984
Views
53
CrossRef citations to date
0
Altmetric
Report

p27Kip1 is required to maintain proliferative quiescence in the adult cochlea and pituitary

Pages 1237-1248 | Received 21 Feb 2011, Accepted 25 Feb 2011, Published online: 15 Apr 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Alessandra Rossetti, Francesco Petragnano, Luisa Milazzo, Francesca Vulcano, Giampiero Macioce, Silvia Codenotti, Matteo Cassandri, Silvia Pomella, Francesca Cicchetti, Irene Fasciani, Cristina Antinozzi, Luigi Di Luigi, Claudio Festuccia, Francesca De Felice, Massimo Vergine, Alessandro Fanzani, Rossella Rota, Roberto Maggio, Antonella Polimeni, Vincenzo Tombolini, Giovanni Luca Gravina & Francesco Marampon. (2021) Romidepsin (FK228) fails in counteracting the transformed phenotype of rhabdomyosarcoma cells but efficiently radiosensitizes, in vitro and in vivo, the alveolar phenotype subtype. International Journal of Radiation Biology 97:7, pages 943-957.
Read now
Cristina E. Pasi & Pier Giuseppe Pelicci. (2011) Inhibition of epithelial-to-mesenchimal transition. Cell Cycle 10:16, pages 2616-2616.
Read now

Articles from other publishers (51)

Liyan Zhang, Yuan Fang, Fangzhi Tan, Fangfang Guo, Ziyu Zhang, Nianci Li, Qiuhan Sun, Jieyu Qi & Renjie Chai. (2023) AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea. Cellular and Molecular Life Sciences 80:4.
Crossref
Jacob B. Swadling, Tobias Warnecke, Kyle L. Morris & Alexis R. Barr. (2022) Conserved Cdk inhibitors show unique structural responses to tyrosine phosphorylation. Biophysical Journal 121:12, pages 2312-2329.
Crossref
Deborah Pajalunga & Marco Crescenzi. (2021) Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle Myotubes. Cells 10:10, pages 2753.
Crossref
Ángela García-Mato, Blanca Cervantes, Silvia Murillo-Cuesta, Lourdes Rodríguez-de la Rosa & Isabel Varela-Nieto. (2021) Insulin-like Growth Factor 1 Signaling in Mammalian Hearing. Genes 12:10, pages 1553.
Crossref
Jiadong Xu, Dongliang Yu, Xuhui Dong, Xiaoling Xie, Mei Xu, Luming Guo, Liang Huang, Qi Tang & Lin Gan. (2021) GATA3 maintains the quiescent state of cochlear supporting cells by regulating p27kip1. Scientific Reports 11:1.
Crossref
A.C. Batissoco, K. Lezirovitz, D.B. Zanatta, C.R.M.L. Hemza, L.R. Vasques, B.E. Strauss, R.C. Mingroni-Netto, L.A. Haddad, R.F. Bento & J. Oiticica. (2021) Cochlea cell-specific marker expression upon in vitro Hes1 knockdown. Brazilian Journal of Medical and Biological Research 54:7.
Crossref
Marta Roccio, Pascal Senn & Stefan Heller. (2020) Novel insights into inner ear development and regeneration for targeted hearing loss therapies. Hearing Research 397, pages 107859.
Crossref
ElShaddai Z. White, Nakea M. Pennant, Jada R. Carter, Ohuod Hawsawi, Valerie Odero-Marah & Cimona V. Hinton. (2020) Serum deprivation initiates adaptation and survival to oxidative stress in prostate cancer cells. Scientific Reports 10:1.
Crossref
Yuu Kimata, Maïté Leturcq & Rajaguru Aradhya. (2020) Emerging roles of metazoan cell cycle regulators as coordinators of the cell cycle and differentiation. FEBS Letters 594:13, pages 2061-2083.
Crossref
Vilte Stonyte, Ruth Martín, Dario Segura-Peña, Nikolina Sekulić & Sandra Lopez-Aviles. (2020) Requirement of PP2A-B56Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/CSte9 during Pre-Start G1 in S. pombe. iScience 23:5, pages 101063.
