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Epigenetics Volume 9, 2014 - Issue 6
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Research Paper

Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer

Shashwat Sharad Center for Prostate Disease Research; Department of Surgery; Uniformed Services University of the Health Sciences; Bethesda, MD USA
,
Lakshmi Ravindranath Center for Prostate Disease Research; Department of Surgery; Uniformed Services University of the Health Sciences; Bethesda, MD USA
,
Michael C Haffner Sidney Kimmel Comprehensive Cancer Center; Johns Hopkins University; Baltimore, MD USA
,
Hua Li Center for Prostate Disease Research; Department of Surgery; Uniformed Services University of the Health Sciences; Bethesda, MD USA
,
Wusheng Yan Center for Prostate Disease Research; Department of Surgery; Uniformed Services University of the Health Sciences; Bethesda, MD USA
,
Isabell A Sesterhenn The Joint Pathology Center; Silver Spring, MD USA
,
Yongmei Chen Center for Prostate Disease Research; Department of Surgery; Uniformed Services University of the Health Sciences; Bethesda, MD USA
,
Amina Ali Center for Prostate Disease Research; Department of Surgery; Uniformed Services University of the Health Sciences; Bethesda, MD USA; Urology Service; Walter Reed National Military Medical Center; Bethesda, MD USA
,
Alagarsamy Srinivasan Center for Prostate Disease Research; Department of Surgery; Uniformed Services University of the Health Sciences; Bethesda, MD USA
,
David G McLeod Center for Prostate Disease Research; Department of Surgery; Uniformed Services University of the Health Sciences; Bethesda, MD USA; Urology Service; Walter Reed National Military Medical Center; Bethesda, MD USA
,
Srinivasan Yegnasubramanian Sidney Kimmel Comprehensive Cancer Center; Johns Hopkins University; Baltimore, MD USA
,
Shiv Srivastava Center for Prostate Disease Research; Department of Surgery; Uniformed Services University of the Health Sciences; Bethesda, MD USA
,
Albert Dobi Center for Prostate Disease Research; Department of Surgery; Uniformed Services University of the Health Sciences; Bethesda, MD USACorrespondence[email protected] [email protected]
&
Gyorgy Petrovics Center for Prostate Disease Research; Department of Surgery; Uniformed Services University of the Health Sciences; Bethesda, MD USACorrespondence[email protected] [email protected]
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Pages 918-927 | Received 26 Nov 2013, Accepted 31 Mar 2014, Published online: 02 Apr 2014

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Chad J. Creighton, Flora Zhang, Yiqun Zhang, Patricia Castro, Rong Hu, Md Islam, Somiranjan Ghosh, Michael Ittmann & Bernard Kwabi-Addo. (2023) Comparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer. Epigenetics 18:1.
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Yongwei Gu, Xinmei Chen, Haiyan Zhang, Heyi Wang, Hang Chen, Sifan Huang, Youfa Xu, Yuansheng Zhang, Xin Wu & Jianming Chen. (2020) Study on the cellular internalization mechanisms and in vivo anti-bone metastasis prostate cancer efficiency of the peptide T7-modified polypeptide nanoparticles. Drug Delivery 27:1, pages 161-169.
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Articles from other publishers (22)

