Citations (82)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (5)
Francien Talens, Mathilde Jalving, Jourik A. Gietema & Marcel A. Van Vugt. (2017) Therapeutic targeting and patient selection for cancers with homologous recombination defects. Expert Opinion on Drug Discovery 12:6, pages 565-581.
Read now
Read now
Sunetra Roy, Abinadabe J. de Melo, Yao Xu, Satish K. Tadi, Aurélie Négrel, Eric Hendrickson, Mauro Modesti & Katheryn Meek. (2015) XRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV Stimulation. Molecular and Cellular Biology 35:17, pages 3017-3028.
Read now
Read now
Catherine J. Pears, C. Anne-Marie Couto, Hong-Yu Wang, Christine Borer, Rhian Kiely & Nicholas D. Lakin. (2012) The role of ADP-ribosylation in regulating DNA double-strand break repair. Cell Cycle 11:1, pages 48-56.
Read now
Read now
Thomas E. Schmid, Günther Dollinger, Wolfgang Beisker, Volker Hable, Christoph Greubel, Susanne Auer, Anja Mittag, Attila Tarnok, Anna A. Friedl, Michael Molls & Barbara Röper. (2010) Differences in the kinetics of γ-H2AX fluorescence decay after exposure to low and high LET radiation. International Journal of Radiation Biology 86:8, pages 682-691.
Read now
Read now
Julien Bouley, Ludovic Deriano, Jozo Delic & Hélène Merle-Béral. (2006) New molecular markers in resistant B-CLL. Leukemia & Lymphoma 47:5, pages 791-801.
Read now
Read now
Articles from other publishers (77)
Christopher J. Buehl, Noah J. Goff, Steven W. Hardwick, Martin Gellert, Tom L. Blundell, Wei Yang, Amanda K. Chaplin & Katheryn Meek. (2023) Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining. Molecular Cell 83:5, pages 698-714.e4.
Crossref
Crossref
Benjamin M. StinsonJoseph J. Loparo. (2021) Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway. Annual Review of Biochemistry 90:1, pages 137-164.
Crossref
Crossref
Rajesh Kumar Chaurasia, N.N. Bhat, Neeraj Gaur, K.B. Shirsath, U.N. Desai & B.K. Sapra. (2021) Establishment and multiparametric-cytogenetic validation of 60Co-gamma-ray induced, phospho-gamma-H2AX calibration curve for rapid biodosimetry and triage management during radiological emergencies. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 866, pages 503354.
Crossref
Crossref
Sang-Min Jang, Christophe E. Redon, Haiqing Fu, Fred E. Indig & Mirit I. Aladjem. (2021) RepID-deficient cancer cells are sensitized to a drug targeting p97/VCP segregase. Molecular & Cellular Toxicology 17:2, pages 141-149.
Crossref
Crossref
Bailin Zhao, Eli Rothenberg, Dale A. Ramsden & Michael R. Lieber. (2020) The molecular basis and disease relevance of non-homologous DNA end joining. Nature Reviews Molecular Cell Biology 21:12, pages 765-781.
Crossref
Crossref
Bailin Zhao, Go Watanabe & Michael R Lieber. (2020) Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system. Nucleic Acids Research 48:7, pages 3605-3618.
Crossref
Crossref
Melike Çağlayan. (2020) Pol μ ribonucleotide insertion opposite 8-oxodG facilitates the ligation of premutagenic DNA repair intermediate. Scientific Reports 10:1.
Crossref
Crossref
Melike Çağlayan. (2019) Interplay between DNA Polymerases and DNA Ligases: Influence on Substrate Channeling and the Fidelity of DNA Ligation. Journal of Molecular Biology 431:11, pages 2068-2081.
Crossref
Crossref
Melike Çağlayan & Samuel H. Wilson. (2018) Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate. Nature Communications 9:1.
Crossref
Crossref
Sreerupa Ray, Gregory Breuer, Michelle DeVeaux, Daniel Zelterman, Ranjit Bindra & Joann B Sweasy. (2018) DNA polymerase beta participates in DNA End-joining. Nucleic Acids Research 46:1, pages 242-255.
Crossref
Crossref
Havva Keskin & Francesca Storici. 2018. Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair. Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair
59
70
.
Edward J. Bartlett & Susan P. Lees-Miller. 2018. Targeting the DNA Damage Response for Anti-Cancer Therapy. Targeting the DNA Damage Response for Anti-Cancer Therapy
315
338
.
