IFNβ and glatiramer acetate trigger different signaling pathways to regulate the IL-1 system in multiple sclerosis

Rakel Carpintero Division of Immunology and Allergy, Inflammation and Allergy Research Group, Hans Wilsdorf Laboratory, University Hospital and Faculty of Medicine, University of Geneva, SwitzerlandCorrespondence[email protected]

Danielle Burger Division of Immunology and Allergy, Inflammation and Allergy Research Group, Hans Wilsdorf Laboratory, University Hospital and Faculty of Medicine, University of Geneva, Switzerland

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Xueyuan Yu, Jiajia Lv, Jun Wu, Yong Chen, Fei Chen & Li Wang. (2022) The autoimmune encephalitis-related cytokine TSLP in the brain primes neuroinflammation by activating the JAK2-NLRP3 axis. Clinical and Experimental Immunology 207:1, pages 113-122.
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María José Zarzuelo-Romero, Cristina Pérez-Ramírez, Yasmín Cura, María Isabel Carrasco-Campos, Luciana María Marangoni-Iglecias, María Carmen Ramírez-Tortosa & Alberto Jiménez-Morales. (2021) Influence of Genetic Polymorphisms on Clinical Outcomes of Glatiramer Acetate in Multiple Sclerosis Patients. Journal of Personalized Medicine 11:10, pages 1032.
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Abigail E. Russi, Margaret E. Walker-Caulfield & Melissa A. Brown. (2018) Mast cell inflammasome activity in the meninges regulates EAE disease severity. Clinical Immunology 189, pages 14-22.
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Chih-Chung Lin & Brian T. Edelson. (2017) New Insights into the Role of IL-1β in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. The Journal of Immunology 198:12, pages 4553-4560.
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Sébastien A. Lévesque, Alexandre Paré, Benoit Mailhot, Victor Bellver-Landete, Hania Kébir, Marc-André Lécuyer, Jorge Ivan Alvarez, Alexandre Prat, Juan Pablo de Rivero Vaccari, Robert W. Keane & Steve Lacroix. (2016) Myeloid cell transmigration across the CNS vasculature triggers IL-1β–driven neuroinflammation during autoimmune encephalomyelitis in mice. Journal of Experimental Medicine 213:6, pages 929-949.
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Serbulent Yigit, Nevin Karakus, Semiha Gülsüm Kurt & Omer Ates. (2013) Association of Missense Mutations of Mediterranean Fever (MEFV) Gene with Multiple Sclerosis in Turkish Population. Journal of Molecular Neuroscience 50:2, pages 275-279.
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Mahmut Alpayci, Nazim Bozan, Seyfettin Erdem, Muslum Gunes & Metin Erden. (2012) The possible underlying pathophysiological mechanisms for development of multiple sclerosis in familial Mediterranean fever. Medical Hypotheses 78:6, pages 717-720.
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IFNβ and glatiramer acetate trigger different signaling pathways to regulate the IL-1 system in multiple sclerosis

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IFNβ and glatiramer acetate trigger different signaling pathways to regulate the IL-1 system in multiple sclerosis

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