Sana Ahuja & Sufian Zaheer. (2023) Multifaceted TGF‐β signaling, a master regulator: From bench‐to‐bedside, intricacies, and complexities. Cell Biology International.
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Daša Jevšinek Skok & Nina Hauptman. (2023) Steadfast Toll Like Receptor 4 (TLR4) 5-Hydroxymethylcytosine Levels in Cell-Free DNA: A Promising Consistency Marker for Colorectal Cancer Patients. Genes 14:8, pages 1636.
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Claire Stevens, Alexandria Hightower, Sarah G. Buxbaum, Sara M. Falzarano & Suhn K. Rhie. (2023) Genomic, epigenomic, and transcriptomic signatures of prostate cancer between African American and European American patients. Frontiers in Oncology 13.
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Sujitha Jayaprakash, Mangala Hegde, Bandari BharathwajChetty, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi & Ajaikumar B. Kunnumakkara. (2022) Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer. International Journal of Molecular Sciences 23:20, pages 12380.
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Shashwat Sharad, Albert Dobi, Shiv Srivastava, Alagarsamy Srinivasan & Hua Li. (2020) PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer. Biomolecules 10:9, pages 1221.
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Shashwat Sharad, Allissa Amanda Dillman, Zsófia M. Sztupinszki, Zoltan Szallasi, Inger Rosner, Jennifer Cullen, Shiv Srivastava, Alagarsamy Srinivasan & Hua Li. (2020) Characterization of unique PMEPA1 gene splice variants (isoforms d and e ) from RNA Seq profiling provides novel insights into prognostic evaluation of prostate cancer . Oncotarget 11:4, pages 362-377.
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Shashwat Sharad, Zsófia M. Sztupinszki, Yongmei Chen, Claire Kuo, Lakshmi Ravindranath, Zoltan Szallasi, Gyorgy Petrovics, Taduru L. Sreenath, Albert Dobi, Inger L. Rosner, Alagarsamy Srinivasan, Shiv Srivastava, Jennifer Cullen & Hua Li. (2019) Analysis of PMEPA1 Isoforms (a and b) as Selective Inhibitors of Androgen and TGF-β Signaling Reveals Distinct Biological and Prognostic Features in Prostate Cancer. Cancers 11:12, pages 1995.
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Richa Rai, Shalini S. Yadav, Heng Pan, Irtaza Khan, James O'Connor, Mohammed Alshalalfa, Elai Davicioni, Emanuela Taioli, Olivier Elemento, Ashutosh K. Tewari & Kamlesh K. Yadav. (2018) Epigenetic analysis identifies factors driving racial disparity in prostate cancer. Cancer Reports 2:2.
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Rohina Rubicz, Shanshan Zhao, Milan Geybels, Jonathan L. Wright, Suzanne Kolb, Brandy Klotzle, Marina Bibikova, Dean Troyer, Raymond Lance, Elaine A. Ostrander, Ziding Feng, Jian-Bing Fan & Janet L. Stanford. (2019) DNA methylation profiles in African American prostate cancer patients in relation to disease progression. Genomics 111:1, pages 10-16.
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Jack Mottahedeh, Michael C. Haffner, Tristan R. Grogan, Takao Hashimoto, Preston D. Crowell, Himisha Beltran, Andrea Sboner, Rohan Bareja, David Esopi, William B. Isaacs, Srinivasan Yegnasubramanian, Matthew B. Rettig, David A. Elashoff, Elizabeth A. Platz, Angelo M. De Marzo, Michael A. Teitell & Andrew S. Goldstein. (2018) CD38 is methylated in prostate cancer and regulates extracellular NAD+. Cancer & Metabolism 6:1.
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Susumu Itoh & Fumiko Itoh. (2018) TMEPAI family: involvement in regulation of multiple signalling pathways. The Journal of Biochemistry 164:3, pages 195-204.
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Mikhail S. Karbyshev, Evgeniya S. Grigoryeva, Viktor V. Volkomorov, Elisabeth Kremmer, Alexander Huber, Irina V. Mitrofanova, Evgeniya V. Kaigorodova, Marina V. Zavyalova, Julia G. Kzhyshkowska, Nadezda V. Cherdyntseva & Evgeny L. Choynzonov. (2017) Development of Novel Monoclonal Antibodies for Evaluation of Transmembrane Prostate Androgen-Induced Protein 1 (TMEPAI) Expression Patterns in Gastric Cancer. Pathology & Oncology Research 24:2, pages 427-438.
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Feng Xie, Li Ling, Hans Van Dam, Fangfang Zhou & Long Zhang. (2018) TGF-β signaling in cancer metastasis. Acta Biochimica et Biophysica Sinica 50:1, pages 121-132.
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Shashwat Sharad, Taduru Sreenath, Shiv Srivastava & Albert Dobi. 2017. Biomarkers in Cancer Screening and Early Detection. Biomarkers in Cancer Screening and Early Detection 16 26 .
Jieping Hu, Gongxian Wang & Ting Sun. (2017) Dissecting the roles of the androgen receptor in prostate cancer from molecular perspectives. Tumor Biology 39:5, pages 101042831769225.
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Jiufeng Wei, Guodong Li, Jinning Zhang, Yuhui Zhou, Shuwei Dang, Hongsheng Chen, Qiong Wu & Ming Liu. (2016) Integrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer. Oncotarget 7:38, pages 62547-62558.
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Andrea S. Link, Svitlana Kurinna, Steven Havlicek, Sandra Lehnert, Martin Reichel, Johannes Kornhuber, Beate Winner, Tobias Huth, Fang Zheng, Sabine Werner & Christian Alzheimer. (2015) Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling. Molecular Neurobiology 53:6, pages 4210-4225.
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Parameet Kumar, Shashwat Sharad, Gyorgy Petrovics, Ahmed Mohamed, Albert Dobi, Taduru L. Sreenath, Shiv Srivastava & Roopa Biswas. (2016) Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1. Oncotarget 7:16, pages 22791-22806.
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D. S. Mikhaylenko, G. D. Efremov, A. V. Sivkov & D. V. Zaletaev. (2016) Hormone resistance and neuroendocrine differentiation due to accumulation of genetic lesions during clonal evolution of prostate cancer. Molecular Biology 50:1, pages 28-36.
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Alexandra M. Blee & Haojie Huang. (2016) PMEPA1 guards against TGF-?-mediated prostate cancer bone metastasis. Asian Journal of Urology 3:1, pages 1-3.
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Hua Li, Ahmed A. Mohamed, Shashwat Sharad, Elizabeth Umeda, Yingjie Song, Denise Young, Gyorgy Petrovics, David G. McLeod, Isabell A. Sesterhenn, Taduru Sreenath, Albert Dobi & Shiv Srivastava. (2015) Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN . Oncotarget 6:17, pages 15137-15149.
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Pierrick?G.J. Fournier, Patricia Ju?rez, Guanglong Jiang, Gregory?A. Clines, Maria Niewolna, Hun?Soo Kim, Holly?W. Walton, Xiang?Hong Peng, Yunlong Liu, Khalid?S. Mohammad, Clark?D. Wells, John?M. Chirgwin & Theresa?A. Guise. (2015) The TGF-? Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone. Cancer Cell 27:6, pages 809-821.
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