Varandt Y. Khodaverdian, Terrence Hanscom, Amy Marie Yu, Taylor L. Yu, Victoria Mak, Alexander J. Brown, Steven A. Roberts & Mitch McVey. (2017) Secondary structure forming sequences drive SD-MMEJ repair of DNA double-strand breaks. Nucleic Acids Research 45:22, pages 12848-12861.
Crossref
Crossref
Sonali Bhattacharjee & Saikat Nandi. (2016) Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer. Clinical and Translational Medicine 5:1.
Crossref
Crossref
Charlene H. EmersonAlison A. Bertuch. (2016) Consider the workhorse: Nonhomologous end-joining in budding yeast. Biochemistry and Cell Biology 94:5, pages 396-406.
Crossref
Crossref
Howard H.Y. Chang & Michael R. Lieber. (2016) Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex. Nucleic Acids Research 44:11, pages 4991-4997.
Crossref
Crossref
Mako Ogino, Mayuko Ichimura, Noriko Nakano, Akari Minami, Yasuko Kitagishi & Satoru Matsuda. (2016) Roles of PTEN with DNA Repair in Parkinson’s Disease. International Journal of Molecular Sciences 17:6, pages 954.
Crossref
Crossref
Thomas G.W. Graham, Johannes C. Walter & Joseph J. Loparo. (2016) Two-Stage Synapsis of DNA Ends during Non-homologous End Joining. Molecular Cell 61:6, pages 850-858.
Crossref
Crossref
J. Setton, R.S. Bindra & S.N. Powell. 2016. DNA Repair in Cancer Therapy. DNA Repair in Cancer Therapy
277
302
.
Mu-Dan He, Feng-Hua Zhang, Hua-Lin Wang, Hou-Peng Wang, Zuo-Yan Zhu & Yong-Hua Sun. (2015) Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 780, pages 86-96.
Crossref
Crossref
E.A. Belousova & O.I. Lavrik. (2015) DNA polymerases β and λ and their roles in cell. DNA Repair 29, pages 112-126.
Crossref
Crossref
Yiheng Hu, Chao Wang, Kun Huang, Fen Xia, Jeffrey D. Parvin & Neelima Mondal. (2014) Regulation of 53BP1 Protein Stability by RNF8 and RNF168 Is Important for Efficient DNA Double-Strand Break Repair. PLoS ONE 9:10, pages e110522.
Crossref
Crossref
Mohamed Hassan, Hidemichi Watari, Ali AbuAlmaaty, Yusuke Ohba & Noriaki Sakuragi. (2014) Apoptosis and Molecular Targeting Therapy in Cancer. BioMed Research International 2014, pages 1-23.
Crossref
Crossref
Bo Huang, Zeng-Fu Shang, Bing Li, Yu Wang, Xiao-Dan Liu, Shi-Meng Zhang, Hua Guan, Wei-Qing Rang, Jian-An Hu & Ping-Kun Zhou. (2014) DNA-PKcs Associates With PLK1 and Is Involved in Proper Chromosome Segregation and Cytokinesis. Journal of Cellular Biochemistry 115:6, pages 1077-1088.
Crossref
Crossref
Crystal A. Waters, Natasha T. Strande, David W. Wyatt, John M. Pryor & Dale A. Ramsden. (2014) Nonhomologous end joining: A good solution for bad ends. DNA Repair 17, pages 39-51.
Crossref
Crossref
Nicholas R. Pannunzio, Sicong Li, Go Watanabe & Michael R. Lieber. (2014) Non-homologous end joining often uses microhomology: Implications for alternative end joining. DNA Repair 17, pages 74-80.
Crossref
Crossref
Shaun Moore, Fintan K.T. Stanley & Aaron A. Goodarzi. (2014) The repair of environmentally relevant DNA double strand breaks caused by high linear energy transfer irradiation – No simple task. DNA Repair 17, pages 64-73.
Crossref
Crossref
Devin P. Champagne & Penny E. Shockett. (2014) Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 761, pages 34-48.
Crossref
Crossref
A.C. Begg. 2014. Comprehensive Biomedical Physics. Comprehensive Biomedical Physics
43
61
.
