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Linear polyubiquitin chains

A new modifier involved in NFκB activation and chronic inflammation, including dermatitis

Pages 3095-3104 | Received 21 Jul 2011, Accepted 25 Jul 2011, Published online: 15 Sep 2011

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Satoshi Shimizu, Hiroaki Fujita, Yoshiteru Sasaki, Tatsuaki Tsuruyama, Kazuhiko Fukuda & Kazuhiro Iwai. (2016) Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection. Molecular and Cellular Biology 36:10, pages 1569-1583.
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Articles from other publishers (30)

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Jaanam Gopalakrishnan, Kandice L. Tessneer, Yao Fu, Satish Pasula, Richard C. Pelikan, Jennifer A. Kelly, Graham B. Wiley & Patrick M. Gaffney. (2021) Variants on the UBE2L3 / YDJC Autoimmune Disease Risk Haplotype Increase UBE2L3 Expression by Modulating CCCTC‐Binding Factor and YY1 Binding . Arthritis & Rheumatology 74:1, pages 163-173.
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Flaviana Marzano, Luisa Guerrini, Graziano Pesole, Elisabetta Sbisà & Apollonia Tullo. (2021) Emerging Roles of TRIM8 in Health and Disease. Cells 10:3, pages 561.
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Hui-Chun Yu, Kuang-Yung Huang, Ming-Chi Lu, Hsien-Yu Huang Tseng, Su-Qin Liu, Ning-Sheng Lai & Hsien-Bin Huang. (2021) Down-Regulation of LOC645166 in T Cells of Ankylosing Spondylitis Patients Promotes the NF-κB Signaling via Decreasingly Blocking Recruitment of the IKK Complex to K63-Linked Polyubiquitin Chains. Frontiers in Immunology 12.
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Annette Aichem & Marcus Groettrup. (2020) The ubiquitin-like modifier FAT10 – much more than a proteasome-targeting signal. Journal of Cell Science 133:14.
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Yuepeng Zang, Yingya Gong, Qian Wang, Huiping Guo & Wei Xiao. (2019) Arabidopsis OTU 1, a linkage‐specific deubiquitinase, is required for endoplasmic reticulum ‐associated protein degradation . The Plant Journal 101:1, pages 141-155.
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Lingjie Tang, Jiaman Wang, Jingna Zhu & Yanhua Liang. (2018) Down‐regulated SHARPIN may accelerate the development of atopic dermatitis through activating interleukin‐33/ ST 2 signalling . Experimental Dermatology 27:12, pages 1328-1335.
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Natalia D. Magnani, Laura A. Dada & Jacob I. Sznajder. (2018) Ubiquitin-proteasome signaling in lung injury. Translational Research 198, pages 29-39.
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Zhengkui Zhang, Yao Fan, Feng Xie, Hang Zhou, Ke Jin, Li Shao, Wenhao Shi, Pengfei Fang, Bing Yang, Hans van Dam, Peter ten Dijke, Xiaofeng Zheng, Xiaohua Yan, Junling Jia, Min Zheng, Jin Jin, Chen Ding, Sheng Ye, Fangfang Zhou & Long Zhang. (2017) Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. Nature Communications 8:1.
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O. A. Buneeva & A. E. Medvedev. (2017) The role of atypical ubiquitination in cell regulation. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 11:1, pages 16-31.
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O.A. Buneeva & A.E. Medvedev. (2016) Atypical ubiquitination of proteins. Biomeditsinskaya Khimiya 62:5, pages 496-509.
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Madalina-Viviana Nastase, Jinyang Zeng-Brouwers, Helena Frey, Louise Tzung-Harn Hsieh, Chiara Poluzzi, Janet Beckmann, Nina Schroeder, Josef Pfeilschifter, Jaime Lopez-Mosqueda, Jan Mersmann, Fumiyo Ikeda, Renato V. Iozzo, Ivan Dikic & Liliana Schaefer. (2016) An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis. The American Journal of Pathology 186:5, pages 1206-1220.
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Daniel Rösner, Tatjana Schneider, Daniel Schneider, Martin Scheffner & Andreas Marx. (2015) Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation. Nature Protocols 10:10, pages 1594-1611.
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Jason De Melo & Damu Tang. (2015) Elevation of SIPL1 (SHARPIN) Increases Breast Cancer Risk. PLOS ONE 10:5, pages e0127546.
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Tatjana Schneider, Daniel Schneider, Daniel Rösner, Saurav Malhotra, Franziska Mortensen, Thomas U. Mayer, Martin Scheffner & Andreas Marx. (2014) Dissecting Ubiquitin Signaling with Linkage-Defined and Protease Resistant Ubiquitin Chains. Angewandte Chemie International Edition 53:47, pages 12925-12929.
