Advanced search
Publication Cover
Epigenetics Volume 9, 2014 - Issue 9
Submit an article Journal homepage
1,405
Views
28
CrossRef citations to date
0
Altmetric
Research Paper

RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia

Anna R Poetsch Division of Epigenomics and Cancer Risk Factors (C010); German Cancer Research Center; Heidelberg, Germany
,
Daniel B Lipka Division of Epigenomics and Cancer Risk Factors (C010); German Cancer Research Center; Heidelberg, Germany
,
Tania Witte Division of Epigenomics and Cancer Risk Factors (C010); German Cancer Research Center; Heidelberg, Germany
,
Rainer Claus Division of Epigenomics and Cancer Risk Factors (C010); German Cancer Research Center; Heidelberg, Germany
,
Peter Nöllke Division of Pediatric Hematology-Oncology; University Medical Center; Freiburg, Germany
,
Manuela Zucknick Division of Biostatistics; German Cancer Research Center; Heidelberg, Germany
,
Christiane Olk-Batz Division of Pediatric Hematology-Oncology; University Medical Center; Freiburg, Germany
,
Silvia Fluhr Division of Pediatric Hematology-Oncology; University Medical Center; Freiburg, Germany
,
Michael Dworzak St. Anna Children's Hospital and Children's Cancer Research Institute; Department of Pediatrics; Medical University of Vienna; Vienna, Austria
,
Barbara De Moerloose Dept. of Pediatric Hematology-Oncology; Ghent University Hospital; Ghent, Belgium
,
Jan Starý Dept. of Pediatric Hematology and Oncology; 2nd Faculty of Medicine; Charles University and University Hospital Motol, Praha; Czech Pediatric Hematology Working Group (CPH); Prague, Czech Republic
,
Marco Zecca Pediatric Hematology-Oncology; Fondazione IRCCS;Policlinico San Matteo; Pavia, Italy
,
Henrik Hasle Department of Pediatrics; Aarhus University Hospital Skejby; Aarhus, Denmark
,
Markus Schmugge Division of Hematology; University Children's Hospital; Zurich, Switzerland
,
Marry M van den Heuvel-Eibrink Department of Pediatric Oncology-Hematology; Erasmus Medical Center; Rotterdam, The Netherlands; Dutch Children’s Oncology Group; The Hague, Netherlands
,
Franco Locatelli Department of Pediatric Hematology-Oncology; IRCCS Ospedale Bambino Gesu; Rome, Italy; University of Pavia; Pavia, Italy
,
Charlotte M Niemeyer The German Cancer Consortium; Heidelberg, Germany; Division of Pediatric Hematology-Oncology; University Medical Center; Freiburg, Germany
,
Christian Flotho The German Cancer Consortium; Heidelberg, Germany; Division of Pediatric Hematology-Oncology; University Medical Center; Freiburg, GermanyCorrespondence[email protected]
&
Christoph Plass Division of Epigenomics and Cancer Risk Factors (C010); German Cancer Research Center; Heidelberg, Germany; The German Cancer Consortium; Heidelberg, Germany
 show all
Pages 1252-1260 | Received 28 May 2014, Accepted 14 Jul 2014, Published online: 31 Jul 2014

Citations (28)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Junying Chen, Jinbing Huang, Qiaoqiao Huang, Ji Li, Erling Chen & Wensheng Xu. (2021) RASA4 inhibits the HIFα signaling pathway to suppress proliferation of cervical cancer cells. Bioengineered 12:2, pages 10723-10733.
Read now
Christian Flotho. (2019) Gene mutations do not operate in a vacuum: the increasing importance of epigenetics in juvenile myelomonocytic leukemia. Epigenetics 14:3, pages 236-244.
Read now
Franco Locatelli, Mattia Algeri, Pietro Merli & Luisa Strocchio. (2018) Novel approaches to diagnosis and treatment of Juvenile Myelomonocytic Leukemia. Expert Review of Hematology 11:2, pages 129-143.
Read now
Silvia Fluhr, Christopher Felix Krombholz, Angelina Meier, Thomas Epting, Oliver Mücke, Christoph Plass, Charlotte M. Niemeyer & Christian Flotho. (2017) Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia. Epigenetics 12:8, pages 715-723.
Read now
Thomas Wilhelm, Daniel B. Lipka, Tania Witte, Justyna A. Wierzbinska, Silvia Fluhr, Monika Helf, Oliver Mücke, Rainer Claus, Carolin Konermann, Peter Nöllke, Charlotte M. Niemeyer, Christian Flotho & Christoph Plass. (2016) Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia. Epigenetics 11:2, pages 110-119.
Read now

