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Review

Flies as the ointment: Drosophila modeling to enhance drug discovery

Aaron J. Bell
,
Sean M.J. McBride
&
Thomas C. DockendorffCorrespondence[email protected]
Pages 39-49 | Received 16 Dec 2008, Accepted 06 Jan 2009, Published online: 15 Feb 2009

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Kathryn K. Chadman. (2017) Animal models for autism in 2017 and the consequential implications to drug discovery. Expert Opinion on Drug Discovery 12:12, pages 1187-1194.
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Alex Dyson, Megan Ryan, Shruti Garg, D. Gareth Evans & Richard A. Baines. (2023) A targeted, low-throughput compound screen in a Drosophila model of neurofibromatosis type 1 identifies simvastatin and BMS-204352 as potential therapies for autism spectrum disorder (ASD). . eneuro, pages ENEURO.0461-22.2023.
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Francesco Antonica, Giuseppe Aiello, Alessia Soldano, Luana Abballe, Evelina Miele & Luca Tiberi. (2022) Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models. Frontiers in Molecular Neuroscience 15.
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Jianzheng He, Botong Li, Shuzhen Han, Yuan Zhang, Kai Liu, Simeng Yi, Yongqi Liu & Minghui Xiu. (2022) Drosophila as a Model to Study the Mechanism of Nociception. Frontiers in Physiology 13.
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Iqra Subhan & Yasir Hasan Siddique. (2021) Modulation of Huntington’s Disease in Drosophila. CNS & Neurological Disorders - Drug Targets 20:10, pages 894-903.
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Andy Y. An, Ka-Yee Grace Choi, Arjun S. Baghela & Robert E. W. Hancock. (2021) An Overview of Biological and Computational Methods for Designing Mechanism-Informed Anti-biofilm Agents. Frontiers in Microbiology 12.
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Subhashree Priyadarsini, Sumit Mukherjee & Monalisa Mishra. 2020. Fundamental Approaches to Screen Abnormalities in Drosophila. Fundamental Approaches to Screen Abnormalities in Drosophila 1 13 .
Deeptiman Chatterjee & Wu-Min Deng. 2019. The Drosophila Model in Cancer. The Drosophila Model in Cancer 1 14 .
Małgorzata Popis, Blanka Borowiec & Maurycy Jankowski. (2018) Drosophila melanogaster research: history, breakthrough and perspectives. Medical Journal of Cell Biology 6:4, pages 182-185.
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Sofia Alves-Pimenta, Bruno Colaço, Paula A. Oliveira & Carlos Venâncio. 2018. Teratogenicity Testing. Teratogenicity Testing 61 93 .
Cecilia Sahlgren, Annika Meinander, Hongbo Zhang, Fang Cheng, Maren Preis, Chunlin Xu, Tiina A. Salminen, Diana Toivola, Daniel Abankwa, Ari Rosling, Didem Şen Karaman, Outi M. H. Salo-Ahen, Ronald Österbacka, John E. Eriksson, Stefan Willför, Ion Petre, Jouko Peltonen, Reko Leino, Mark Johnson, Jessica Rosenholm & Niklas Sandler. (2017) Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems. Advanced Healthcare Materials 6:21, pages 1700258.
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Jun Tomita, Gosuke Ban & Kazuhiko Kume. (2017) Genes and neural circuits for sleep of the fruit fly. Neuroscience Research 118, pages 82-91.
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Matthew J. Moulton & Anthea Letsou. (2016) Modeling congenital disease and inborn errors of development in Drosophila melanogaster . Disease Models & Mechanisms 9:3, pages 253-269.
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Siddhita D. Mhatre, Sarah J. Michelson, Janine Gomes, Loni Philip Tabb, Aleister J. Saunders & Daniel R. Marenda. (2014) Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster. Experimental Neurology 261, pages 772-781.
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Calvin Leung, Yana Wilson, Thang M Khuong & G Gregory Neely. (2013) Fruit flies as a powerful model to drive or validate pain genomics efforts. Pharmacogenomics 14:15, pages 1879-1887.
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Sharma Prabhakar. (2023) Translational Research Challenges: Finding the Right Animal Models. Journal of Investigative Medicine 60:8, pages 1141-1146.
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Amy R. Jones, Tiffany R. Bell-Horwath, Guorui Li, Stephanie M. Rollmann & Edward J. Merino. (2012) Novel Oxidatively Activated Agents Modify DNA and Are Enhanced by Ercc1 Silencing . Chemical Research in Toxicology 25:11, pages 2542-2552.
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Sean M. McBride, Aaron J. Bell & Thomas A. Jongens. 2012. Modeling Fragile X Syndrome. Modeling Fragile X Syndrome 83 117 .
Manfred Westphal & Katrin Lamszus. (2011) The neurobiology of gliomas: from cell biology to the development of therapeutic approaches. Nature Reviews Neuroscience 12:9, pages 495-508.
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Barbara H. Jennings. (2011) Drosophila – a versatile model in biology & medicine. Materials Today 14:5, pages 190-195.
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