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Spotlight on HIF

An Unexpected Role for Hypoxic Response: Oxygenation and Inflammation

Pages 163-166 | Published online: 03 Dec 2003

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Xinkun Guo, Zhaoqin Zhu, Wanju Zhang, Xiaoxiao Meng, Yong Zhu, Peng Han, Xiaohui Zhou, Yunwen Hu & Ruilan Wang. (2017) Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines. Emerging Microbes & Infections 6:1, pages 1-8.
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Articles from other publishers (31)

Irena Maček. 2022. Extremophilic Fungi. Extremophilic Fungi 219 243 .
Shiwen Xu, Chunyan Yu, Xiaoxia Ma, Yan Li, Yangyang Shen, Yan Chen, Suhui Huang, Tongshuo Zhang, Weimin Deng & Yue Wang. (2021) IL-6 promotes nuclear translocation of HIF-1α to aggravate chemoresistance of ovarian cancer cells. European Journal of Pharmacology 894, pages 173817.
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John Quiroga, Pablo Alarcón, Carolina Manosalva, Anja Taubert, Carlos Hermosilla, María Angélica Hidalgo, María Daniella Carretta & Rafael Agustín Burgos. (2020) Glycolysis and mitochondrial function regulate the radical oxygen species production induced by platelet-activating factor in bovine polymorphonuclear leukocytes. Veterinary Immunology and Immunopathology 226, pages 110074.
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Irena Maček. 2019. Fungi in Extreme Environments: Ecological Role and Biotechnological Significance. Fungi in Extreme Environments: Ecological Role and Biotechnological Significance 3 19 .
Deepti Rane, Tejaswini Patil, Vasundhara More, Sushree Sangita Patra, Neeelam Bodhale, Jagneswar Dandapat & Arup Sarkar. (2018) Neutrophils: Interplay between host defense, cellular metabolism and intracellular infection. Cytokine 112, pages 44-51.
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Robert Crichton. 2016. Iron Metabolism. Iron Metabolism 418 443 .
Xiaoyan Huang, Zhiying He, Xinwei Jiang, Mengjun Hou, Zhihong Tang, Xiaozhou Zhen, Yuming Liang & Jing Ma. (2016) Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α Pathway. PLOS ONE 11:3, pages e0151553.
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Carol Shoshkes Reiss. 2016. Neurotropic Viral Infections. Neurotropic Viral Infections 251 303 .
Estefania P. Azevedo, Natalia C. Rochael, Anderson B. Guimarães-Costa, Thiago S. de Souza-Vieira, Juliana Ganilho, Elvira M. Saraiva, Fernando L. Palhano & Debora Foguel. (2015) A Metabolic Shift toward Pentose Phosphate Pathway Is Necessary for Amyloid Fibril- and Phorbol 12-Myristate 13-Acetate-induced Neutrophil Extracellular Trap (NET) Formation. Journal of Biological Chemistry 290:36, pages 22174-22183.
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Jing Li, Kyungho Kim, Andrew Barazia, Alan Tseng & Jaehyung Cho. (2015) Platelet–neutrophil interactions under thromboinflammatory conditions. Cellular and Molecular Life Sciences 72:14, pages 2627-2643.
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Oscar Rodríguez-Espinosa, Oscar Rojas-Espinosa, María Maximina Bertha Moreno-Altamirano, Edgar Oliver López-Villegas & Francisco Javier Sánchez-García. (2015) Metabolic requirements for neutrophil extracellular traps formation. Immunology 145:2, pages 213-224.
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Rossana G. Iannitti, Andrea Casagrande, Antonella De Luca, Cristina Cunha, Guglielmo Sorci, Francesca Riuzzi, Monica Borghi, Claudia Galosi, Cristina Massi-Benedetti, Tim D. Oury, Lisa Cariani, Maria Russo, Luigi Porcaro, Carla Colombo, Fabio Majo, Vincenzina Lucidi, Ersilia Fiscarelli, Gabriella Ricciotti, Cornelia Lass-Flörl, Luigi Ratclif, Antonella Esposito, Fernando Maria De Benedictis, Rosario Donato, Agostinho Carvalho & Luigina Romani. (2013) Hypoxia Promotes Danger-mediated Inflammation via Receptor for Advanced Glycation End Products in Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine 188:11, pages 1338-1350.
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Maria Andonova & Valentina Urumova. (2013) Immune surveillance mechanisms of the skin against the stealth infection strategy of Pseudomonas aeruginosa—Review. Comparative Immunology, Microbiology and Infectious Diseases 36:5, pages 433-448.
