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The TSC/Rheb/TOR Signaling Pathway in Fission Yeast and Mammalian Cells: Temperature Sensitive and Constitutive Active Mutants of TOR

Pages 1692-1695 | Published online: 16 Jul 2007

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Dana Laor, Adiel Cohen, Metsada Pasmanik-Chor, Varda Oron-Karni, Martin Kupiec & Ronit Weisman. (2014) Isp7 Is a Novel Regulator of Amino Acid Uptake in the TOR Signaling Pathway. Molecular and Cellular Biology 34:5, pages 794-806.
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Marjatta Raudaskoski, Erika Kothe, Thomas J. Fowler, Elke-Martina Jung & Stephen J. Horton. (2012) Ras and Rho small G Proteins: Insights from the Schizophyllum commune genome sequence and comparisons to other fungi. Biotechnology and Genetic Engineering Reviews 28:1, pages 61-100.
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Yoko Otsubo & Masayuki Yamamato. (2008) TOR Signaling in Fission Yeast. Critical Reviews in Biochemistry and Molecular Biology 43:4, pages 277-283.
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Articles from other publishers (34)

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Gabriella M. Forte, Elizabeth Davie, Shervi Lie, Mirita Franz-Wachtel, Ashley J. Ovens, Tingting Wang, Jonathan S. Oakhill, Boris Maček, Iain M. Hagan & Janni Petersen. (2019) Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling. Journal of Cell Science.
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Lianghua He, Xin Zhang, Ying Huang, Huiping Yang, Yilei Wang & Ziping Zhang. (2017) The characterization of RHEB gene and its responses to hypoxia and thermal stresses in the small abalone Haliotis diversicolor. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 210, pages 48-54.
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Charalampos Rallis, StJohn Townsend & Jürg Bähler. (2017) Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Scientific Reports 7:1.
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Bruno D. Fonseca, Tyson E. Graber, Huy-Dung Hoang, Asier González, Alexander A. Soukas, Greco Hernández, Tommy Alain, Stephanie L. Swift, Ronit Weisman, Christian Meyer, Christophe Robaglia, Joseph Avruch & Michael N. Hall. 2016. Evolution of the Protein Synthesis Machinery and Its Regulation. Evolution of the Protein Synthesis Machinery and Its Regulation 327 411 .
Mohamad-Ali Fawal, Marta Brandt & Nabil Djouder. (2015) MCRS1 Binds and Couples Rheb to Amino Acid-Dependent mTORC1 Activation. Developmental Cell 33:1, pages 67-81.
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Akio Nakashima, Shinji Kamada, Fuyuhiko Tamanoi & Ushio Kikkawa. (2014) Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter. Biology Open 3:6, pages 542-552.
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Sebastiano Sciarretta, Derek Yee, Varun Shenoy, Narayani Nagarajan & Junichi Sadoshima. (2013) The Importance of Autophagy in Cardioprotection. High Blood Pressure & Cardiovascular Prevention 21:1, pages 21-28.
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Christopher B. Marshall, Mohammad T. Mazhab-Jafari, Vuk Stambolic & Mitsuhiko Ikura. 2014. Ras Superfamily Small G Proteins: Biology and Mechanisms 1. Ras Superfamily Small G Proteins: Biology and Mechanisms 1 281 324 .
Wei Sun, Ye Julia Zhu, Zhizhi Wang, Qiang Zhong, Feng Gao, Jizhong Lou, Weimin Gong & Wenqing Xu. (2013) Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nature Communications 4:1.
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Miriam Schonbrun, Masha Kolesnikov, Martin Kupiec & Ronit Weisman. (2013) TORC2 Is Required to Maintain Genome Stability during S Phase in Fission Yeast. Journal of Biological Chemistry 288:27, pages 19649-19660.