Elizabeth Blackwood, Jennifer Epler, Ivana Yen, Michael Flagella, Tom O'Brien, Marie Evangelista, Stephen Schmidt, Yang Xiao, Jonathan Choi, Kaska Kowanetz, Judi Ramiscal, Kenton Wong, Diana Jakubiak, Sharon Yee, Gary Cain, Lewis Gazzard, Karen Williams, Jason Halladay, Peter K. Jackson & Shiva Malek. (2013) Combination Drug Scheduling Defines a “Window of Opportunity” for Chemopotentiation of Gemcitabine by an Orally Bioavailable, Selective ChK1 Inhibitor, GNE-900. Molecular Cancer Therapeutics 12:10, pages 1968-1980.
Crossref
Crossref
Celia Keim, David Kazadi, Gerson Rothschild & Uttiya Basu. (2013) Regulation of AID, the B-cell genome mutator. Genes & Development 27:1, pages 1-17.
Crossref
Crossref
Inken Wierstra. 2013.
97
398
.
Pablo De Ioannes, Shruti Malu, Patricia Cortes & Aneel K. Aggarwal. (2012) Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining. Cell Reports 2:6, pages 1505-1512.
Crossref
Crossref
Shruti Malu, Vidyasagar Malshetty, Dailia Francis & Patricia Cortes. (2012) Role of non-homologous end joining in V(D)J recombination. Immunologic Research 54:1-3, pages 233-246.
Crossref
Crossref
Benito Baños, Laurentino Villar, Margarita Salas & Miguel de Vega. (2012) DNA stabilization at the Bacillus subtilis PolX core —a binding model to coordinate polymerase, AP-endonuclease and 3′-5′ exonuclease activities. Nucleic Acids Research 40:19, pages 9750-9762.
Crossref
Crossref
Giuseppe Minniti, Christy Goldsmith & Michael Brada. 2012. Neuro-Oncology. Vol 104 HCN Series. Neuro-Oncology. Vol 104 HCN Series
215
228
.
Aroumougame Asaithamby & David J. Chen. (2011) Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 711:1-2, pages 87-99.
Crossref
Crossref
Brian D. Beck, Sung-Sook Lee, Elizabeth Williamson, Robert A. Hromas & Suk-Hee Lee. (2011) Biochemical Characterization of Metnase’s Endonuclease Activity and Its Role in NHEJ Repair. Biochemistry 50:20, pages 4360-4370.
Crossref
Crossref
Ping Xie. (2011) A model for the dynamics of mammalian family X DNA polymerases. Journal of Theoretical Biology 277:1, pages 111-122.
Crossref
Crossref
Hiroyuki Marusawa, Atsushi Takai & Tsutomu Chiba. 2011.
109
141
.
E. A. Belousova & O. I. Lavrik. (2010) DNA polymerases β and λ and their roles in DNA replication and repair. Molecular Biology 44:6, pages 839-855.
Crossref
Crossref
Aleš Tichý, Jiřina Vávrová, Jaroslav Pejchal & Martina Řezáčová. (2010) Ataxia-telangiectasia Mutated Kinase (ATM) as a Central Regulator of Radiation-induced DNA Damage Response. Acta Medica (Hradec Kralove, Czech Republic) 53:1, pages 13-17.
Crossref
Crossref
Aya KUROSAWA & Noritaka ADACHI. (2010) Functions and Regulation of Artemis: A Goddess in the Maintenance of Genome Integrity. Journal of Radiation Research 51:5, pages 503-509.
Crossref
Crossref
Janet Stavnezer, Andrea Björkman, Likun Du, Alberto Cagigi & Qiang Pan-Hammarström. 2010.
45
109
.
K. Osakabe, K. Abe, M. Endo & S. Toki. 2010. Plant Developmental Biology - Biotechnological Perspectives. Plant Developmental Biology - Biotechnological Perspectives
371
391
.
María A. Recuero-Checa, Andrew S. Doré, Ernesto Arias-Palomo, Angel Rivera-Calzada, Sjors H.W. Scheres, Joseph D. Maman, Laurence H. Pearl & Oscar Llorca. (2009) Electron microscopy of Xrcc4 and the DNA ligase IV–Xrcc4 DNA repair complex. DNA Repair 8:12, pages 1380-1389.
Crossref
Crossref
Nicole Bennardo, Amanda Gunn, Anita Cheng, Paul Hasty & Jeremy M. Stark. (2009) Limiting the Persistence of a Chromosome Break Diminishes Its Mutagenic Potential. PLoS Genetics 5:10, pages e1000683.
Crossref
Crossref
Qishen Pang & Paul R. Andreassen. (2009) Fanconi anemia proteins and endogenous stresses. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 668:1-2, pages 42-53.
