1,503
Views
55
CrossRef citations to date
0
Altmetric
Report

Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis

, , , , , , , , , , , & show all
Pages 2348-2358 | Published online: 15 Jun 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Yumeng Zhao, Xiaojie Zhang, Min An, Juntao Zhang & Yanhua Liu. (2023) Recent advancements in nanomedicine based lipid metabolism for tumour immunotherapy. Journal of Drug Targeting 31:10, pages 1050-1064.
Read now
Antonin Lamaziere, Claude Wolf & Peter J Quinn. (2014) How lipidomics provides new insight into drug discovery. Expert Opinion on Drug Discovery 9:7, pages 819-836.
Read now

Articles from other publishers (53)

Qing Zhou, Deshui Kong, Wenzhi Li, Zhengzheng Shi, Yao Liu, Rui Sun, Xiaohong Ma, Chunping Qiu, Zhiming Liu, Yixin Hou & Jie Jiang. (2023) LncRNA HOXB-AS3 binding to PTBP1 protein regulates lipid metabolism by targeting SREBP1 in endometrioid carcinoma. Life Sciences 320, pages 121512.
Crossref
Lianhua Wang, Qiyang Shi & Shaorong Chen. (2022) FoxM1 contributes to progestin resistance and epithelial-to-mesenchymal transition in endometrial carcinoma. Molecular & Cellular Toxicology 19:2, pages 229-236.
Crossref
Yunkuo Li, Shouwang Wu, Xiaodong Zhao, Shiming Hao, Faping Li, Yuxiong Wang, Bin Liu, Difei Zhang, Yishu Wang & Honglan Zhou. (2023) Key events in cancer: Dysregulation of SREBPs. Frontiers in Pharmacology 14.
Crossref
Om Saswat Sahoo, Karthikeyan Pethusamy, Tryambak P. Srivastava, Joyeeta Talukdar, Mohammed S. Alqahtani, Mohamed Abbas, Ruby Dhar & Subhradip Karmakar. (2022) The metabolic addiction of cancer stem cells. Frontiers in Oncology 12.
Crossref
Sheng-Dean Luo, Hsin-Ting Tsai, Tai-Jan Chiu, Shau-Hsuan Li, Ya-Ling Hsu, Li-Jen Su, Meng-Hsiu Tsai, Ching-Yi Lee, Chang-Chun Hsiao & Chang-Han Chen. (2022) Leptin Silencing Attenuates Lipid Accumulation through Sterol Regulatory Element-Binding Protein 1 Inhibition in Nasopharyngeal Carcinoma. International Journal of Molecular Sciences 23:10, pages 5700.
Crossref
Yumi Kim, Wona Jee, Eun-Jin An, Hyun Min Ko, Ji Hoon Jung, Yun-Cheol Na & Hyeung-Jin Jang. (2022) Timosaponin A3 Inhibits Palmitate and Stearate through Suppression of SREBP-1 in Pancreatic Cancer. Pharmaceutics 14:5, pages 945.
Crossref
Peter S. Coleman & Risa A. Parlo. (2022) Cancer’s camouflage: Microvesicle shedding from cholesterol-rich tumor plasma membranes might blindfold first-responder immunosurveillance strategies. European Journal of Cell Biology 101:2, pages 151219.
Crossref
Peter Micallef, Yanling Wu, Marco Bauzá-Thorbrügge, Belén Chanclón, Milica Vujičić, Eduard Peris, C. Joakim Ek & Ingrid Wernstedt Asterholm. (2021) Adipose Tissue—Breast Cancer Crosstalk Leads to Increased Tumor Lipogenesis Associated with Enhanced Tumor Growth. International Journal of Molecular Sciences 22:21, pages 11881.
Crossref
Xiaohong Ma, Tianyi Zhao, Hong Yan, Kui Guo, Zhiming Liu, Lina Wei, Wei Lu, Chunping Qiu & Jie Jiang. (2021) Fatostatin reverses progesterone resistance by inhibiting the SREBP1-NF-κB pathway in endometrial carcinoma. Cell Death & Disease 12:6.
Crossref
Qiong Wang, Ruofan Hu, Weihua Li, Yanhong Tai, Weiting Gu, Bhaskar C. Das, Fajun Yang, Junyuan Ji, Chenguang Wang & Jie Zhou. (2021) BF175 inhibits endometrial carcinoma through SREBP-regulated metabolic pathways in vitro. Molecular and Cellular Endocrinology 523, pages 111135.
