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Editorials: Cell Cycle Features

Nrf2: A central regulator of UV protection in the epidermis

Pages 2917-2918 | Published online: 01 Aug 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Alena Ryšavá, Jitka Vostálová & Alena Rajnochová Svobodová. (2021) Effect of ultraviolet radiation on the Nrf2 signaling pathway in skin cells. International Journal of Radiation Biology 97:10, pages 1383-1403.
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Hui Wang, Ming Zhan, Ruimeng Yang, Yongheng Shi, Qiang Liu & Jian Wang. (2018) Elevated expression of NFE2L3 predicts the poor prognosis of pancreatic cancer patients. Cell Cycle 17:17, pages 2164-2174.
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Huaping Li, Zhenjie Li, Liqian Peng, Na Jiang, Qing Liu, Erting Zhang, Bihua Liang, Runxiang Li & Huilan Zhu. (2017) Lycium barbarum polysaccharide protects human keratinocytes against UVB-induced photo-damage. Free Radical Research 51:2, pages 200-210.
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Qiankun Li, Yan Chen, Kui Ma, Along Zhao, Cuiping Zhang & Xiaobing Fu. (2016) Regenerative and reparative effects of human chorion-derived stem cell conditioned medium on photo-aged epidermal cells. Cell Cycle 15:8, pages 1144-1155.
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Lawrence N. Barrera, Stuart A. Rushworth, Kristian M. Bowles & David J. MacEwan. (2012) Bortezomib induces heme oxygenase-1 expression in multiple myeloma. Cell Cycle 11:12, pages 2248-2252.
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Articles from other publishers (29)