Crossref
Crossref
Ron Ram, Orit Uziel, Orit Eldan, Eyal Fenig, Einat Beery, Shelly Lichtenberg, Yardena Nordenberg & Meir Lahav. (2009) Ionizing Radiation Up-regulates Telomerase Activity in Cancer Cell Lines by Post-translational Mechanism via Ras/Phosphatidylinositol 3-Kinase/Akt Pathway. Clinical Cancer Research 15:3, pages 914-923.
Crossref
Crossref
Marzena Gajecka, Andrew J. Gentles, Albert Tsai, David Chitayat, Katherine L. Mackay, Caron D. Glotzbach, Michael R. Lieber & Lisa G. Shaffer. (2008) Unexpected complexity at breakpoint junctions in phenotypically normal individuals and mechanisms involved in generating balanced translocations t(1;22)(p36;q13). Genome Research 18:11, pages 1733-1742.
Crossref
Crossref
Haihui Lu, Noriko Shimazaki, Prafulla Raval, Jiafeng Gu, Go Watanabe, Klaus Schwarz, Patrick C. Swanson & Michael R. Lieber. (2008) A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination. Molecular Cell 31:4, pages 485-497.
Crossref
Crossref
Geoffrey A. Mueller, Andrea F. Moon, Eugene F. DeRose, Jody M. Havener, Dale A. Ramsden, Lars C. Pedersen & Robert E. London. (2008) A comparison of BRCT domains involved in nonhomologous end-joining: Introducing the solution structure of the BRCT domain of polymerase lambda. DNA Repair 7:8, pages 1340-1351.
Crossref
Crossref
M. R. Lieber, S. C. Raghavan & K. Yu. (2008) Mechanistic Aspects of Lymphoid Chromosomal Translocations. JNCI Monographs 2008:39, pages 8-11.
Crossref
Crossref
Rika Kusumoto, Lala Dawut, Caterina Marchetti, Jae Wan Lee, Alessandro Vindigni, Dale Ramsden & Vilhelm A. Bohr. (2008) Werner Protein Cooperates with the XRCC4-DNA Ligase IV Complex in End-Processing. Biochemistry 47:28, pages 7548-7556.
Crossref
Crossref
Steven M. Yannone, Imran S. Khan, Rui-Zhe Zhou, Tong Zhou, Kristoffer Valerie & Lawrence F. Povirk. (2008) Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase. Nucleic Acids Research 36:10, pages 3354-3365.
Crossref
Crossref
Vincent Dion, Yunfu Lin, Leroy HubertJr.Jr., Robert A. Waterland & John H. Wilson. (2008) Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline. Human Molecular Genetics 17:9, pages 1306-1317.
Crossref
Crossref
Janet StavnezerJeroen E.J. GuikemaCarol E. Schrader. (2008) Mechanism and Regulation of Class Switch Recombination. Annual Review of Immunology 26:1, pages 261-292.
Crossref
Crossref
Alokes Majumdar, Parameswary A. Muniandy, Jia Liu, Ji-lan Liu, Su-ting Liu, Bernard Cuenoud & Michael M. Seidman. (2008) Targeted Gene Knock In and Sequence Modulation Mediated by a Psoralen-linked Triplex-forming Oligonucleotide*. Journal of Biological Chemistry 283:17, pages 11244-11252.
Crossref
Crossref
Yan-Ying Huo, Gang Li, Rui-Feng Duan, Qiao Gou, Chun-Ling Fu, Ying-Chun Hu, Bo-Qiang Song, Zhi-Hua Yang, De-Chang Wu & Ping-Kun Zhou. (2008) PTEN deletion leads to deregulation of antioxidants and increased oxidative damage in mouse embryonic fibroblasts. Free Radical Biology and Medicine 44:8, pages 1578-1591.
Crossref
Crossref
Roland Kanaar, Claire Wyman & Rodney Rothstein. (2008) Quality control of DNA break metabolism: in the ‘end’, it's a good thing. The EMBO Journal 27:4, pages 581-588.
Crossref
Crossref
Aya KurosawaHideki KoyamaShinichi TakayamaKensuke MikiDai AyusawaMichihiko FujiiSusumu IiizumiNoritaka Adachi. (2008) The Requirement of Artemis in Double-Strand Break Repair Depends on the Type of DNA Damage. DNA and Cell Biology 27:1, pages 55-61.
