, Khaldoun S. Abdelwahed, Abu Bakar Siddique & Khalid A. El Sayed. (2021) Comparative Gene Signature of (−)-Oleocanthal Formulation Treatments in Heterogeneous Triple Negative Breast Tumor Models: Oncological Therapeutic Target Insights. Nutrients 13:5, pages 1706.
Crossref
Jesús Burillo, Patricia Marqués, Beatriz Jiménez, Carlos González-Blanco, Manuel Benito & Carlos Guillén. (2021) Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease. Cells 10:5, pages 1236.
Crossref
Afshan Kaleem, Sabahat Javed, Nayab Rehman, Roheena Abdullah, Mehwish Iqtedar, Mohammad Nauman Aftab, Daniel C. Hoessli & Ikram-Ul Haq. (2021) Phosphorylated and O-GlcNAc Modified IRS-1 (Ser1101) and -2 (Ser1149) Contribute to Human Diabetes Type II. Protein & Peptide Letters 28:3, pages 333-339.
Crossref
Kamila Roszczyc-Owsiejczuk & Piotr Zabielski. (2021) Sphingolipids as a Culprit of Mitochondrial Dysfunction in Insulin Resistance and Type 2 Diabetes. Frontiers in Endocrinology 12.
Crossref
Marc Tatar. (2021) Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function. Frontiers in Endocrinology 12.
Crossref
Xiangming Xu, Jiao Nie, Lin Lu, Chao Du, Fansheng Meng & Duannuo Song. (2021) YAP‐TEAD up‐regulates IRS2 expression to induce and deteriorate oesophageal cancer. Journal of Cellular and Molecular Medicine 25:5, pages 2584-2595.
Crossref
Yujie Shi, Zhikun Ma, Qiong Cheng, Yudan Wu, Amanda B. Parris, Lingfei Kong & Xiaohe Yang. (2021) FGFR1 overexpression renders breast cancer cells resistant to metformin through activation of IRS1/ERK signaling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868:1, pages 118877.
Crossref
Adriana Monroy, Laura Gómez-Laguna, Carlos E. Aranda-Flores & Silvestre Alavez. 2020. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1 18 .
Iwona Bednarz-Misa, Mariusz A. Bromke & Małgorzata Krzystek-Korpacka. 2021. Tumor Microenvironment. Tumor Microenvironment 9 49 .
Chantal Hoi Yin Cheung, Chia-Lang Hsu, Tsai-Yu Lin, Wei-Ting Chen, Yi-Ching Wang, Hsuan-Cheng Huang & Hsueh-Fen Juan. (2020) ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer. Journal of Biomedical Science 27:1.
Crossref
Jaanis Lodjak & Simon Verhulst. (2020) Insulin-like growth factor 1 of wild vertebrates in a life-history context. Molecular and Cellular Endocrinology 518, pages 110978.
Crossref
Luyao Zhang, Xue Li, Nan Zhang, Xin Yang, Tianyun Hou, Wan Fu, Fengjie Yuan, Lina Wang, He Wen, Yuan Tian, Hongquan Zhang, Xifeng Lu & Wei-Guo Zhu. (2020) WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2. Diabetes 69:9, pages 1887-1902.
Crossref
Soonwoong Jung, Hyeonwi Son, Chung Eun Hwang, Kye Man Cho, Sang Won Park, Hwajin Kim & Hyun Joon Kim. (2020) The Root of Polygonum multiflorum Thunb. Alleviates Non-Alcoholic Steatosis and Insulin Resistance in High Fat Diet-Fed Mice. Nutrients 12:8, pages 2353.
Crossref
Masayoshi IshidaKohei TatsumiKatsumi OkumotoHiroshi Kaji. (2020) Adipose Tissue-Derived Stem Cell Sheet Improves Glucose Metabolism in Obese Mice. Stem Cells and Development 29:8, pages 488-497.