Mélanie Salamito, Benjamin Gillet, Delfien Syx, Elisabeth Vaganay, Marilyne Malbouyres, Catherine Cerutti, Nicolas Tissot, Chloé Exbrayat-Héritier, Philippe Perez, Christophe Jones, Sandrine Hughes, Fransiska Malfait, Valérie Haydont, Sibylle Jäger & Florence Ruggiero. (2023) NRF2 Shortage in Human Skin Fibroblasts Dysregulates Matrisome Gene Expression and Affects Collagen Fibrillogenesis. Journal of Investigative Dermatology 143:3, pages 386-397.e12.
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Eleni Mavrogonatou, Maria Angelopoulou, Sophia V. Rizou, Harris Pratsinis, Vassilis G. Gorgoulis & Dimitris Kletsas. (2022) Activation of the JNKs/ATM-p53 axis is indispensable for the cytoprotection of dermal fibroblasts exposed to UVB radiation. Cell Death & Disease 13:7.
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Shen Yan, Raphael Ripamonti, Hiroshi Kawabe, Maya Ben-Yehuda Greenwald & Sabine Werner. (2022) NEDD4-1 Is a Key Regulator of Epidermal Homeostasis and Wound Repair. Journal of Investigative Dermatology 142:6, pages 1703-1713.e11.
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Salvador González, José Aguilera, Brian Berman, Piergiacomo Calzavara-Pinton, Yolanda Gilaberte, Chee-Leok Goh, Henry W. Lim, Sergio Schalka, Fernando Stengel, Peter Wolf & Flora Xiang. (2022) Expert Recommendations on the Evaluation of Sunscreen Efficacy and the Beneficial Role of Non-filtering Ingredients. Frontiers in Medicine 9.
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Charareh Pourzand, Andrea Albieri-Borges & Nico N. Raczek. (2022) Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants. Antioxidants 11:3, pages 471.
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Fabien P. Chevalier, Julie Rorteau & Jérôme Lamartine. 2020. Non-Coding RNAs. Non-Coding RNAs.
Paulina Hennig, Gabriele Fenini, Michela Di Filippo & Hans-Dietmar Beer. (2020) Electrophiles against (Skin) Diseases: More Than Nrf2. Biomolecules 10:2, pages 271.
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Xianye Cheng, Wen Qian, Fang Chen, Yi Jin, Fengdi Wang, Xiaoyi Lu, Sae Lee, Dongming Su & Bin Chen. (2019) ATRA protects skin fibroblasts against UV‑induced oxidative damage through inhibition of E3 ligase Hrd1. Molecular Medicine Reports.
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Shirin Kahremany, Ilana Babaev, Raanan Gvirtz, Navit Ogen-Stern, Salome Azoulay-Ginsburg, Hanoch Senderowitz, Guy Cohen & Arie Gruzman. (2019) Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage. Skin Pharmacology and Physiology 32:4, pages 173-181.
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Eunson Hwang, Wei Gao, Yong‐kun Xiao, Hien T. T. Ngo & Tae‐Hoo Yi. (2018) Helianthus annuus L. flower prevents UVB‐induced photodamage in human dermal fibroblasts by regulating the MAPK/AP‐1, NFAT, and Nrf2 signaling pathways . Journal of Cellular Biochemistry 120:1, pages 601-612.
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Bihua Liang, Liqian Peng, Runxiang Li, Huaping Li, Ziyin Mo, Xinyue Dai, Na Jiang, Qing Liu, Erting Zhang, Huiyan Deng, Zhenjie Li & Huilan Zhu. (2018) Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2. Cellular & Molecular Biology Letters 23:1.
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Dehai Xian, Xiaoqing Gao, Xia Xiong, Jixiang Xu, Lingyu Yang, Lun Pan & Jianqiao Zhong. (2017) Photoprotection against UV-induced damage by skin-derived precursors in hairless mice. Journal of Photochemistry and Photobiology B: Biology 175, pages 73-82.
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Farhad Jeddi, Narges Soozangar, Mohammad Reza Sadeghi, Mohammad Hossein Somi & Nasser Samadi. (2017) Contradictory roles of Nrf2/Keap1 signaling pathway in cancer prevention/promotion and chemoresistance. DNA Repair 54, pages 13-21.
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Carla Abdo Brohem, Valéria Maria Di Mambro & Márcio Lorencini. 2017. Textbook of Aging Skin. Textbook of Aging Skin 1917 1927 .
Alexandra Gerstgrasser, Hassan Melhem, Irina Leonardi, Kirstin Atrott, Matthias Schäfer, Sabine Werner, Gerhard Rogler & Isabelle Frey-Wagner. (2016) Cell-specific Activation of the Nrf2 Antioxidant Pathway Increases Mucosal Inflammation in Acute but Not in Chronic Colitis. Journal of Crohn's and Colitis, pages jjw172.
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Michelle L. Kerns, Jill M.C. Hakim, Rosemary G. Lu, Yajuan Guo, Andreas Berroth, Roger L. Kaspar & Pierre A. Coulombe. (2016) Oxidative stress and dysfunctional NRF2 underlie pachyonychia congenita phenotypes. Journal of Clinical Investigation 126:6, pages 2356-2366.
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Weibing Wu, Dan Ma, Ping Wang, Lu Cao, Tangsheng Lu, Qin Fang, Jiangyuan Zhao & Jishi Wang. (2016) Potential crosstalk of the interleukin-6-heme oxygenase-1-dependent mechanism involved in resistance to lenalidomide in multiple myeloma cells. FEBS Journal 283:5, pages 834-849.
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Maya Ben-Yehuda Greenwald, Shmuel Ben-Sasson, Havazelet Bianco-Peled & Ron Kohen. (2016) Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System. Cosmetics 3:1, pages 1.
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Matthias Schäfer & Sabine Werner. (2015) Nrf2—A regulator of keratinocyte redox signaling. Free Radical Biology and Medicine 88, pages 243-252.
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J. Antoni Sirerol, Fatima Feddi, Salvador Mena, María L. Rodriguez, Paula Sirera, Miguel Aupí, Salvador Pérez, Miguel Asensi, Angel Ortega & José M. Estrela. (2015) Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis. Free Radical Biology and Medicine 85, pages 1-11.
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Carla Abdo Brohem, Valéria Maria Di Mambro & Márcio Lorencini. 2016. Textbook of Aging Skin. Textbook of Aging Skin 1 11 .
Kyung-Soo Chun, Juthika Kundu, Joydeb Kumar Kundu & Young-Joon Surh. (2014) Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals. Toxicology Letters 229:1, pages 73-84.
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Ximena Paredes-Gonzalez, Francisco Fuentes, Zheng-Yuan Su & Ah-Ng Tony Kong. (2014) Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications. The AAPS Journal 16:4, pages 727-735.
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Márcio Lorencini, Carla A. Brohem, Gustavo C. Dieamant, Nilson I.T. Zanchin & Howard I. Maibach. (2014) Active ingredients against human epidermal aging. Ageing Research Reviews 15, pages 100-115.
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Ji Young Kim, Do Young Kim, Hyojung Son, Yoon Jee Kim & Sang Ho Oh. (2014) Protease-activated receptor-2 activates NQO-1 via Nrf2 stabilization in keratinocytes. Journal of Dermatological Science 74:1, pages 48-55.
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Stuart A. Rushworth, Lyubov Zaitseva, Megan Y. Murray, Niraj M. Shah, Kristian M. Bowles & David J. MacEwan. (2012) The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance. Blood 120:26, pages 5188-5198.
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James D. Hoerter, Patrick Bradley, Alexandria Casillas, Danielle Chambers, Carli Denholm, Kimberly Johnson & Brandon Weiswasser. (2012) Extrafollicular Dermal Melanocyte Stem Cells and Melanoma. Stem Cells International 2012, pages 1-10.
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Kris Nys, Hannelore Maes, Aleksandra Maria Dudek & Patrizia Agostinis. (2011) Uncovering the role of hypoxia inducible factor-1α in skin carcinogenesis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1816:1, pages 1-12.
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Wanakee J. Carr, Rebecca E. Oberley-Deegan, Yuping Zhang, Christopher C. Oberley, Larry W. Oberley & Martine Dunnwald. (2011) Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics. Histochemistry and Cell Biology 135:3, pages 293-304.
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