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Editorials: Cell Cycle Features

p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN

Pages 2055-2056 | Published online: 01 Jun 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Yoshihiro Ito, Jonathan R. Hart & Peter K. Vogt. (2018) Isoform-specific activities of the regulatory subunits of phosphatidylinositol 3-kinases – potentially novel therapeutic targets. Expert Opinion on Therapeutic Targets 22:10, pages 869-877.
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William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Michelle M. LaHair, Giuseppe Montalto, Melchiorre Cervello, Alberto M. Martelli, Ferdinando Nicoletti, Saverio Candido, Massimo Libra, Jerry Polesel, Renato Talamini, Michele Milella, Agostino Tafuri, Linda S. Steelman & James A. McCubrey. (2012) Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine. Cell Cycle 11:23, pages 4447-4461.
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Articles from other publishers (16)

Nader Akbari Dilmaghani, Ava Safaroghli‐Azar, Atieh Pourbagheri‐Sigaroodi & Davood Bashash. (2021) The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: Possibilities for therapeutic interventions either as single agents or in combination with conventional therapies. IUBMB Life 73:4, pages 618-642.
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Deborah H. Anderson. 2021. Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance. Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance 1 22 .
Millie FoxHelen R. MottDarerca Owen. (2020) Class IA PI3K regulatory subunits: p110-independent roles and structures. Biochemical Society Transactions 48:4, pages 1397-1417.
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Yoshio Kano, Fukumi Hiragami, Hirotoshi Motoda, Junichi Akiyama, Yoshihisa Koike, Yutaka Gomita, Shigeki Inoue, Akihiko Kawaura, Tomohisa Furuta & Kenji Kawamura. (2019) C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene. Scientific Reports 9:1.
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Qi Cheng, Yong Wen Li, Cheng Fang Yang, Yu Juan Zhong & Li Li. (2019) Ethanol-Induced Hepatic Insulin Resistance is Ameliorated by Methyl Ferulic Acid Through the PI3K/AKT Signaling Pathway. Frontiers in Pharmacology 10.
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Paul Mellor, Jeremy D. S. Marshall, Xuan Ruan, Dielle E. Whitecross, Rebecca L. Ross, Margaret A. Knowles, Stanley A. Moore & Deborah H. Anderson. (2018) Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation. Scientific Reports 8:1.
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Yoshihiro Ito, Peter K. Vogt & Jonathan R. Hart. (2017) Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β. Oncotarget 8:34, pages 55863-55876.
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Xiaojuan Feng, Chao Wu, Min Yang, Qingjuan Liu, Hongbo Li, Jinxi Liu, Yujun Zhang, Yongmei Hao, Lin Kang, Yuling Zhang & Shuxia Liu. (2016) Role of PI3K/Akt signal pathway on proliferation of mesangial cell induced by HMGB1. Tissue and Cell 48:2, pages 121-125.
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Xiangdong Zhu, Zuo-Hui Shao, Changqing Li, Jing Li, Qiang Zhong, Jonathan Learoyd, Angelo Meliton, Lucille Meliton, Alan R. Leff & Terry L. Vanden Hoek. (2014) TAT-Protein Blockade during Ischemia/Reperfusion Reveals Critical Role for p85 PI3K-PTEN Interaction in Cardiomyocyte Injury. PLoS ONE 9:4, pages e95622.
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Guihua Wang, Cheng Chen, Rui Yang, Xiaonian Cao, Senyan Lai, Xuelai Luo, Yongdong Feng, Xianmin Xia, Jianping Gong & Junbo Hu. (2013) p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-κB pathway. Angiogenesis 16:3, pages 561-573.
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N I Noguera, M S Song, M Divona, G Catalano, K L Calvo, F García, T Ottone, F Florenzano, I Faraoni, L Battistini, E Colombo, S Amadori, P P Pandolfi & F Lo-Coco. (2012) Nucleophosmin/B26 regulates PTEN through interaction with HAUSP in acute myeloid leukemia. Leukemia 27:5, pages 1037-1043.
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Thomas Laurent, Yutaro Kataoka, Satoru Kobayashi, Misaki Ando, Seishi Nagamori & Hiroaki Oda. (2012) Spherical cell shape of FLC-4 cell, a human hepatoma cell, enhances hepatocyte-specific function and suppresses tumor phenotype through the integration of mRNA–microRNA interaction. Biology Open 1:10, pages 958-964.
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James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria C. Mazzarino, Saverio Candido, Massimo Libra, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini & Alberto M. Martelli. (2012) Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response.. Oncotarget 3:9, pages 954-987.
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Janet D. SparksCharles E. SparksKhosrow Adeli. (2012) Selective Hepatic Insulin Resistance, VLDL Overproduction, and Hypertriglyceridemia. Arteriosclerosis, Thrombosis, and Vascular Biology 32:9, pages 2104-2112.
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Sirigiri Divijendra Natha Reddy, Suresh B. Pakala, Poonam R. Molli, Neil Sahni, Narasimha Kumar Karanam, Prakriti Mudvari & Rakesh Kumar. (2012) Metastasis-associated Protein 1/Histone Deacetylase 4-Nucleosome Remodeling and Deacetylase Complex Regulates Phosphatase and Tensin Homolog Gene Expression and Function. Journal of Biological Chemistry 287:33, pages 27843-27850.
Crossref
Paul Mellor, Levi A. Furber, Jennifer N. K. Nyarko & Deborah H. Anderson. (2011) Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking. Biochemical Journal 441:1, pages 23-37.
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