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Ubiquitination of PCNA and the Polymerase Switch in Human Cells

Pages 1009-1011 | Published online: 21 May 2004

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Sumeet Nayak, Jennifer A. Calvo & Sharon B. Cantor. (2021) Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability. Expert Opinion on Therapeutic Targets 25:1, pages 27-36.
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Stephanie Tirman, Emily Cybulla, Annabel Quinet, Alice Meroni & Alessandro Vindigni. (2021) PRIMPOL ready, set, reprime!. Critical Reviews in Biochemistry and Molecular Biology 56:1, pages 17-30.
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A. N. Sakamoto, H. Kaya & M. Endo. (2018) Deletion of TLS polymerases promotes homologous recombination in Arabidopsis. Plant Signaling & Behavior 13:7.
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Dechen Fu, Fred Dudimah, Jun Zhang, Anna Pickering, Jayabal Paneerselvam, Manikandan Palrasu, Hong Wang & Peiwen Fei. (2013) Recruitment of DNA polymerase eta by FANCD2 in the early response to DNA damage. Cell Cycle 12:5, pages 803-809.
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Parameswary A Muniandy, Jia Liu, Alokes Majumdar, Su-ting Liu & Michael M. Seidman. (2010) DNA interstrand crosslink repair in mammalian cells: step by step. Critical Reviews in Biochemistry and Molecular Biology 45:1, pages 23-49.
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Alihossein Saberi, Helfrid Hochegger, David Szuts, Li Lan, Akira Yasui, Julian E. Sale, Yoshihito Taniguchi, Yasuhiro Murakawa, Weihua Zeng, Kyoko Yokomori, Thomas Helleday, Hirobumi Teraoka, Hiroshi Arakawa, Jean-Marie Buerstedde & Shunichi Takeda. (2007) RAD18 and Poly(ADP-Ribose) Polymerase Independently Suppress the Access of Nonhomologous End Joining to Double-Strand Breaks and Facilitate Homologous Recombination-Mediated Repair. Molecular and Cellular Biology 27:7, pages 2562-2571.
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Miguel Garcia-Diaz & Katarzyna Bebenek. (2007) Multiple Functions of DNA Polymerases. Critical Reviews in Plant Sciences 26:2, pages 105-122.
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Sanjay D'Souza & Graham C. Walker. (2006) Novel Role for the C Terminus of Saccharomyces cerevisiae Rev1 in Mediating Protein-Protein Interactions. Molecular and Cellular Biology 26:21, pages 8173-8182.
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Marina A. Bellani, Althaf Shaik, Ishani Majumdar, Chen Ling & Michael M. Seidman. (2023) The Response of the Replication Apparatus to Leading Template Strand Blocks. Cells 12:22, pages 2607.
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Jameson R. Averill & Hunmin Jung. (2023) Mutagenic incorporation of inosine into DNA via T:I mismatch formation by human DNA polymerase eta (polη). Biochemical Journal 480:9, pages 649-664.
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Xiaolu Ma, Chen Wang, Bo Zhou, Zina Cheng, Zhiyong Mao, Tie-Shan Tang & Caixia Guo. (2022) DNA polymerase η promotes nonhomologous end joining upon etoposide exposure dependent on the scaffolding protein Kap1. Journal of Biological Chemistry 298:5, pages 101861.
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Dana Sherill-Rofe, Oded Raban, Steven Findlay, Dolev Rahat, Irene Unterman, Arash Samiei, Amber Yasmeen, Zafir Kaiser, Hellen Kuasne, Morag Park, William D Foulkes, Idit Bloch, Aviad Zick, Walter H Gotlieb, Yuval Tabach & Alexandre Orthwein. (2022) Multi-omics data integration analysis identifies the spliceosome as a key regulator of DNA double-strand break repair. NAR Cancer 4:2.
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Leticia K. Lerner, Dorine Bonte, Morwenna Le Guillou, Mahwish Mian Mohammad, Zeinab Kasraian, Alain Sarasin, Emmanuelle Despras & Said Aoufouchi. (2022) Expression of Constitutive Fusion of Ubiquitin to PCNA Restores the Level of Immunoglobulin A/T Mutations During Somatic Hypermutation in the Ramos Cell Line. Frontiers in Immunology 13.
