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Research Paper

Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo

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Pages 54-65 | Published online: 05 Dec 2012

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N. Divya Rajaselvi, M. D. Jida, K. K. Ajeeshkumar, Suresh N. Nair, Preethy John, Zarina Aziz & A. R. Nisha. (2023) Antineoplastic activity of plant-derived compounds mediated through inhibition of histone deacetylase: a review. Amino Acids.
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Jianyu Liu, Minghai Tang, Tao Li, Zhengying Su, Zejiang Zhu, Caixia Dou, Yan Liu, Heying Pei, Jianhong Yang, Haoyu Ye & Lijuan Chen. (2022) Honokiol Ameliorates Post-Myocardial Infarction Heart Failure Through Ucp3-Mediated Reactive Oxygen Species Inhibition. Frontiers in Pharmacology 13.
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Sheng-Mao Wu, Yee-Jee Jan, Shih-Chuan Tsai, Hung-Chuan Pan, Chin-Chang Shen, Cheng-Ning Yang, Shu-Hua Lee, Shing-Hwa Liu, Li-Wei Shen, Chien-Shan Chiu, Jack L. Arbiser, Menghsiao Meng & Meei-Ling Sheu. (2022) Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer. Cell Biology and Toxicology.
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Sunil Kumar, Abhishek Kumar Sharma, H. Lalhlenmawia & Deepak Kumar. 2021. Targeting Cellular Signalling Pathways in Lung Diseases. Targeting Cellular Signalling Pathways in Lung Diseases 821 846 .
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Jih‐Tung Pai, Chia‐Yun Hsu, Yei‐San Hsieh, Tsung‐Yu Tsai, Kuo‐Tai Hua & Meng‐Shih Weng. (2020) Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6‐mediated matrix metalloproteinase 9. Food Science & Nutrition 8:3, pages 1534-1545.
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Chon Phin Ong, Wai Leong Lee, Yin Quan Tang & Wei Hsum Yap. (2019) Honokiol: A Review of Its Anticancer Potential and Mechanisms. Cancers 12:1, pages 48.
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Jie Zhang, Yueming Zhang, Wen Shen, Ran Fu, Zongli Ding, Yulong Zhen & Yufeng Wan. (2019) Cytological effects of honokiol treatment and its potential mechanism of action in non-small cell lung cancer. Biomedicine & Pharmacotherapy 117, pages 109058.
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Quankun Zhuang, Ruili Pan, Xuemei Liu, Wen Xu, Hanping Wang, Xiaotong Zhang, Xintian Lai, Hongyun Wang, Li Zhang & Ji Jiang. (2019) A validated ultra-HPLC–MS/MS method for determination of honokiol in human plasma and its application to a clinical pharmacokinetic study. Bioanalysis 11:11, pages 1085-1098.
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Omchit Surien, Ahmad Rohi Ghazali & Siti Fathiah Masre. (2019) Lung Cancers and the Roles of Natural Compounds as Potential Chemotherapeutic and Chemopreventive Agents. Biomedical and Pharmacology Journal 12:1, pages 85-98.
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Jianfei Zhu, Shuonan Xu, Wenli Gao, Jianyu Feng & Guolong Zhao. (2019) Honokiol induces endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells. Life Sciences 221, pages 204-211.
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Mengyuan Cen, Yinan Yao, Luyun Cui, Guangdie Yang, Guohua Lu, Liangjie Fang, Zhang Bao & Jianying Zhou. (2018) Honokiol induces apoptosis of lung squamous cell carcinoma by targeting FGF2-FGFR1 autocrine loop. Cancer Medicine 7:12, pages 6205-6218.
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Huan Tang, Yongguang Zhang, Dan Li, Suhong Fu, Minghai Tang, Li Wan, Kai Chen, Zhuowei Liu, Linlin Xue, Aihua Peng, Haoyu Ye & Lijuan Chen. (2018) Discovery and synthesis of novel magnolol derivatives with potent anticancer activity in non-small cell lung cancer. European Journal of Medicinal Chemistry 156, pages 190-205.
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Zhuming Lu, Minghui Wang, Shuoyun Wu, Min Ye, Zhichao Lin, Tao Shun & Chuxiao Duan. (2018) MicroRNA‑137‑regulated AKT serine/threonine kinase 2 inhibits tumor growth and sensitizes cisplatin in patients with non‑small cell lung cancer. Oncology Letters.