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Tatjana Schneider, Daniel Schneider, Daniel Rösner, Saurav Malhotra, Franziska Mortensen, Thomas U. Mayer, Martin Scheffner & Andreas Marx. (2014) Analyse des Ubiquitincodes durch proteasebeständige Ubiquitinketten mit definierter Verknüpfung. Angewandte Chemie 126:47, pages 13139-13143.
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Yiming Zhang, Hai Huang, Huimin Zhou, Tao Du, Lexiang Zeng, Yi Cao, Jieqing Chen, Yiming Lai, Jin Li, Ganping Wang & Zhenghui Guo. (2014) Activation of nuclear factor κB pathway and downstream targets survivin and livin by SHARPIN contributes to the progression and metastasis of prostate cancer. Cancer 120:20, pages 3208-3218.
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Markus A. Queisser, Laura A. Dada, Nimrod Deiss-Yehiely, Martin Angulo, Guofei Zhou, Fotini M. Kouri, Lawrence M. Knab, Jing Liu, Alexander H. Stegh, Malcolm M. DeCamp, G. R. Scott Budinger, Navdeep S. Chandel, Aaron Ciechanover, Kazuhiro Iwai & Jacob I. Sznajder. (2014) HOIL-1L Functions as the PKCζ Ubiquitin Ligase to Promote Lung Tumor Growth. American Journal of Respiratory and Critical Care Medicine 190:6, pages 688-698.
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Ramalingam Radjacommare, Raju Usharani, Chih-Horng Kuo & Hongyong Fu. (2014) Distinct phylogenetic relationships and biochemical properties of Arabidopsis ovarian tumor-related deubiquitinases support their functional differentiation. Frontiers in Plant Science 5.
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T. Holm, D. Rutishauser, Y. Kai‐Larsen, Y. Lyutvinskiy, F. Stenius, R. A. Zubarev, B. Agerberth, J. Alm & A. Scheynius. (2013) Protein biomarkers in vernix with potential to predict the development of atopic eczema in early childhood. Allergy 69:1, pages 104-112.
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Kazuhiro Iwai. (2014) Diverse roles of the ubiquitin system in NF-κB activation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:1, pages 129-136.
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Tycho E.T. Mevissen, Manuela K. Hospenthal, Paul P. Geurink, Paul R. Elliott, Masato Akutsu, Nadia Arnaudo, Reggy Ekkebus, Yogesh Kulathu, Tobias Wauer, Farid El Oualid, Stefan M.V. Freund, Huib Ovaa & David Komander. (2013) OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis. Cell 154:1, pages 169-184.
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Elena Rivkin, Stephanie M. Almeida, Derek F. Ceccarelli, Yu-Chi Juang, Teresa A. MacLean, Tharan Srikumar, Hao Huang, Wade H. Dunham, Ryutaro Fukumura, Gang Xie, Yoichi Gondo, Brian Raught, Anne-Claude Gingras, Frank Sicheri & Sabine P. Cordes. (2013) The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature 498:7454, pages 318-324.
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Manuela K Hospenthal, Stefan M V Freund & David Komander. (2013) Assembly, analysis and architecture of atypical ubiquitin chains. Nature Structural & Molecular Biology 20:5, pages 555-565.
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Yu Ye, Georg Blaser, Mathew H. Horrocks, Maria J. Ruedas-Rama, Shehu Ibrahim, Alexander A. Zhukov, Angel Orte, David Klenerman, Sophie E. Jackson & David Komander. (2012) Ubiquitin chain conformation regulates recognition and activity of interacting proteins. Nature 492:7428, pages 266-270.
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Zhe Wang, Christopher S. Potter, John P. Sundberg & Harm Hogenesch. (2012) SHARPIN is a key regulator of immune and inflammatory responses. Journal of Cellular and Molecular Medicine 16:10, pages 2271-2279.
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James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria C. Mazzarino, Saverio Candido, Massimo Libra, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini & Alberto M. Martelli. (2012) Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response.. Oncotarget 3:9, pages 954-987.
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Kazuhiro Iwai. (2012) Diverse ubiquitin signaling in NF-κB activation. Trends in Cell Biology 22:7, pages 355-364.
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Han Liu, Sylvie Urbé & Michael J. Clague. (2012) Selective protein degradation in cell signalling. Seminars in Cell & Developmental Biology 23:5, pages 509-514.
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Kirstin Keusekotten & David Komander. (2012) New Tools for Ubiquitin Signaling. Journal of Molecular Biology 418:3-4, pages 129-130.
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