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Cell Cycle Volume 12, 2013 - Issue 4
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An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation

Lisa Postow Laboratory of Chromosome and Cell Biology; Rockefeller University; New York, NY USACorrespondence[email protected]
&
Hironori Funabiki Laboratory of Chromosome and Cell Biology; Rockefeller University; New York, NY USA
Pages 587-595 | Published online: 16 Jan 2013

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Noriko Ishida, Tadashi Nakagawa, Shun-Ichiro Iemura, Akira Yasui, Hiroki Shima, Yasutake Katoh, Yuko Nagasawa, Toru Natsume, Kazuhiko Igarashi & Keiko Nakayama. (2017) Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair. Molecular and Cellular Biology 37:4.
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Fuminori Tsuruta, Ai Takebe, Kousuke Haratake, Yoshinori Kanemori, Jaehyun Kim, Tomoyuki Endo, Yu Kigoshi, Tomomi Fukuda, Hatsumi Miyahara, Manato Ebina, Tadashi Baba & Tomoki Chiba. (2016) SCFFbl12 Increases p21Waf1/Cip1 Expression Level through Atypical Ubiquitin Chain Synthesis. Molecular and Cellular Biology 36:16, pages 2182-2194.
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Mallikarjun Patil, Navjotsingh Pabla, Han-Fei Ding & Zheng Dong. (2013) Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression. Cell Cycle 12:16, pages 2608-2616.
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Hae Ryung Chang. (2023) RNF126, 168 and CUL1: The Potential Utilization of Multi-Functional E3 Ubiquitin Ligases in Genome Maintenance for Cancer Therapy. Biomedicines 11:9, pages 2527.
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Mengfan Tang, Siting Li & Junjie Chen. (2021) Ubiquitylation in DNA double-strand break repair. DNA Repair 103, pages 103129.
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Benjamin M. StinsonJoseph J. Loparo. (2021) Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway. Annual Review of Biochemistry 90:1, pages 137-164.
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Bethany Mason & Heike Laman. (2020) The FBXL family of F-box proteins: variations on a theme. Open Biology 10:11.
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Zongpei Guo, Shaozheng Wang, Ying Xie, Yang Han, Sai Hu, Hua Guan, Dafei Xie, Chenjun Bai, Xiaodan Liu, Yongqing Gu, Ping-Kun Zhou & Teng Ma. (2020) HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response. Cell Death & Disease 11:5.
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Somaira Nowsheen, Min Deng & Zhenkun Lou. (2019) Ubiquitin and the DNA double-strand break repair pathway. Genome Instability & Disease 1:2, pages 69-80.
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Shahd Fouad, Owen S. Wells, Mark A. Hill & Vincenzo D’Angiolella. (2019) Cullin Ring Ubiquitin Ligases (CRLs) in Cancer: Responses to Ionizing Radiation (IR) Treatment. Frontiers in Physiology 10.
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Fangzhou Li, Qianqian Sun, Kun Liu, Haichao Han, Ning Lin, Zhongyi Cheng, Yueming Cai, Feng Tian, Zebin Mao, Tanjun Tong & Wenhui Zhao. (2019) The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining. Cellular and Molecular Life Sciences 76:19, pages 3861-3873.
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Ryotaro Nishi, Paul W. G. Wijnhoven, Yusuke Kimura, Misaki Matsui, Rebecca Konietzny, Qian Wu, Keisuke Nakamura, Tom L. Blundell & Benedikt M. Kessler. (2018) The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage. Scientific Reports 8:1.
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Joonyoung Her & Samuel F. Bunting. (2018) How cells ensure correct repair of DNA double-strand breaks. Journal of Biological Chemistry 293:27, pages 10502-10511.
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Christopher JennessSimona GiuntaManuel M. MüllerHiroshi Kimura, Tom W. MuirHironori Funabiki. (2018) HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome. Proceedings of the National Academy of Sciences 115:5.
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Ignacio Torrecilla, Judith Oehler & Kristijan Ramadan. (2017) The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks. Philosophical Transactions of the Royal Society B: Biological Sciences 372:1731, pages 20160282.
