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Review

Recent advances in the development of p21-activated kinase inhibitors

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Pages 132-135 | Published online: 16 Sep 2012

Keep up to date with the latest research on this topic with citation updates for this article.

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Chetan K Rane & Audrey Minden. (2014) P21 activated kinases. Small GTPases 5:1.
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Jeffrey Field & Ed Manser. (2012) The PAKs come of age. Cellular Logistics 2:2, pages 54-58.
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Articles from other publishers (14)

Fu-Chun Huo, Yao-Jie Pan, Tong-Tong Li, Jie Mou & Dong-Sheng Pei. (2018) PAK5 promotes the migration and invasion of cervical cancer cells by phosphorylating SATB1. Cell Death & Differentiation 26:6, pages 994-1006.
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Qingfeng Yu, Christian Gratzke, Yiming Wang, Xiaolong Wang, Bingsheng Li, Frank Strittmatter, Annika Herlemann, Ruixiao Wang, Alexander Tamalunas, Raphaela Waidelich, Christian G. Stief & Martin Hennenberg. (2019) New strategies for inhibition of non‐adrenergic prostate smooth muscle contraction by pharmacologic intervention. The Prostate 79:7, pages 746-756.
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Simona John Von Freyend, Terry Kwok-Schuelein, Hans Netter, Gholamreza Haqshenas, Jean-Philippe Semblat & Christian Doerig. (2017) Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens. Pathogens 6:2, pages 17.
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Sandra Liliana Vargas-Torres, Elyzabeth Avvad Portari, Amanda Lima Silva, Evandro Mendes Klumb, Heloísa Carneiro da Rocha Guillobel, Maria José de Camargo, Cíntia Barros Santos-Rebouças, Fábio Bastos Russomano & Jacyara Maria Brito Macedo. (2016) Roles of CDKN1A gene polymorphisms (rs1801270 and rs1059234) in the development of cervical neoplasia. Tumor Biology 37:8, pages 10469-10478.
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Yiming Wang, Christian Gratzke, Alexander Tamalunas, Nicolas Wiemer, Anna Ciotkowska, Beata Rutz, Raphaela Waidelich, Frank Strittmatter, Chunxiao Liu, Christian G. Stief & Martin Hennenberg. (2016) P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate. PLOS ONE 11:4, pages e0153312.
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Andrea Volkamer, Sameh Eid, Samo Turk, Friedrich Rippmann & Simone Fulle. (2016) Identification and Visualization of Kinase-Specific Subpockets. Journal of Chemical Information and Modeling 56:2, pages 335-346.
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Maria M. Alves, Gwenny M. Fuhler, Karla C.S. Queiroz, Jetse Scholma, Susan Goorden, Jasper Anink, C. Arnold Spek, Marianne Hoogeveen-Westerveld, Marco J. Bruno, Mark Nellist, Ype Elgersma, Eleonora Aronica & Maikel P. Peppelenbosch. (2015) PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex. Scientific Reports 5:1.
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Jian Zheng, Xiao-dong Li, Ping Wang, Xiao-bai Liu, Yi-xue Xue, Yi Hu, Zhen Li, Zhi-qing Li, Zhen-hua Wang & Yun-hui Liu. (2015) CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186. Oncotarget 6:28, pages 25339-25355.
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Alexei S. Karpov, Payman Amiri, Cornelia Bellamacina, Marie-Helene Bellance, Werner Breitenstein, Dylan Daniel, Regis Denay, Doriano Fabbro, Cesar Fernandez, Inga Galuba, Stephanie Guerro-Lagasse, Sascha Gutmann, Linda Hinh, Wolfgang Jahnke, Julia Klopp, Albert Lai, Mika K. Lindvall, Sylvia Ma, Henrik Möbitz, Sabina Pecchi, Gabriele Rummel, Kevin Shoemaker, Joerg Trappe, Charles Voliva, Sandra W. Cowan-Jacob & Andreas L. Marzinzik. (2015) Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Medicinal Chemistry Letters 6:7, pages 776-781.
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André P. Koth, Bruno R. Oliveira, Gustavo M. Parfitt, Juliana de Quadros Buonocore & Daniela M. Barros. (2014) Participation of group I p21-activated kinases in neuroplasticity. Journal of Physiology-Paris 108:4-6, pages 270-277.
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D R Cook, K L Rossman & C J Der. (2013) Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene 33:31, pages 4021-4035.
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Todd M. Pitts, S. Lindsey Davis, S. Gail Eckhardt & Erica L. Bradshaw-Pierce. (2014) Targeting nuclear kinases in cancer: Development of cell cycle kinase inhibitors. Pharmacology & Therapeutics 142:2, pages 258-269.
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Melina Shoni, Zoltan Nagymanyoki, Allison F. Vitonis, Cynthia Jimenez, Shu-Wing Ng, Bradley J. Quade & Ross S. Berkowitz. (2013) p-21-Activated kinase-1, -4 and -6 and estrogen receptor expression pattern in normal placenta and gestational trophoblastic diseases. Gynecologic Oncology 131:3, pages 759-763.
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Sean C. Warren, Anca Margineanu, Dominic Alibhai, Douglas J. Kelly, Clifford Talbot, Yuriy Alexandrov, Ian Munro, Matilda Katan, Chris Dunsby & Paul M. W. French. (2013) Rapid Global Fitting of Large Fluorescence Lifetime Imaging Microscopy Datasets. PLoS ONE 8:8, pages e70687.
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