Citations (53)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (4)
Idris Arslan. (2023) Natural PAK1 inhibitors: potent anti-inflammatory effectors for prevention of pulmonary fibrosis in COVID-19 therapy. Natural Product Research 0:0, pages 1-13.
Read now
Read now
Julia V Kichina, Anna Goc, Belal Al-Husein, Payaningal R Somanath & Eugene S Kandel. (2010) PAK1 as a therapeutic target. Expert Opinion on Therapeutic Targets 14:7, pages 703-725.
Read now
Read now
Xiaodong Li, Funan Liu & Feng Li. (2010) PAK as a therapeutic target in gastric cancer. Expert Opinion on Therapeutic Targets 14:4, pages 419-433.
Read now
Read now
Guang-Hui Xiao, Ryan Gallagher, Justin Shetler, Kristine Skele, Deborah A. Altomare, Richard G. Pestell, Suresh Jhanwar & Joseph R. Testa. (2005) The NF2 Tumor Suppressor Gene Product, Merlin, Inhibits Cell Proliferation and Cell Cycle Progression by Repressing Cyclin D1 Expression. Molecular and Cellular Biology 25:6, pages 2384-2394.
Read now
Read now
Articles from other publishers (49)
Sankar Jagadeeshan, Ofra Z. Novoplansky, Oded Cohen, Ina Kurth, Jochen Hess, Ari J. Rosenberg, Jennifer R. Grandis & Moshe Elkabets. (2023) New insights into RAS in head and neck cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:6, pages 188963.
Crossref
Crossref
Xiaodong Li & Feng Li. (2022) p21-Activated Kinase: Role in Gastrointestinal Cancer and Beyond. Cancers 14:19, pages 4736.
Crossref
Crossref
Kinjal Shah & Julhash U. Kazi. (2022) Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling. Frontiers in Oncology 12.
Crossref
Crossref
ZAHRA NASRPOUR NAVAEI, GHAZALEH KHALILI-TANHA, AMIR SADRA ZANGOUEI, MOHAMMAD REZA ABBASZADEGAN & MEYSAM MOGHBELI. (2021) PI3K/AKT signaling pathway as a critical regulator of Cisplatin response in tumor cells. Oncology Research 29:4, pages 235-250.
Crossref
Crossref
Chen-Chen Zhao, Meng-Na Zhan, Wan-Ting Liu, Yang Jiao, Yi-Yin Zhang, Yu Lei, Teng-Teng Zhang, Cong-Jun Zhang, Ying-Ying Du, Kang-Sheng Gu & Wei Wei. (2020) Combined LIM kinase 1 and p21-Activated kinase 4 inhibitor treatment exhibits potent preclinical antitumor efficacy in breast cancer. Cancer Letters 493, pages 120-127.
Crossref
Crossref
Wided Najahi‐Missaoui, Nhat D. Quach, Amber Jenkins, Isha Dabke, Payaningal R. Somanath & Brian S. Cummings. (2019) Effect of P21‐activated kinase 1 (PAK‐1) inhibition on cancer cell growth, migration, and invasion. Pharmacology Research & Perspectives 7:5.
Crossref
Crossref
Yinghui Zhang, Lynn Wester, Jichao He, Tamar Geiger, Marja Moerkens, Ram Siddappa, Jean A. Helmijr, Mieke M. Timmermans, Maxime P. Look, Caroline H. M. van Deurzen, John W. M. Martens, Chantal Pont, Marjo de Graauw, Erik H. J. Danen, Els M. J. J. Berns, John H. N. Meerman, Maurice P. H. M. Jansen & Bob van de Water. (2018) IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer. Oncogene 37:14, pages 1869-1884.
Crossref
Crossref
Thomas E. Adrian & Peter Collin. (2018) The Anti-Cancer Effects of Frondoside A. Marine Drugs 16:2, pages 64.
Crossref
Crossref
Hiroshi Maruta & Mok-Ryeon Ahn. (2017) From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. European Journal of Medicinal Chemistry 142, pages 229-243.