Crossref
Michael Hoa, Rafal Olszewski, Xiaoyi Li, Ian Taukulis, Shoujun Gu, Alvin DeTorres, Ivan A. Lopez, Fred H. Linthicum Jr.Akira Ishiyama, Daniel Martin, Robert J. Morell & Matthew W. Kelley. (2020) Characterizing Adult Cochlear Supporting Cell Transcriptional Diversity Using Single-Cell RNA-Seq: Validation in the Adult Mouse and Translational Implications for the Adult Human Cochlea. Frontiers in Molecular Neuroscience 13.
Crossref
Muhammad Waqas & Renjie Chai. 2020. New Therapies to Prevent or Cure Auditory Disorders. New Therapies to Prevent or Cure Auditory Disorders 89 111 .
Yilai Shu, Wenyan Li, Mingqian Huang, Yi-Zhou Quan, Deborah Scheffer, Chunjie Tian, Yong Tao, Xuezhong Liu, Konrad Hochedlinger, Artur A. Indzhykulian, Zhengmin Wang, Huawei Li & Zheng-Yi Chen. (2019) Renewed proliferation in adult mouse cochlea and regeneration of hair cells. Nature Communications 10:1.
Crossref
Sebastián A. Silva & Juan C. Maass. (2019) p27Kip1 down-regulation as achieved by two clinically feasible means did not induce proliferation of supporting cells in the rat neonatal cochlea in vivo. Hearing Research 373, pages 10-22.
Crossref
Melissa M. McGovern, Michelle R. Randle, Candice L. Cuppini, Kaley A. Graves & Brandon C. Cox. (2019) Multiple supporting cell subtypes are capable of spontaneous hair cell regeneration in the neonatal mouse cochlea. Development 146:4.
Crossref
Swaathi Jayaraman, Shirisha Chittiboyina, Yunfeng Bai, Patricia C. Abad, Pierre-Alexandre Vidi, Cynthia V. Stauffacher & Sophie A. Lelièvre. (2017) The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner. Nucleic Acids Research 45:20, pages 11725-11742.
Crossref
Fei Zheng & Jian Zuo. (2017) Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development?. Hearing Research 349, pages 182-196.
Crossref
Cheng Cheng, Luo Guo, Ling Lu, Xiaochen Xu, ShaSha Zhang, Junyan Gao, Muhammad Waqas, Chengwen Zhu, Yan Chen, Xiaoli Zhang, Chuanying Xuan, Xia Gao, Mingliang Tang, Fangyi Chen, Haibo Shi, Huawei Li & Renjie Chai. (2017) Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea. Frontiers in Molecular Neuroscience 10.
Crossref
Karen E. Weis & Lori T. Raetzman. (2016) Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function. Toxicology and Applied Pharmacology 313, pages 204-214.
Crossref
Juan Cristóbal Maass, Francisca Hanuch & Macarena Ormazábal. (2016) AVANCES EN REGENERACIÓN AUDITIVA. ESTADO ACTUAL Y PERSPECTIVAS FUTURAS. Revista Médica Clínica Las Condes 27:6, pages 812-818.
Crossref
Muhammad Waqas, Shasha Zhang, Zuhong He, Mingliang Tang & Renjie Chai. (2016) Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea. Frontiers of Medicine 10:3, pages 237-249.
Crossref
Magdalena Żak, Thijs van Oort, Ferry G. Hendriksen, Marie-Isabelle Garcia, Gilbert Vassart & Wilko Grolman. (2016) LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea. Frontiers in Cellular Neuroscience 10.
Crossref
Lingling Jiang, Ran Jin, Jincao Xu, Yubin Ji, Meiguang Zhang, Xuebo Zhang, Xinwen Zhang, Zhongming Han & Shaoju Zeng. (2016) Hair cell regeneration or the expression of related factors that regulate the fate specification of supporting cells in the cochlear ducts of embryonic and posthatch chickens. Hearing Research 332, pages 17-28.
