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Cell Cycle Volume 12, 2013 - Issue 10
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Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override

Neil Beeharry Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA USACorrespondence[email protected]
,
Jerome Rattner Department of Cell Biology & Anatomy, University of Calgary, Calgary, AB Canada
,
Juliane Caviston Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA USA
&
Tim Yen Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA USACorrespondence[email protected]
Pages 1588-1597 | Received 04 Feb 2013, Accepted 18 Apr 2013, Published online: 24 Apr 2013

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Ken Dornfeld, James Bjork, Gavin Folkert, Andrew Skildum & Kendall B. Wallace. (2021) Mitochondrial activities play a pivotal role in regulating cell cycle in response to doxorubicin. Cell Cycle 20:11, pages 1067-1079.
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Neil Beeharry, Andrea Ghelli Luserna Di Rora, Mitchell R Smith & Timothy J Yen. (2015) Pixantrone induces cell death through mitotic perturbations and subsequent aberrant cell divisions. Cancer Biology & Therapy 16:9, pages 1397-1406.
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Nicoletta Coccaro, Giuseppina Tota, Luisa Anelli, Antonella Zagaria, Paola Casieri, Angelo Cellamare, Angela Minervini, Crescenzio Francesco Minervini, Claudia Brunetti, Alessandra Ricco, Paola Orsini, Cosimo Cumbo, Giorgina Specchia & Francesco Albano. (2015) Centromeric fragment of chromosome 7 in atypical chronic myeloid leukemia with the SET binding protein 1 gene mutation. Leukemia & Lymphoma 56:3, pages 826-828.
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V Bhattacharjee, Y Zhou & TJ Yen. (2014) A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells. Cell Cycle 13:24, pages 3839-3856.
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Neil Beeharry, Eugenia Banina, James Hittle, Natalia Skobeleva, Vladimir Khazak, Sean Deacon, Mark Andrake, Brian L Egleston, Jeffrey R Peterson, Igor Astsaturov & Timothy J Yen. (2014) Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints. Cell Cycle 13:14, pages 2172-2191.
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Ailine Stolz & Holger Bastians. (2013) Therapeutic S and G2 checkpoint override causes centromere fragmentation in mitosis. Cell Cycle 12:12, pages 1826-1827.
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. (2013) Mitotic checkpoints, MUGs and kinetochores. Cell Cycle 12:12, pages 1822-1822.
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Articles from other publishers (16)

Christopher J. Carnie, Lucy Armstrong, Marek Sebesta, Antonio Ariza, Xiaomeng Wang, Emily Graham, Kang Zhu & Dragana Ahel. (2023) ERCC6L2 mitigates replication stress and promotes centromere stability. Cell Reports 42:4, pages 112329.
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Kaushiki Roy, Debapriya Banik, Gordon K. Chan, Ondrej Krejcar & Debotosh Bhattacharjee. (2023) 2pClPr: A Two-Phase Clump Profiler for Segmentation of Cancer Cells in Fluorescence Microscopic Images. IEEE Transactions on Instrumentation and Measurement 72, pages 1-14.
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Amirali B. Bukhari, Gordon K. Chan & Armin M. Gamper. (2022) Targeting the DNA Damage Response for Cancer Therapy by Inhibiting the Kinase Wee1. Frontiers in Oncology 12.
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Kaushiki RoyCody W. LewisGordon K. ChanDebotosh Bhattacharjee. (2021) Automated classification of mitotic catastrophe by use of the centromere fragmentation morphology. Biochemistry and Cell Biology 99:2, pages 261-271.
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Katelyn J. Siegrist, Steven H. Reynolds, Dale W. Porter, Robert R. Mercer, Alison K. Bauer, David Lowry, Lorenzo Cena, Todd A. Stueckle, Michael L. Kashon, John Wiley, Jeffrey L. Salisbury, John Mastovich, Kristin Bunker, Mark Sparrow, Jason S. Lupoi, Aleksandr B. Stefaniak, Michael J. Keane, Shuji Tsuruoka, Mauricio Terrones, Michael McCawley & Linda M. Sargent. (2019) Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells. Particle and Fibre Toxicology 16:1.
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Cody W. Lewis, Amirali B. Bukhari, Edric J. Xiao, Won-Shik Choi, Joanne D. Smith, Ellen Homola, John R. Mackey, Shelagh D. Campbell, Armin M. Gamper & Gordon K. Chan. (2019) Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition. Cancer Research 79:23, pages 5971-5985.
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Amirali B. Bukhari, Cody W. Lewis, Joanna J. Pearce, Deandra Luong, Gordon K. Chan & Armin M. Gamper. (2019) Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis. Journal of Clinical Investigation 129:3, pages 1329-1344.
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Cody W. Lewis, Zhigang Jin, Dawn Macdonald, Wenya Wei, Xu Jing Qian, Won Shik Choi, Ruicen He, Xuejun Sun & Gordon Chan. (2017) Prolonged mitotic arrest induced by Wee1 inhibition sensitizes breast cancer cells to paclitaxel. Oncotarget 8:43, pages 73705-73722.
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Susan Forsburg & Kuo-Fang Shen. (2017) Centromere Stability: The Replication Connection. Genes 8:1, pages 37.
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Hylke W. Wieringa, Ate G.J. van der Zee, Elisabeth G.E. de Vries & Marcel A.T.M. van Vugt. (2016) Breaking the DNA damage response to improve cervical cancer treatment. Cancer Treatment Reviews 42, pages 30-40.
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Sarah A. Sabatinos, Nimna S. Ranatunga, Ji-Ping Yuan, Marc D. Green & Susan L. Forsburg. (2015) Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast. Molecular Biology of the Cell 26:19, pages 3439-3450.
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Sarah Sabatinos & Susan Forsburg. (2015) Managing Single-Stranded DNA during Replication Stress in Fission Yeast. Biomolecules 5:3, pages 2123-2139.
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Siang-Boon Koh, Aurélie Courtin, Richard J. Boyce, Robert G. Boyle, Frances M. Richards & Duncan I. Jodrell. (2015) CHK1 Inhibition Synergizes with Gemcitabine Initially by Destabilizing the DNA Replication Apparatus. Cancer Research 75:17, pages 3583-3595.
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A Thomas, T Perry, S Berhane, C Oldreive, A Zlatanou, L R Williams, V J Weston, T Stankovic, P Kearns, K Pors, R J Grand & G S Stewart. (2014) The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53. Oncogene 34:25, pages 3336-3348.
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Martin Eifler, Ralf Uecker, Henry Weisbach, Boris Bogdanow, Ellen Richter, Lydia König, Barbara Vetter, Tihana Lenac-Rovis, Stipan Jonjic, Heidemarie Neitzel, Christian Hagemeier & Lüder Wiebusch. (2014) PUL21a-Cyclin A2 Interaction is Required to Protect Human Cytomegalovirus-Infected Cells from the Deleterious Consequences of Mitotic Entry. PLoS Pathogens 10:11, pages e1004514.
Crossref
Susan L. Forsburg. (2013) The CINs of the centromere. Biochemical Society Transactions 41:6, pages 1706-1711.
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