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Research Paper

Immunogenicity and safety of an inactivated 2012/2013 trivalent influenza vaccine produced in mammalian cell culture (Optaflu®)

An open label, uncontrolled study

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Pages 441-448 | Received 03 Sep 2013, Accepted 10 Nov 2013, Published online: 15 Nov 2013

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Read on this site (4)

Alberto Pérez Rubio & Jose María Eiros. (2018) Cell culture-derived flu vaccine: Present and future. Human Vaccines & Immunotherapeutics 14:8, pages 1874-1882.
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Stephan Bart, Kevin Cannon, Darrell Herrington, Richard Mills, Eduardo Forleo-Neto, Kelly Lindert & Ahmed Abdul Mateen. (2016) Immunogenicity and safety of a cell culture-based quadrivalent influenza vaccine in adults: A Phase III, double-blind, multicenter, randomized, non-inferiority study. Human Vaccines & Immunotherapeutics 12:9, pages 2278-2288.
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Ilaria Manini, Alexander Domnich, Daniela Amicizia, Stefania Rossi, Teresa Pozzi, Roberto Gasparini, Donatella Panatto & Emanuele Montomoli. (2015) Flucelvax (Optaflu) for seasonal influenza. Expert Review of Vaccines 14:6, pages 789-804.
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Nagendra R Hegde. (2015) Cell culture-based influenza vaccines: A necessary and indispensable investment for the future. Human Vaccines & Immunotherapeutics 11:5, pages 1223-1234.
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Articles from other publishers (7)

Karen Jordan, Eamon O. Murchu, Laura Comber, Sarah Hawkshaw, Liam Marshall, Michelle O’Neill, Conor Teljeur, Patricia Harrington, Annasara Carnahan, Jaime Jesús Pérez‐Martín, Anna Hayman Robertson, Kari Johansen, Jorgen de Jonge, Tyra Krause, Nathalie Nicolay, Hanna Nohynek, Ioanna Pavlopoulou, Richard Pebody, Pasi Penttinen, Marta Soler‐Soneira, Ole Wichmann & Máirín Ryan. (2022) Systematic review of the efficacy, effectiveness and safety of cell‐based seasonal influenza vaccines for the prevention of laboratory‐confirmed influenza in individuals ≥18 years of age. Reviews in Medical Virology 33:3.
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Yvette N. Lamb. (2019) Cell-Based Quadrivalent Inactivated Influenza Virus Vaccine (Flucelvax® Tetra/Flucelvax Quadrivalent®): A Review in the Prevention of Influenza. Drugs 79:12, pages 1337-1348.
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Surender Khurana, Megan Hahn, Elizabeth M. Coyle, Lisa R. King, Tsai-Lien Lin, John Treanor, Andrea Sant & Hana Golding. (2019) Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans. Nature Communications 10:1.
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Micha Loebermann, Carlos Fritzsche, Hilte Geerdes-Fenge, Esther Heijnen, Daniel Kirby & Emil C. Reisinger. (2018) A phase III, open-label, single-arm, study to evaluate the safety and immunogenicity of a trivalent, surface antigen inactivated subunit influenza virus vaccine produced in mammalian cell culture (Optaflu®) in healthy adults. Infection 47:1, pages 105-109.
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Donald Y.M. Leung, Brett Jepson, Lisa A. Beck, Jon M. Hanifin, Lynda C. Schneider, Amy S. Paller, Katherine Monti, Gloria David, Jennifer Canniff, Margarita Gomez Lorenzo & Adriana Weinberg. (2017) A clinical trial of intradermal and intramuscular seasonal influenza vaccination in patients with atopic dermatitis. Journal of Allergy and Clinical Immunology 139:5, pages 1575-1582.e8.
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V.H. Basavaraj, G. Sampath, Nagendra R. Hegde, V. Krishna Mohan & Krishna M. Ella. (2014) Evaluation of safety and immunogenicity of HNVAC, an MDCK-based H1N1 pandemic influenza vaccine, in Phase I single centre and Phase II/III multi-centre, double-blind, randomized, placebo-controlled, parallel assignment studies. Vaccine 32:35, pages 4592-4597.
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Christopher Stobart & Martin Moore. (2014) RNA Virus Reverse Genetics and Vaccine Design. Viruses 6:7, pages 2531-2550.
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