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Autocatalytic Phosphorylation of CDK2 at the Activating Thr160

Pages 843-852 | Published online: 28 Mar 2007

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Ruiling Mu, John Tat, Robert Zamudio, Yaoyang Zhang, John R. Yates$suffix/text()$suffix/text(), Akiko Kumagai, William G. Dunphy & Steven I. Reed. (2017) CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin. Molecular and Cellular Biology 37:20.
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Miguel Ganuza & David Santamaría. (2012) Cdk7: Open questions beyond the prevailing model. Cell Cycle 11:19, pages 3519-3520.
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Articles from other publishers (23)

Mingyar N. López‐Hernández & Jorge M. Vázquez‐Ramos. (2022) Maize CDKA2 ;1a and CDKB1 ;1 kinases have different requirements for their activation and participate in substrate recognition . The FEBS Journal 290:9, pages 2463-2488.
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Severine Isabelle Gharbi, Laura A. Pelletier, Alfonso Espada, Jesus Gutiérrez, Sonia Maria Gutiérrez Sanfeliciano, Charles T. Rauch, Maria Patricia Ganado, Carmen Baquero, Elisabet Zapatero, Aiping Zhang, Jordi Benach, Anna-Maria Russell, Leticia Cano, Sandra Gomez, Howard Broughton, Nicholas Pulliam, Carmen Maria Perez, Raquel Torres, Marjoke F. Debets, Alfonso de Dios, Oscar Puig, Mark T. Hilgers & Maria Jose Lallena. (2022) Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy. npj Breast Cancer 8:1.
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Kim R. Kampen, Laura Fancello, Tiziana Girardi, Gianmarco Rinaldi, Mélanie Planque, Sergey O. Sulima, Fabricio Loayza-Puch, Benno Verbelen, Stijn Vereecke, Jelle Verbeeck, Joyce Op de Beeck, Jonathan Royaert, Pieter Vermeersch, David Cassiman, Jan Cools, Reuven Agami, Mark Fiers, Sarah-Maria Fendt & Kim De Keersmaecker. (2019) Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells. Nature Communications 10:1.
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Bang-Jau You, Li-Yun Chen, Po-Hsiang Hsu, Pei-Hsuan Sung, Yu-Ching Hung & Hong-Zin Lee. (2019) Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells. Chemical Research in Toxicology 32:2, pages 255-264.
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Biqing Zhu, Yinpeng Pan, Xiufen Zheng, Quanli Zhang, Yaqin Wu, Jing Luo, Qian Li, Emei Lu, Lin Xu, Guangfu Jin & Binhui Ren. (2019) A clinical, biologic and mechanistic analysis of the role of ZNF692 in cervical cancer. Gynecologic Oncology 152:2, pages 396-407.
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B. Madhu Krishna, Sanjib Chaudhary, Dipti Ranjan Mishra, Sanoj K. Naik, S. Suklabaidya, A. K. Adhya & Sandip K. Mishra. (2018) Estrogen receptor α dependent regulation of estrogen related receptor β and its role in cell cycle in breast cancer. BMC Cancer 18:1.
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Xue Yang, Xieqiong Ye, Le Sun, Fangyuan Gao, Yuxin Li, Xiaomin Ji, Xuejiang Wang, Ying Feng & Xianbo Wang. (2017) Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling. Oncotarget 8:37, pages 61118-61132.
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Debora Bencivenga, Ilaria Caldarelli, Emanuela Stampone, Francesco Paolo Mancini, Maria Luisa Balestrieri, Fulvio Della Ragione & Adriana Borriello. (2017) p27 Kip1 and human cancers: A reappraisal of a still enigmatic protein. Cancer Letters 403, pages 354-365.
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Atish R. Mohanty, Qiuming Kan, Saumya Srivastava, Baasanjav Uranbileg, Shiho Arakawa-Takeuchi, Naoya Fujita & Hiroto Okayama. (2012) Successive Phosphorylation of p27KIP1 Protein at Serine-10 and C Terminus Crucially Controls Its Potency to Inactivate Cdk2. Journal of Biological Chemistry 287:26, pages 21757-21764.