Crossref
Crossref
Mehdi Yeganeh, Eleonora Gambineri, Kamran Abolmaali, Banafshe Tamizifar & Teresa Español. 2008. Primary Immunodeficiency Diseases. Primary Immunodeficiency Diseases
251
290
.
Christie Vermeulen, Barbara Bertocci, Adrian C. Begg & Conchita Vens. (2007) Ionizing Radiation Sensitivity of DNA Polymerase Lambda-Deficient Cells. Radiation Research 168:6, pages 683-688.
Crossref
Crossref
Andrea F. Moon, Miguel Garcia-Diaz, Vinod K. Batra, William A. Beard, Katarzyna Bebenek, Thomas A. Kunkel, Samuel H. Wilson & Lars C. Pedersen. (2007) The X family portrait: Structural insights into biological functions of X family polymerases. DNA Repair 6:12, pages 1709-1725.
Crossref
Crossref
Katsuya Inagaki, Congrong Ma, Theresa A. Storm, Mark A. Kay & Hiroyuki Nakai. (2007) The Role of DNA-PKcs and Artemis in Opening Viral DNA Hairpin Termini in Various Tissues in Mice. Journal of Virology 81:20, pages 11304-11321.
Crossref
Crossref
Sathees C. Raghavan, Jiafeng Gu, Patrick C. Swanson & Michael R. Lieber. (2007) The structure-specific nicking of small heteroduplexes by the RAG complex: Implications for lymphoid chromosomal translocations. DNA Repair 6:6, pages 751-759.
Crossref
Crossref
Steffi Kuhfittig-Kulle, Elke Feldmann, Andrea Odersky, Aneta Kuliczkowska, Wolfgang Goedecke, Angelika Eggert & Petra Pfeiffer. (2007) The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV. Mutagenesis 22:3, pages 217-233.
Crossref
Crossref
Zhi Li & Yung Chang. (2007) V(D)J recombination in zebrafish: Normal joining products with accumulation of unresolved coding ends and deleted signal ends. Molecular Immunology 44:7, pages 1793-1802.
Crossref
Crossref
Jiafeng Gu, Haihui Lu, Brigette Tippin, Noriko Shimazaki, Myron F Goodman & Michael R Lieber. (2007) XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps. The EMBO Journal 26:4, pages 1010-1023.
Crossref
Crossref
Rika Kusumoto, Meltem Muftuoglu & Vilhelm A. Bohr. (2007) The role of WRN in DNA repair is affected by post-translational modifications. Mechanisms of Ageing and Development 128:1, pages 50-57.
Crossref
Crossref
Claire WymanRoland Kanaar. (2006) DNA Double-Strand Break Repair: All's Well that Ends Well. Annual Review of Genetics 40:1, pages 363-383.
Crossref
Crossref
Karel RihaMichelle L. HeacockDorothy E. Shippen. (2006) The Role of the Nonhomologous End-Joining DNA Double-Strand Break Repair Pathway in Telomere Biology. Annual Review of Genetics 40:1, pages 237-277.
Crossref
Crossref
Pierre Hentges, Peter Ahnesorg, Robert S. Pitcher, Chris K. Bruce, Boris Kysela, Andrew J. Green, Julie Bianchi, Thomas E. Wilson, Stephen P. Jackson & Aidan J. Doherty. (2006) Evolutionary and Functional Conservation of the DNA Non-homologous End-joining Protein, XLF/Cernunnos. Journal of Biological Chemistry 281:49, pages 37517-37526.
Crossref
Crossref
Janet M. Murray, J. Patrick O’Neill, Terri Messier, Jami Rivers, Vernon E. Walker, Brien McGonagle, Lucy Trombley, Lindsay G. Cowell, Garnett Kelsoe, Fraser McBlane & Barry A. Finette. (2006) V(D)J Recombinase-Mediated Processing of Coding Junctions at Cryptic Recombination Signal Sequences in Peripheral T Cells during Human Development. The Journal of Immunology 177:8, pages 5393-5404.
Crossref
Crossref
Sonia Franco, Frederick W. Alt & John P. Manis. (2006) Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. DNA Repair 5:9-10, pages 1030-1041.
Crossref
Crossref
Michael R. Lieber, Kefei Yu & Sathees C. Raghavan. (2006) Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations. DNA Repair 5:9-10, pages 1234-1245.
Crossref
Crossref
Mark O'Driscoll & Penny A. Jeggo. (2006) The role of double-strand break repair — insights from human genetics. Nature Reviews Genetics 7:1, pages 45-54.
Crossref
Crossref