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Research Paper

Frequent epigenetic inactivation of KIBRA, an upstream member of the Salvador/Warts/Hippo (SWH) tumor suppressor network, is associated with specific genetic event in B-cell acute lymphocytic leukemia

Pages 326-332 | Received 14 Oct 2010, Accepted 06 Dec 2010, Published online: 01 Mar 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Sujata Bhoi, Viktor Ljungström, Panagiotis Baliakas, Mattias Mattsson, Karin E. Smedby, Gunnar Juliusson, Richard Rosenquist & Larry Mansouri. (2016) Prognostic impact of epigenetic classification in chronic lymphocytic leukemia: The case of subset #2. Epigenetics 11:6, pages 449-455.
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Thoraia Shinawi, Victoria Hill, Antonis Dagklis, Panagiotis Baliakas, Kostas Stamatopoulos, Angleo Agathanggelou, Tanja Stankovic, Eamonn R. Maher, Paolo Ghia & Farida Latif. (2012) KIBRA gene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemia. Epigenetics 7:3, pages 211-215.
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Articles from other publishers (35)

Liemei Lv & Xiangxiang Zhou. (2023) Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential. MedComm 4:5.
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Kai Wang, Baoqiang Li, Lei Ge & Yi Xie. (2022) Molecular insight into the systematic affinity and selectivity of partner recognition sites between the WW1 and WW2 domains of human KIBRA neuroprotein. Journal of Molecular Graphics and Modelling 116, pages 108258.
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Milad Moloudizargari, Mohammad Hossein Asghari, Seyed Fazel Nabavi, Diana Gulei, Ioana Berindan-Neagoe, Anupam Bishayee & Seyed Mohammad Nabavi. (2022) Targeting Hippo signaling pathway by phytochemicals in cancer therapy. Seminars in Cancer Biology 80, pages 183-194.
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Srikanth Swamy Swaroop B, Rahul Kanumuri, Inemai Ezhil, Jagadeesh Kumar Naidu Sampangi, Joachim Kremerskothen, Suresh Kumar Rayala & Ganesh Venkatraman. (2021) KIBRA connects Hippo signaling and cancer. Experimental Cell Research 403:2, pages 112613.
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Suman Mohajan, Praveen Kumar Jaiswal, Mousa Vatanmakarian, Hassan Yousefi, Saikolappan Sankaralingam, Suresh K. Alahari, Sweaty Koul & Hari K. Koul. (2021) Hippo pathway: Regulation, deregulation and potential therapeutic targets in cancer. Cancer Letters 507, pages 112-123.
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Ísis Salviano Soares de Amorim, Mariana Moreno de Sousa Rodrigues & Andre Luiz Mencalha. (2021) The tumor suppressor role of salvador family WW domain-containing protein 1 (SAV1): one of the key pieces of the tumor puzzle. Journal of Cancer Research and Clinical Oncology 147:5, pages 1287-1297.
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Alessandro Allegra, Giovanni Pioggia, Vanessa Innao, Caterina Musolino & Sebastiano Gangemi. (2021) New Insights into YES-Associated Protein Signaling Pathways in Hematological Malignancies: Diagnostic and Therapeutic Challenges. Cancers 13:8, pages 1981.
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Verena Höffken, Anke Hermann, Hermann Pavenstädt & Joachim Kremerskothen. (2021) WWC Proteins: Important Regulators of Hippo Signaling in Cancer. Cancers 13:2, pages 306.
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Jacqueline E. Mann, Aditi Kulkarni, Andrew C. Birkeland, Judy Kafelghazal, Julia Eisenberg, Brittany M. Jewell, Megan L. Ludwig, Matthew E. Spector, Hui Jiang, Thomas E. Carey & J. Chad Brenner. (2019) The molecular landscape of the University of Michigan laryngeal squamous cell carcinoma cell line panel. Head & Neck 41:9, pages 3114-3124.
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Zhanwei Wang, Dionyssios Katsaros, Nicoletta Biglia, Yi Shen, Yuanyuan Fu, Maarit Tiirikainen & Herbert Yu. (2019) Low expression of WWC1 , a tumor suppressor gene, is associated with aggressive breast cancer and poor survival outcome . FEBS Open Bio 9:7, pages 1270-1280.
