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Brief Report

Tumor-Specific Methylation of the 8p22 Tumor Suppressor Gene DLC1 is an Epigenetic Biomarker for Hodgkin, Nasal NK/T-Cell and Other Types of Lymphomas

Pages 15-21 | Received 24 Nov 2006, Accepted 15 Jan 2007, Published online: 14 Mar 2007

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Hai-ying Fu, Dan-sen Wu, Hua-rong Zhou & Jian-zhen Shen. (2014) CpG island methylator phenotype and its relationship with prognosis in adult acute leukemia patients. Hematology 19:6, pages 329-337.
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Articles from other publishers (22)

Ajay Major, Pierluigi Porcu & Bradley M. Haverkos. (2023) Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma. Cancers 15:5, pages 1366.
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Guilherme Jeremias, Fernando J. M. Gonçalves, Joana L. Pereira & Jana Asselman. (2020) Prospects for incorporation of epigenetic biomarkers in human health and environmental risk assessment of chemicals. Biological Reviews 95:3, pages 822-846.
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Can Küçük, Junli Wang, Ying Xiang & Hua You. (2020) Epigenetic aberrations in natural killer/T-cell lymphoma: diagnostic, prognostic and therapeutic implications. Therapeutic Advances in Medical Oncology 12, pages 175883591990085.
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Jiaqin Yan, Junhui Zhang, Xudong Zhang, Xin Li, Ling Li, Zhaoming Li, Renyin Chen, Lei Zhang, Jingjing Wu, Xinhua Wang, Zhenchang Sun, Xiaorui Fu, Yu Chang, Feifei Nan, Hui Yu, Xiaolong Wu, Xiaoyan Feng, Wencai Li & Mingzhi Zhang. (2018) SPARC is down-regulated by DNA methylation and functions as a tumor suppressor in T-cell lymphoma. Experimental Cell Research 364:2, pages 125-132.
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Zhang Zhang, Li Liang, Dong Li, Lin Nong, Jumei Liu, Linlin Qu, Yalin Zheng, Bo Zhang & Ting Li. (2017) Hypermethylation of PRDM1/Blimp-1 promoter in extranodal NK/T-cell lymphoma, nasal type: an evidence of predominant role in its downregulation. Hematological Oncology 35:4, pages 645-654.
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Yufei Liu, Jun Zhou, Yuchang Hu, Junjie Wang & Chengfu Yuan. (2016) Curcumin inhibits growth of human breast cancer cells through demethylation of DLC1 promoter. Molecular and Cellular Biochemistry 425:1-2, pages 47-58.
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Giulia Brisotto, Alessandra di Gennaro, Valentina Damiano, Michela Armellin, Tiziana Perin, Roberta Maestro & Manuela Santarosa. (2015) An improved sequencing-based strategy to estimate locus-specific DNA methylation. BMC Cancer 15:1.
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YUQI SU, LI LIN, JINGWEN ZHANG, YAQI JIANG, CHANGQIE PAN, LI SUN, JIANGMAN DUAN & WANGJUN LIAO. (2015) Low expression of DLC1 is predictive of poor therapeutic efficiency of fluoropyrimidine and oxaliplatin as adjuvant chemotherapy in gastric cancer. Molecular Medicine Reports 12:4, pages 5771-5779.
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Cecilia Sjoestroem, Shahram Khosravi, Yabin Cheng, Gholamreza Safaee Ardekani, Magdalena Martinka & Gang Li. (2014) DLC1 expression is reduced in human cutaneous melanoma and correlates with patient survival. Modern Pathology 27:9, pages 1203-1211.
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Debmalya Barh, Angelo Carpi, Mukesh Verma & Mehmet GunduzEsin Demir, Burak Yılmaz, Mehmet Gunduz & Esra Gunduz. 2014. Cancer Biomarkers. Cancer Biomarkers 849 870 .
Nicole Bethge, Hilde Honne, Vera Hilden, Gunhild Trøen, Mette Eknæs, Knut Liestøl, Harald Holte, Jan Delabie, Erlend B. Smeland & Guro E. Lind. (2013) Identification of Highly Methylated Genes across Various Types of B-Cell Non-Hodgkin Lymphoma. PLoS ONE 8:11, pages e79602.
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Zhaohui Wang, Lili Li, Xianwei Su, Zifen Gao, Gopesh Srivastava, Paul G Murray, Richard Ambinder & Qian Tao. (2012) Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas. Journal of Translational Medicine 10:1.
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Nicholas C. Wong & David M. Ashley. 2012. Epigenomics. Epigenomics 338 346 .
Torsten Wuestefeld & Lars Zender. (2010) DLC1 and Liver Cancer: The Akt Connection. Gastroenterology 139:4, pages 1093-1096.
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Martin Sebastian Staege & Dieter Körholz. (2009) New treatment strategies for Hodgkin's lymphoma. Leukemia Research 33:7, pages 886-888.
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Hans Helmut Niller, Hans Wolf & Janos Minarovits. (2009) Epigenetic dysregulation of the host cell genome in Epstein–Barr virus-associated neoplasia. Seminars in Cancer Biology 19:3, pages 158-164.
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Lo-Kong Chan, Frankie Chi Fat Ko, Irene Oi-Lin Ng & Judy Wai Ping Yam. (2009) Deleted in Liver Cancer 1 (DLC1) Utilizes a Novel Binding Site for Tensin2 PTB Domain Interaction and Is Required for Tumor-Suppressive Function. PLoS ONE 4:5, pages e5572.
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Li Fu, Zifen Gao, Xiaohua Zhang, Ying Hung Tsang, Hwee Koon Goh, Hua Geng, Norio Shimizu, Junjiro Tsuchiyama, Gopesh Srivastava & Qian Tao. (2009) Frequent concomitant epigenetic silencing of the stress‐responsive tumor suppressor gene CADM1 , and its interacting partner DAL‐1 in nasal NK/T‐cell lymphoma . International Journal of Cancer 124:7, pages 1572-1578.
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V Ullmannova-Benson, M Guan, X Zhou, V Tripathi, X-Y Yang, D B Zimonjic & N C Popescu. (2008) DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway. Leukemia 23:2, pages 383-390.
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Vincenzo Calvanese, Angelica Horrillo, Abdelkrim Hmadcha, Beatriz Suarez-Álvarez, Agustín F. Fernandez, Ester Lara, Sara Casado, Pablo Menendez, Clara Bueno, Javier Garcia-Castro, Ruth Rubio, Pablo Lapunzina, Miguel Alaminos, Lodovica Borghese, Stefanie Terstegge, Neil J. Harrison, Harry D. Moore, Oliver Brüstle, Carlos Lopez-Larrea, Peter W. Andrews, Bernat Soria, Manel Esteller & Mario F. Fraga. (2008) Cancer Genes Hypermethylated in Human Embryonic Stem Cells. PLoS ONE 3:9, pages e3294.
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Wen Xue, Alexander Krasnitz, Robert Lucito, Raffaella Sordella, Linda VanAelst, Carlos Cordon-Cardo, Stephan Singer, Florian Kuehnel, Michael Wigler, Scott Powers, Lars Zender & Scott W. Lowe. (2008) DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma . Genes & Development 22:11, pages 1439-1444.
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Tai Young KimIn Sook KimHyun-Soon JongJung Weon LeeTae-You KimMira JungYung-Jue Bang. (2008) Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells. Experimental and Molecular Medicine 40:6, pages 639.
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