Crossref
Tomas Koltai, Stephan J. Reshkin, Fátima Baltazar & Larry Fliegel. 2021. Prostate Cancer Metabolism. Prostate Cancer Metabolism 71 135 .
Gui-Li Xu, Cai-Fang Ni, Han-Si Liang, Yun-Hua Xu, Wan-Sheng Wang, Jian Shen, Ming-Ming Li & Xiao-Li Zhu. (2020) Upregulation of PD-L1 expression promotes epithelial-to-mesenchymal transition in sorafenib-resistant hepatocellular carcinoma cells. Gastroenterology Report 8:5, pages 390-398.
Crossref
Lan Yao, Shucheng Chen & Wansheng Li. (2020) Fatostatin inhibits the development of endometrial carcinoma in endometrial carcinoma cells and a xenograft model by targeting lipid metabolism. Archives of Biochemistry and Biophysics 684, pages 108327.
Crossref
Cuilin Li, Xiaowei Peng, Jing Lv, Hecun Zou, Jianqiu Liu, Ke Zhang & Zhi Li. (2020) SREBP1 as a potential biomarker predicts levothyroxine efficacy of differentiated thyroid cancer. Biomedicine & Pharmacotherapy 123, pages 109791.
Crossref
Xiangjin Meng, Xin Guo, Jing Zhang, Junji Moriya, Junji Kobayashi, Reimon Yamaguchi & Sohsuke Yamada. (2019) Acupuncture on ST36, CV4 and KI1 Suppresses the Progression of Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in Mice. Metabolites 9:12, pages 299.
Crossref
Kexin Shen, Zhe Cao, Ruizhe Zhu, Lei You & Taiping Zhang. (2019) The dual functional role of MicroRNA‐18a (miR‐18a) in cancer development. Clinical and Translational Medicine 8:1.
Crossref
Wenzhi Li, Shufen Wang, Chunping Qiu, Zhiming Liu, Qing Zhou, Deshui Kong, Xiaohong Ma & Jie Jiang. (2019) Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line. Journal of Translational Medicine 17:1.
Crossref
Domenica Roberto, Shamini Selvarajah, Paul C. Park, David Berman & Vasundara Venkateswaran. (2019) Functional validation of metabolic genes that distinguish Gleason 3 from Gleason 4 prostate cancer foci. The Prostate 79:15, pages 1777-1788.
Crossref
Xin Li, Shuhong Gao, Wenzhi Li, Zhiming Liu, Zhengzheng Shi, Chunping Qiu & Jie Jiang. (2019) Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer. Journal of Obstetrics and Gynaecology Research 45:10, pages 2043-2054.
Crossref
Ning Zhang, Hanwen Zhang, Ying Liu, Peng Su, Jiashu Zhang, Xiaolong Wang, Mingjuan Sun, Bing Chen, Wenjing Zhao, Lijuan Wang, Huiyun Wang, Meena S. Moran, Bruce G. Haffty & Qifeng Yang. (2018) SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2. Cell Death & Differentiation 26:5, pages 843-859.
Crossref
Lamia Mouhid, Marta Gómez de Cedrón, Elena García-Carrascosa, Guillermo Reglero, Tiziana Fornari & Ana Ramírez de Molina. (2019) Yarrow supercritical extract exerts antitumoral properties by targeting lipid metabolism in pancreatic cancer. PLOS ONE 14:3, pages e0214294.
Crossref
Zhengzheng Shi, Qing Zhou, Shuhong Gao, Wenzhi Li, Xin Li, Zhiming Liu, Pengpeng Jin & Jie Jiang. (2019) Silibinin inhibits endometrial carcinoma via blocking pathways of STAT3 activation and SREBP1-mediated lipid accumulation. Life Sciences 217, pages 70-80.
Crossref
Xiaonan Zhang, Song Wang, Linlin Hu, Jian Wang, Yajing Liu & Ping Shi. (2018) Gemfibrozil reduces lipid accumulation in SMMC‑7721 cells via the involvement of PPARα and SREBP1. Experimental and Therapeutic Medicine.
Crossref
Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li & Bo Xiang. (2018) Emerging role of lipid metabolism alterations in Cancer stem cells. Journal of Experimental & Clinical Cancer Research 37:1.