Articles from other publishers (23)

Roshani Sinha, Mai Dvorak, Ananthakrishnan Ganesan, Larry Kalesinskas, Charlotte M. Niemeyer, Christian Flotho, Kathleen M. Sakamoto, Norman Lacayo, Rachana Vinay Patil, Rhonda Perriman, Alma-Martina Cepika, Yunying Lucy Liu, Alex Kuo, Paul J. Utz, Purvesh Khatri & Alice Bertaina. (2023) Epigenetic Profiling of PTPN11 Mutant JMML Hematopoietic Stem and Progenitor Cells Reveals an Aberrant Histone Landscape. Cancers 15:21, pages 5204.
Crossref
Claudia Fiñana, Noel Gómez-Molina, Sandra Alonso-Moreno & Laura Belver. (2022) Genomic and Epigenomic Landscape of Juvenile Myelomonocytic Leukemia. Cancers 14:5, pages 1335.
Crossref
Matthew R.M. Jotte & Megan E. McNerney. (2022) The significance of CUX1 and chromosome 7 in myeloid malignancies. Current Opinion in Hematology 29:2, pages 92-102.
Crossref
Maximilian Schönung, Julia Meyer, Peter Nöllke, Adam B. Olshen, Mark Hartmann, Norihiro Murakami, Manabu Wakamatsu, Yusuke Okuno, Christoph Plass, Mignon L. Loh, Charlotte M. Niemeyer, Hideki Muramatsu, Christian Flotho, Elliot Stieglitz & Daniel B. Lipka. (2021) International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia. Clinical Cancer Research 27:1, pages 158-168.
Crossref
Arianna Bellazzo & Licio Collavin. (2020) Cutting the Brakes on Ras—Cytoplasmic GAPs as Targets of Inactivation in Cancer. Cancers 12:10, pages 3066.
Crossref
Sonia Meynier & Frédéric Rieux-Laucat. (2020) After 95 years, it's time to eRASe JMML. Blood Reviews 43, pages 100652.
Crossref
Andra Marcu, Andrei Colita, Letitia Elena Radu, Cristina Georgiana Jercan, Ana Maria Bica, Minodora Asan, Daniel Coriu, Alina Daniela Tanase, Carmen C. Diaconu, Cristina Mambet, Anca Botezatu, Sergiu Pasca, Patric Teodorescu, Gabriela Anton, Petruta Gurban & Anca Colita. (2020) Single-Center Experience With Epigenetic Treatment for Juvenile Myelomonocytic Leukemia. Frontiers in Oncology 10.
Crossref
Lili Li, Yichao Fan, Xin Huang, Jie Luo, Lan Zhong, Xing-sheng Shu, Li Lu, Tingxiu Xiang, Anthony T.C. Chan, Winnie Yeo, Ceshi Chen, Wai Yee Chan, Richard L. Huganir & Qian Tao. (2019) Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas. iScience 21, pages 1-18.
Crossref
Charlotte M. Niemeyer & Christian Flotho. (2019) Juvenile myelomonocytic leukemia: who’s the driver at the wheel?. Blood 133:10, pages 1060-1070.
Crossref
Alan Harrison, Kristina Pentieva, Mari Ozaki, Helene McNulty & Anne Parle‐McDermott. (2018) Assessment of candidate folate sensitive‐differentially methylated regions in a randomised controlled trial of continued folic acid supplementation during the second and third trimesters of pregnancy. Annals of Human Genetics 83:1, pages 23-33.
Crossref
B. V. Afanasyev & L. Zubarovskaya. (2018) Pediatric myelodysplastic syndrome. Russian Journal of Children Hematology and Oncology 5:3, pages 23-35.
Crossref
Pier Paolo Leoncini, Patrizia Vitullo, Francesca Di Florio, Valeria Tocco, Maria Giuseppina Cefalo, Angela Pitisci, Katia Girardi, Charlotte Niemeyer, Franco Locatelli & Alice Bertaina. (2018) Whole Genome MBD-seq reveals different CpG methylation patterns in Azacytidine-treated Juvenile Myelomonocytic Leukaemia (JMML) patients. British Journal of Haematology 182:6, pages 909-912.
