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Epigenetics Volume 8, 2013 - Issue 6
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Research Paper

C2ORF40 suppresses breast cancer cell proliferation and invasion through modulating expression of M phase cell cycle genes

Jing Lu Department of Anatomy and Key Laboratory of Experimental Teratology; Ministry of Education; Shandong University School of Medicine; Jinan, Shandong, P.R. China
,
Mingxin Wen Department of Anatomy and Key Laboratory of Experimental Teratology; Ministry of Education; Shandong University School of Medicine; Jinan, Shandong, P.R. China
,
Yurong Huang Life Sciences Division; Lawrence Berkeley National Laboratory; Berkeley, CA USA
,
Xiuquan He Department of Anatomy and Key Laboratory of Experimental Teratology; Ministry of Education; Shandong University School of Medicine; Jinan, Shandong, P.R. China
,
Yunshan Wang Department of Anatomy and Key Laboratory of Experimental Teratology; Ministry of Education; Shandong University School of Medicine; Jinan, Shandong, P.R. China
,
Qi Wu Department of Anatomy and Key Laboratory of Experimental Teratology; Ministry of Education; Shandong University School of Medicine; Jinan, Shandong, P.R. China
,
Zengchun Li East Hospital; Tongji University; Shanghai, P.R. China
,
Andres Castellanos-Martin Instituto de Biología Molecular y Celular del Cáncer (IBMCC); Instituto Mixto Universidad de Salamanca/CSIC; Campus Miguel de Unamuno s/n; Salamanca, Spain
,
Mar Abad Department of Pathology; Hospital Universitario de Salamanca; Salamanca, Spain
,
Juan J. Cruz-Hernandez Department of Medical Oncology; Hospital Universitario de Salamanca; Salamanca, Spain
,
Cesar A. Rodriguez Department of Medical Oncology; Hospital Universitario de Salamanca; Salamanca, Spain
,
Jesus Perez-Losada Instituto de Biología Molecular y Celular del Cáncer (IBMCC); Instituto Mixto Universidad de Salamanca/CSIC; Campus Miguel de Unamuno s/n; Salamanca, Spain
,
Jian-Hua Mao Life Sciences Division; Lawrence Berkeley National Laboratory; Berkeley, CA USACorrespondence[email protected] [email protected]
&
Guangwei Wei Department of Anatomy and Key Laboratory of Experimental Teratology; Ministry of Education; Shandong University School of Medicine; Jinan, Shandong, P.R. China; Life Sciences Division; Lawrence Berkeley National Laboratory; Berkeley, CA USACorrespondence[email protected] [email protected]
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Pages 571-583 | Received 17 Jan 2013, Accepted 09 Apr 2013, Published online: 26 Apr 2013

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Peng Deng, Xiao-Jing Chang, Zi-Ming Gao, Xiao-Yang Xu, An-Qi Sun, Kai Li & Dong-Qiu Dai. (2018) Downregulation and DNA methylation of ECRG4 in gastric cancer. OncoTargets and Therapy 11, pages 4019-4028.
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Steven Kao, Ashkaun Shaterian, David M. Cauvi, Xitong Dang, Hyun Bae Chun, Antonio De Maio, Todd W. Costantini, Raul Coimbra, Brian P. Eliceiri & Andrew Baird. (2015) Pulmonary preconditioning, injury, and inflammation modulate expression of the candidate tumor suppressor gene ECRG4 in lung. Experimental Lung Research 41:3, pages 162-172.
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Andrew Baird, Jisook Lee, Sonia Podvin, Arwa Kurabi, Xitong Dang, Raul Coimbra, Todd Costantini, Vishal Bansal & Brian P Eliceiri. (2014) Esophageal cancer-related gene 4 at the interface of injury, inflammation, infection, and malignancy. Gastrointestinal Cancer: Targets and Therapy 4, pages 131-142.
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Articles from other publishers (29)

Chaoying Wang, Jianghui He, Chunyue Chen, Wenjun Luo, Xitong Dang & Liang Mao. (2024) A potential role of human esophageal cancer-related gene-4 in cardiovascular homeostasis. Gene 894, pages 147977.
