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Cell Cycle Volume 11, 2012 - Issue 18
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Androgen receptor serine 81 mediates Pin1 interaction and activity

Raffaele La Montagna Sbarro Institute for Cancer Research and Molecular Medicine; Center for Biotechnology; College of Science and Technology; Temple University; Philadelphia, PA USA; Human Health Foundation; Terni and Spoleto, Perugia, Italy
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Isabella Caligiuri Sbarro Institute for Cancer Research and Molecular Medicine; Center for Biotechnology; College of Science and Technology; Temple University; Philadelphia, PA USA; Human Health Foundation; Terni and Spoleto, Perugia, Italy; Department of Human Pathology and Oncology; University of Siena; Siena, Italy
,
Pasquale Maranta Sbarro Institute for Cancer Research and Molecular Medicine; Center for Biotechnology; College of Science and Technology; Temple University; Philadelphia, PA USA
,
Chiara Lucchetti Sbarro Institute for Cancer Research and Molecular Medicine; Center for Biotechnology; College of Science and Technology; Temple University; Philadelphia, PA USA
,
Luca Esposito INT-CROM; Pascale Foundation; National Cancer Institute - Cancer Research Center; Mercogliano, Italy
,
Marco G. Paggi National Cancer Institute Regina Elena; Rome, Italy
,
Giuseppe Toffoli Division of Experimental and Clinical Pharmacology; Department of Molecular Biology and Translational Research; National Cancer Institute and Center for Molecular Biomedicine; Aviano, Pordenone, Italy
,
Flavio Rizzolio Sbarro Institute for Cancer Research and Molecular Medicine; Center for Biotechnology; College of Science and Technology; Temple University; Philadelphia, PA USA; Division of Experimental and Clinical Pharmacology; Department of Molecular Biology and Translational Research; National Cancer Institute and Center for Molecular Biomedicine; Aviano, Pordenone, Italy
&
Antonio Giordano Sbarro Institute for Cancer Research and Molecular Medicine; Center for Biotechnology; College of Science and Technology; Temple University; Philadelphia, PA USA; Human Health Foundation; Terni and Spoleto, Perugia, Italy; Department of Human Pathology and Oncology; University of Siena; Siena, Italy; INT-CROM; Pascale Foundation; National Cancer Institute - Cancer Research Center; Mercogliano, ItalyCorrespondence[email protected]
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Pages 3415-3420 | Received 13 Jun 2012, Accepted 03 Aug 2012, Published online: 16 Aug 2012

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Giulio Poli, Miriana Di Stefano, Joan Arias Estevez, Filippo Minutolo, Carlotta Granchi, Antonio Giordano, Salvatore Parisi, Matteo Mauceri, Vincenzo Canzonieri, Marco Macchia, Isabella Caligiuri, Tiziano Tuccinardi & Flavio Rizzolio. (2022) New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 145-150.
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Articles from other publishers (21)