Crossref
Cemalettin KİSMİROĞLU, Serdar CENGİZ & Mustafa YAMAN. (2020) AMPK'nin Biyokimyası: Etki Mekanizmaları ve Diyabetin Tedavisindeki Önemi. European Journal of Science and Technology, pages 162-170.
Crossref
Yulan Zhao, Melanie Tran, Li Wang, Dong‐Ju Shin & Jianguo Wu. (2020) PDK4‐Deficiency Reprograms Intrahepatic Glucose and Lipid Metabolism to Facilitate Liver Regeneration in Mice. Hepatology Communications 4:4, pages 504-517.
Crossref
Liske M. Kotzé-Hörstmann & Hanél Sadie-Van Gijsen. (2020) Modulation of Glucose Metabolism by Leaf Tea Constituents: A Systematic Review of Recent Clinical and Pre-clinical Findings. Journal of Agricultural and Food Chemistry 68:10, pages 2973-3005.
Crossref
R. Chao, D. Li, Z. Yue, C. Huang, Y. Kou, Q. Zhou, Y. Gao, T. Hasegawa, J. Guo & M. Li. (2020) Interleukin-4 Restores Insulin Sensitivity in Insulin-Resistant Osteoblasts by Increasing the Expression of Insulin Receptor Substrate 1. Biochemistry (Moscow) 85:3, pages 334-343.
Crossref
Bruna Alves Fenerich, Jaqueline Cristina Fernandes, Ana Paula Nunes Rodrigues Alves, Juan Luiz Coelho-Silva, Renata Scopim-Ribeiro, Priscila Santos Scheucher, Christopher A. Eide, Cristina E. Tognon, Brian J. Druker, Eduardo Magalhães Rego, João Agostinho Machado-Neto & Fabiola Traina. (2020) NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells. Signal Transduction and Targeted Therapy 5:1.
Crossref
Lei YANG, Qizhuang LV, Jianyun LIU, Shikai QI & Denggang FU. (2020) miR-431 regulates granulosa cell function through the IRS2/PI3K/AKT signaling pathway. Journal of Reproduction and Development 66:3, pages 231-239.
Crossref
Yan Shi, Li Liu, Tsuyoshi Hamada, Jonathan A. Nowak, Marios Giannakis, Yanan Ma, Mingyang Song, Daniel Nevo, Keisuke Kosumi, Mancang Gu, Sun A. Kim, Teppei Morikawa, Kana Wu, Jing Sui, Kyriaki Papantoniou, Molin Wang, Andrew T. Chan, Charles S. Fuchs, Jeffrey A. Meyerhardt, Edward Giovannucci, Shuji Ogino, Eva S. Schernhammer, Reiko Nishihara & Xuehong Zhang. (2020) Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression . Cancer Epidemiology, Biomarkers & Prevention 29:1, pages 133-140.
Crossref
Akhlaq A. Farooqui. 2020. Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders. Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders 1 70 .
Tasuku Nishino, Kota Tamada, Akane Maeda, Takaya Abe, Hiroshi Kiyonari, Yasuhiro Funahashi, Kozo Kaibuchi, Toru Takumi & Hiroaki Konishi. (2019) Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain. Molecular Brain 12:1.
Crossref
Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Chiara C. Bortolasci, Ken Walder & Michael Berk. (2019) Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders. Neuroscience & Biobehavioral Reviews 107, pages 862-882.
Crossref
Taylor E. Novak, Sandra L. Rodriguez‐Zas, Bruce R. Southey, Jessica D. Starkey, Ricardo M. Stockler, Gastón F. Alfaro & Sonia J. Moisá. (2019) Jersey steer ruminal papillae histology and nutrigenomics with diet changes. Journal of Animal Physiology and Animal Nutrition 103:6, pages 1694-1707.
Crossref
Bhoomika M. Patel & Ramesh K. Goyal. (2019) Liver and insulin resistance: New wine in old bottle!!!. European Journal of Pharmacology 862, pages 172657.
