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Perspectives

Initiation of mRNA Translation in Oncogenesis: The Role of eIF4E

Pages 1387-1389 | Published online: 03 Sep 2004

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Filippa Pettersson, Sonia V del Rincon & Wilson H Miller$suffix/text()$suffix/text(). (2014) Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond. Expert Opinion on Therapeutic Targets 18:9, pages 1035-1048.
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Ivan Topisirovic, Nadeem Siddiqui, Slobodanka Orolicki, Lucy A. Skrabanek, Mathieu Tremblay, Trang Hoang & Katherine L. B. Borden. (2009) Stability of Eukaryotic Translation Initiation Factor 4E mRNA Is Regulated by HuR, and This Activity Is Dysregulated in Cancer. Molecular and Cellular Biology 29:5, pages 1152-1162.
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Articles from other publishers (19)

Jinbae Yu, Youngsik Woo, Heesun Kim, Sihyeon An, Sang Ki Park & Sung Key Jang. (2023) FMRP Enhances the Translation of 4EBP2 mRNA during Neuronal Differentiation. International Journal of Molecular Sciences 24:22, pages 16319.
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Oshrat Attar-Schneider, Victoria Zismanov, Mahmoud Dabbah, Shelly Tartakover-Matalon, Liat Drucker & Michael Lishner. (2016) Multiple myeloma and bone marrow mesenchymal stem cells’ crosstalk: Effect on translation initiation. Molecular Carcinogenesis 55:9, pages 1343-1354.
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Cheryl M. Koh, Arianna Sabò & Ernesto Guccione. (2016) Targeting MYC in cancer therapy: RNA processing offers new opportunities. BioEssays 38:3, pages 266-275.
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Maxwell S. Bush, Natalie Crowe, Tao Zheng & John H. Doonan. (2015) The RNA helicase, eIF4A-1, is required for ovule development and cell size homeostasis in Arabidopsis. The Plant Journal 84:5, pages 989-1004.
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Oshrat Attar-Schneider, Metsada Pasmanik-Chor, Shelly Tartakover-Matalon, Liat Drucker & Michael Lishner. (2015) eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling. Oncotarget 6:6, pages 4315-4329.
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VICTORIA ZISMANOV, OSHRAT ATTAR-SCHNEIDER, MICHAEL LISHNER, RACHEL HEFFEZ AIZENFELD, SHELLY TARTAKOVER MATALON & LIAT DRUCKER. (2015) Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E. International Journal of Oncology 46:2, pages 860-870.
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Leonarda D’Angelo, Giulia Piazzi, Annalisa Pacilli, Anna Prossomariti, Chiara Fazio, Lorenzo Montanaro, Giulia Graziani, Vincenzo Fogliano, Alessandra Munarini, Francesca Bianchi, Andrea Belluzzi, Franco Bazzoli & Luigi Ricciardiello. (2014) A combination of eicosapentaenoic acid-free fatty acid, epigallocatechin-3-gallate and proanthocyanidins has a strong effect on mTOR signaling in colorectal cancer cells. Carcinogenesis 35:10, pages 2314-2320.
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Denis Drygin, Sean E. O’Brien, Ross D. Hannan, Grant A. McArthur & Daniel D. Von Hoff. (2014) Targeting the nucleolus for cancer-specific activation of p53. Drug Discovery Today 19:3, pages 259-265.
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Wei Mei Guo, Kiat Whye Kong, Christopher John Brown, Soo Tng Quah, Hui Ling Yeo, Shawn Hoon & Yiqi Seow. (2014) Identification and Characterization of an eIF4e DNA Aptamer That Inhibits Proliferation With High Throughput Sequencing. Molecular Therapy - Nucleic Acids 3, pages e217.
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Dilraj Lama, Soo T. Quah, Chandra S. Verma, Rajamani Lakshminarayanan, Roger W. Beuerman, David P. Lane & Christopher J. Brown. (2013) Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces. Scientific Reports 3:1.
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Oshrat Attar-Schneider, Liat Drucker, Victoria Zismanov, Shelly Tartakover-Matalon, Gloria Rashid & Michael Lishner. (2012) Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells. Laboratory Investigation 92:2, pages 178-190.
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Mark F. McCarty. (2011) mTORC1 activity as a determinant of cancer risk – Rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low-protein vegan diets. Medical Hypotheses 77:4, pages 642-648.
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C.J. Brown, J.J. Lim, T. Leonard, H.C.A. Lim, C.S.B. Chia, C.S. Verma & D.P. Lane. (2011) Stabilizing the eIF4G1 α-Helix Increases Its Binding Affinity with eIF4E: Implications for Peptidomimetic Design Strategies. Journal of Molecular Biology 405:3, pages 736-753.
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Barbara Cisterna & Marco Biggiogera. 2010. 67 111 .
Ivan Topisirovic, Nadeem Siddiqui, Vincent Leroux Lapointe, Matthias Trost, Pierre Thibault, Catherine Bangeranye, Serafin Piñol-Roma & Katherine L B Borden. (2009) Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP. The EMBO Journal 28:8, pages 1087-1098.
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Lorenzo Montanaro, Davide Treré & Massimo Derenzini. (2008) Nucleolus, Ribosomes, and Cancer. The American Journal of Pathology 173:2, pages 301-310.
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Cherie-Ann O. Nathan, Nazanin Amirghahari, Xiaohua Rong, Tony Giordano, Don Sibley, Mary Nordberg, Jonathan Glass, Anshul Agarwal & Gloria Caldito. (2007) Mammalian Target of Rapamycin Inhibitors as Possible Adjuvant Therapy for Microscopic Residual Disease in Head and Neck Squamous Cell Cancer. Cancer Research 67:5, pages 2160-2168.
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Josep Castellvi, Angel Garcia, Federico Rojo, Carmen Ruiz‐Marcellan, Antonio Gil, Jose Baselga & Santiago Ramon y Cajal. (2006) Phosphorylated 4E binding protein 1: A hallmark of cell signaling that correlates with survival in ovarian cancer. Cancer 107:8, pages 1801-1811.
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Kwang-Jin Oh, Anna Kalinina, No-Hee Park & Srilata Bagchi. (2006) Deregulation of eIF4E: 4E-BP1 in Differentiated Human Papillomavirus-Containing Cells Leads to High Levels of Expression of the E7 Oncoprotein. Journal of Virology 80:14, pages 7079-7088.
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