Crossref
Xiaoling Lu, Yilai Shu, Mingliang Tang & Huawei Li. (2016) Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation. Neural Plasticity 2016, pages 1-9.
Crossref
Bradley J. Walters, Tetsuji Yamashita & Jian Zuo. (2015) Sox2-CreER mice are useful for fate mapping of mature, but not neonatal, cochlear supporting cells in hair cell regeneration studies. Scientific Reports 5:1.
Crossref
Li Wang, Kaiqing Zhang, Helen He Zhu & Wei-Qiang Gao. (2015) Autonomous assembly of epithelial structures by subrenal implantation of dissociated embryonic inner-ear cells. NeuroReport 26:8, pages 473-477.
Crossref
Patrick J. Atkinson, Elvis Huarcaya Najarro, Zahra N. Sayyid & Alan G. Cheng. (2015) Sensory hair cell development and regeneration: similarities and differences. Development 142:9, pages 1561-1571.
Crossref
Yang Song, Yonghong Zhang, Haoxiang Jiang, Yanting Zhu, Lu Liu, Wei Feng, Lan Yang, Yibin Wang & Manxiang Li. (2015) Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway. FEBS Open Bio 5:1, pages 656-660.
Crossref
Bradley J. Walters, Zhiyong Liu, Mark Crabtree, Emily Coak, Brandon C. Cox & Jian Zuo. (2014) Auditory Hair Cell-Specific Deletion of p27 Kip1 in Postnatal Mice Promotes Cell-Autonomous Generation of New Hair Cells and Normal Hearing . The Journal of Neuroscience 34:47, pages 15751-15763.
Crossref
Quanwen Liu, Ping Chen & Jinfu Wang. (2014) Molecular mechanisms and potentials for differentiating inner ear stem cells into sensory hair cells. Developmental Biology 390:2, pages 93-101.
Crossref
Linjia Jiang, Andres Romero-Carvajal, Jeff S. Haug, Christopher W. Seidel & Tatjana Piotrowski. (2014) Gene-expression analysis of hair cell regeneration in the zebrafish lateral line. Proceedings of the National Academy of Sciences 111:14.
Crossref
Brandon J. Walters, Wenwei Lin, Shiyong Diao, Mark Brimble, Luigi I. Iconaru, Jennifer Dearman, Asli Goktug, Taosheng Chen & Jian Zuo. (2014) High-Throughput Screening Reveals Alsterpaullone, 2-Cyanoethyl as a Potent p27Kip1 Transcriptional Inhibitor. PLoS ONE 9:3, pages e91173.
Crossref
Konstantinos Sousounis, Joelle A. Baddour & Panagiotis A. Tsonis. 2014. Mechanisms of Regeneration. Mechanisms of Regeneration 217 246 .
Tomoko Tateya. 2014. Regenerative Medicine for the Inner Ear. Regenerative Medicine for the Inner Ear 101 113 .
Azel Zine, Hubert Löwenheim & Bernd Fritzsch. 2014. Adult Stem Cells. Adult Stem Cells 111 161 .
Fuxin Shi, Lingxiang Hu & Albert S. B. Edge. (2013) Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors. Proceedings of the National Academy of Sciences 110:34, pages 13851-13856.
Crossref
Juan C. Maass, F. Andrés Berndt, José Cánovas & Manuel Kukuljan. (2013) p27Kip1 Knockdown Induces Proliferation in the Organ of Corti in Culture after Efficient shRNA Lentiviral Transduction. Journal of the Association for Research in Otolaryngology 14:4, pages 495-508.