Crossref
Ni Qiu, Yu-fang He, Si-ming Zhang, Yong-tao Zhan, Guo-dong Han, Ming Jiang, Wei-xing He, Jie Zhou, Hong-ling Liang, Xiang Ao, Hao-ming Xia, Jia Li, Yu-yang Yang, Zhi-min He, Zheng-zhi Zou & Hong-sheng Li. (2019) Cullin7 enhances resistance to trastuzumab therapy in Her2 positive breast cancer via degrading IRS-1 and downregulating IGFBP-3 to activate the PI3K/AKT pathway. Cancer Letters 464, pages 25-36.
Crossref
T. V. S. Tsosura, F. Y. Chiba, M. S. L. C. Mattera, R. F. Pereira, L. T. A. Cintra, L. C. Conti, R. M. dos Santos, J. H. P. Mateus, C. A. S. Garbin & D. H. Sumida. (2019) Maternal apical periodontitis is associated with insulin resistance in adult offspring. International Endodontic Journal 52:7, pages 1040-1050.
Crossref
Michael G. Sugiyama, Gregory D. Fairn & Costin N. Antonescu. (2019) Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling. Frontiers in Cell and Developmental Biology 7.
Crossref
Ayman Khalil & Antonious Al-Daoude. (2019) Fractionated whole body gamma irradiation modulates the hepatic response in type II diabetes of high fat diet model rats. Molecular Biology Reports 46:2, pages 2273-2283.
Crossref
Gokhan Gorgisen, Fatma Zehra Hapil, Ozlem Yilmaz, Zafer Cetin, Suray Pehlivanoglu, Irem Hicran Ozbudak, Abdullah Erdogan & Osman Nidai Ozes. (2019) Identification of novel mutations of Insulin Receptor Substrate 1 (IRS1) in tumor samples of non-small cell lung cancer (NSCLC): Implications for aberrant insulin signaling in development of cancer. Genetics and Molecular Biology 42:1, pages 15-25.
Crossref
Nur P. Damayanti, Justin A. Budka, Heba W.Z Khella, Mary W. Ferris, Sheng Yu Ku, Eric Kauffman, Anthony C. Wood, Khunsha Ahmed, Venkata Nithinsai Chintala, Remi Adelaiye-Ogala, May Elbanna, Ashley Orillion, Sreenivasulu Chintala, Chinghai Kao, W. Marston Linehan, George M. Yousef, Peter C. Hollenhorst & Roberto Pili. (2018) Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma. Clinical Cancer Research 24:23, pages 5977-5989.
Crossref
Kristina B. Emdal, Anna-Kathrine Pedersen, Dorte B. Bekker-JensenAlicia LundbyShana Claeys, Katleen De Preter, Frank SpelemanChiara Francavilla & Jesper V. Olsen. (2018) Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma. Science Signaling 11:557.
Crossref
Hyun Goo Kim, Sang Uk Woo, Hoon Yub Kim, Gil Soo Son, Jae Bok Lee, Jeong Won Bae, Ok Hee Woo, Dae Sik Yang, Jae Hong Seo & Ae-Ree Kim. (2018) The expression of insulin receptor substrate 1 and estrogen receptor as prognostic factor on breast cancer patient. Journal of Cancer Research and Therapeutics 14:Suppl 2, pages S494-S498.
Crossref
Gianluca Figlia, Daniel Gerber & Ueli Suter. (2018) Myelination and mTOR. Glia 66:4, pages 693-707.
Crossref
João Agostinho Machado-Neto, Bruna Alves Fenerich, Ana Paula Nunes Rodrigues Alves, Jaqueline Cristina Fernandes, Renata Scopim-Ribeiro, Juan Luiz Coelho-Silva & Fabiola Traina. (2018) Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis. Clinics 73, pages e566s.
Crossref
Lanjie LEI, Feng HAN, Qiuyan CUI, Weifang LIAO, Hui LIU, Gaopeng GUAN & Lei YANG. (2018) IRS2 depletion inhibits cell proliferation and decreases hormone secretion in mouse granulosa cells. Journal of Reproduction and Development 64:5, pages 409-416.