Crossref
Yilin Wang, Lili Zhang, Xiaoxia Che, Wenzhi Li, Zhiming Liu & Jie Jiang. (2018) Roles of SIRT1/FoxO1/SREBP-1 in the development of progestin resistance in endometrial cancer. Archives of Gynecology and Obstetrics 298:5, pages 961-969.
Crossref
M. Presler, A. Wojtczyk-Miaskowska, B. Schlichtholz, A. Kaluzny, M. Matuszewski, A. Mika, T. Sledzinski & J. Swierczynski. (2018) Increased expression of the gene encoding stearoyl-CoA desaturase 1 in human bladder cancer. Molecular and Cellular Biochemistry 447:1-2, pages 217-224.
Crossref
Monde Ntwasa & Ubanako Njende. 2018. Neoplasm. Neoplasm.
Xiaoping Zhao, Li Zhao, Hao Yang, Jiajin Li, Xuejie Min, Fajun Yang, Jianjun Liu & Gang Huang. (2018) Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma. Journal of Biological Chemistry 293:17, pages 6623-6634.
Crossref
Weihua Li, Huimin Bai, Shiping Liu, Dongyan Cao, Hongying Wu, Keng Shen, Yanhong Tai & Jiaxin Yang. (2018) Targeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression. Oncotarget 9:15, pages 12064-12078.
Crossref
Duanyang Zhai, Chunhui Cui, Lang Xie, Lianxu Cai & Jinlong Yu. (2018) Sterol regulatory element-binding protein 1 cooperates with c-Myc to promote epithelial-mesenchymal transition in colorectal cancer. Oncology Letters.
Crossref
V L Sodi, Z A Bacigalupa, C M Ferrer, J V Lee, W A Gocal, D Mukhopadhyay, K E Wellen, M Ivan & M J Reginato. (2017) Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation. Oncogene 37:7, pages 924-934.
Crossref
Mohamad N. Shafiee, Nigel Mongan, Claire Seedhouse, Caroline Chapman, Suha Deen, Jafaru Abu & William Atiomo. (2017) Sterol regulatory element binding protein-1 ( SREBP1 ) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer . Acta Obstetricia et Gynecologica Scandinavica 96:5, pages 556-562.
Crossref
Rafaela Lacerda, Juliane Menezes & Luísa Romão. (2016) More than just scanning: the importance of cap-independent mRNA translation initiation for cellular stress response and cancer. Cellular and Molecular Life Sciences 74:9, pages 1659-1680.
Crossref
Hongbiao Jing, Tailing Li, Shujian Zhai, Yan Xi & Qingda Meng. (2017) Renal myolipoosteoma: A distinctive lesion in a child. Surgical Oncology 26:1, pages 91-95.
Crossref
Yifang Zhang, Lili Zhang, Hengzi Sun, Qingtao Lv, Chunping Qiu, Xiaoxia Che, Zhiming Liu & Jie Jiang. (2017) Forkhead transcription factor 1 inhibits endometrial cancer cell proliferation via sterol regulatory element-binding protein 1. Oncology Letters 13:2, pages 731-737.
Crossref
Dan Luo, Huiwen Xiao, Jiali Dong, Yuan Li, Guoxing Feng, Ming Cui & Saijun Fan. (2017) B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN. Biochemical and Biophysical Research Communications 482:4, pages 1246-1251.
Crossref
R. Ariel Igal. (2016) Stearoyl CoA desaturase-1: New insights into a central regulator of cancer metabolism. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861:12, pages 1865-1880.
Crossref
Jisheng Bao, Liping Zhu, Qi Zhu, Jianhua Su, Menglan Liu & Wei Huang. (2016) SREBP-1 is an independent prognostic marker and promotes invasion and migration in breast cancer. Oncology Letters 12:4, pages 2409-2416.
Crossref
Jiajin Li, Hui Yan, Li Zhao, Wenzhi Jia, Hao Yang, Liu Liu, Xiang Zhou, Ping Miao, Xiaoguang Sun, Shaoli Song, Xiaoping Zhao, Jianjun Liu & Gang Huang. (2016) Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells. Oncotarget 7:32, pages 52392-52403.
Crossref
JIANGMAN DUAN, LI SUN, HONGXIANG HUANG, ZHENZHEN WU, LIN WANG & WANGJUN LIAO. (2016) Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer. Molecular Medicine Reports 13:4, pages 3027-3035.