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Jing-Ping Li, François Y. L. Li, Aimin Xu, Bin Cheng, Sai Wah Tsao, Man-Lung Fung & W. Keung Leung. (2012) Lipopolysaccharide and Hypoxia-Induced HIF-1 Activation in Human Gingival Fibroblasts. Journal of Periodontology 83:6, pages 816-824.
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Nora Grahl, Kelly M. Shepardson, Dawoon Chung & Robert A. Cramer. (2012) Hypoxia and Fungal Pathogenesis: To Air or Not To Air?. Eukaryotic Cell 11:5, pages 560-570.
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Jamie J. Bernard & Richard L. Gallo. (2011) Protecting the boundary: the sentinel role of host defense peptides in the skin. Cellular and Molecular Life Sciences 68:13, pages 2189-2199.
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Benoit Marteyn, Francesco Berlanda Scorza, Philippe J. Sansonetti & Christoph Tang. (2011) Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract. Cellular Microbiology 13:2, pages 171-176.
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Christian Werno, Tobias Schmid, Steffen E. Schnitzer, Kathrin Peters, Larissa Milke & Bernhard Brüne. (2010) A Combination of Hypoxia and Lipopolysaccharide Activates Tristetraprolin to Destabilize Proinflammatory mRNAs such as Tumor Necrosis Factor-α. The American Journal of Pathology 177:3, pages 1104-1112.
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Tissa Hata & Richard Gallo. 2009. Atopic Dermatitis, Second Edition. Atopic Dermatitis, Second Edition 101 119 .
Stilla Frede, Christian Stockmann, Sandra Winning, Patricia Freitag & Joachim Fandrey. (2009) Hypoxia-Inducible Factor (HIF) 1α Accumulation and HIF Target Gene Expression Are Impaired after Induction of Endotoxin Tolerance. The Journal of Immunology 182:10, pages 6470-6476.
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Carol Shoshkes Reiss. 2009. Neurotropic Viral Infections. Neurotropic Viral Infections 265 291 .
Carol Shoshkes Reiss. 2009. Neurotropic Viral Infections. Neurotropic Viral Infections 263 264 .
Tissa R. Hata & Richard L. Gallo. (2008) Antimicrobial Peptides, Skin Infections, and Atopic Dermatitis. Seminars in Cutaneous Medicine and Surgery 27:2, pages 144-150.
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Bram J. van Raam, Wim Sluiter, Elly de Wit, Dirk Roos, Arthur J. Verhoeven & Taco W. Kuijpers. (2008) Mitochondrial Membrane Potential in Human Neutrophils Is Maintained by Complex III Activity in the Absence of Supercomplex Organisation. PLoS ONE 3:4, pages e2013.
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Daniel P. Schuster, Steven L. Brody, Zhaohui Zhou, Matt Bernstein, Robert Arch, Daniel Link & Michael Mueckler. (2007) Regulation of lipopolysaccharide-induced increases in neutrophil glucose uptake. American Journal of Physiology-Lung Cellular and Molecular Physiology 292:4, pages L845-L851.
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Katherine Radek & Richard Gallo. (2007) Antimicrobial peptides: natural effectors of the innate immune system. Seminars in Immunopathology 29:1, pages 27-43.
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M. Christiane Brahimi-Horn & Jacques Pouysségur. (2007) Harnessing the hypoxia-inducible factor in cancer and ischemic disease. Biochemical Pharmacology 73:3, pages 450-457.
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Stilla Frede, Christian Stockmann, Patricia Freitag & Joachim Fandrey. (2006) Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB. Biochemical Journal 396:3, pages 517-527.
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John J. Haddad & Hisham L. Harb. (2005) l-γ-Glutamyl-l-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)?. Molecular Immunology 42:9, pages 987-1014.
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Karen D. Cowden Dahl, Sarah E. Robertson, Valerie M. Weaver & M. Celeste Simon. (2005) Hypoxia-inducible Factor Regulates αvβ3 Integrin Cell Surface Expression. Molecular Biology of the Cell 16:4, pages 1901-1912.
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John J. Haddad & Hisham L. Harb. (2005) Cytokines and the regulation of hypoxia-inducible factor (HIF)-1α. International Immunopharmacology 5:3, pages 461-483.
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