Crossref
Abigail K. Brown & Ashley E. Webb. 2018. Forkhead FOXO Transcription Factors in Development and Disease. Forkhead FOXO Transcription Factors in Development and Disease 165 192 .
K.S. Ramos, T. Camenisch & Q. He. 2018. Comprehensive Toxicology. Comprehensive Toxicology 664 679 .
K.S. Ramos, E. Reyes-Reyes & T.J. Weber. 2018. Comprehensive Toxicology. Comprehensive Toxicology 221 243 .
K.S. Ramos & P. Bojang. 2018. Comprehensive Toxicology. Comprehensive Toxicology 626 643 .
Zhiying Guo, Ming Zhao, Erin W. Howard, Qingxia Zhao, Amanda B. Parris, Zhikun Ma & Xiaohe Yang. (2017) Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway. Oncotarget 8:36, pages 60342-60357.
Crossref
Mei-Lin Wei, Peng Duan, Zhi-Ming Wang, Miao Ding & Ping Tu. (2017) High glucose and high insulin conditions promote MCF-7 cell proliferation and invasion by upregulating IRS1 and activating the Ras/Raf/ERK pathway. Molecular Medicine Reports 16:5, pages 6690-6696.
Crossref
Katarzyna Głombik, Joanna Ślusarczyk, Ewa Trojan, Katarzyna Chamera, Bogusława Budziszewska, Władysław Lasoń & Agnieszka Basta-Kaim. (2017) Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment. European Neuropsychopharmacology 27:2, pages 120-131.
Crossref
I. S. Stafeev, A. V. Vorotnikov, E. I. Ratner, M. Y. Menshikov & Ye. V. Parfyonova. (2017) Latent Inflammation and Insulin Resistance in Adipose Tissue. International Journal of Endocrinology 2017, pages 1-12.
Crossref
Sonja M. Kessler & Alexandra K. Kiemer. 2017. Mechanisms of Molecular Carcinogenesis – Volume 1. Mechanisms of Molecular Carcinogenesis – Volume 1 61 75 .
Heiner Koch, Mathias Wilhelm, Benjamin Ruprecht, Scarlet Beck, Martin Frejno, Susan Klaeger & Bernhard Kuster. (2016) Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells. Journal of Proteome Research 15:12, pages 4490-4504.
Crossref
Kendra K. Bence. 2016. Protein Tyrosine Phosphatases in Cancer. Protein Tyrosine Phosphatases in Cancer 307 333 .
G. Anjali, Surleen Kaur, Ruchi Lakra, Jyoti Taneja, Gaganjot S. Kalsey, Anjali Nagendra, T.G. Shrivastav, M. Gouri Devi, Neena Malhotra, Alka Kriplani & Rita Singh. (2015) FSH stimulates IRS-2 expression in human granulosa cells through cAMP/SP1, an inoperative FSH action in PCOS patients. Cellular Signalling 27:12, pages 2452-2466.
Crossref
Hamza Chettouh, Marie Lequoy, Laetitia Fartoux, Corinne Vigouroux & Christèle Desbois-Mouthon. (2015) Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma. Liver International 35:10, pages 2203-2217.
Crossref
Shanshan Gao, Chunli Duan, Ge Gao, Xiaoming Wang & Hui Yang. (2015) Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling. The International Journal of Biochemistry & Cell Biology 64, pages 25-33.
Crossref
Mychael V. Lourenco, Sergio T. Ferreira & Fernanda G. De Felice. (2015) Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes. Progress in Neurobiology 129, pages 37-57.
Crossref
H. Bobby Fokidis, Mei Yieng Chin, Victor W. Ho, Hans H. Adomat, Kiran K. Soma, Ladan Fazli, Ka Mun Nip, Michael Cox, Gerald Krystal, Amina Zoubeidi & Emma S. Tomlinson Guns. (2015) A low carbohydrate, high protein diet suppresses intratumoral androgen synthesis and slows castration-resistant prostate tumor growth in mice. The Journal of Steroid Biochemistry and Molecular Biology 150, pages 35-45.