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Clémentine Beuzelin, Irini Evnouchidou, Pascal Rigolet, Anne Cauvet-Burgevin, Pierre-Marie Girard, Delphine Dardalhon, Slobodan Culina, Abdelaziz Gdoura, Peter van Endert & Stefania Francesconi. (2013) Deletion of the Fission Yeast Homologue of Human Insulinase Reveals a TORC1-Dependent Pathway Mediating Resistance to Proteotoxic Stress. PLoS ONE 8:6, pages e67705.
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Sebastiano SciarrettaPeiyong ZhaiDan ShaoYasuhiro MaejimaJeffrey RobbinsMassimo VolpeGianluigi CondorelliJunichi Sadoshima. (2012) Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia. Circulation 125:9, pages 1134-1146.
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Daniel Rosel, Taruna Khurana, Amit Majithia, Xiuli Huang, Ramanath Bhandari & Alan R. Kimmel. (2012) TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing . Journal of Cell Science 125:1, pages 37-48.
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Jaco Serfontein, R. Ellen R. Nisbet, Christopher J. Howe & Petrus J. de Vries. (2011) Conservation of Structural and Functional Elements of TSC1 and TSC2: A Bioinformatic Comparison Across Animal Models. Behavior Genetics 41:3, pages 349-356.
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Molly Hardt, Naphat Chantaravisoot & Fuyuhiko Tamanoi. (2011) Activating mutations of TOR (target of rapamycin). Genes to Cells 16:2, pages 141-151.
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Sebastiano Sciarretta, Daniela Zablocki & Junichi Sadoshima. (2010) New Insights into the Role and Regulation of Autophagy during Myocardial Ischaemia. High Blood Pressure & Cardiovascular Prevention 17:4, pages 235-236.
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Cecelia A Shertz, Robert J Bastidas, Wenjun Li, Joseph Heitman & Maria E Cardenas. (2010) Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom. BMC Genomics 11:1.
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Akio Nakashima, Tatsuhiro Sato & Fuyuhiko Tamanoi. (2010) Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin. Journal of Cell Science 123:5, pages 777-786.
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Sophya Konstantinovsky, Yoav Smith, Sofia Zilber, Helene Tuft Stavnes, Anne-Marie Becker, Jahn M. Nesland, Reuven Reich & Ben Davidson. (2010) Breast Carcinoma Cells in Primary Tumors and Effusions Have Different Gene Array Profiles. Journal of Oncology 2010, pages 1-14.
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Naphat Chantaravisoot & Fuyuhiko Tamanoi. 2010. Structure, Function and Regulation of Tor Complexes from Yeasts to Mammals Part B. Structure, Function and Regulation of Tor Complexes from Yeasts to Mammals Part B 301 316 .
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Mitsuhiro Yanagida. (2009) Cellular quiescence: are controlling genes conserved?. Trends in Cell Biology 19:12, pages 705-715.
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Alexandre Soulard, Adiel Cohen & Michael N Hall. (2009) TOR signaling in invertebrates. Current Opinion in Cell Biology 21:6, pages 825-836.
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Joseph Avruch, Xiaomeng Long, Sara Ortiz-Vega, Joseph Rapley, Angela Papageorgiou & Ning Dai. (2009) Amino acid regulation of TOR complex 1. American Journal of Physiology-Endocrinology and Metabolism 296:4, pages E592-E602.
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Chang-Chih Tsao, Yu-Ting Chen & Chung-Yu Lan. (2009) A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans. Fungal Genetics and Biology 46:2, pages 126-136.
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Paul-Joseph Aspuria & Fuyuhiko Tamanoi. (2008) The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast. Molecular Genetics and Genomics 279:5, pages 441-450.
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Takeshi Hayashi, Mitsuko Hatanaka, Koji Nagao, Yukinobu Nakaseko, Junko Kanoh, Aya Kokubu, Masahiro Ebe & Mitsuhiro Yanagida. (2007) Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits . Genes to Cells 12:12, pages 1357-1370.
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