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Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21Cip1

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Pages 1030-1041 | Published online: 21 Feb 2013

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Alejandra González-Loyola, Gonzalo Fernández-Miranda, Marianna Trakala, David Partida, Kumiko Samejima, Hiromi Ogawa, Marta Cañamero, Alba de Martino, Ángel Martínez-Ramírez, Guillermo de Cárcer, Ignacio Pérez de Castro, William C. Earnshaw & Marcos Malumbres. (2015) Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development. Molecular and Cellular Biology 35:20, pages 3566-3578.
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Geeta Kumari, Tanja Ulrich & Stefan Gaubatz. (2013) A role for p38 in transcriptional elongation of p21CIP1 in response to Aurora B inhibition. Cell Cycle 12:13, pages 2051-2060.
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Randy Y.C. Poon. (2013) Aurora B: Hooking up with cyclin-dependent kinases. Cell Cycle 12:7, pages 1019-1019.
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Articles from other publishers (24)

Melissa Lúcia Melo, Rafael Fonseca, Fernanda Pauli, Bruno Zavan, João Adolfo Costa Hanemann, Marta Miyazawa, Ester Siqueira Caixeta, Júlia Louise Moreira Nacif, Alexandre Ferro Aissa, Eliezer J. Barreiro & Marisa Ionta. (2023) N-acylhydrazone derivative modulates cell cycle regulators promoting mitosis arrest and apoptosis in estrogen positive MCF-7 breast cancer cells. Toxicology in Vitro 93, pages 105686.
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Heeren M. Gordhan, Steven T. Miller, Daphne C. Clancy, Maria Ina, Alan V. McDougal, D’Quan K. Cutno, Robert V. Brown, Cynthia L. Lichorowic, Jill M. Sturdivant, Kyle A. Vick, Stuart S. Williams, Mitchell A. deLong, Jeffrey C. White, Casey C. Kopczynski & David A. Ellis. (2023) Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. Journal of Medicinal Chemistry 66:13, pages 8929-8950.
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Jun Muto, Shinji Fukuda, Kenji Watanabe, Xiuju Dai, Teruko Tsuda, Takeshi Kiyoi, Kenji Kameda, Ryosuke Kawakami, Hideki Mori, Ken Shiraishi, Masamoto Murakami, Takeshi Imamura, Shigeki Higashiyama, Yasuhiro Fujisawa, Yoichi Mizukami & Koji Sayama. (2023) Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21. Communications Biology 6:1.
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Moumita Sarkar, Matteo Martufi, Monica Roman-Trufero, Yi-Fang Wang, Chad Whilding, Dirk Dormann, Pierangela Sabbattini & Niall Dillon. (2021) CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells. Molecular Biology of the Cell 32:22.
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Eman M.E. Dokla, Amal Kamal Abdel-Aziz, Sandra N. Milik, Amr H. Mahmoud, Mona Kamal Saadeldin, Martin J. McPhillie, Saverio Minucci & Khaled A.M. Abouzid. (2021) Indolin-2-one derivatives as selective Aurora B kinase inhibitors targeting breast cancer. Bioorganic Chemistry 117, pages 105451.
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Ainsley Mike Antao, Kamini Kaushal, Soumyadip Das, Vijai Singh, Bharathi Suresh, Kye-Seong Kim & Suresh Ramakrishna. (2021) USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B. International Journal of Molecular Sciences 22:16, pages 8508.
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Natalia Sanz-Gómez, Isabel de Pedro, Beatriz Ortigosa, David Santamaría, Marcos Malumbres, Guillermo de Cárcer & Alberto Gandarillas. (2020) Squamous differentiation requires G2/mitosis slippage to avoid apoptosis. Cell Death & Differentiation 27:8, pages 2451-2467.
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Hoi Tang Ma & Randy Y.C. Poon. (2020) Aurora kinases and DNA damage response. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 821, pages 111716.
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Francesco D. Naso, Valentina Sterbini, Elena Crecca, Italia A. Asteriti, Alessandra D. Russo, Maria Giubettini, Enrico Cundari, Catherine Lindon, Alessandro Rosa & Giulia Guarguaglini. (2020) Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit. Cells 9:2, pages 374.