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Jae Heon Kim, Kwang Woo Lee, Hee Jo Yang, Jae Joon Park, Chang Ho Lee, Youn Soo Jeon, Jong Hyun Yun, Suyeon Park, Su Jung Song, Yon Hee Kim, Ji-Hye Lee, Ahrim Moon & Yun Seob Song. (2023) The correlation between the expression of ubiquitin-conjugating enzyme 2C and prostate cancer prognosis. Journal of Cancer Research and Clinical Oncology 149:9, pages 6351-6360.
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Zuozhong Xie, Wei Li, Jingang Ai, Jun Xie & Xiaowei Zhang. (2022) C2orf40 inhibits metastasis and regulates chemo-resistance and radio-resistance of nasopharyngeal carcinoma cells by influencing cell cycle and activating the PI3K/AKT/mTOR signaling pathway. Journal of Translational Medicine 20:1.
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Yanjie You & Shengjuan Hu. (2022) Dysregulation of ECRG4 is associated with malignant properties and of prognostic importance in human gastric cancer. Cancer Biomarkers 34:1, pages 55-66.
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Zhenyu Ye, Yecheng Li, Jiaming Xie, Zhenyu Feng, Xiaodong Yang, Yong Wu, Yuwei Pu, Jiawei Gao, Xiangrong Xu, Zhaobi Zhu, Wei Li, Wei Chen & Chungen Xing. (2021) Integrated bioinformatics identifies the dysregulation induced by aberrant gene methylation in colorectal carcinoma. Genes & Diseases 8:4, pages 521-530.
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Liao Chen, Huirong Tang, Guobin Liu, Shufeng Xiao, Daoming Liang, Jun Ma, Yanlong Yang, Haibo Luo, Yong Zhu, Fujia Xie, Xi Cheng, Junlin Chi & Xuesong Wu. (2021) MicroRNA-196b promotes gastric cancer progression by targeting ECRG4. Anti-Cancer Drugs 32:2, pages 127-137.
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Xin Liang, Jiangang Gao, Quan Wang, Sichuan Hou & Changli Wu. (2020) ECRG4 Represses Cell Proliferation and Invasiveness via NFIC/OGN/NF-κB Signaling Pathway in Bladder Cancer. Frontiers in Genetics 11.
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Jia Li & Xinzheng Li. (2020) Comprehensive analysis of prognosis‐related methylated sites in breast carcinoma. Molecular Genetics & Genomic Medicine 8:4.
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Xin Qin & Ping Zhang. (2018) ECRG4: a new potential target in precision medicine. Frontiers of Medicine 13:5, pages 540-546.
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Gao-Yan Tang, Guo-Jun Tang, Lu Yin, Chen Chao, Ren Zhou, Guo-Ping Ren, Jia-Yu Chen & Wei Zhang. (2019) ECRG4 acts as a tumor suppressor gene frequently hypermethylated in human breast cancer. Bioscience Reports 39:5.
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Guo Wang, Jian Huang, Yuan Liu, Yang Wu, Xiao Chen, Yun Zhao & Da Wang. (2018) Deletion of C9orf53 promotes the growth of head and neck squamous cell carcinoma and is associated with poor prognosis of patients with head and neck squamous cell carcinoma. Oncology Letters.
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Pedro Nicolau-Neto, Antonio Palumbo, Marco De Martino, Francesco Esposito, Tatiana de Almeida Simão, Alfredo Fusco, Luiz Nasciutti, Nathalia Meireles Da Costa & Luis Ribeiro Pinto. (2018) UBE2C Is a Transcriptional Target of the Cell Cycle Regulator FOXM1. Genes 9:4, pages 188.
