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Research Paper

HIV-1 Tat B-cell epitope vaccination was ineffectual in preventing viral rebound after ART cessation

HIV rebound with current ART appears to be due to infection with new endogenous founder virus and not to resurgence of pre-existing Tat-dependent viremia

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Pages 1425-1430 | Received 03 May 2012, Accepted 25 Jul 2012, Published online: 01 Oct 2012

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Yuqing Sun, Miaotian Cai, Ying Liang & Yulin Zhang. (2023) Disruption of blood–brain barrier: effects of HIV Tat on brain microvascular endothelial cells and tight junction proteins. Journal of NeuroVirology.
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Elahe Akbari, Masoud Seyedinkhorasani & Azam Bolhassani. (2023) Conserved multiepitope vaccine constructs: A potent HIV-1 therapeutic vaccine in clinical trials. The Brazilian Journal of Infectious Diseases, pages 102774.
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Virgil Schijns, Alberto Fernández‐Tejada, Žarko Barjaktarović, Ilias Bouzalas, Jens Brimnes, Sergey Chernysh, Sveinbjorn Gizurarson, Ihsan Gursel, Žiga Jakopin, Maria Lawrenz, Cristina Nativi, Stephane Paul, Gabriel Kristian Pedersen, Camillo Rosano, Ane Ruiz‐de‐Angulo, Bram Slütter, Aneesh Thakur, Dennis Christensen & Ed C. Lavelle. (2020) Modulation of immune responses using adjuvants to facilitate therapeutic vaccination. Immunological Reviews 296:1, pages 169-190.
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Mala K. Maini & Dimitra Peppa. (2020) Shared immunotherapeutic approaches in HIV and hepatitis B virus. Current Opinion in HIV and AIDS 15:3, pages 157-164.
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Mona Sadat Larijani, Amitis Ramezani & Seyed Mehdi Sadat. (2019) Updated Studies on the Development of HIV Therapeutic Vaccine. Current HIV Research 17:2, pages 75-84.
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Aurelio Cafaro, Antonella Tripiciano, Orietta Picconi, Cecilia Sgadari, Sonia Moretti, Stefano Buttò, Paolo Monini & Barbara Ensoli. (2019) Anti-Tat Immunity in HIV-1 Infection: Effects of Naturally Occurring and Vaccine-Induced Antibodies Against Tat on the Course of the Disease. Vaccines 7:3, pages 99.
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Jillian S.Y. Lau, Miranda Z. Smith, Sharon R. Lewin & James H. McMahon. (2019) Clinical trials of antiretroviral treatment interruption in HIV-infected individuals. AIDS 33:5, pages 773-791.
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Kathryn E. Stephenson. (2018) Therapeutic vaccination for HIV. Current Opinion in HIV and AIDS 13:5, pages 408-415.
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Ying Wen, Katharine J. Bar & Jonathan Z. Li. (2018) Lessons learned from HIV antiretroviral treatment interruption trials. Current Opinion in HIV and AIDS 13:5, pages 416-421.
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Michael C. Sneller, J. Shawn JustementKathleen R. GittensMary E. PetroneKatherine E. Clarridge, Michael A. Proschan, Richard KwanVictoria ShiJana Blazkova, Eric W. Refsland, Daryl E. Morris, Kristen W. Cohen, M. Juliana McElrath, Rong Xu, Michael A. EganJohn H. EldridgeErika BenkoColin KovacsSusan MoirTae-Wook Chun & Anthony S. Fauci. (2017) A randomized controlled safety/efficacy trial of therapeutic vaccination in HIV-infected individuals who initiated antiretroviral therapy early in infection. Science Translational Medicine 9:419.
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Denise C. Hsu & Jintanat Ananworanich. 2018. HIV-1 Latency. HIV-1 Latency 181 210 .
Barbara Ensoli, Maphoshane Nchabeleng, Fabrizio Ensoli, Antonella Tripiciano, Stefania Bellino, Orietta Picconi, Cecilia Sgadari, Olimpia Longo, Lara Tavoschi, Daniel Joffe, Aurelio Cafaro, Vittorio Francavilla, Sonia Moretti, Maria Rosaria Pavone Cossut, Barbara Collacchi, Angela Arancio, Giovanni Paniccia, Anna Casabianca, Mauro Magnani, Stefano Buttò, Elise Levendal, John Velaphi Ndimande, Bennett Asia, Yogan Pillay, Enrico Garaci & Paolo Monini. (2016) HIV-Tat immunization induces cross-clade neutralizing antibodies and CD4+ T cell increases in antiretroviral-treated South African volunteers: a randomized phase II clinical trial. Retrovirology 13:1.
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Erwann P. Loret, Albert Darque, Elisabeth Jouve, Elvenn A. Loret, Corinne Nicolino-Brunet, Sophie Morange, Elisabeth Castanier, Josiane Casanova, Christine Caloustian, Charléric Bornet, Julie Coussirou, Jihen Boussetta, Vincent Couallier, Olivier Blin, Bertrand Dussol & Isabelle Ravaux. (2016) Intradermal injection of a Tat Oyi-based therapeutic HIV vaccine reduces of 1.5 log copies/mL the HIV RNA rebound median and no HIV DNA rebound following cART interruption in a phase I/II randomized controlled clinical trial. Retrovirology 13:1.
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Giuseppe Pantaleo & Yves Levy. (2016) Therapeutic vaccines and immunological intervention in HIV infection. Current Opinion in HIV and AIDS 11:6, pages 576-584.
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Gina M Graziani & Jonathan B Angel. (2015) Evaluating the efficacy of therapeutic HIV vaccines through analytical treatment interruptions. Journal of the International AIDS Society 18:1, pages 20497.
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Venkatesh P. Kashi, Rajesh A. Jacob, Raghavendra A. Shamanna, Malini Menon, Anangi Balasiddaiah, Rebu K. Varghese, Mahesh Bachu & Udaykumar Ranga. (2014) The Grafting of Universal T-Helper Epitopes Enhances Immunogenicity of HIV-1 Tat Concurrently Improving Its Safety Profile. PLoS ONE 9:12, pages e114155.
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Sonia Mediouni, Albert Darque, Isabelle Ravaux, Gilbert Baillat, Christian Devaux & Erwann P. Loret. (2013) Identification of a Highly Conserved Surface on Tat Variants. Journal of Biological Chemistry 288:26, pages 19072-19080.
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