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A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature

Jeffrey D. Hancock
&
Stephen L. Lessnick
Pages 250-256 | Published online: 04 Feb 2008

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Concetta Schiano, Andrea Soricelli, Filomena De Nigris & Claudio Napoli. (2019) New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions. Expert Review of Clinical Immunology 15:3, pages 289-301.
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Heinrich Kovar. (2014) Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy. Expert Opinion on Therapeutic Targets 18:11, pages 1315-1328.
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Jenny Potratz, Heribert Jürgens, Alan Craft & Uta Dirksen. (2012) Ewing Sarcoma: Biology-Based Therapeutic Perspectives. Pediatric Hematology and Oncology 29:1, pages 12-27.
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Susan Ann Burchill. (2008) Molecular abnormalities in Ewing’s sarcoma. Expert Review of Anticancer Therapy 8:10, pages 1675-1687.
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Le Yu, Ian J. Davis & Pengda Liu. (2023) Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications. Cancers 15:2, pages 382.
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Jialin Mo, Kezhe Tan, Yu Dong, Wenjie Lu, Fang Liu, Yanqing Mei, Hongting Huang, Kewen Zhao, Zhibao Lv, Youqiong Ye & Yujie Tang. (2022) Therapeutic targeting the oncogenic driver EWSR1::FLI1 in Ewing sarcoma through inhibition of the FACT complex. Oncogene 42:1, pages 11-25.
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Shan Wang, Xiaofang Huo, Yiping Yang, Yingxi Mo, Rahul K. Kollipara & Ralf Kittler. (2023) Ablation of EWS-FLI1 by USP9X inhibition suppresses cancer cell growth in Ewing sarcoma. Cancer Letters 552, pages 215984.
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April A. Apfelbaum, Emma D. Wrenn & Elizabeth R. Lawlor. (2022) The importance of fusion protein activity in Ewing sarcoma and the cell intrinsic and extrinsic factors that regulate it: A review. Frontiers in Oncology 12.
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Iftekhar A Showpnil, Julia Selich-Anderson, Cenny Taslim, Megann A Boone, Jesse C Crow, Emily R Theisen & Stephen L Lessnick. (2022) EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma. Nucleic Acids Research 50:17, pages 9814-9837.
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Cristina Molnar, Jose Reina, Anastasia Herrero, Jan Peter Heinen, Victoria Méndiz, Sophie Bonnal, Manuel Irimia, María Sánchez-Jiménez, Sara Sánchez-Molina, Jaume Mora & Cayetano Gonzalez. (2022) Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis. PNAS Nexus 1:4.
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Vadim Saratov, Quy A. Ngo, Gloria Pedot, Semjon Sidorov, Marco Wachtel, Felix K. Niggli & Beat W. Schäfer. (2022) CRISPR activation screen identifies TGFβ-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma. Scientific Reports 12:1.
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