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Zileuton, a new efficient and safe systemic anti-acne drug

Pages 188-192 | Published online: 01 Jun 2009

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Neirita Hazarika. (2021) Acne vulgaris: new evidence in pathogenesis and future modalities of treatment. Journal of Dermatological Treatment 32:3, pages 277-285.
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Christos C. Zouboulis, Clio Dessinioti, Fragkiski Tsatsou & Harald P. M. Gollnick. (2017) Anti-acne drugs in phase 1 and 2 clinical trials. Expert Opinion on Investigational Drugs 26:7, pages 813-823.
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Isabel Cristina Valente Duarte de Sousa. (2014) Novel pharmacological approaches for the treatment of acne vulgaris. Expert Opinion on Investigational Drugs 23:10, pages 1389-1410.
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Anja Thielitz & Harald Gollnick. (2013) Recent therapeutic developments for acne. Expert Review of Dermatology 8:1, pages 37-50.
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Pit Sertznig & Jörg Reichrath. (2011) Peroxisome proliferator-activated receptors (PPARs) in dermatology. Dermato-Endocrinology 3:3, pages 130-135.
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Thrasivoulos Tzellos, Vasiliki Zampeli, Evgenia Makrantonaki & Christos C Zouboulis. (2011) Treating acne with antibiotic-resistant bacterial colonization. Expert Opinion on Pharmacotherapy 12:8, pages 1233-1247.
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Hossein Heli, Siamak Mirtorabi & Khashayar Karimian. (2011) Advances in iron chelation: an update. Expert Opinion on Therapeutic Patents 21:6, pages 819-856.
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Ghanshyam Parmar, Jay Mukesh Chudasama, Ashish Shah & Ashish Patel. 2023. CADD and Informatics in Drug Discovery. CADD and Informatics in Drug Discovery 253 281 .
Negin Fazelzadeh Haghighi, Ladan Dastgheib, Nasrin Saki, Shohreh Alipour & Sara Ranjbar. (2022) Montelukast as an effective adjuvant in the treatment of moderate acne vulgaris. Dermatologic Therapy 35:10.
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Kabir Sardana & Soumya Sachdeva. (2021) Role of nutritional supplements in selected dermatological disorders: A review. Journal of Cosmetic Dermatology 21:1, pages 85-98.
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Ghasem Rahmatpour Rokni, Farzaneh Mohammadnezhad, Majid Saeedi, Shiva Shadi, Aseem Sharma, Sunmeet Sandhu, Atula Gupta & Mohamad Goldust. (2021) Efficacy, tolerability, and safety of montelukast versus finasteride for the treatment of moderate acne in women: A prospective, randomized, single‐blinded, active‐controlled trial. Journal of Cosmetic Dermatology 20:11, pages 3580-3585.
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Romana Mahivish, Manjunath SY & Hemant Kumar. (2021) RP-HPLC METHOD FOR THE ESTIMATION OF ZILEUTON IN TABLET FORMULATION. International Journal of Research -GRANTHAALAYAH 9:1, pages 141-149.
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Hilary Baldwin & Jerry Tan. (2020) Effects of Diet on Acne and Its Response to Treatment. American Journal of Clinical Dermatology 22:1, pages 55-65.
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Harald P. M. Gollnick, Clio Dessinioti & Christos C. Zouboulis. 2021. Acne. Acne 55 73 .
Farid A. Badria & Abdullah A. Elgazar. 2020. Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications. Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications.
Zípora Santos, Maiara Velho, Fátima Zan, Virgínia Rech & Aline Ferreira Ourique. (2020) Review of Clinical Factors That Cause Acne Vulgaris. International Journal for Innovation Education and Research 8:9, pages 434-447.
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Christos C. Zouboulis. (2020) Endocrinology and immunology of acne: Two sides of the same coin. Experimental Dermatology 29:9, pages 840-859.
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Khushbo Bhardwaj, Deepak Meshram & Kapil Kumar Soni. (2020) A Review on Leukotriene Antagonistic Agents of Plant Origin. Asian Journal of Organic & Medicinal Chemistry 5:1, pages 30-35.
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Rajesh Kumar, Seetha Harilal, Sheeba Varghese Gupta, Jobin Jose, Della Grace Thomas Parambi, Md. Sahab Uddin, Muhammad Ajmal Shah & Bijo Mathew. (2019) Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work. European Journal of Medicinal Chemistry 182, pages 111602.
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William P. Esler, Gregory J. Tesz, Marc K. HellersteinCarine BeysenRaja Sivamani, Scott M. TurnerSteven M. WatkinsPaul A. AmorSantos Carvajal-Gonzalez, Frank J. Geoly, Kathleen E. BiddleJulie J. Purkal, Mark Fitch, Clare BuckeridgeAnnette M. Silvia, David A. GriffithMatthew GorgoglioneLauren HassounSuzana S. Bosanac, Nicholas B. Vera, Timothy P. Rolph, Jeffrey A. PfefferkornGabriele E. Sonnenberg. (2019) Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition. Science Translational Medicine 11:492.