Crossref
Christian Flotho, Sebastian Sommer & Michael Lübbert. (2018) DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and juvenile myelomonocytic leukemia. Seminars in Cancer Biology 51, pages 68-79.
Crossref
In-sang Jeon. (2018) Understanding the Molecular Basis of Juvenile Myelomonocytic Leukemia and Its Application for Novel Drugs Development. Clinical Pediatric Hematology-Oncology 25:1, pages 23-30.
Crossref
Beenu Thakral, John Anastasi & Sa A. Wang. 2018. Hematopathology. Hematopathology 488 538.e4 .
Xin Zhao, Shouguo GaoZhijie WuSachiko KajigayaXingmin FengQingguo LiuDanielle M. TownsleyJames CooperJinguo Chen, Keyvan KeyvanfarMaria del Pilar Fernandez IbanezXujing Wang & Neal S. Young. (2017) Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells. Blood 130:25, pages 2762-2773.
Crossref
Daniel B. Lipka, Tania Witte, Reka Toth, Jing Yang, Manuel Wiesenfarth, Peter Nöllke, Alexandra Fischer, David Brocks, Zuguang Gu, Jeongbin Park, Brigitte Strahm, Marcin Wlodarski, Ayami Yoshimi, Rainer Claus, Michael Lübbert, Hauke Busch, Melanie Boerries, Mark Hartmann, Maximilian Schönung, Umut Kilik, Jens Langstein, Justyna A. Wierzbinska, Caroline Pabst, Swati Garg, Albert Catalá, Barbara De Moerloose, Michael Dworzak, Henrik Hasle, Franco Locatelli, Riccardo Masetti, Markus Schmugge, Owen Smith, Jan Stary, Marek Ussowicz, Marry M. van den Heuvel-Eibrink, Yassen Assenov, Matthias Schlesner, Charlotte Niemeyer, Christian Flotho & Christoph Plass. (2017) RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia. Nature Communications 8:1.
Crossref
Michael W. N. Deininger, Jeffrey W. Tyner & Eric Solary. (2017) Turning the tide in myelodysplastic/myeloproliferative neoplasms. Nature Reviews Cancer 17:7, pages 425-440.
Crossref
Silvia Fluhr, Melanie Boerries, Hauke Busch, Aikaterini Symeonidi, Tania Witte, Daniel B Lipka, Oliver Mücke, Peter Nöllke, Christopher Felix Krombholz, Charlotte M Niemeyer, Christoph Plass & Christian Flotho. (2016) CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia. Clinical Epigenetics 8:1.
Crossref
Kazuo Sakashita, Kazuyuki Matsuda & Kenichi Koike. (2016) Diagnosis and treatment of juvenile myelomonocytic leukemia. Pediatrics International 58:8, pages 681-690.
Crossref
Jasmine C Wong, Kelley M Weinfurtner, Maria del pilar Alzamora, Scott C Kogan, Michael R Burgess, Yan Zhang, Joy Nakitandwe, Jing Ma, Jinjun Cheng, Shann-Ching Chen, Theodore T Ho, Johanna Flach, Damien Reynaud, Emmanuelle Passegué, James R Downing & Kevin Shannon. (2015) Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis. eLife 4.
Crossref
Franco Locatelli & Charlotte M. Niemeyer. (2015) How I treat juvenile myelomonocytic leukemia. Blood 125:7, pages 1083-1090.
Crossref
Lili Li, Yichao Fan, Xin Huang, Lan Zhong, Xing-sheng Shu, Jie Luo, Li Lu, Tingxiu Xiang, Anthony TC Chan, Winnie Yeo, Ceshi Chen, Wai Yee Chan, Richard L. Huganir & Qian Tao. (2019) Novel Tumor Suppressive Role of the RAS GTPase-Activating Protein RASA5 to RAS Signaling Perturbation in Human Carcinomas. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.