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Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma

Domenico Di Marzo Oncology Research Center of Mercogliano (CROM); Istituto Nazionale Per Lo Studio E La Cura Dei Tumori “Fondazione Giovanni Pascale”; IRCCS; Italy
,
Iris Maria Forte Oncology Research Center of Mercogliano (CROM); Istituto Nazionale Per Lo Studio E La Cura Dei Tumori “Fondazione Giovanni Pascale”; IRCCS; Italy
,
Paola Indovina Department of Medicine, Surgery and Neuroscience; University of Siena; Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine; Center for Biotechnology; College of Science and Technology; Temple University; Philadelphia, PA USA
,
Elena Di Gennaro Experimental Pharmacology Unit; Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” - IRCCS; Naples, Italy
,
Valeria Rizzo Department of Medicine, Surgery and Neuroscience; University of Siena; Siena, Italy
,
Francesca Giorgi Department of Medicine, Surgery and Neuroscience; University of Siena; Siena, Italy
,
Eliseo Mattioli Department of Medicine, Surgery and Neuroscience; University of Siena; Siena, Italy; National Cancer Research Centre; Istituto Tumori “Giovanni Paolo II”; Bari, Italy
,
Carmelina Antonella Iannuzzi Oncology Research Center of Mercogliano (CROM); Istituto Nazionale Per Lo Studio E La Cura Dei Tumori “Fondazione Giovanni Pascale”; IRCCS; Italy; Department of Medicine, Surgery and Neuroscience; University of Siena; Siena, Italy
,
Alfredo Budillon Oncology Research Center of Mercogliano (CROM); Istituto Nazionale Per Lo Studio E La Cura Dei Tumori “Fondazione Giovanni Pascale”; IRCCS; Italy; Experimental Pharmacology Unit; Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” - IRCCS; Naples, Italy
,
Antonio Giordano Oncology Research Center of Mercogliano (CROM); Istituto Nazionale Per Lo Studio E La Cura Dei Tumori “Fondazione Giovanni Pascale”; IRCCS; Italy; Department of Medicine, Surgery and Neuroscience; University of Siena; Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine; Center for Biotechnology; College of Science and Technology; Temple University; Philadelphia, PA USACorrespondence[email protected] [email protected]
&
Francesca Pentimalli Oncology Research Center of Mercogliano (CROM); Istituto Nazionale Per Lo Studio E La Cura Dei Tumori “Fondazione Giovanni Pascale”; IRCCS; ItalyCorrespondence[email protected] [email protected]
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Pages 652-665 | Received 11 Jul 2013, Accepted 16 Dec 2013, Published online: 17 Dec 2013

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Paola Indovina, Eleonora Marcelli, Domenico Di Marzo, Nadia Casini, Iris Maria Forte, Francesca Giorgi, Luigi Alfano, Francesca Pentimalli & Antonio Giordano. (2014) Abrogating G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma. Cancer Biology & Therapy 15:4, pages 380-388.
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Juuso Paajanen, Raphael Bueno & Assunta De Rienzo. (2022) The Rocky Road from Preclinical Findings to Successful Targeted Therapy in Pleural Mesothelioma. International Journal of Molecular Sciences 23:21, pages 13422.
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S. Pinelli, R. Alinovi, M. Corradi, D. Poli, D. Cavallo, G. Pelosi, L. Ampollini, M. Goldoni & P Mozzoni. (2021) A comparison between the effects of over-expression of miRNA-16 and miRNA-34a on cell cycle progression of mesothelioma cell lines and on their cisplatin sensitivity. Cancer Treatment and Research Communications 26, pages 100276.
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Carmelina Antonella Iannuzzi, Paola Indovina, Iris Maria Forte, Sarah Di Somma, Anna Maria Malfitano, Martina Bruno, Giuseppe Portella, Francesca Pentimalli & Antonio Giordano. (2020) Pharmacological Inhibition of WEE1 Potentiates the Antitumoral Effect of the dl922-947 Oncolytic Virus in Malignant Mesothelioma Cell Lines. International Journal of Molecular Sciences 21:19, pages 7333.