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Alexander J. Garvin & Joanna R. Morris. (2017) SUMO, a small, but powerful, regulator of double-strand break repair. Philosophical Transactions of the Royal Society B: Biological Sciences 372:1731, pages 20160281.
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Zhifeng Wang, Wei-Guo Zhu & Xingzhi Xu. (2017) Ubiquitin-like modifications in the DNA damage response. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 803-805, pages 56-75.
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Charlene H. EmersonAlison A. Bertuch. (2016) Consider the workhorse: Nonhomologous end-joining in budding yeast. Biochemistry and Cell Biology 94:5, pages 396-406.
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Johannes van den Boom, Markus Wolf, Lena Weimann, Nina Schulze, Fanghua Li, Farnusch Kaschani, Anne Riemer, Christian Zierhut, Markus Kaiser, George Iliakis, Hironori Funabiki & Hemmo Meyer. (2016) VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Molecular Cell 64:1, pages 189-198.
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Petra Schwertman, Simon Bekker-Jensen & Niels Mailand. (2016) Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers. Nature Reviews Molecular Cell Biology 17:6, pages 379-394.
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Nana Zheng, Zhiwei Wang & Wenyi Wei. (2016) Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins. The International Journal of Biochemistry & Cell Biology 73, pages 99-110.
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Kyung-Jong Lee, Janapriya Saha, Jingxin Sun, Kazi R. Fattah, Shu-Chi Wang, Burkhard Jakob, Linfeng Chi, Shih-Ya Wang, Gisela Taucher-Scholz, Anthony J. Davis & David J. Chen. (2016) Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase. Nucleic Acids Research 44:4, pages 1732-1745.
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Suzanne J. Randle & Heike Laman. (2016) F-box protein interactions with the hallmark pathways in cancer. Seminars in Cancer Biology 36, pages 3-17.
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Nico P Dantuma & Haico van Attikum. (2015) Spatiotemporal regulation of posttranslational modifications in the DNA damage response . The EMBO Journal 35:1, pages 6-23.
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Simon Bekker-Jensen & Niels Mailand. (2015) RNF138 joins the HR team. Nature Cell Biology 17:11, pages 1375-1377.
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Fuminori Tsuruta, Jaehyun Kim, Tomomi Fukuda, Yu Kigoshi & Tomoki Chiba. (2015) The intronic region of Fbxl12 functions as an alternative promoter regulated by UV irradiation. Biochemistry and Biophysics Reports 3, pages 100-107.
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Jessica S. Brown, Natalia Lukashchuk, Matylda Sczaniecka-Clift, Sébastien Britton, Carlos le Sage, Patrick Calsou, Petra Beli, Yaron Galanty & Stephen P. Jackson. (2015) Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites. Cell Reports 11:5, pages 704-714.
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Jessica S. Brown & Stephen P. Jackson. (2015) Ubiquitylation, neddylation and the DNA damage response. Open Biology 5:4, pages 150018.
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Gabrielle J. Grundy, Hayley A. Moulding, Keith W. Caldecott & Stuart L. Rulten. (2014) One ring to bring them all—The role of Ku in mammalian non-homologous end joining. DNA Repair 17, pages 30-38.
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Guoxiong Xu, Miriam Barrios-Rodiles, Mirjana Jerkic, Andrei L. Turinsky, Robert Nadon, Sonia Vera, Despina Voulgaraki, Jeffrey L. Wrana, Mourad Toporsian & Michelle Letarte. (2014) Novel Protein Interactions with Endoglin and Activin Receptor-like Kinase 1: Potential Role in Vascular Networks. Molecular & Cellular Proteomics 13:2, pages 489-502.
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P.Y. Billie Au, Bob Argiropoulos, Jillian S. Parboosingh & A. Micheil Innes. (2014) Refinement of the critical region of 1q41q42 microdeletion syndrome identifies FBXO28 as a candidate causative gene for intellectual disability and seizures . American Journal of Medical Genetics Part A 164:2, pages 441-448.
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Hiroyuki Inuzuka & Wenyi WeiBrian J. North, Yueyong Liu, Hiroyuki Inuzuka & Wenyi Wei. 2014. SCF and APC E3 Ubiquitin Ligases in Tumorigenesis. SCF and APC E3 Ubiquitin Ligases in Tumorigenesis 47 71 .

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