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The EphB2 tumor suppressor induces autophagic cell death via concomitant activation of the ERK1/2 and PI3K pathways

Pages 398-407 | Published online: 15 Jan 2010

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Huazhi Zhang, Zhihui Cui, Du Cheng, Yanyun Du, Xiaoli Guo, Ru Gao, Jianwen Chen, Wanwei Sun, Ruirui He, Xiaojian Ma, Qianwen Peng, Bradley N. Martin, Wei Yan, Yueguang Rong & Chenhui Wang. (2021) RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis. Autophagy 17:10, pages 3030-3047.
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Oscar J Buckens, Btissame El Hassouni, Elisa Giovannetti & Godefridus J Peters. (2020) The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment. Expert Opinion on Investigational Drugs 29:6, pages 567-582.
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William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Michelle M. LaHair, Giuseppe Montalto, Melchiorre Cervello, Alberto M. Martelli, Ferdinando Nicoletti, Saverio Candido, Massimo Libra, Jerry Polesel, Renato Talamini, Michele Milella, Agostino Tafuri, Linda S. Steelman & James A. McCubrey. (2012) Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine. Cell Cycle 11:23, pages 4447-4461.
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Wei Liu, Chengpeng Yu, Jianfeng Li & Jiwei Fang. (2022) The Roles of EphB2 in Cancer. Frontiers in Cell and Developmental Biology 10.
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Xiaogang Chen, Dan Zhang, Yi Wang, Ke Chen, Limeng Zhao, Yating Xu, Hulin Jiang & Shuzhen Wang. (2020) Synergistic antifibrotic effects of miR-451 with miR-185 partly by co-targeting EphB2 on hepatic stellate cells. Cell Death & Disease 11:5.
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Thierry N’Tumba-Byn, Makiko Yamada & Marco Seandel. (2020) Loss of tyrosine kinase receptor Ephb2 impairs proliferation and stem cell activity of spermatogonia in culture†. Biology of Reproduction 102:4, pages 950-962.
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Yvonne Münster, Kathy Keyvani & Arne Herring. (2020) Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model. Experimental Neurology 324, pages 113115.
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Simon Brayford, Fiona N. Kenny, Toru Hiratsuka, Eduardo Serna-Morales, Lawrence Yolland, Andrei Luchici & Brian M. Stramer. (2019) Heterotypic contact inhibition of locomotion can drive cell sorting between epithelial and mesenchymal cell populations. Journal of Cell Science.
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Mustapha Kandouz. (2018) Dying to communicate: apoptotic functions of Eph/Ephrin proteins. Apoptosis 23:5-6, pages 265-289.
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Guangyu Xu, Xu Liu, Chunmei Wang, He Li, Chengyi Zhang, Jianguang Chen & Jinghui Sun. (2019) The Mechanisms of Shcisandrol A in Immune Function Modulation in Immunosuppressed Mice. Natural Product Communications 13:2, pages 1934578X1801300.
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Fei Han, Qing‐Qing Xiao, Shi Peng, Xin‐Yu Che, Li‐Sheng Jiang, Qin Shao & Ben He. (2017) Atorvastatin ameliorates LPS‐induced inflammatory response by autophagy via AKT/mTOR signaling pathway. Journal of Cellular Biochemistry 119:2, pages 1604-1615.
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Jane FraserAinara G. CabodevillaJoanne SimpsonNoor Gammoh. (2017) Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking. Essays in Biochemistry 61:6, pages 597-607.
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Thomas Jungas, Renaud T. Perchey, Mohamad Fawal, Caroline Callot, Carine Froment, Odile Burlet-Schiltz, Arnaud Besson & Alice Davy. (2016) Eph-mediated tyrosine phosphorylation of citron kinase controls abscission. Journal of Cell Biology 214:5, pages 555-569.
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Xiaoli Li, Yanyan Cen, Yongqing Cai, Tao Liu, Huan Liu, Guanqun Cao, Dan Liu, Bin Li, Wei Peng, Jintao Zou, Xueli Pang, Jiang Zheng & Hong Zhou. (2016) TLR9-ERK-mTOR signaling is critical for autophagic cell death induced by CpG oligodeoxynucleotide 107 combined with irradiation in glioma cells. Scientific Reports 6:1.
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Maria Carmela Cantisani, Alessia Parascandolo, Merja Perälä, Chiara Allocca, Vidal Fey, Niko Sahlberg, Francesco Merolla, Fulvio Basolo, Mikko O. Laukkanen, Olli Pekka Kallioniemi, Massimo Santoro & Maria Domenica Castellone. (2016) A loss-of-function genetic screening identifies novel mediators of thyroid cancer cell viability. Oncotarget 7:19, pages 28510-28522.
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Pedram Kharaziha, Dimitris Chioureas, George Baltatzis, Pedro Fonseca, Patricia Rodriguez, Vladimir Gogvadze, Lena Lennartsson, Ann-Charlotte Björklund, Boris Zhivotovsky, Dan Grandér, Lars Egevad, Sten Nilsson & Theocharis Panaretakis. (2015) Sorafenib-induced defective autophagy promotes cell death by necroptosis. Oncotarget 6:35, pages 37066-37082.
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Mohamed Amessou & Mustapha Kandouz. 2015. Intercellular Communication in Cancer. Intercellular Communication in Cancer 255 286 .
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Sahiti Chukkapalli, Mohamed Amessou, Ashok K. Dilly, Hafedh Dekhil, Jing Zhao, Qiang Liu, Alex Bejna, Ron D. Thomas, Sudeshna Bandyopadhyay, Tarek A. Bismar, Daniel Neill, Laurent Azoulay, Gerald Batist & Mustapha Kandouz. (2014) Role of the EphB2 receptor in autophagy, apoptosis and invasion in human breast cancer cells. Experimental Cell Research 320:2, pages 233-246.
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Hee-Jin Ahn, Gwangil Kim & Kyung-Soon Park. (2013) Ell3 stimulates proliferation, drug resistance, and cancer stem cell properties of breast cancer cells via a MEK/ERK-dependent signaling pathway. Biochemical and Biophysical Research Communications 437:4, pages 557-564.
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Marc Pretze, Manuela Kuchar, Ralf Bergmann, Jörg Steinbach, Jens Pietzsch & Constantin Mamat. (2013) An Efficient Bioorthogonal Strategy Using CuAAC Click Chemistry for Radiofluorinations of SNEW Peptides and the Role of Copper Depletion. ChemMedChem 8:6, pages 935-945.
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James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria C. Mazzarino, Saverio Candido, Massimo Libra, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini & Alberto M. Martelli. (2012) Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response.. Oncotarget 3:9, pages 954-987.
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