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Caterina Costa, Paola Indovina, Eliseo Mattioli, Iris Maria Forte, Carmelina Antonella Iannuzzi, Luca Luzzi, Cristiana Bellan, Simona De Summa, Enrico Bucci, Domenico Di Marzo, Marisa De Feo, Luciano Mutti, Francesca Pentimalli & Antonio Giordano. (2020) P53-regulated miR-320a targets PDL1 and is downregulated in malignant mesothelioma. Cell Death & Disease 11:9.
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Haitang Yang, Duo Xu, Zhang Yang, Feng Yao, Heng Zhao, Ralph A. Schmid & Ren-Wang Peng. (2020) Systematic Analysis of Aberrant Biochemical Networks and Potential Drug Vulnerabilities Induced by Tumor Suppressor Loss in Malignant Pleural Mesothelioma. Cancers 12:8, pages 2310.
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Boya Zhong, Masato Shingyoji, Michiko Hanazono, Thi Thanh Nguyễn, Takao Morinaga, Yuji Tada, Hideaki Shimada, Kenzo Hiroshima & Masatoshi Tagawa. (2020) Combination of a p53-activating CP-31398 and an MDM2 or a FAK inhibitor produces growth suppressive effects in mesothelioma with wild-type p53 genotype. Apoptosis 25:7-8, pages 535-547.
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Trista K. Hinz & Lynn E. Heasley. (2020) Translating mesothelioma molecular genomics and dependencies into precision oncology-based therapies. Seminars in Cancer Biology 61, pages 11-22.
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Haitang Yang, Duo Xu, Ralph A. Schmid & Ren-Wang Peng. (2020) Biomarker-guided targeted and immunotherapies in malignant pleural mesothelioma. Therapeutic Advances in Medical Oncology 12, pages 175883592097142.
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Anand Singh, Nisan Bhattacharyya, Abhishek Srivastava, Nathanael Pruett, R. Taylor Ripley, David S. Schrump & Chuong D. Hoang. (2019) MicroRNA-215-5p Treatment Suppresses Mesothelioma Progression via the MDM2-p53-Signaling Axis. Molecular Therapy 27:9, pages 1665-1680.
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Sarah Di Somma, Carmelina Antonella Iannuzzi, Carmela Passaro, Iris Maria Forte, Raffaella Iannone, Vincenzo Gigantino, Paola Indovina, Gerardo Botti, Antonio Giordano, Pietro Formisano, Giuseppe Portella, Anna Maria Malfitano & Francesca Pentimalli. (2019) The Oncolytic Virus dl922-947 Triggers Immunogenic Cell Death in Mesothelioma and Reduces Xenograft Growth. Frontiers in Oncology 9.
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Yiyang Qin, Ikuo Sekine, Michiko Hanazono, Takao Morinaga, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Naoto Yamaguchi & Masatoshi Tagawa. (2019) AMPK activation induced in pemetrexed‐treated cells is associated with development of drug resistance independently of target enzyme expression. Molecular Oncology 13:6, pages 1419-1432.
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Iris Forte, Paola Indovina, Carmelina Iannuzzi, Donatella Cirillo, Domenico Di Marzo, Daniela Barone, Francesca Capone, Francesca Pentimalli & Antonio Giordano. (2019) Targeted therapy based on p53 reactivation reduces both glioblastoma cell growth and resistance to temozolomide. International Journal of Oncology.
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Kun Tian, Emyr Bakker, Michelle Hussain, Alice Guazzelli, Hasen Alhebshi, Parisa Meysami, Constantinos Demonacos, Jean-Marc Schwartz, Luciano Mutti & Marija Krstic-Demonacos. (2018) p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification. Journal of Translational Medicine 16:1.
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Eleonora Sementino, Craig W. Menges, Yuwaraj Kadariya, Suraj Peri, Jinfei Xu, Zemin Liu, Richard G. Wilkes, Kathy Q. Cai, Frank J. RauscherIIIIII, Andres J. Klein‐Szanto & Joseph R. Testa. (2018) Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas . Journal of Cellular Physiology 233:11, pages 8952-8961.