Crossref
Crossref
Mahamat Babagana, Sydney Johnson, Hannah Slabodkin, Wiam Bshara, Carl Morrison & Eugene S. Kandel. (2017) P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells. Molecular Carcinogenesis 56:5, pages 1515-1525.
Crossref
Crossref
Binh Cao Quan Nguyen, Kazuki Yoshimura, Shigenori Kumazawa, Shinkichi Tawata & Hiroshi Maruta. (2017) Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 <i>in vitro </i>. Drug Discoveries & Therapeutics 11:2, pages 110-114.
Crossref
Crossref
Natalia Zaldua, Francisco Llavero, Alain Artaso, Patricia Gálvez, Hadriano M. Lacerda, Luis A. Parada & José L. Zugaza. (2016) Rac1/p21‐activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes. The FEBS Journal 283:4, pages 647-661.
Crossref
Crossref
Xiang-Rong Shu, Jing Wu, He Sun, Li-Qun Chi & Jin-Huan Wang. (2015) PAK4 confers the malignance of cervical cancers and contributes to the cisplatin-resistance in cervical cancer cells via PI3K/AKT pathway. Diagnostic Pathology 10:1.
Crossref
Crossref
Yi Zeng, Hal E. Broxmeyer, Karl Staser, Brahmananda Reddy Chitteti, Su-Jung Park, Seongmin Hahn, Scott Cooper, Zejin Sun, Li Jiang, XianLin Yang, Jin Yuan, Rachelle Kosoff, George Sandusky, Edward F. Srour, Jonathan Chernoff & D. Wade Clapp. (2015) Pak2 Regulates Hematopoietic Progenitor Cell Proliferation, Survival, and Differentiation. Stem Cells 33:5, pages 1630-1641.
Crossref
Crossref
Hiroshi Maruta. (2014) Herbal Therapeutics that Block the Oncogenic Kinase PAK1: A Practical Approach towards PAK1-dependent Diseases and Longevity. Phytotherapy Research 28:5, pages 656-672.
Crossref
Crossref
Xueqiong Fu, Jiarui Feng, Duan Zeng, Yu Ding, Changshou Yu & Bing Yang. (2014) PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways. Bioscience Reports 34:2.
Crossref
Crossref
Shengke Hou, Xiaodong Zheng, Haiming Wei, Zhigang Tian & Rui Sun. (2014) Recombinant soluble CD226 protein directly inhibits cancer cell proliferation in vitro. International Immunopharmacology 19:1, pages 119-126.
Crossref
Crossref
Karin Zins, Sandun Gunawardhana, Trevor Lucas, Dietmar Abraham & Seyedhossein Aharinejad. (2013) Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. Journal of Translational Medicine 11:1.
Crossref
Crossref
Hiroshi Maruta & Shanta M. Messerli. 2013. Paks, Rac/Cdc42 (p21)-activated Kinases. Paks, Rac/Cdc42 (p21)-activated Kinases
87
106
.
Hong He & Hiroshi Maruta. 2013. Paks, Rac/Cdc42 (p21)-activated Kinases. Paks, Rac/Cdc42 (p21)-activated Kinases
23
51
.
Philip C. Logan, Michael Steiner, Anna P. Ponnampalam & Murray D. Mitchell. (2012) Cell Cycle Regulation of Human Endometrial Stromal Cells During Decidualization. Reproductive Sciences 19:8, pages 883-894.
Crossref
Crossref
G Zhu, Y Wang, B Huang, J Liang, Y Ding, A Xu & W Wu. (2011) A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells. Oncogene 31:8, pages 1001-1012.
Crossref
Crossref
Philippe Noriel Q. Pascua, Jun-Han Lee, Min-Suk Song, Soo-Jin Park, Yun Hee Baek, Byung-Hoon Ann, Eun-Young Shin, Eung-Gook Kim & Young-Ki Choi. (2011) Role of the p21-activated kinases (PAKs) in influenza A virus replication. Biochemical and Biophysical Research Communications 414:3, pages 569-574.
