PI3K-γ inhibitors in the therapeutic intervention of diseases caused by obligate intracellular pathogens

Steve Oghumu Department of Pathology; The Ohio State University Medical Center; Columbus, OH USA; Department of Oral Biology; The Ohio State University College of Dentistry; Columbus, OH USA

Abhay R. Satoskar Department of Pathology; The Ohio State University Medical Center; Columbus, OH USA; Department of Microbiology; The Ohio State University; Columbus, OH USACorrespondence[email protected]

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Renee Fleeman. (2023) Repurposing inhibitors of phosphoinositide 3-kinase as adjuvant therapeutics for bacterial infections. Frontiers in Antibiotics 2.
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Alicia Mas, Abel Martínez-Rodrigo, Javier Carrión, José Antonio Orden, Juan F. Alzate, Gustavo Domínguez-Bernal & Pilar Horcajo. (2022) Transcriptomic Profile of Canine DH82 Macrophages Infected by Leishmania infantum Promastigotes with Different Virulence Behavior. International Journal of Molecular Sciences 23:3, pages 1466.
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Thanh Kha Phan, Guneet K. Bindra, Scott A. Williams, Ivan K.H. Poon & Mark D. Hulett. (2019) Combating Human Pathogens and Cancer by Targeting Phosphoinositides and Their Metabolism. Trends in Pharmacological Sciences 40:11, pages 866-882.
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Cristiana T. Trinconi, Danilo C. Miguel, Ariel M. Silber, Christopher Brown, John G.M. Mina, Paul W. Denny, Norton Heise & Silvia R.B. Uliana. (2018) Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania. International Journal for Parasitology: Drugs and Drug Resistance 8:3, pages 475-487.
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Peter E. Kima. (2016) PI3K signaling in Leishmania infections. Cellular Immunology 309, pages 19-22.
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Teresa C. Calegari-Silva, Áislan C. Vivarini, Marina Miqueline, Guilherme R. R. M. Dos Santos, Karina Luiza Teixeira, Alessandra Mattos Saliba, Simone Nunes de Carvalho, Laís de Carvalho & Ulisses G. Lopes. (2015) The human parasite Leishmania amazonensis downregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway . Open Biology 5:9, pages 150118.
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Tecia M. U. de Carvalho, Emile S. Barrias & Wanderley de Souza. (2015) Macropinocytosis: a pathway to protozoan infection. Frontiers in Physiology 6.
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PI3K-γ inhibitors in the therapeutic intervention of diseases caused by obligate intracellular pathogens

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PI3K-γ inhibitors in the therapeutic intervention of diseases caused by obligate intracellular pathogens

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