Gloria Saorin, Matteo Mauceri, Enrico Cavarzerani, Isabella Caligiuri, Giulia Bononi, Carlotta Granchi, Michele Bartoletti, Tiziana Perin, Tiziano Tuccinardi, Vincenzo Canzonieri, Muhammad Adeel & Flavio Rizzolio. (2023) Enhanced activity of a pluronic F127 formulated Pin1 inhibitor for ovarian cancer therapy. Journal of Drug Delivery Science and Technology 87, pages 104718.
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Jacky K. Leung, Amy H. Tien & Marianne D. Sadar. 2021. Nuclear Receptors. Nuclear Receptors 411 461 .
Woo Jin Kim, Bong Soo Kim, Hyun Jung Kim, Young Dan Cho, Hye Lim Shin, Hee In Yoon, Yun Sil Lee, Jeong-Hwa Baek, Kyung Mi Woo & Hyun-Mo Ryoo. (2020) Intratesticular Peptidyl Prolyl Isomerase 1 Protein Delivery Using Cationic Lipid-Coated Fibroin Nanoparticle Complexes Rescues Male Infertility in Mice. ACS Nano 14:10, pages 13217-13231.
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Simeng Wen, Yuanjie Niu & Haojie Huang. (2020) Posttranslational regulation of androgen dependent and independent androgen receptor activities in prostate cancer. Asian Journal of Urology 7:3, pages 203-218.
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Ji Hoon Yu, Chun Young Im & Sang-Hyun Min. (2020) Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics. Frontiers in Cell and Developmental Biology 8.
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Concetta Russo Spena, Lucia De Stefano, Giulio Poli, Carlotta Granchi, Maguie El Boustani, Fabrizio Ecca, Gabriele Grassi, Mario Grassi, Vincenzo Canzonieri, Antonio Giordano, Tiziano Tuccinardi, Isabella Caligiuri & Flavio Rizzolio. (2019) Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects. Journal of Cellular Physiology 234:9, pages 15708-15716.
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Alessandro Zannini, Alessandra Rustighi, Elena Campaner & Giannino Del Sal. (2019) Oncogenic Hijacking of the PIN1 Signaling Network. Frontiers in Oncology 9.
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Maguie El Boustani, Lucia De Stefano, Isabella Caligiuri, Nayla Mouawad, Carlotta Granchi, Vincenzo Canzonieri, Tiziano Tuccinardi, Antonio Giordano & Flavio Rizzolio. (2019) A Guide to PIN1 Function and Mutations Across Cancers. Frontiers in Pharmacology 9.
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Justin X. Nicoll, Andrew C. Fry & Eric M. Mosier. (2019) Sex-based differences in resting MAPK, androgen, and glucocorticoid receptor phosphorylation in human skeletal muscle. Steroids 141, pages 23-29.
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Joshua W. Russo, Xiaming Liu, Huihui Ye, Carla Calagua, Sen Chen, Olga Voznesensky, James Condulis, Fen Ma, Mary-Ellen Taplin, David J. Einstein, Steven P. Balk & Shaoyong Chen. (2018) Phosphorylation of androgen receptor serine 81 is associated with its reactivation in castration-resistant prostate cancer. Cancer Letters 438, pages 97-104.
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Concetta Russo Spena, Lucia De Stefano, Stefano Palazzolo, Barbara Salis, Carlotta Granchi, Filippo Minutolo, Tiziano Tuccinardi, Roberto Fratamico, Sara Crotti, Sara D'Aronco, Marco Agostini, Giuseppe Corona, Isabella Caligiuri, Vincenzo Canzonieri & Flavio Rizzolio. (2018) Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer. Journal of Controlled Release 281, pages 1-10.
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Sang-Hyun Min, Xiao Zhen Zhou & Kun Ping Lu. (2016) The role of Pin1 in the development and treatment of cancer. Archives of Pharmacal Research 39:12, pages 1609-1620.
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Nooshin Mirkheshti, Sulgi Park, Shoulei Jiang, Jodie Cropper, Sherry L. Werner, Chung S. Song & Bandana Chatterjee. (2016) Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer. Oncotarget 7:38, pages 62240-62254.
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Xiao Zhen Zhou & Kun Ping Lu. (2016) The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target. Nature Reviews Cancer 16:7, pages 463-478.
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Ryuhei Kanaoka, Akifumi Kushiyama, Yasuyuki Seno, Yusuke Nakatsu, Yasuka Matsunaga, Toshiaki Fukushima, Yoshihiro Tsuchiya, Hideyuki Sakoda, Midori Fujishiro, Takeshi Yamamotoya, Hideaki Kamata, Akio Matsubara & Tomoichiro Asano. (2015) Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines. PLOS ONE 10:6, pages e0127467.
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Prashant Rajbhandari, Mary Szatkowski Ozers, Natalia M. Solodin, Christopher L. Warren & Elaine T. Alarid. (2015) Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α. Journal of Biological Chemistry 290:22, pages 13749-13762.
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Nithya Krishnan, Mark A. Titus & Roopa Thapar. (2014) The Prolyl Isomerase Pin1 Regulates mRNA Levels of Genes with Short Half-Lives by Targeting Specific RNA Binding Proteins. PLoS ONE 9:1, pages e85427.
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T. M. Poolman, S. N. Farrow, L. Matthews, A. S. Loudon & D. W. Ray. (2013) Pin1 promotes GR transactivation by enhancing recruitment to target genes. Nucleic Acids Research 41:18, pages 8515-8525.
Crossref
Lindsey S. Treviño & Nancy L. Weigel. (2013) Phosphorylation: a fundamental regulator of steroid receptor action. Trends in Endocrinology & Metabolism 24:10, pages 515-524.
Crossref
Raffaele La Montagna, Isabella Caligiuri, Antonio Giordano & Flavio Rizzolio. (2013) Pin1 and Nuclear Receptors: A New Language?. Journal of Cellular Physiology 228:9, pages 1799-1801.
Crossref
Travis Van der Steen, Donald Tindall & Haojie Huang. (2013) Posttranslational Modification of the Androgen Receptor in Prostate Cancer. International Journal of Molecular Sciences 14:7, pages 14833-14859.
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