Crossref
Crossref
Jing Tao, Peter Oladimeji, Leah Rider & Maria Diakonova. (2011) PAK1-Nck Regulates Cyclin D1 Promoter Activity in Response to Prolactin. Molecular Endocrinology 25:9, pages 1565-1578.
Crossref
Crossref
Zhi-yi Guo, Xiao-hui Hao, Fei-Fei Tan, Xin Pei, Li-Mei Shang, Xue-lian Jiang & Fang Yang. (2011) The elements of human cyclin D1 promoter and regulation involved. Clinical Epigenetics 2:2, pages 63-76.
Crossref
Crossref
Tanya Nekrasova & Audrey Minden. (2011) PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression. Journal of Cellular Biochemistry 112:7, pages 1795-1806.
Crossref
Crossref
Xiang Li, Weihong Wen, Kangdong Liu, Feng Zhu, Margarita Malakhova, Cong Peng, Tingting Li, Hong-Gyum Kim, Weiya Ma, Yong Yeon Cho, Ann M. Bode, Ziming Dong & Zigang Dong. (2011) Phosphorylation of Caspase-7 by p21-activated Protein Kinase (PAK) 2 Inhibits Chemotherapeutic Drug-induced Apoptosis of Breast Cancer Cell Lines. Journal of Biological Chemistry 286:25, pages 22291-22299.
Crossref
Crossref
Palak Parekh, Leena Motiwale, Nishigandha Naik & K.V.K. Rao. (2011) Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells. Experimental and Toxicologic Pathology 63:1-2, pages 167-173.
Crossref
Crossref
Yi-Wen Heng & Cheng-Gee Koh. (2010) Actin cytoskeleton dynamics and the cell division cycle. The International Journal of Biochemistry & Cell Biology 42:10, pages 1622-1633.
Crossref
Crossref
Hendrik J. M. de JongePeter J. M. ValkNic J. G. M. VeegerArja ter ElstMonique L. den BoerJacqueline Cloos, Valérie de Haas, Marry M. van den Heuvel-Eibrink, Gertjan J. L. Kaspers, Christian M. Zwaan, Willem A. Kamps, Bob LöwenbergEveline S. J. M. de Bont. (2010) High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia. Blood 116:10, pages 1747-1754.
Crossref
Crossref
P R Molli, D Q Li, B W Murray, S K Rayala & R Kumar. (2009) PAK signaling in oncogenesis. Oncogene 28:28, pages 2545-2555.
Crossref
Crossref
P R Somanath, J Vijai, J V Kichina, T Byzova & E S Kandel. (2009) The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt. Oncogene 28:25, pages 2365-2369.
Crossref
Crossref
Xiao-ming Huang, Cheng-bo Dai, Zhong-lin Mou, Li-juan Wang, Wei-ping Wen, Shu-guang Lin, Geng Xu & Hua-bin Li. (2009) Overproduction of Cyclin D1 is dependent on activated mTORC1 signal in nasopharyngeal carcinoma: Implication for therapy. Cancer Letters 279:1, pages 47-56.
Crossref
Crossref
Ellen Puré & Richard K. Assoian. (2009) Rheostatic signaling by CD44 and hyaluronan. Cellular Signalling 21:5, pages 651-655.
Crossref
Crossref
Zhen ZhaoCheryl ParkMelissa A. McDevittChristine Glidewell-Kenney, Pierre Chambon, Jeffrey Weiss, J. Larry Jameson & Jon E. Levine. (2009) p21-Activated kinase mediates rapid estradiol-negative feedback actions in the reproductive axis. Proceedings of the National Academy of Sciences 106:17, pages 7221-7226.
Crossref
Crossref
Mark C. Wilkes, Claire E. Repellin, Min Hong, Margarita Bracamonte, Sumedha G. Penheiter, Jean-Paul Borg & Edward B. Leof. (2009) Erbin and the NF2 Tumor Suppressor Merlin Cooperatively Regulate Cell-Type-Specific Activation of PAK2 by TGF-β. Developmental Cell 16:3, pages 433-444.
