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Review

Reactivation of Epigenetically Silenced Genes by DNA Methyltransferase Inhibitors: Basic Concepts and Clinical Applications

Pages 8-14 | Published online: 10 Mar 2006

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Alfonso Dueñas-Gonzalez, Jaime Coronel, Lucely Cetina, Aurora González-Fierro, Alma Chavez-Blanco & Lucia Taja-Chayeb. (2014) Hydralazine–valproate: a repositioned drug combination for the epigenetic therapy of cancer. Expert Opinion on Drug Metabolism & Toxicology 10:10, pages 1433-1444.
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Marika Matoušová, Ivan Votruba, Miroslav Otmar, Eva Tloušťová, Jana Günterová & Helena Mertlíková-Kaiserová. (2011) 2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine. Epigenetics 6:6, pages 769-776.
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Pierre Dehan, Gaelle Kustermans, Samuel Guenin, Julie Horion, Jacques Boniver & Philippe Delvenne. (2009) DNA methylation and cancer diagnosis: new methods and applications. Expert Review of Molecular Diagnostics 9:7, pages 651-657.
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Alvin Gomez & Magnus Ingelman-Sundberg. (2009) Pharmacoepigenetic aspects of gene polymorphism on drug therapies: effects of DNA methylation on drug response. Expert Review of Clinical Pharmacology 2:1, pages 55-65.
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Xinyan Jia, Wenzhong Yang, Xiaohui Zhou, Lu Han & Jumei Shi. (2019) Influence of demethylation on regulatory T and Th17�cells in myelodysplastic syndrome. Oncology Letters.
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Zhijun Huang, Zhengbin Han, Fengwei Zhang, Hongjuan He, Shihuan Yu & Qiong Wu. (2014) Spatiotemporal expression of retrogene–host pair Mcts2/H13 in mouse embryo, and Mcts2 has no influence on H13 transcription pattern in NIH/3T3 cells. Acta Histochemica 116:2, pages 312-318.
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Hyehyeon Lee, Jin Bae Sohn, Soo Shin Kim & Kyung Lib Jang. (2013) DNA methyltransferase inhibitor assay system based on the HBx-induced DNA methylation of E-cadherin. Biochemical and Biophysical Research Communications 438:3, pages 540-545.
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Diego Mastroeni, Andrew Grover, Elaine Delvaux, Charisse Whiteside, Paul D. Coleman & Joseph Rogers. (2011) Epigenetic mechanisms in Alzheimer's disease. Neurobiology of Aging 32:7, pages 1161-1180.
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Christopher A. Hamm & Fabricio F. Costa. (2011) The impact of epigenomics on future drug design and new therapies. Drug Discovery Today 16:13-14, pages 626-635.
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Juan Ren, Brahma N. Singh, Qiang Huang, Zongfang Li, Ya Gao, Prachi Mishra, Yi L. Hwa, Jinping Li, Sean C. Dowdy & Shi-Wen Jiang. (2011) DNA hypermethylation as a chemotherapy target. Cellular Signalling 23:7, pages 1082-1093.
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Gwen A. Lomberk. (2011) Epigenetic Silencing of Tumor Suppressor Genes in Pancreatic Cancer. Journal of Gastrointestinal Cancer 42:2, pages 93-99.
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B Weber, S Kimhi, G Howard, A Eden & F Lyko. (2010) Demethylation of a LINE-1 antisense promoter in the cMet locus impairs Met signalling through induction of illegitimate transcription. Oncogene 29:43, pages 5775-5784.
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Constanze Zeller & Robert Brown. (2010) Therapeutic modulation of epigenetic drivers of drug resistance in ovarian cancer. Therapeutic Advances in Medical Oncology 2:5, pages 319-329.
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Paul M. HowellJr.Jr., Zixing Liu & Hung T. Khong. (2010) Demethylating Agents in the Treatment of Cancer. Pharmaceuticals 3:7, pages 2022-2044.
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Allison JonesMatthias LechnerEvangelia-Ourania FourkalaRebecca Kristeleit & Martin Widschwendter. (2010) Emerging promise of epigenetics and DNA methylation for the diagnosis and management of women’s cancers. Epigenomics 2:1, pages 9-38.
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Silke Götze, Valeska Feldhaus, Thilo Traska, Marietta Wolter, Guido Reifenberger, Andrea Tannapfel, Cornelius Kuhnen, Dirk Martin, Oliver Müller & Sonja Sievers. (2009) ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma. BMC Cancer 9:1.
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S. Amatori, F. Papalini, R. Lazzarini, B. Donati, I. Bagaloni, M.R. Rippo, A. Procopio, P.G. Pelicci, A. Catalano & M. Fanelli. (2009) Decitabine, differently from DNMT1 silencing, exerts its antiproliferative activity through p21 upregulation in malignant pleural mesothelioma (MPM) cells. Lung Cancer 66:2, pages 184-190.
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Ole Ammerpohl, José I. Martín-Subero, Julia Richter, Inga Vater & Reiner Siebert. (2009) Hunting for the 5th base: Techniques for analyzing DNA methylation. Biochimica et Biophysica Acta (BBA) - General Subjects 1790:9, pages 847-862.
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K. Poláková, E. Bandžuchová, D. Kuba & G. Russ. (2009) Demethylating agent 5-aza-2′-deoxycytidine activates HLA-G expression in human leukemia cell lines. Leukemia Research 33:4, pages 518-524.
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Jon A. Oyer, Adrian Chu, Sukhmani Brar & Mitchell S. Turker. (2009) Aberrant Epigenetic Silencing Is Triggered by a Transient Reduction in Gene Expression. PLoS ONE 4:3, pages e4832.
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Marcin Łukasik, Jolanta Karmalska, Mirosław M. Szutowski & Jacek Łukaszkiewicz. (2009) WPŁYW METYLACJI DNA NA FUNKCJONOWANIE GENOMU. Prospects in Pharmaceutical Sciences 7:2, pages 13-18.
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Mark F. Mehler. (2008) Epigenetics and the nervous system. Annals of Neurology 64:6, pages 602-617.
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Gwen Lomberk, Angela J Mathison, Adrienne Grzenda & Raul Urrutia. (2008) The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research. Current Opinion in Gastroenterology 24:5, pages 597-602.
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Hongjie Yao, Pingxin Li, Bryan J. Venters, Suting Zheng, Paul R. Thompson, B. Franklin Pugh & Yanming Wang. (2008) Histone Arg Modifications and p53 Regulate the Expression of OKL38, a Mediator of Apoptosis. Journal of Biological Chemistry 283:29, pages 20060-20068.
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Carlo Stresemann & Frank Lyko. (2008) Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine. International Journal of Cancer 123:1, pages 8-13.
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