Crossref
Antonio Mancini, Giuseppe Ettore Martorana, Marinella Magini, Roberto Festa, Sebastiano Raimondo, Andrea Silvestrini, Nicola Nicolotti, Alvaro Mordente, Maria Cristina Mele, Giacinto Abele Donato Miggiano & Elisabetta Meucci. (2015) Oxidative stress and metabolic syndrome: Effects of a natural antioxidants enriched diet on insulin resistance. Clinical Nutrition ESPEN 10:2, pages e52-e60.
Crossref
Peter Lanzerstorfer, Yosuke Yoneyama, Fumihiko Hakuno, Ulrike Müller, Otmar Höglinger, Shin‐Ichiro Takahashi & Julian Weghuber. (2015) Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces. The FEBS Journal 282:6, pages 987-1005.
Crossref
Sérgio Henrique Sousa Santos & Fernando Pablo Dominici. 2015. The Protective Arm of the Renin Angiotensin System (RAS). The Protective Arm of the Renin Angiotensin System (RAS) 249 254 .
Liyan Jiang, Wei Zhu, Katie Streicher, Chris Morehouse, Philip Brohawn, Xiaoxiao Ge, Zhengwei Dong, Xiaolu Yin, Guanshan Zhu, Yi Gu, Koustubh Ranade, Brandon W Higgs, Yihong Yao & Jiaqi Huang. (2014) Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma. BMC Cancer 14:1.
Crossref
Naokazu Ibuki, Mazyar Ghaffari, Hadas Reuveni, Mitali Pandey, Ladan Fazli, Haruhito Azuma, Martin E. Gleave, Alexander Levitzki & Michael E. Cox. (2014) The Tyrphostin NT157 Suppresses Insulin Receptor Substrates and Augments Therapeutic Response of Prostate Cancer. Molecular Cancer Therapeutics 13:12, pages 2827-2839.
Crossref
Qinhao Wang, Yi Ru, Daixing Zhong, Jing Zhang, Libo Yao & Xia Li. (2014) Engineered ubiquitin ligase PTB-U-box targets insulin/insulin-like growth factor receptor for degradation and coordinately inhibits cancer malignancy. Oncotarget 5:13, pages 4945-4958.
Crossref
Justine Landis & Leslie M. Shaw. (2014) Insulin Receptor Substrate 2-mediated Phosphatidylinositol 3-kinase Signaling Selectively Inhibits Glycogen Synthase Kinase 3β to Regulate Aerobic Glycolysis. Journal of Biological Chemistry 289:26, pages 18603-18613.
Crossref
Fernando P. Dominici, Valeria Burghi, Marina C. Muñoz & Jorge F. Giani. (2014) Modulation of the action of insulin by angiotensin-(1–7). Clinical Science 126:9, pages 613-630.
Crossref
Jing-bin Li, Li-jun Xu, Hui Dong, Zhao-yi Huang, Yan Zhao, Guang Chen & Fu-er Lu. (2013) Effects of Chinese Fructus Mume formula and its separated prescription extract on insulin resistance in type 2 diabetic rats. Journal of Huazhong University of Science and Technology [Medical Sciences] 33:6, pages 877-885.
Crossref
Jing Ding, Jie Tang, Xin Chen, Hai-Tao Men, Wu-Xia Luo, Yang Du, Jun Ge, Cong Li, Ye Chen, Ke Cheng, Meng Qiu & Ji-Yan Liu. (2013) Expression Characteristics of Proteins of the Insulin-like Growth Factor Axis in Non-small Cell Lung Cancer Patients with Preexisting Type 2 Diabetes Mellitus. Asian Pacific Journal of Cancer Prevention 14:10, pages 5675-5680.
