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Research Paper

MF59 oil-in-water emulsion in combination with a synthetic TLR4 agonist (E6020) is a potent adjuvant for a combination Meningococcus vaccine

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Pages 486-490 | Received 17 Nov 2011, Accepted 01 Jan 2012, Published online: 01 Apr 2012

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Read on this site (4)

Eun-Ju Ko & Sang-Moo Kang. (2018) Immunology and efficacy of MF59-adjuvanted vaccines. Human Vaccines & Immunotherapeutics 14:12, pages 3041-3045.
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David A Johnson. (2013) TLR4 agonists as vaccine adjuvants: a chemist’s perspective. Expert Review of Vaccines 12:7, pages 711-713.
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Articles from other publishers (27)

Gang Hu, David J. Varisco, Sayan Das, C. Russell Middaugh, Francesca Gardner, Robert K. Ernst, Wendy L. Picking & William D. Picking. (2023) Physicochemical characterization of biological and synthetic forms of two lipid A-based TLR4 agonists. Heliyon 9:7, pages e18119.
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Archana Gopalakrishnan, Katharina Richard, Rezwanul Wahid, Regina Harley, Marcelo B. Sztein, Lynn D. Hawkins & Stefanie N. Vogel. (2022) E6020, a TLR4 Agonist Adjuvant, Enhances Both Antibody Titers and Isotype Switching in Response to Immunization with Hapten-Protein Antigens and Is Diminished in Mice with TLR4 Signaling Insufficiency. The Journal of Immunology 209:10, pages 1950-1959.
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Jing Jie, Guomu Liu, Jingyue Feng, Desheng Huo, Yixuan Wu, Hongyan Yuan, Guixiang Tai & Weihua Ni. (2022) MF59 Promoted the Combination of CpG ODN1826 and MUC1-MBP Vaccine-Induced Antitumor Activity Involved in the Enhancement of DC Maturation by Prolonging the Local Retention Time of Antigen and Down-Regulating of IL-6/STAT3. International Journal of Molecular Sciences 23:18, pages 10887.
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Sabna Kotta, Abdul Wadood Kha, Shahid H. Ansari, Rakesh Kumar Shar, Y.T. Kamal, Hibah Mubarak Al, Nabil Abdulhafiz, Sanjula Baboota & Javed Ali. (2022) Efavirenz nanoemulsion: Formulation Optimization by Box-Behnken Design, in vivo Pharmacokinetic Evaluation and Stability Assessment. International Journal of Pharmacology 18:4, pages 732-745.
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Liliana E. Villanueva‐Lizama, Julio V. Cruz‐Chan, Leroy Versteeg, Christian F. Teh‐Poot, Kristyn Hoffman, April Kendricks, Brian Keegan, Jeroen Pollet, Fabian Gusovsky, Peter J. Hotez, Maria Elena Bottazzi & Kathryn M. Jones. (2020) TLR4 agonist protects against Trypanosoma cruzi acute lethal infection by decreasing cardiac parasite burdens . Parasite Immunology 42:10.
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Nadeem Ullah, Ling Hao, Yaqi Wu, Yandi Zhang, Qing Lei, Jo-Lewis Banga Ndzouboukou, Xiaosong Lin & Xionglin Fan. (2020) Differential Immunogenicity and Protective Efficacy Elicited by MTO- and DMT-Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection . Journal of Immunology Research 2020, pages 1-8.
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Katharina Richard, Darren J. Perkins, Erin M. Harberts, Yang Song, Archana Gopalakrishnan, Kari Ann Shirey, Wendy Lai, Alexandra Vlk, Anup Mahurkar, Shreeram Nallar, Lynn D. Hawkins, Robert K. Ernst & Stefanie N. Vogel. (2020) Dissociation of TRIF bias and adjuvanticity. Vaccine 38:27, pages 4298-4308.
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Leroy Versteeg, Junfei Wei, Zhuyun Liu, Brian Keegan, Ricardo T. Fujiwara, Kathryn M. Jones, Oluwatoyin Asojo, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez & Bin Zhan. (2020) Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection. PLOS Neglected Tropical Diseases 14:2, pages e0008057.
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Thomas Ebensen, Barbara Fuchs, Kai Schulze & Carlos Alberto Guzmán. 2020. Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids. Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids 285 315 .
Meagan A. Barry, Leroy Versteeg, Qian Wang, Jeroen Pollet, Bin Zhan, Fabian Gusovsky, Maria Elena Bottazzi, Peter J. Hotez & Kathryn M. Jones. (2019) A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection. PLOS Neglected Tropical Diseases 13:5, pages e0007413.