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Hedia ChagraouiMira KassoufSreemoti BanerjeeNicolas GoardonKevin ClarkAnn AtzbergerAndrew C. PearceRadek C. Skoda, David J. P. Ferguson, Steve P. WatsonParesh VyasCatherine Porcher. (2011) SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis. Blood 118:3, pages 723-735.
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Ying Jia, James V. Anderson & Wun S. Chao. (2011) Autophosphorylation is crucial for CDK-activating kinase (Ee;CDKF;1) activity and complex formation in leafy spurge. Plant Science 180:2, pages 259-267.
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Shao-Yong Lu, Yong-Jun Jiang, Jian-Wei Zou & Tian-Xing Wu. (2011) Dissection of the difference between the group I metal ions in inhibiting GSK3β: a computational study. Physical Chemistry Chemical Physics 13:15, pages 7014.
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Laetitia Fouillen, Wassim Abdulrahman, Dino Moras, Alain Van Dorsselaer, Arnaud Poterszman & Sarah Sanglier-Cianférani. (2010) Analysis of recombinant phosphoprotein complexes with complementary mass spectrometry approaches. Analytical Biochemistry 407:1, pages 34-43.
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Felipe C. Gomes, Nahla Osman M. Ali, Elaine Brown, Roderick G. Walker, Karen M. Grant & Jeremy C. Mottram. (2010) Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178. Molecular and Biochemical Parasitology 171:2, pages 89-96.
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David J. Matthews & Mary E. Gerritsen. 2010. Targeting Protein Kinases for Cancer Therapy. Targeting Protein Kinases for Cancer Therapy 327 390 .
David J. Matthews & Mary E. Gerritsen. 2010. Targeting Protein Kinases for Cancer Therapy. Targeting Protein Kinases for Cancer Therapy 75 117 .
Xi Kai Wee, Wee Kiang Yeo, Bing Zhang, Vincent B.C. Tan, Kian Meng Lim, Tong Earn Tay & Mei-Lin Go. (2009) Synthesis and evaluation of functionalized isoindigos as antiproliferative agents. Bioorganic & Medicinal Chemistry 17:21, pages 7562-7571.
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Juan Casado-Vela, Jorge Luis Martínez-Torrecuadrada & J. Ignacio Casal. (2009) Differential phosphorylation patterns between the Cyclin-A2/CDK2 complex and their monomers. Protein Expression and Purification 66:1, pages 15-21.
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Tarek Abbas & Anindya Dutta. (2009) p21 in cancer: intricate networks and multiple activities. Nature Reviews Cancer 9:6, pages 400-414.
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Elena Sotillo, Judit Garriga, Amol Padgaonkar, Alison Kurimchak, Jeanette Gowen Cook & Xavier Graña. (2009) Coordinated Activation of the Origin Licensing Factor CDC6 and CDK2 in Resting Human Fibroblasts Expressing SV40 Small T Antigen and Cyclin E. Journal of Biological Chemistry 284:21, pages 14126-14135.
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Józefa Węsierska‐Gądek, Andreea Borza, Eva Walzi, Vladimir Krystof, Margarita Maurer, Oxana Komina & Stefanie Wandl. (2009) Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment. Journal of Cellular Biochemistry 106:5, pages 937-955.
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Tsutomu Sasaki, Bernhard Maier, Katarzyna D. Koclega, Maksymilian Chruszcz, Wendy Gluba, P. Todd Stukenberg, Wladek Minor & Heidi Scrable. (2008) Phosphorylation Regulates SIRT1 Function. PLoS ONE 3:12, pages e4020.
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Eric S. Simon, Matthew Young, Antonia Chan, Zhao-Qin Bao & Philip C. Andrews. (2008) Improved enrichment strategies for phosphorylated peptides on titanium dioxide using methyl esterification and pH gradient elution. Analytical Biochemistry 377:2, pages 234-242.
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