Crossref
Tomonori Taniguchi, Shigeru Tanaka, Ayumi Ishii, Miyuki Watanabe, Noriko Fujitani, Ayusa Sugeo, Shuhei Gotoh, Takeshi Ohta, Mineyoshi Hiyoshi, Hideki Matsuzaki, Norio Sakai & Hiroaki Konishi. (2013) A Brain-specific Grb2-associated Regulator of Extracellular Signal-regulated Kinase (Erk)/Mitogen-activated Protein Kinase (MAPK) (GAREM) Subtype, GAREM2, Contributes to Neurite Outgrowth of Neuroblastoma Cells by Regulating Erk Signaling. Journal of Biological Chemistry 288:41, pages 29934-29942.
Crossref
Hamza Chettouh, Laetitia Fartoux, Lynda Aoudjehane, Dominique Wendum, Audrey Clapéron, Yves Chrétien, Colette Rey, Olivier Scatton, Olivier Soubrane, Filomena Conti, Françoise Praz, Chantal Housset, Olivier Rosmorduc & Christèle Desbois-Mouthon. (2013) Mitogenic Insulin Receptor-A Is Overexpressed in Human Hepatocellular Carcinoma due to EGFR-Mediated Dysregulation of RNA Splicing Factors. Cancer Research 73:13, pages 3974-3986.
Crossref
Filip Janku, Helen J. Huang, Laura S. Angelo & Razelle Kurzrock. (2013) A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R): Implications for Inhibition of the IGF-1R signal. Oncotarget 4:3, pages 463-473.
Crossref
Colin E. ChampRenato Baserga, Mark V. MishraLianjin JinFederica Sotgia, Michael P. Lisanti, Richard G. Pestell, Adam P. DickerNicole L. Simone. (2013) Nutrient Restriction and Radiation Therapy for Cancer Treatment: When Less Is More. The Oncologist 18:1, pages 97-103.
Crossref
Albert E. Berman, Olga V. Leontieva, Venkatesh Natarajan, James A. McCubrey, Zoya N. Demidenko & Mikhail A. Nikiforov. (2012) Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget 3:12, pages 1522-1532.
Crossref
Martin Heni, Jörg Hennenlotter, Marcus Scharpf, Stefan Z. Lutz, Christian Schwentner, Tilman Todenhöfer, David Schilling, Ursula Kühs, Valentina Gerber, Fausto Machicao, Harald Staiger, Hans-Ulrich Häring & Arnulf Stenzl. (2012) Insulin Receptor Isoforms A and B as well as Insulin Receptor Substrates-1 and -2 Are Differentially Expressed in Prostate Cancer. PLoS ONE 7:12, pages e50953.
Crossref
Edoardo Mannucci. (2012) Insulin Therapy and Cancer in Type 2 Diabetes. ISRN Endocrinology 2012, pages 1-12.
Crossref
Olgica Nedić, Dragana Lagundžin & Romana Masnikosa. (2012) Posttranslational modifications of the insulin-like growth factor-binding protein 3 in patients with type 2 diabetes mellitus assessed by affinity chromatography. Journal of Chromatography B 904, pages 93-98.
Crossref
Adedayo A. Onitilo, Jessica M. Engel, Ingrid Glurich, Rachel V. Stankowski, Gail M. Williams & Suhail A. Doi. (2012) Diabetes and cancer II: role of diabetes medications and influence of shared risk factors. Cancer Causes & Control 23:7, pages 991-1008.
Crossref
Spike D. L. Postnikoff, Mackenzie E. Malo, Berchman Wong & Troy A. A. Harkness. (2012) The Yeast Forkhead Transcription Factors Fkh1 and Fkh2 Regulate Lifespan and Stress Response Together with the Anaphase-Promoting Complex. PLoS Genetics 8:3, pages e1002583.
Crossref
Jerry R GreenfieldAnn I McCormack. (2012) Medication to prevent breast cancer — too much to swallow?. Medical Journal of Australia 196:5, pages 314-314.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.