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Thomas Ebensen, Barbara Fuchs, Kai Schulze & Carlos Alberto Guzmán. 2018. Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids. Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids 1 31 .
Saeed Nazeri, Sedigheh Zakeri, Akram A. Mehrizi, Navid D. Djadid, Georges Snounou, Chiara Andolina & François Nosten. (2018) Vaccine adjuvants CpG (oligodeoxynucleotides ODNs), MPL (3-O-deacylated monophosphoryl lipid A) and naloxone-enhanced Th1 immune response to the Plasmodium vivax recombinant thrombospondin-related adhesive protein (TRAP) in mice. Medical Microbiology and Immunology 207:5-6, pages 271-286.
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Rushit N. Lodaya, Luis A. Brito, Tom Y.H. Wu, Andrew T. Miller, Gillis R. Otten, Manmohan Singh & Derek T. O'Hagan. (2018) Stable Nanoemulsions for the Delivery of Small Molecule Immune Potentiators. Journal of Pharmaceutical Sciences 107:9, pages 2310-2314.
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Emilie Seydoux, Hong Liang, Natasha Dubois Cauwelaert, Michelle Archer, Nicholas D. Rintala, Ryan Kramer, Darrick Carter, Christopher B. Fox & Mark T. Orr. (2018) Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses. The Journal of Immunology 201:1, pages 98-112.
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Agnese Donadei, Cristiana Balocchi, Maria R. Romano, Luigi Panza, Roberto Adamo, Francesco Berti, Derek T. O'Hagan, Simona Gallorini & Barbara C. Baudner. (2017) Optimizing adjuvants for intradermal delivery of MenC glycoconjugate vaccine. Vaccine 35:32, pages 3930-3937.
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Jeroen Pollet, Leroy Versteeg, Wanderson Rezende, Ulrich Strych, Fabian Gusovsky, Peter J. Hotez & Maria Elena Bottazzi. (2017) A simple fluorescence-based assay for quantification of the Toll-Like Receptor agonist E6020 in vaccine formulations. Vaccine 35:10, pages 1410-1416.
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C.B. Fox, D. Carter, R.M. Kramer, A.M. Beckmann & S.G. Reed. 2017. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 105 127 .
Jean Haensler, Patricia Probeck, Jin Su, Fabienne Piras, François Dalençon, Jean-François Cotte, Véronique Chambon, Shehzad M. Iqbal, Lynn Hawkins & Nicolas Burdin. (2015) Design and preclinical characterization of a novel vaccine adjuvant formulation consisting of a synthetic TLR4 agonist in a thermoreversible squalene emulsion. International Journal of Pharmaceutics 486:1-2, pages 99-111.
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Mi-Gyeong Kim, Joo Yeon Park, Yuna Shon, Gunwoo Kim, Gayong Shim & Yu-Kyoung Oh. (2014) Nanotechnology and vaccine development. Asian Journal of Pharmaceutical Sciences 9:5, pages 227-235.
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Benoît Levast, Sunita Awate, Lorne Babiuk, George Mutwiri, Volker Gerdts & Sylvia van Drunen Littel-van den Hurk. (2014) Vaccine Potentiation by Combination Adjuvants. Vaccines 2:2, pages 297-322.
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Alexis García & Juan B. De Sanctis. (2014) An overview of adjuvant formulations and delivery systems. APMIS 122:4, pages 257-267.
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Steven G Reed, Mark T Orr & Christopher B Fox. (2013) Key roles of adjuvants in modern vaccines. Nature Medicine 19:12, pages 1597-1608.
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Francesco Berti & Roberto Adamo. (2013) Recent Mechanistic Insights on Glycoconjugate Vaccines and Future Perspectives. ACS Chemical Biology 8:8, pages 1653-1663.
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Ernesto Oviedo-Orta, Chris Ka-Fai Li & Rino Rappuoli. (2013) Perspectives on vaccine development for the elderly. Current Opinion in Immunology 25:4, pages 529-534.
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Julie S Lefebvre & Laura Haynes. (2013) Vaccine strategies to enhance immune responses in the aged. Current Opinion in Immunology 25:4, pages 523-528.
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Luis A. Brito, Padma Malyala & Derek T. O’Hagan. (2013) Vaccine adjuvant formulations: A pharmaceutical perspective. Seminars in Immunology 25:2, pages 130-145.
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