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Lin Song, Shi Tang, Xiaolei Han, Ziying Jiang, Lingling Dong, Cuicui Liu, Xiaoyan Liang, Jixin Dong, Chengxuan Qiu, Yongxiang Wang & Yifeng Du. (2019) KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a. Nature Communications 10:1.
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Xiong Liu, Chun Li, Rendong Zhang, Wenjun Xiao, Xia Niu, Xiajun Ye, Zijia Li, Yuxian Guo, Junyu Tan & Yaochen Li. (2018) The EZH2- H3K27me3-DNMT1 complex orchestrates epigenetic silencing of the wwc1 gene, a Hippo/YAP pathway upstream effector, in breast cancer epithelial cells. Cellular Signalling 51, pages 243-256.
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Ran Wu, Hui Yang, Jiangbo Wan, Xiaohui Deng, Linjun Chen, Siguo Hao & Liyuan Ma. (2018) Knockdown of the Hippo transducer YAP reduces proliferation and promotes apoptosis in the Jurkat leukemia cell. Molecular Medicine Reports.
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Ashley L. Mussell, Kayla E. Denson, He Shen, Yanmin Chen, Nuo Yang, Costa Frangou & Jianmin Zhang. (2018) Loss of KIBRA function activates EGFR signaling by inducing AREG. Oncotarget 9:52, pages 29975-29984.
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Yan Zhang, Haibo Zhou, Hongxu Sun, Jie Chen, Di Huang, Xu Han, Xiyun Ren, Shangqun Lin, Qing Fan, Wenjing Tian & Yashuang Zhao. (2018) Association of peripheral blood leukocyte KIBRA methylation with gastric cancer risk: a case–control study . Cancer Medicine 7:6, pages 2682-2690.
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Katrin Schelleckes, Boris Schmitz, Malte Lenders, Mirja Mewes, Stefan-Martin Brand & Eva Brand. (2018) ZFP226 is a novel artificial transcription factor for selective activation of tumor suppressor KIBRA. Scientific Reports 8:1.
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Jennifer F. Knight, Vanessa Y.C. Sung, Elena Kuzmin, Amber L. Couzens, Danielle A. de Verteuil, Colin D.H. Ratcliffe, Paula P. Coelho, Radia M. Johnson, Payman Samavarchi-Tehrani, Tina Gruosso, Harvey W. Smith, Wontae Lee, Sadiq M. Saleh, Dongmei Zuo, Hong Zhao, Marie-Christine Guiot, Ryan R. Davis, Jeffrey P. Gregg, Christopher Moraes, Anne-Claude Gingras & Morag Park. (2018) KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer. Cell Reports 22:12, pages 3191-3205.
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Wei Kang, Tingting Huang, Yuhang Zhou, Jinglin Zhang, Raymond W. M. Lung, Joanna H. M. Tong, Anthony W. H. Chan, Bin Zhang, Chi Chun Wong, Feng Wu, Yujuan Dong, Shiyan Wang, Weiqin Yang, Yi Pan, Wing Po Chak, Alvin H. K. Cheung, Jesse C. S. Pang, Jun Yu, Alfred S. L. Cheng & Ka Fai To. (2018) miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis. Cell Death & Disease 9:2.
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Katrin Schelleckes, Boris Schmitz, Giuliano Ciarimboli, Malte Lenders, Hermann J. Pavenstädt, Edwin Herrmann, Stefan-Martin Brand & Eva Brand. (2017) Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma. Clinical Epigenetics 9:1.
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Agnieszka Paziewska, Andrzej Habior, Agnieszka Rogowska, Włodzimierz Zych, Krzysztof Goryca, Jakub Karczmarski, Michalina Dabrowska, Filip Ambrozkiewicz, Bozena Walewska-Zielecka, Marek Krawczyk, Halina Cichoz-Lach, Piotr Milkiewicz, Agnieszka Kowalik, Krzysztof Mucha, Joanna Raczynska, Joanna Musialik, Grzegorz Boryczka, Michal Wasilewicz, Irena Ciecko-Michalska, Malgorzata Ferenc, Maria Janiak, Alina Kanikowska, Rafal Stankiewicz, Marek Hartleb, Tomasz Mach, Marian Grzymislawski, Joanna Raszeja-Wyszomirska, Ewa Wunsch, Tomasz Bobinski, Michal Mikula & Jerzy Ostrowski. (2017) A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients. BMC Medical Genomics 10:1.