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A. N. Lvov, M. S. Kornyat, A. V. Igoshina & A. R. Nazarenko. (2019) Perspectives in acne therapy: an analytical review (in Russian only). Klinicheskaya dermatologiya i venerologiya 18:2, pages 115.
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Solee Jin & Mi-Young Lee. (2018) The ameliorative effect of hemp seed hexane extracts on the Propionibacterium acnes-induced inflammation and lipogenesis in sebocytes. PLOS ONE 13:8, pages e0202933.
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Megha K. Trivedi, Suzana S. Bosanac, Raja K. Sivamani & Larissa N. Larsen. (2018) Emerging Therapies for Acne Vulgaris. American Journal of Clinical Dermatology 19:4, pages 505-516.
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Xinchao Li, Congfen He, Zhou Chen, Cheng Zhou, Yao Gan & Yan Jia. (2017) A review of the role of sebum in the mechanism of acne pathogenesis. Journal of Cosmetic Dermatology 16:2, pages 168-173.
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Saurabh B. Ganorkar & Atul A. Shirkhedkar. (2017) Novel HPTLC and UV-AUC analyses: For simple, economical, and rapid determination of Zileuton racemate. Arabian Journal of Chemistry 10:3, pages 360-367.
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Saurabh B. Ganorkar, Dinesh M. Dhumal & Atul A. Shirkhedkar. (2017) Development and validation of simple RP-HPLC-PDA analytical protocol for zileuton assisted with Design of Experiments for robustness determination. Arabian Journal of Chemistry 10:2, pages 273-282.
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Z. I. Krutetskaya, L. S. Milenina, A. A. Naumova, V. G. Antonov & A. D. Nozdrachev. (2016) 5-Lipoxygenase inhibitor zileuton inhibits Ca2+-responses induced by glutoxim and molixan in macrophages. Doklady Biochemistry and Biophysics 469:1, pages 302-304.
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Mrinal Gupta, Vikram K. Mahajan, Karaninder S. Mehta, Pushpinder S. Chauhan & Ritu Rawat. (2015) Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics?. Archives of Dermatological Research 307:9, pages 767-780.
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Sara Moradi Tuchayi, Evgenia Makrantonaki, Ruta Ganceviciene, Clio Dessinioti, Steven R. Feldman & Christos C. Zouboulis. (2015) Acne vulgaris. Nature Reviews Disease Primers 1:1.
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C.C. Zouboulis & V. Bettoli. (2015) Management of severe acne. British Journal of Dermatology 172, pages 27-36.
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Christos C. Zouboulis, Eric Jourdan & Mauro Picardo. 2015. Lipids and Skin Health. Lipids and Skin Health 331 342 .
B. Bergler-Czop. (2014) The aetiopathogenesis of acne vulgaris - what's new?. International Journal of Cosmetic Science 36:3, pages 187-194.
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C.C. Zouboulis, E. Jourdan & M. Picardo. (2014) Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. Journal of the European Academy of Dermatology and Venereology 28:5, pages 527-532.
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Dieter Steinhilber & Bettina Hofmann. (2014) Recent Advances in the Search for Novel 5-Lipoxygenase Inhibitors. Basic & Clinical Pharmacology & Toxicology 114:1, pages 70-77.
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Clio Dessinioti & Christos C. Zouboulis. 2014. Pathogenesis and Treatment of Acne and Rosacea. Pathogenesis and Treatment of Acne and Rosacea 537 542 .
Phillip Pian, Edward Labovitz, Keith Hoffman, Claudia F. Clavijo, Rachael Rzasa Lynn, Jeffrey L. Galinkin, Alexander A. Vinks, Punam Malik & Uwe Christians. (2013) Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography–tandem mass spectrometry. Journal of Chromatography B 937, pages 79-83.
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S. B. Ganorkar, D. M Dhumal & A. A Shirkhedkar. (2013) APPLICATION OF UV-SPECTROPHOTOMETRY FOR DETERMINATION OF ZILEUTON IN BULK AND IN TABLETS. INDIAN DRUGS 50:06, pages 40-44.
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C.C. Zouboulis. (2013) Pathophysiologie der AknePathophysiology of acne. Der Hautarzt 64:4, pages 235-240.
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Sundarapandian Thangapandian, Shalini John, Minky Son, Venkatesh Arulalapperumal & Keun Woo Lee. (2013) Development of predictive quantitative structure–activity relationship model and its application in the discovery of human leukotriene A4 hydrolase inhibitors. Future Medicinal Chemistry 5:1, pages 27-40.
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Tamás Géczy, Attila Oláh, Balázs I. Tóth, Gabriella Czifra, Attila G. Szöllősi, Tamás Szabó, Christos C. Zouboulis, Ralf Paus & Tamás Bíró. (2012) Protein Kinase C Isoforms Have Differential Roles in the Regulation of Human Sebocyte Biology. Journal of Investigative Dermatology 132:8, pages 1988-1997.
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Sundarapandian Thangapandian, Shalini John, Sugunadevi Sakkiah & Keun Woo Lee. (2011) Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors. European Journal of Medicinal Chemistry 46:5, pages 1593-1603.
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Bodo C. Melnik. (2010) FoxO1 - the key for the pathogenesis and therapy of acne?. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 8:2, pages 105-114.
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