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Research Paper

The depletion of DNA methyltransferase-1 and the epigenetic effects of 5-aza-2’deoxycytidine (decitabine) are differentially regulated by cell cycle progression

Pages 1021-1028 | Received 14 Apr 2011, Accepted 09 Jun 2011, Published online: 01 Aug 2011

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Read on this site (2)

Ratnam S. Seelan, Partha Mukhopadhyay, M. Michele Pisano & Robert M. Greene. (2018) Effects of 5-Aza-2′-deoxycytidine (decitabine) on gene expression. Drug Metabolism Reviews 50:2, pages 193-207.
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Christian Huisman, Monique GP van der Wijst, Fahimeh Falahi, Juul Overkamp, Gellért Karsten, Martijn M Terpstra, Klaas Kok, Ate GJ van der Zee, Ed Schuuring, G Bea A Wisman & Marianne G Rots. (2015) Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. Epigenetics 10:5, pages 384-396.
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Articles from other publishers (18)

Jianying Tian, Haiming Xu, Yawen Zhang, Xinchen Shi, Wencheng Wang, Huanmin Gao & Yongyi Bi. (2019) SAM targeting methylation by the methyl donor, a novel therapeutic strategy for antagonize PFOS transgenerational fertilitty toxicity. Ecotoxicology and Environmental Safety 184, pages 109579.
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Joel M Michalski, Elizabeth R Lyden, Andrea J Lee, Zaid S Al-Kadhimi, Lori J Maness, Krishna Gundabolu & Vijaya Raj Bhatt. (2019) Intensity of chemotherapy for the initial management of newly diagnosed acute myeloid leukemia in older patients. Future Oncology 15:17, pages 1989-1995.
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Jessica Tang, Nicholas Pulliam, Ali Özeş, Aaron Buechlein, Ning Ding, Harold Keer, Doug Rusch, Heather O'Hagan, M. Sharon Stack & Kenneth P. Nephew. (2018) Epigenetic Targeting of Adipocytes Inhibits High-Grade Serous Ovarian Cancer Cell Migration and Invasion. Molecular Cancer Research 16:8, pages 1226-1240.
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Richard Daifuku, Sheila Grimes & Murray Stackhouse. (2018) NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2′,2′-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer. Pharmaceuticals 11:2, pages 36.
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Richard Daifuku, Zhenbo Hu & Yogen Saunthararajah. (2017) 5-aza-2′,2′-Difluoro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of Cancer. Pharmaceuticals 10:3, pages 65.
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Jadd Shelton, Xiao Lu, Joseph A. Hollenbaugh, Jong Hyun Cho, Franck Amblard & Raymond F. Schinazi. (2016) Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs. Chemical Reviews 116:23, pages 14379-14455.
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Giuseppe Costa, Viviana Barra, Laura Lentini, Danilo Cilluffo & Aldo Di Leonardo. (2016) DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy. Oncotarget 7:4, pages 3726-3739.
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Kumiko Ueda, Mika Hosokawa & Seigo Iwakawa. (2015) Cellular Uptake of Decitabine by Equilibrative Nucleoside Transporters in HCT116 Cells. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 38:8, pages 1113-1119.
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Jing Lai, Weiwei Nie, Wenwen Zhang, Yucai Wang, Ruilian Xie, Yanru Wang, Jun Gu, Jing Xu, Wei Song, Fang Yang, Guichun Huang, Peng Cao & Xiaoxiang Guan. (2014) Transcriptional regulation of the p73 gene by Nrf-2 and promoter CpG methylation in human breast cancer. Oncotarget 5:16, pages 6909-6922.
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Nicholas Hatzirodos, Katja Hummitzsch, Helen F. Irving-Rodgers & Raymond J. Rodgers. (2014) Transcriptome Profiling of the Theca Interna in Transition from Small to Large Antral Ovarian Follicles. PLoS ONE 9:5, pages e97489.
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Sarah M. Leonard, Tracey Perry, Ciar?n B. Woodman & Pamela Kearns. (2014) Sequential Treatment with Cytarabine and Decitabine Has an Increased Anti-Leukemia Effect Compared to Cytarabine Alone in Xenograft Models of Childhood Acute Myeloid Leukemia. PLoS ONE 9:1, pages e87475.
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Claire Westerland & Tom C. Karagiannis. 2014. Molecular mechanisms and physiology of disease. Molecular mechanisms and physiology of disease 81 112 .
Philip C. Logan, Anna P. Ponnampalam, Michael Steiner & Murray D. Mitchell. (2013) Effect of cyclic AMP and estrogen/progesterone on the transcription of DNA methyltransferases during the decidualization of human endometrial stromal cells. MHR: Basic science of reproductive medicine 19:5, pages 302-312.
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Jeffery M. Klco, David H. Spencer, Tamara L. LamprechtShawn M. SarkariaTodd Wylie, Vincent Magrini, Jasreet Hundal, Jason Walker, Nobish Varghese, Petra Erdmann-Gilmore, Cheryl F. Lichti, Matthew R. Meyer, R. Reid Townsend, Richard K. Wilson, Elaine R. Mardis & Timothy J. Ley. (2013) Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood 121:9, pages 1633-1643.
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Juan Liu, Yi-Shan Xie, Fu-Liang Wang, Li-Jun Zhang, Yan Zhang & He-Sheng Luo. (2013) Cytotoxicity of 5-Aza-2′-deoxycytidine against gastric cancer involves DNA damage in an ATM-P53 dependent signaling pathway and demethylation of P16INK4A. Biomedicine & Pharmacotherapy 67:1, pages 78-87.
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Angela Nebbioso, Vincenzo Carafa, Rosaria Benedetti & Lucia Altucci. (2012) Trials with ‘epigenetic’ drugs: An update. Molecular Oncology 6:6, pages 657-682.
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Sebastian Bultmann, Robert Morbitzer, Christine S. Schmidt, Katharina Thanisch, Fabio Spada, Janett Elsaesser, Thomas Lahaye & Heinrich Leonhardt. (2012) Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers. Nucleic Acids Research 40:12, pages 5368-5377.
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Kamaleshwar P. Singh, Justin Treas, Tulika Tyagi & Weimin Gao. (2012) DNA demethylation by 5-aza-2-deoxycytidine treatment abrogates 17 beta-estradiol-induced cell growth and restores expression of DNA repair genes in human breast cancer cells. Cancer Letters 316:1, pages 62-69.
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