Crossref
Sibgat Choudhury, Vanessa Almendro, Vanessa F. Merino, Zhenhua Wu, Reo Maruyama, Ying Su, Filipe C. Martins, Mary Jo Fackler, Marina Bessarabova, Adam Kowalczyk, Thomas Conway, Bryan Beresford-Smith, Geoff Macintyre, Yu-Kang Cheng, Zoila Lopez-Bujanda, Antony Kaspi, Rong Hu, Judith Robens, Tatiana Nikolskaya, Vilde D. Haakensen, Stuart J. Schnitt, Pedram Argani, Gabrielle Ethington, Laura Panos, Michael Grant, Jason Clark, William Herlihy, S. Joyce Lin, Grace Chew, Erik W. Thompson, April Greene-Colozzi, Andrea L. Richardson, Gedge D. Rosson, Malcolm Pike, Judy E. Garber, Yuri Nikolsky, Joanne L. Blum, Alfred Au, E. Shelley Hwang, Rulla M. Tamimi, Franziska Michor, Izhak Haviv, X. Shirley Liu, Saraswati Sukumar & Kornelia Polyak. (2013) Molecular Profiling of Human Mammary Gland Links Breast Cancer Risk to a p27+ Cell Population with Progenitor Characteristics. Cell Stem Cell 13:1, pages 117-130.
Crossref
Thomas Schimmang & Ulla Pirvola. (2013) Coupling the cell cycle to development and regeneration of the inner ear. Seminars in Cell & Developmental Biology 24:5, pages 507-513.
Crossref
Ting-Ting Chao, Chih-Hung Wang, Hsin-Chien Chen, Cheng-Ping Shih, Huey-Kang Sytwu, Kun-Lun Huang & Shao-Yuan Chen. (2013) Adherent culture conditions enrich the side population obtained from the cochlear modiolus-derived stem/progenitor cells. International Journal of Pediatric Otorhinolaryngology 77:5, pages 779-784.
Crossref
Joseph C. Burns & Jeffrey T. Corwin. (2013) A historical to present-day account of efforts to answer the question: “What puts the brakes on mammalian hair cell regeneration?”. Hearing Research 297, pages 52-67.
Crossref
Edwin W. Rubel, Stephanie A. Furrer & Jennifer S. Stone. (2013) A brief history of hair cell regeneration research and speculations on the future. Hearing Research 297, pages 42-51.
Crossref
Elizabeth C. Oesterle. (2013) Changes in the adult vertebrate auditory sensory epithelium after trauma. Hearing Research 297, pages 91-98.
Crossref
Bradley J. Walters & Jian Zuo. (2013) Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration. Hearing Research 297, pages 68-83.
Crossref
Benjamin J. Kopecky, Israt Jahan & Bernd Fritzsch. (2013) Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability. Developmental Dynamics 242:2, pages 132-147.
Crossref
Joel Sng & Thomas Lufkin. (2012) Filling the Silent Void: Genetic Therapies for Hearing Impairment. Genetics Research International 2012, pages 1-9.
Crossref
Joseph C. Burns, James J. Yoo, Anthony Atala & John D. Jackson. (2012) MYC Gene Delivery to Adult Mouse Utricles Stimulates Proliferation of Postmitotic Supporting Cells In Vitro. PLoS ONE 7:10, pages e48704.
Crossref
Ning Pan, Benjamin Kopecky, Israt Jahan & Bernd Fritzsch. (2012) Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation. Cell and Tissue Research 349:2, pages 415-432.
Crossref
Brandon C. Cox, Zhiyong Liu, Marcia M. Mellado Lagarde & Jian Zuo. (2012) Conditional Gene Expression in the Mouse Inner Ear Using Cre-loxP. Journal of the Association for Research in Otolaryngology 13:3, pages 295-322.
Crossref
Pamela Monahan, Ashley D. Himes, Agata Parfieniuk & Lori T. Raetzman. (2012) p21, an important mediator of quiescence during pituitary tumor formation, is dispensable for normal pituitary development during embryogenesis. Mechanisms of Development 128:11-12, pages 640-652.
Crossref
Olivia Bermingham-McDonogh & Thomas A. Reh. (2011) Regulated Reprogramming in the Regeneration of Sensory Receptor Cells. Neuron 71:3, pages 389-405.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.