Crossref
Crossref
Hiroshi Maruta & Toshiro Ohta. 2009. Complementary and Alternative Therapies and the Aging Population. Complementary and Alternative Therapies and the Aging Population
523
539
.
B Maroto, M B Ye, K von Lohneysen, A Schnelzer & U G Knaus. (2008) P21-activated kinase is required for mitotic progression and regulates Plk1. Oncogene 27:36, pages 4900-4908.
Crossref
Crossref
Akio Horiguchi, Rong Zheng, Ruoqian Shen & David M. Nanus. (2008) Inactivation of the NF2 tumor suppressor protein merlin in DU145 prostate cancer cells. The Prostate 68:9, pages 975-984.
Crossref
Crossref
Luis E. Arias-Romero & Jonathan Chernoff. (2008) A tale of two Paks. Biology of the Cell 100:2, pages 97-108.
Crossref
Crossref
Mirjam Zegers. 2008.
253
298
.
Mark W. Mayhew, Erin D. Jeffery, Nicholas E. Sherman, Kristina Nelson, Joy M. Polefrone, Stephen J. Pratt, Jeffrey Shabanowitz, J. Thomas Parsons, Jay W. Fox, Donald F. Hunt & Alan F. Horwitz. (2007) Identification of phosphorylation sites in βPIX and PAK1. Journal of Cell Science 120:22, pages 3911-3918.
Crossref
Crossref
M Thullberg, A Gad, A Beeser, J Chernoff & S Strömblad. (2006) The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity. Oncogene 26:12, pages 1820-1828.
Crossref
Crossref
F Chiaradonna, E Sacco, R Manzoni, M Giorgio, M Vanoni & L Alberghina. (2006) Ras-dependent carbon metabolism and transformation in mouse fibroblasts. Oncogene 25:39, pages 5391-5404.
Crossref
Crossref
Sanggyu LeeJianjun ChenGuolin ZhouRun Zhang ShiGerard G. BouffardMasha KocherginskyXijin GeMiao SunNimanthi JayathilakaYeong Cheol KimNeelmini EmmanuelStefan K. BohlanderMark MindenJustin KlineOzden OzerRichard A. LarsonMichelle M. LeBeauEric D. GreenJeffery TrentTheodore KarrisonPiu Paul LiuSan Ming WangJanet D. Rowley. (2006) Gene expression profiles in acute myeloid leukemia with common translocations using SAGE. Proceedings of the National Academy of Sciences 103:4, pages 1030-1035.
Crossref
Crossref
Kiran S. Nadella & Lawrence S. Kirschner. (2005) Disruption of Protein Kinase A Regulation Causes Immortalization and Dysregulation of D-Type Cyclins. Cancer Research 65:22, pages 10307-10315.
Crossref
Crossref
Guoxiang Shen, Changjiang Xu, Rong Hu, Mohit R. Jain, Sujit Nair, Wen Lin, Chung S. Yang, Jefferson Y. Chan & A.-N. Tony Kong. (2005) Comparison of (−)-Epigallocatechin-3-Gallate Elicited Liver and Small Intestine Gene Expression Profiles Between C57BL/6J Mice and C57BL/6J/Nrf2 (−/−) Mice. Pharmaceutical Research 22:11, pages 1805-1820.
Crossref
Crossref
Joyce J. Fernandes, Krishan B. Atreya, Krishna M. Desai, Rachel E. Hall, Meatal D. Patel, Amita A. Desai, Amy E. Benham, Jessica L. Mable & Jennifer L. Straessle. (2005) A dominant negative form of Rac1 affects myogenesis of adult thoracic muscles in Drosophila. Developmental Biology 285:1, pages 11-27.
Crossref
Crossref
Eliezer Masliah, Eleanor S. Roberts, Dianne Langford, Ian Everall, Leslie Crews, Anthony Adame, Edward Rockenstein & Howard S. Fox. (2004) Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis. Journal of Neuroimmunology 157:1-2, pages 163-175.
Crossref
Crossref