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p53 Codon 72 Alleles Influence the Response to Anticancer Drugs in Cells from Aged People by Regulating the Cell Cycle Inhibitor p21WAF1

Pages 1264-1271 | Published online: 28 Jun 2005

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Gregory A. Azzam, Amanda K. Frank, Monica Hollstein & Maureen E. Murphy. (2011) Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model. Cell Cycle 10:9, pages 1352-1355.
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Amanda K. Frank, Julia I-Ju Leu, Yan Zhou, Karthik Devarajan, Tatiana Nedelko, Andres Klein-Szanto, Monica Hollstein & Maureen E. Murphy. (2011) The Codon 72 Polymorphism of p53 Regulates Interaction with NF-κB and Transactivation of Genes Involved in Immunity and Inflammation. Molecular and Cellular Biology 31:6, pages 1201-1213.
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S. Salvioli, F. Olivieri, F. Marchegiani, M. Cardelli, A. Santoro, E. Bellavista, M. Mishto, L. Invidia, M. Capri, S. Valensin, F. Sevini, E. Cevenini, L. Celani, F. Lescai, E. Gonos, C. Caruso, G. Paolisso, G. De Benedictis, D. Monti & C. Franceschi. (2006) Genes, ageing and longevity in humans: Problems, advantages and perspectives. Free Radical Research 40:12, pages 1303-1323.
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Articles from other publishers (37)

Yuhan Zhao, Lihua Wu, Xuetian Yue, Cen Zhang, Jianming Wang, Jun Li, Xiaohui Sun, Yiming Zhu, Zhaohui Feng & Wenwei Hu. (2018) A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models. eLife 7.
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T L Slatter, N Hung, S Bowie, H Campbell, C Rubio, D Speidel, M Wilson, M Baird, J A Royds & A W Braithwaite. (2015) Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant. Cell Death & Disease 6:6, pages e1783-e1783.
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Che-Pei Kung, Sakina Khaku, Matthew Jennis, Yan Zhou & Maureen E. Murphy. (2015) Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes. Molecular Cancer Research 13:2, pages 250-262.
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Simona Panni, Stefano Salvioli, Elena Santonico, Francesca Langone, Francesca Storino, Serena Altilia, Claudio Franceschi, Gianni Cesareni & Luisa Castagnoli. (2015) The adapter protein CD2AP binds to p53 protein in the cytoplasm and can discriminate its polymorphic variants P72R. The Journal of Biochemistry 157:2, pages 101-111.
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Ahsan S. Farooqi, Rebecca A. Dagg, L. Mi Rim Choi, Jerry W. Shay, C. Patrick Reynolds & Loretta M. S. Lau. (2014) Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations. Journal of Neuro-Oncology 119:1, pages 17-26.
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Patty B. Garcia & Laura D. Attardi. (2014) Illuminating p53 function in cancer with genetically engineered mouse models. Seminars in Cell & Developmental Biology 27, pages 74-85.
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L. R. Fraga, C. G. Dutra, J. A. Boquett, F. S. L. Vianna, R. O. Gonçalves, D. D. Paskulin, O. L. Costa, P. Ashton-Prolla, M. T. V. Sanseverino & L. Schuler-Faccini. (2014) p53 signaling pathway polymorphisms associated to recurrent pregnancy loss. Molecular Biology Reports 41:3, pages 1871-1877.
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Paolo Garagnani, Chiara Pirazzini, Cristina Giuliani, Marco Candela, Patrizia Brigidi, Federica Sevini, Donata Luiselli, Maria Giulia Bacalini, Stefano Salvioli, Miriam Capri, Daniela Monti, Daniela Mari, Sebastiano Collino, Massimo Delledonne, Patrick Descombes & Claudio Franceschi. (2014) The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms. BioMed Research International 2014, pages 1-14.
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Xiaoxue Xie, Hui Wang, Hekun Jin, Shuyu Ouyang, Jumei Zhou, Jun Hu, Xuping Xi, Junming Luo, Yingying Zhang & Bingqiang Hu. (2013) Expression of pAkt affects p53 codon 72 polymorphism-based prediction of response to radiotherapy in nasopharyngeal carcinoma. Radiation Oncology 8:1.
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Gregory Azzam, Xuting Wang, Douglas Bell & Maureen E. Murphy. (2013) CSF1 Is a Novel p53 Target Gene Whose Protein Product Functions in a Feed-Forward Manner to Suppress Apoptosis and Enhance p53-Mediated Growth Arrest. PLoS ONE 8:9, pages e74297.
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Stefano Giaimo & Fabrizio d’Adda di Fagagna. (2012) Is cellular senescence an example of antagonistic pleiotropy?. Aging Cell 11:3, pages 378-383.
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Jonathan D. Wasserman, Gerard P. Zambetti & David Malkin. (2012) Towards an understanding of the role of p53 in adrenocortical carcinogenesis. Molecular and Cellular Endocrinology 351:1, pages 101-110.
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Wei-feng ZHU, Da-ya LUO, Shuo TU, Xia-li ZHANG, Ke-min JIE & Fu-sheng WAN. (2012) A rapid salting out method for DNA extraction from buccal swabs. Academic Journal of Second Military Medical University 31:12, pages 1370-1374.
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Marina Naldi, Marco Pistolozzi, Carlo Bertucci, Angela De Simone, Serena Altilia, Michela Pierini, Claudio Franceschi, Stefano Salvioli & Vincenza Andrisano. (2010) Structural characterization of p53 isoforms due to the polymorphism at codon 72 by mass spectrometry and circular dichroism. Journal of Pharmaceutical and Biomedical Analysis 53:2, pages 200-206.
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Devapregasan Moodley, Girish M. Mody & Anil A. Chuturgoon. (2010) Functional analysis of the p53 codon 72 polymorphism in black South Africans with rheumatoid arthritis—a pilot study. Clinical Rheumatology 29:10, pages 1099-1105.
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Byeong-Seon Jeong, Wenwei Hu, Vladimir Belyi, Raul Rabadan & Arnold J. Levine. (2010) Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis. The FASEB Journal 24:5, pages 1347-1353.
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