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Wen TianYong-sheng LiJing-hua ZhangJi-jun LiJing-hua Gao. (2018) Comprehensive Analysis of DNA Methylation and Gene Expression Datasets Identified MMP9 and TWIST1 as Important Pathogenic Genes of Lung Adenocarcinoma . DNA and Cell Biology 37:4, pages 336-346.
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Kao-Jean Huang, Chin-Ho Kuo, Shu-Hsin Chen, Ching-Yen Lin & Ying-Ray Lee. (2018) Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy . Journal of Cellular and Molecular Medicine 22:3, pages 1894-1908.
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Sahar Bayat, Mahmoud Shekari Khaniani, Jalal Choupani, Mohammad Reza Alivand & Sima Mansoori Derakhshan. (2018) HDACis (class I), cancer stem cell, and phytochemicals: Cancer therapy and prevention implications. Biomedicine & Pharmacotherapy 97, pages 1445-1453.
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Jianhong Yang, Wenshuang Wu, Jiaolin Wen, Haoyu Ye, Hong Luo, Peng Bai, Minghai Tang, Fang Wang, Li Zheng, Shengyong Yang, Weimin Li, Aihua Peng, Li Yang, Li Wan & Lijuan Chen. (2017) Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells. Biomaterials 141, pages 188-198.
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Harish C. Pal, Ram Prasad & Santosh K. Katiyar. (2017) Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKα1/2-LKB1. Scientific Reports 7:1.
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Chandraiah Godugu, Ravi Doddapaneni & Mandip Singh. (2017) Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC). Colloids and Surfaces B: Biointerfaces 153, pages 208-219.
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Bin Zhou, Haiying Li, Chongyun Xing, Haige Ye, Jianhua Feng, Jianbo Wu, Zhongqiu Lu, Jing Fang & Shenmeng Gao. (2017) Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia. Biochemical Pharmacology 128, pages 12-25.
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A. S. Prakasha Gowda, Zucai Suo & Thomas E. Spratt. (2017) Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells. Chemical Research in Toxicology 30:2, pages 715-725.
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Shang-Ying Wu, Yung-Shin Sun, Kuan-Chen Cheng & Kai-Yin Lo. (2017) A Wound-Healing Assay Based on Ultraviolet Light Ablation. SLAS Technology 22:1, pages 36-43.
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Chieh-Hsiang Lu, Shu-Hsin Chen, Yi-Sheng Chang, Yi-Wen Liu, Jin-Yi Wu, Yun-Ping Lim, Hui-I Yu & Ying-Ray Lee. (2017) Honokiol, a potential therapeutic agent, induces cell cycle arrest and program cell death in vitro and in vivo in human thyroid cancer cells. Pharmacological Research 115, pages 288-298.
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Santosh Katiyar. (2016) Emerging Phytochemicals for the Prevention and Treatment of Head and Neck Cancer. Molecules 21:12, pages 1610.
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Jung Min Song, Arunkumar Anandharaj, Pramod Upadhyaya, Ameya R. Kirtane, Jong-Hyuk Kim, Kwon Ho Hong, Jayanth Panyam & Fekadu Kassie. (2016) Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors. Oncotarget 7:36, pages 57752-57769.
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Yuting Liu, Yunli Tong, Xia Yang, Fangyuan Li, Liang Zheng, Wenqin Liu, Jinjun Wu, Rilan Ou, Guiyu Zhang, Ming Hu, Zhongqiu Liu & Linlin Lu. (2016) Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer. Pharmacological Research 111, pages 113-125.
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Jing Pan, Yongik Lee, Yian Wang & Ming You. (2016) Honokiol targets mitochondria to halt cancer progression and metastasis. Molecular Nutrition & Food Research 60:6, pages 1383-1395.
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Ram Prasad, John C. Kappes & Santosh K. Katiyar. (2016) Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells. Oncotarget 7:7, pages 7899-7912.
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Weidong Li, Qian Wang, Qiaozhen Su, Dandan Ma, Chang An, Lei Ma & Hongfeng Liang. (2014) Honokiol Suppresses Renal Cancer Cells? Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling. Molecules and Cells 37:5, pages 383-388.
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