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Taming the Hippo: Raf-1 Controls Apoptosis by Suppressing MST2/Hippo

Pages 365-367 | Published online: 01 Feb 2005

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Su An, Yang Yang, Richard Ward, Ying Liu, Xiao-Xi Guo & Tian-Rui Xu. (2015) A-Raf: A new star of the family of raf kinases. Critical Reviews in Biochemistry and Molecular Biology 50:6, pages 520-531.
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Lan K Nguyen, David G Matallanas, David Romano, Boris N Kholodenko & Walter Kolch. (2015) Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device. Cell Cycle 14:2, pages 189-199.
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Angela M Liu, Michelle Z Xu, Jinfei Chen, Ronnie T Poon & John M Luk. (2010) Targeting YAP and Hippo signaling pathway in liver cancer. Expert Opinion on Therapeutic Targets 14:8, pages 855-868.
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Ke Sun, Yize Sun, Yunna Jia, Xinran Duan, Zhenhua Ma, Xiqing Zhang, Lixia Wang, Yanbin Zhu, Yunhang Gao & Wangdui Basang. (2023) MicroRNA miR-212-5p Regulates the MEK/ERK Signaling Pathway by Targeting A-Raf proto-oncogene serine/threonine-protein kinase (ARAF) to Regulate Cowshed PM2.5-Induced NR8383 Apoptosis. Toxics 11:12, pages 981.
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Yunfei Yin, Mingyue Tan, Lianhua Han, Lei Zhang, Yue Zhang, Jun Zhang, Wanqian Pan, Jiaxiang Bai, Tingbo Jiang & Hongxia Li. (2023) The hippo kinases MST1/2 in cardiovascular and metabolic diseases: A promising therapeutic target option for pharmacotherapy. Acta Pharmaceutica Sinica B 13:5, pages 1956-1975.
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Sofiia KarchuginaDorothy BentonJonathan Chernoff. (2021) Regulation of MST complexes and activity via SARAH domain modifications. Biochemical Society Transactions 49:2, pages 675-683.
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Shilpi Verghese, Indrayani Waghmare, Shree Ram Singh & Madhuri Kango-Singh. 2020. Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye. Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye 215 257 .
S. Pauliina Turunen, Pernilla von Nandelstadh, Tiina Öhman, Erika Gucciardo, Brinton Seashore-Ludlow, Beatriz Martins, Ville Rantanen, Huini Li, Katrin Höpfner, Päivi Östling, Markku Varjosalo & Kaisa Lehti. (2019) FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. Cell Death & Differentiation 26:12, pages 2577-2593.
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Mubarak A. AlAmri, Hachemi Kadri, Luke J. Alderwick, Mark Jeeves & Youcef Mehellou. (2018) The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 Kinases. ChemBioChem 19:19, pages 2072-2080.
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Helena J. Janse van Rensburg, Taha Azad, Min Ling, Yawei Hao, Brooke Snetsinger, Prem Khanal, Lori M. Minassian, Charles H. Graham, Michael J. Rauh & Xiaolong Yang. (2018) The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1. Cancer Research 78:6, pages 1457-1470.
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Clara Ugolini, Nicla Borrelli, Cristina Niccoli, Rossella Elisei, David Viola, Paolo Vitti, Paolo Miccoli & Fulvio Basolo. (2017) Role of YAP-1 in Thyroid Tumor Progression and Outcome. Applied Immunohistochemistry & Molecular Morphology 25:8, pages 581-585.
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Barbara Bassani, Antonino Bruno, Nicoletta Macrì, Paola Corradino, Douglas M. Noonan & Adriana Albini. 2017. Manual of Cardio-oncology. Manual of Cardio-oncology 107 122 .
Devin G. Roller, Brian Capaldo, Stefan Bekiranov, Aaron J. Mackey, Mark R. Conaway, Emanuel F. Petricoin, Daniel Gioeli & Michael J. Weber. (2015) Combinatorial drug screening and molecular profiling reveal diverse mechanisms of intrinsic and adaptive resistance to BRAF inhibition in V600E BRAF mutant melanomas. Oncotarget 7:3, pages 2734-2753.
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Yulei Zhao & Xiaolong Yang. (2014) The H ippo pathway in chemotherapeutic drug resistance . International Journal of Cancer 137:12, pages 2767-2773.
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Indrayani Waghmare, Shilpi Verghese & Madhuri Kango‐Singh. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences 1 9 .
Sonali J. Rawat & Jonathan Chernoff. (2015) Regulation of mammalian Ste20 (Mst) kinases. Trends in Biochemical Sciences 40:3, pages 149-156.