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Anuj, Lakshmi Arivazhagan, Rohan Prasad Surabhi, Archana Kanakarajan, Sandhya Sundaram, Ravi Shankar Pitani, Lakmini Mudduwa, Joachim Kremerskothen, Ganesh Venkatraman & Suresh K Rayala. (2017) KIBRA attains oncogenic activity by repressing RASSF1A. British Journal of Cancer 117:4, pages 553-562.
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Maira da Costa Cacemiro, Maria Gabriela Berzoti-Coelho, Juçara Gastaldi Cominal, Sandra Mara Burin & Fabíola Attié de Castro. (2017) Hippo pathway deregulation: implications in the pathogenesis of haematological malignancies. Journal of Clinical Pathology 70:1, pages 9-14.
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Srinivas Vinod Saladi, Kenneth Ross, Mihriban Karaayvaz, Purushothama R. Tata, Hongmei Mou, Jayaraj Rajagopal, Sridhar Ramaswamy & Leif W. Ellisen. (2017) ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell 31:1, pages 35-49.
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Seth Stauffer, Xingcheng Chen, Lin Zhang, Yuanhong Chen & Jixin Dong. (2016) KIBRA promotes prostate cancer cell proliferation and motility. The FEBS Journal 283:10, pages 1800-1811.
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W Mi, Q Lin, C Childress, M Sudol, J Robishaw, C H Berlot, M Shabahang & W Yang. (2014) Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration. Oncogene 34:24, pages 3095-3106.
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Lin Zhang, Shuping Yang, Dirk Oliver Wennmann, Yuanhong Chen, Joachim Kremerskothen & Jixin Dong. (2014) KIBRA: In the brain and beyond. Cellular Signalling 26:7, pages 1392-1399.
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Zhongyuan Wang, Yanping Wu, Haifeng Wang, Yangqing Zhang, Lin Mei, Xuexun Fang, Xudong Zhang, Fang Zhang, Hongbo Chen, Ying Liu, Yuyang Jiang, Shengnan Sun, Yi Zheng, Na Li & Laiqiang Huang. (2013) Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proceedings of the National Academy of Sciences 111:1.
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Sarah E Kerr, Catherine A Schnabel, Peggy S Sullivan, Yi Zhang, Vivian J Huang, Mark G Erlander, Elena F Brachtel & Sarah M Dry. (2014) A 92-gene cancer classifier predicts the site of origin for neuroendocrine tumors. Modern Pathology 27:1, pages 44-54.
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Hyun Woo Park & Kun-Liang Guan. (2013) Regulation of the Hippo pathway and implications for anticancer drug development. Trends in Pharmacological Sciences 34:10, pages 581-589.
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Yohei Yoshihama, Yusuke Izumisawa, Kazunori Akimoto, Yoshinori Satoh, Taichi Mizushima, Kei Satoh, Kazuhiro Chida, Ryo Takagawa, Hirotoshi Akiyama, Yasushi Ichikawa, Chikara Kunisaki, Yoshiaki Inayama, Itaru Endo, Yoji Nagashima & Shigeo Ohno. (2013) High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis. Cancer Science 104:2, pages 259-265.
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Lin Zhang, Jyoti Iyer, Aparajita Chowdhury, Ming Ji, Ling Xiao, Shuping Yang, Yuanhong Chen, Ming-Ying Tsai & Jixin Dong. (2012) KIBRA Regulates Aurora Kinase Activity and Is Required for Precise Chromosome Alignment During Mitosis. Journal of Biological Chemistry 287:41, pages 34069-34077.
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Ming JiShuping YangYuanhong ChenLing XiaoLin ZhangJixin Dong. (2012) Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression. Biochemical Journal 447:1, pages 93-102.
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John M. Lamar, Patrick Stern, Hui Liu, Jeffrey W. Schindler, Zhi-Gang Jiang & Richard O. Hynes. (2012) The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Proceedings of the National Academy of Sciences 109:37.
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Ling Xiao, Yuanhong Chen, Ming Ji, Deanna J. Volle, Robert E. Lewis, Ming-Ying Tsai & Jixin Dong. (2011) KIBRA Protein Phosphorylation Is Regulated by Mitotic Kinase Aurora and Protein Phosphatase 1. Journal of Biological Chemistry 286:42, pages 36304-36315.
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