Crossref
Z Zhu, X Zhao, L Zhao, H Yang, L Liu, J Li, J Wu, F Yang, G Huang & J Liu. (2015) p54nrb/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A. Oncogene 35:11, pages 1399-1410.
Crossref
S Li, Y-T Oh, P Yue, F R Khuri & S-Y Sun. (2015) Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells. Oncogene 35:5, pages 642-650.
Crossref
Antoine M. Snijders, Yueyong Liu, Li Su, Yurong Huang & Jian-Hua Mao. (2015) Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas. Oncotarget 6:42, pages 44794-44805.
Crossref
Yan Sun, Weiwei He, Man Luo, Yuhong Zhou, Guilin Chang, Weiying Ren, Kefen Wu, Xi Li, Jiping Shen, Xiaoping Zhao & Yu Hu. (2015) SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism. Tumor Biology 36:6, pages 4133-4141.
Crossref
LI LIN, XIAOXIA ZHENG, CHUNPING QIU, SAMINA DONGOL, QINGTAO LV, JIE JIANG, BEIHUA KONG & CHENGUANG WANG. (2014) SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. Oncology Reports 32:6, pages 2831-2835.
Crossref
Alexey Antonov, Massimiliano Agostini, Maria Morello, Marilena Minieri, Gerry Melino & Ivano Amelio. (2014) Bioinformatics analysis of the serine and glycine pathway in cancer cells. Oncotarget 5:22, pages 11004-11013.
Crossref
Nicole M. Davis, Melissa Sokolosky, Kristin Stadelman, Stephen L. Abrams, Massimo Libra, Saverio Candido, Ferdinando Nicoletti, Jerry Polesel, Roberta Maestro, Antonino D’Assoro, Lyudmyla Drobot, Dariusz Rakus, Agnieszka Gizak, Piotr Laidler, Joanna Dulińska-Litewka, Joerg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Giuseppe Montalto, Melchiorre Cervello, Timothy L. Fitzgerald, Zoya N. Demidenko, Alberto M. Martelli, Lucio Cocco, Linda S. Steelman & James A. McCubrey. (2014) Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention. Oncotarget 5:13, pages 4603-4650.
Crossref
Chao Li, Wei Yang, Junli Zhang, Xin Zheng, Yingmin Yao, Kangsheng Tu & Qingguang Liu. (2014) SREBP-1 Has a Prognostic Role and Contributes to Invasion and Metastasis in Human Hepatocellular Carcinoma. International Journal of Molecular Sciences 15:5, pages 7124-7138.
Crossref
Chun-Ping Qiu, Qing-Tao Lv, Samina Dongol, Chenguang Wang & Jie Jiang. (2014) Single Nucleotide Polymorphism of SREBF-1 Gene Associated with an Increased Risk of Endometrial Cancer in Chinese Women. PLoS ONE 9:3, pages e90491.
Crossref
Shuo Qie, Clarissa Chu, Weihua Li, Chenguang Wang & Nianli Sang. (2014) ErbB2 Activation Upregulates Glutaminase 1 Expression Which Promotes Breast Cancer Cell Proliferation. Journal of Cellular Biochemistry 115:3, pages 498-509.
Crossref
Chunping Qiu, Samina Dongol, Qing-tao Lv, Ximei Gao & Jie Jiang. (2013) Sterol Regulatory Element-Binding Protein–1/Fatty Acid Synthase Involvement in Proliferation Inhibition and Apoptosis Promotion Induced by Progesterone in Endometrial Cancer. International Journal of Gynecologic Cancer 23:9, pages 1629-1634.
Crossref
Mohamad N. Shafiee, Caroline Chapman, David Barrett, Jafaru Abu & William Atiomo. (2013) Reviewing the molecular mechanisms which increase endometrial cancer (EC) risk in women with polycystic ovarian syndrome (PCOS): Time for paradigm shift?. Gynecologic Oncology 131:2, pages 489-492.
Crossref
ZHI LI LIU, JIAN HUA MAO, AI FEN PENG, QING SHUI YIN, YANG ZHOU, XIN HUA LONG & SHAN HU HUANG. (2013) Inhibition of fatty acid synthase suppresses osteosarcoma cell invasion and migration via downregulation of the PI3K/Akt signaling pathway in vitro. Molecular Medicine Reports 7:2, pages 608-612.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.