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Thanigaivelan Kanagasabai, Thiagarajan Venkatesan, Umamaheswari Natarajan, Saad Alobid, Khalid Alhazzani, Mohammad Algahtani & Appu Rathinavelu. (2020) Regulation of cell cycle by MDM2 in prostate cancer cells through Aurora Kinase-B and p21WAF1/CIP1 mediated pathways. Cellular Signalling 66, pages 109435.
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Serene S. L. Gwee, Rowan A. W. Radford, Sharron Chow, Monisha D. Syal, Marco Morsch, Isabel Formella, Albert Lee, Emily K. Don, Andrew P. Badrock, Nicholas J. Cole, Adrian K. West, Steve N. S. Cheung & Roger S. Chung. (2018) Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish. Cellular and Molecular Life Sciences 75:23, pages 4269-4285.
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David S. Moura, Ignacio Campillo-Marcos, Marta Vázquez-Cedeira & Pedro A. Lazo. (2018) VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis. Cellular and Molecular Life Sciences 75:14, pages 2591-2611.
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Anna-Maria Olziersky & S. Intidhar Labidi-Galy. 2017. Cell Division Machinery and Disease. Cell Division Machinery and Disease 125 152 .
Yu Huang, Di Huang, Jiefeng Weng, Shuai Zhang, Qiang Zhang, Zhenhao Mai & Weili Gu. (2016) Effect of reversine on cell cycle, apoptosis, and activation of hepatic stellate cells. Molecular and Cellular Biochemistry 423:1-2, pages 9-20.
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Victoria L. Fell, Elizabeth A. Walden, Sarah M. Hoffer, Stephanie R. Rogers, Amelia S. Aitken, Louisa M. Salemi & Caroline Schild-Poulter. (2016) Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response. Scientific Reports 6:1.
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V Quereda, E Porlan, M Cañamero, P Dubus & M Malumbres. (2015) An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress. Cell Death & Differentiation 23:3, pages 430-441.
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Vijay Pratap Singh & Jennifer L Gerton. (2015) Cohesin and human disease: lessons from mouse models. Current Opinion in Cell Biology 37, pages 9-17.
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N-N Kreis, F Louwen & J Yuan. (2014) Less understood issues: p21Cip1 in mitosis and its therapeutic potential. Oncogene 34:14, pages 1758-1767.
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Ilaria Dutto, Micol Tillhon, Ornella Cazzalini, Lucia A. Stivala & Ennio Prosperi. (2014) Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology. Archives of Toxicology 89:2, pages 155-178.
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Marianna Trakala, Sara Rodríguez-Acebes, María Maroto, Catherine E. Symonds, David Santamaría, Sagrario Ortega, Mariano Barbacid, Juan Méndez & Marcos Malumbres. (2015) Functional Reprogramming of Polyploidization in Megakaryocytes. Developmental Cell 32:2, pages 155-167.
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N-N Kreis, M Sanhaji, M A Rieger, F Louwen & J Yuan. (2013) p21Waf1/Cip1 deficiency causes multiple mitotic defects in tumor cells. Oncogene 33:50, pages 5716-5728.
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Geeta Kumari, Tanja Ulrich, Michael Krause, Florian Finkernagel & Stefan Gaubatz. (2014) Induction of p21CIP1 Protein and Cell Cycle Arrest after Inhibition of Aurora B Kinase Is Attributed to Aneuploidy and Reactive Oxygen Species. Journal of Biological Chemistry 289:23, pages 16072-16084.
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P Zuazua-Villar, R Rodriguez, M E Gagou, P A Eyers & M Meuth. (2014) DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B. Cell Death & Disease 5:5, pages e1253-e1253.
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Yu TogashiJun ShirakawaKazuki OrimeMitsuyo KajiEri SakamotoKazuki TajimaHideaki InoueAkinobu NakamuraYoshihiro Tochino, Yoshio GoshimaIichiro Shimomura & Yasuo Terauchi. (2014) β-Cell Proliferation After a Partial Pancreatectomy Is Independent of IRS-2 in Mice. Endocrinology 155:5, pages 1643-1652.
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