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Kodavati Manohar, Prashant Khandagale, Shraddheya Kumar Patel, Jugal Kishor Sahu & Narottam Acharya. (2022) The ubiquitin-binding domain of DNA polymerase η directly binds to DNA clamp PCNA and regulates translesion DNA synthesis. Journal of Biological Chemistry 298:2, pages 101506.
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Simone Sabbioneda. 2021. Encyclopedia of Biological Chemistry III. Encyclopedia of Biological Chemistry III 345 351 .
Sumeet Nayak, Jennifer A. CalvoKe CongMin PengEmily BerthiaumeJessica JacksonAngela M. ZainoAlessandro VindigniM. Kyle HaddenSharon B. Cantor. (2020) Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability. Science Advances 6:24.
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Hyun Je Kang, Hyun Park, Eun Jin Yoo, Jun Ho Lee, Soo Youn Choi, Whaseon Lee-Kwon, Kyoo-young Lee, Jin-Hoe Hur, Jeong Kon Seo, Jae Sun Ra, Eun-A. Lee, Kyungjae Myung & Hyug Moo Kwon. (2019) TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1. iScience 19, pages 177-190.
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Yanzhe Gao, Jordan Kardos, Yang Yang, Tigist Y. Tamir, Elizabeth Mutter-Rottmayer, Bernard Weissman, Michael B. Major, William Y. Kim & Cyrus Vaziri. (2018) The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells. Scientific Reports 8:1.
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R R Somasagara, S M Spencer, K Tripathi, D W Clark, C Mani, L Madeira da Silva, J Scalici, H Kothayer, A D Westwell, R P Rocconi & K Palle. (2017) RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance. Oncogene 36:48, pages 6680-6690.
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Marietta Lee, Xiaoxiao Wang, Sufang Zhang, Zhongtao Zhang & Ernest Lee. (2017) Regulation and Modulation of Human DNA Polymerase δ Activity and Function. Genes 8:7, pages 190.
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Matthew A. Sanders, Brittany Haynes, Pratima Nangia-Makker, Lisa A. Polin & Malathy P. Shekhar. (2017) Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs. Journal of Biological Chemistry 292:25, pages 10347-10363.
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Britny Blumenfeld, Micha Ben-Zimra & Itamar Simon. (2017) Perturbations in the Replication Program Contribute to Genomic Instability in Cancer. International Journal of Molecular Sciences 18:6, pages 1138.
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Young Joo Jeon, Jong Ho Park & Chin Ha Chung. (2017) Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress. Molecules and Cells 40:2, pages 83-89.
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Yanzhe Gao, Elizabeth Mutter-Rottmayer, Anastasia Zlatanou, Cyrus Vaziri & Yang Yang. (2017) Mechanisms of Post-Replication DNA Repair. Genes 8:2, pages 64.
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Emmanuelle Despras, Méghane Sittewelle, Caroline Pouvelle, Noémie Delrieu, Agnès M Cordonnier & Patricia L Kannouche. (2016) Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA. Nature Communications 7:1.
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Linda Millyard, Jack Lee, Cunjin Zhang, Gary Yates & Ari Sadanandom. (2016) The ubiquitin conjugating enzyme, TaU4 regulates wheat defence against the phytopathogen Zymoseptoria tritici. Scientific Reports 6:1.
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Yanzhe Gao, Elizabeth Mutter-Rottmayer, Alicia M. Greenwalt, Dennis Goldfarb, Feng Yan, Yang Yang, Raquel C. Martinez-Chacin, Kenneth H. Pearce, Satoshi Tateishi, Michael B. Major & Cyrus Vaziri. (2016) A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis. Nature Communications 7:1.
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Lina Cipolla, Antonio Maffia, Federica Bertoletti & Simone Sabbioneda. (2016) The Regulation of DNA Damage Tolerance by Ubiquitin and Ubiquitin-Like Modifiers. Frontiers in Genetics 7.
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