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Lin YuJoseph P. DanielsHuihui WuMatthew J. Wolf. (2015) Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription. Science Signaling 8:362.
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Su An, Yang Yang, Richard Ward, Ying Liu, Xiao-Xi Guo & Tian-Rui Xu. (2015) Raf-interactome in tuning the complexity and diversity of Raf function. FEBS Journal 282:1, pages 32-53.
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David Romano, David Matallanas, Dennie T. FrederickKeith T. FlahertyWalter Kolch. (2014) One Hippo and many masters: differential regulation of the Hippo pathway in cancer. Biochemical Society Transactions 42:4, pages 816-821.
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Guoguang Liu, Zhubing Shi, Shi Jiao, Zhenzhen Zhang, Wenjia Wang, Cuicui Chen, Qiao Hao, Meng Zhang, Miao Feng, Liang Xu, Zhen Zhang, Zhaocai Zhou & Min Zhang. (2014) Structure of MST2 SARAH domain provides insights into its interaction with RAPL. Journal of Structural Biology 185:3, pages 366-374.
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S E Lee, J U Lee, M H Lee, M J Ryu, S J Kim, Y K Kim, M J Choi, K S Kim, J M Kim, J W Kim, Y W Koh, D-S Lim, Y S Jo & M Shong. (2013) RAF kinase inhibitor-independent constitutive activation of Yes-associated protein 1 promotes tumor progression in thyroid cancer. Oncogenesis 2:7, pages e55-e55.
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Mingqian FengWei GaoRuoqi WangWeizao Chen, Yan-Gao Man, William Douglas Figg, Xin Wei WangDimiter S. Dimitrov & Mitchell Ho. (2013) Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma. Proceedings of the National Academy of Sciences 110:12.
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Lan K Nguyen, Walter Kolch & Boris N Kholodenko. (2013) When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling. Cell Communication and Signaling 11:1, pages 52.
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Shilpi Verghese, Indrayani Waghmare, Shree Ram Singh & Madhuri Kango-Singh. 2013. Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye. Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye 229 270 .
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Chuan-Ming XU & Fu-Sheng WAN. (2012) Hippo signaling pathway in mammals:a new therapeutic target for tumors. Hereditas (Beijing) 34:3, pages 269-280.
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Diana Constantinescu Aruxandei, Cihan Makbul, Agne Koturenkiene, Maik-Borris Lüdemann & Christian Herrmann. (2011) Dimerization-Induced Folding of MST1 SARAH and the Influence of the Intrinsically Unstructured Inhibitory Domain: Low Thermodynamic Stability of Monomer. Biochemistry 50:51, pages 10990-11000.
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Seong Jin Lee, Min Hee Lee, Dong Wook Kim, SeongEun Lee, Songmei Huang, Min Jeong Ryu, Yong Kyung Kim, Sung Jin Kim, Soung Jung Kim, Jung Hwan Hwang, Sangphil Oh, Heeyeong Cho, Jin Man Kim, Dae-Sik Lim, Young Suk Jo & Minho Shong. (2011) Cross-Regulation between Oncogenic BRAFV600E Kinase and the MST1 Pathway in Papillary Thyroid Carcinoma. PLoS ONE 6:1, pages e16180.
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David Romano, David Matallanas, Gregory Weitsman, Christian Preisinger, Tony Ng & Walter Kolch. (2010) Proapoptotic Kinase MST2 Coordinates Signaling Crosstalk between RASSF1A, Raf-1, and Akt. Cancer Research 70:3, pages 1195-1203.
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Katherine R. Schouest, Yasuhiro Kurasawa, Tokiko Furuta, Naoki Hisamoto, Kunihiro Matsumoto & Jill M. Schumacher. (2009) The Germinal Center Kinase GCK-1 Is a Negative Regulator of MAP Kinase Activation and Apoptosis in the C. elegans Germline. PLoS ONE 4:10, pages e7450.
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L S Steelman, S L Abrams, J Whelan, F E Bertrand, D E Ludwig, J Bäsecke, M Libra, F Stivala, M Milella, A Tafuri, P Lunghi, A Bonati, A M Martelli & J A McCubrey. (2008) Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. Leukemia 22:4, pages 686-707.
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Deborah T. Leicht, Vitaly Balan, Alexander Kaplun, Vinita Singh-Gupta, Ludmila Kaplun, Melissa Dobson & Guri Tzivion. (2007) Raf kinases: Function, regulation and role in human cancer. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:8, pages 1196-1212.
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