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Rashideh N. Mobaraki, Maryam Karimi, Fatemeh Alikarami, Elham Farhadi, Ali Amini, Davood Bashash, Mostafa Paridar, Parviz Kokhaei, Mohammad R. Rezvani, Ahmad Kazemi & Majid Safa. (2018) RITA induces apoptosis in p53-null K562 leukemia cells by inhibiting STAT5, Akt, and NF-κB signaling pathways. Anti-Cancer Drugs 29:9, pages 847-853.
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Francesca Pentimalli, Iris M. Forte, Luca Esposito, Paola Indovina, Carmelina A. Iannuzzi, Luigi Alfano, Caterina Costa, Daniela Barone, Gaetano Rocco & Antonio Giordano. (2018) RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines. Oncogene 37:27, pages 3657-3671.
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Kuan Chai, Xuerao Ning, Thảo Thi Thanh Nguyễn, Boya Zhong, Takao Morinaga, Zhihan Li, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Naoto Yamaguchi & Masatoshi Tagawa. (2018) Heat shock protein 90 inhibitors augment endogenous wild-type p53 expression but down-regulate the adenovirally-induced expression by inhibiting a proteasome activity. Oncotarget 9:40, pages 26130-26143.
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Barbara Nuvoli, Emanuela Camera, Arianna Mastrofrancesco, Stefania Briganti & Rossella Galati. (2018) Modulation of reactive oxygen species via ERK and STAT3 dependent signalling are involved in the response of mesothelioma cells to exemestane. Free Radical Biology and Medicine 115, pages 266-277.
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Yiyang Qin, Ikuo Sekine, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Michiko Hanazono, Naoto Yamaguchi & Masatoshi Tagawa. (2017) Augmented expression of cardiac ankyrin repeat protein is induced by pemetrexed and a possible marker for the pemetrexed resistance in mesothelioma cells. Cancer Cell International 17:1.
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Kengo Shimazu, Yuji Tada, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Hideaki Shimada, Kenzo Hiroshima, Takao Namiki, Koichiro Tatsumi & Masatoshi Tagawa. (2017) Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways. BMC Cancer 17:1.
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Aline Gottlieb, Kristina Althoff, Laura Grunewald, Theresa Thor, Andrea Odersky, Marc Schulte, Hedwig E. Deubzer, Lukas Heukamp, Angelika Eggert, Alexander Schramm, Johannes H. Schulte & Annette Künkele. (2017) RITA displays anti-tumor activity in medulloblastomas independent of TP53 status . Oncotarget 8:17, pages 27882-27891.
Crossref
Armin Wiegering, Niels Matthes, Bettina Mühling, Monika Koospal, Anne Quenzer, Stephanie Peter, Christoph-Thomas Germer, Michael Linnebacher & Christoph Otto. (2017) Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin. Neoplasia 19:4, pages 301-309.
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Yuanyuan Jiang, Boya Zhong, Kiyoko Kawamura, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima & Masatoshi Tagawa. (2016) Combination of a third generation bisphosphonate and replication-competent adenoviruses augments the cytotoxicity on mesothelioma. BMC Cancer 16:1.
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Marco Lo Iacono, Valentina Monica, Luisella Righi, Federica Grosso, Roberta Libener, Simona Vatrano, Paolo Bironzo, Silvia Novello, Loredana Musmeci, Marco Volante, Mauro Papotti & Giorgio V. Scagliotti. (2015) Targeted Next-Generation Sequencing of Cancer Genes in Advanced Stage Malignant Pleural Mesothelioma: A Retrospective Study. Journal of Thoracic Oncology 10:3, pages 492-499.
Crossref
Xiao-Lan Li. (2015) p53 mutations in colorectal cancer- molecular pathogenesis and pharmacological reactivation . World Journal of Gastroenterology 21:1, pages 84.
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Marzia Leotta, Lavinia Biamonte, Lavinia Raimondi, Domenica Ronchetti, Maria Teresa Di Martino, Cirino Botta, Emanuela Leone, Maria Rita Pitari, Antonino Neri, Antonio Giordano, Pierosandro Tagliaferri, Pierfrancesco Tassone & Nicola Amodio. (2014) A p53-Dependent Tumor Suppressor Network Is Induced by Selective miR-125a-5p Inhibition in Multiple Myeloma Cells. Journal of Cellular Physiology 229:12, pages 2106-2116.
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