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Evgeny V. Denisov, Nikolay A. Skryabin, Tatiana S. Gerashchenko, Lubov A. Tashireva, Jochen Wilhelm, Mikhail A. Buldakov, Aleksei A. Sleptcov, Igor N. Lebedev, Sergey V. Vtorushin, Marina V. Zavyalova, Nadezhda V. Cherdyntseva & Vladimir M. Perelmuter. (2017) Clinically relevant morphological structures in breast cancer represent transcriptionally distinct tumor cell populations with varied degrees of epithelial-mesenchymal transition and CD44+CD24- stemness. Oncotarget 8:37, pages 61163-61180.
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Chaoyang Li, Pengju Zhang, Anli Jiang, Jian-Hua Mao & Guangwei Wei. (2017) A short synthetic peptide fragment of human C2ORF40 has therapeutic potential in breast cancer. Oncotarget 8:26, pages 41963-41974.
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Nannan Feng, Yu Wang, Min Zheng, Xiao Yu, Hongyan Lin, Rong-Na Ma, Oumin Shi, Xiangqian Zheng, Ming Gao, Herbert Yu, Lana Garmire & Biyun Qian. (2017) Genome-wide analysis of DNA methylation and their associations with long noncoding RNA/mRNA expression in non-small-cell lung cancer. Epigenomics 9:2, pages 137-153.
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J.-Y. Chen, X. Wu, C.-Q. Hong, J. Chen, X.-L. Wei, L. Zhou, H.-X. Zhang, Y.-T. Huang & L. Peng. (2016) Downregulated ECRG4 is correlated with lymph node metastasis and predicts poor outcome for nasopharyngeal carcinoma patients. Clinical and Translational Oncology 19:1, pages 84-90.
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Lingmi Hou, Maoshan Chen, Minghao Wang, Xiang Cui, Yanchun Gao, Tianyong Xing, Jingdong Li, Shishan Deng, Jiani Hu, Hongwei Yang & Jun Jiang. (2016) Systematic analyses of key genes and pathways in the development of invasive breast cancer. Gene 593:1, pages 1-12.
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Antonio PalumboJr.Jr., Nathalia Meireles Da Costa, Marco De Martino, Romina Sepe, Simona Pellecchia, Vanessa Paiva Leite de Sousa, Pedro Nicolau Neto, Cleber Dario Kruel, Anke Bergman, Luiz Eurico Nasciutti, Alfredo Fusco & Luis Felipe Ribeiro Pinto. (2016) UBE2C is overexpressed in ESCC tissues and its abrogation attenuates the malignant phenotype of ESCC cell lines. Oncotarget 7:40, pages 65876-65887.
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Linwei Li, Xiaoyan Li, Wenyu Wang, Tianhui Gao, Yun Zhou & Shixin Lu. (2016) Soluble purified recombinant C2ORF40 protein inhibits tumor cell growth in vivo by decreasing telomerase activity in esophageal squamous cell carcinoma. Oncology Letters 12:4, pages 2820-2824.
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FENG XIE, FANG ZHU, ZAIMING LU, ZHENGRONG LIU & HONGYAN WANG. (2016) Investigation of potential molecular biomarkers and small molecule drugs for hepatocellular carcinoma transformed from cirrhosis. Oncology Letters 12:1, pages 495-503.
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Yanjie You, Haijun Li, Xin Qin, Yonggang Ran & Fei Wang. (2015) Down-regulated ECRG4 expression in breast cancer and its correlation with tumor progression and poor prognosis - A short Report. Cellular Oncology 39:1, pages 89-95.
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XIAOYAN LI, LINWEI LI, WENYU WANG, YANG YANG, YUN ZHOU & SHIXIN LU. (2015) Soluble purified recombinant C2ORF40 protein inhibits esophageal cancer cell proliferation by inducing cell cycle G1 phase block. Oncology Letters 10:3, pages 1593-1596.
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Lei Zhang, Biao Xu, Yong Qiang, Hairong Huang, Changtian Wang, Demin Li & Jianjun Qian. (2015) Overexpression of deubiquitinating enzyme USP 28 promoted non‐small cell lung cancer growth . Journal of Cellular and Molecular Medicine 19:4, pages 799-805.
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