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Alex C. D. Salyer & Sunil A. David. (2018) Transcriptomal signatures of vaccine adjuvants and accessory immunostimulation of sentinel cells by toll-like receptor 2/6 agonists. Human Vaccines & Immunotherapeutics 14:7, pages 1686-1696.
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Melania Pilz, Philipp Cavelius, Farah Qoura, Dania Awad & Thomas Brück. (2023) Lipopeptides development in cosmetics and pharmaceutical applications: A comprehensive review. Biotechnology Advances 67, pages 108210.
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Deepender Kaushik, Arshpreet Kaur, Nikolai Petrovsky & Deepak B. Salunke. (2021) Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles. RSC Medicinal Chemistry 12:7, pages 1065-1120.
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Yunlong Hu, Li Tang, Zhengyu Zhu, He Meng, Tingting Chen, Sheng Zhao, Zhenchao Jin, Zhulin Wang & Guangyi Jin. (2020) A novel TLR7 agonist as adjuvant to stimulate high quality HBsAg-specific immune responses in an HBV mouse model. Journal of Translational Medicine 18:1.
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Hyo-Ji Lee, Su-Jin Kang, Yunseo Woo, Tae-Wook Hahn, Hyun-Jeong Ko & Yu-Jin Jung. (2020) TLR7 Stimulation With Imiquimod Induces Selective Autophagy and Controls Mycobacterium tuberculosis Growth in Mouse Macrophages. Frontiers in Microbiology 11.
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Diego A. Diaz-Dinamarca, Ricardo A. Manzo, Daniel A. Soto, María José Avendaño-Valenzuela, Diego N. Bastias, Paulina I. Soto, Daniel F. Escobar, Valeria Vasquez-Saez, Flavio Carrión, Magdalena S. Pizarro-Ortega, Christian A. M. Wilson, Julio Berrios, Alexis M. Kalergis & Abel E. Vasquez. (2020) Surface Immunogenic Protein of Streptococcus Group B is an Agonist of Toll-Like Receptors 2 and 4 and a Potential Immune Adjuvant. Vaccines 8:1, pages 29.
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Nour Bou Karroum, Georges Moarbess, Jean-François Guichou, Pierre-Antoine Bonnet, Cindy Patinote, Hasnaa Bouharoun-Tayoun, Soulaima Chamat, Pierre Cuq, Mona Diab-Assaf, Issam Kassab & Carine Deleuze-Masquefa. (2019)
Novel and Selective TLR7 Antagonists among the Imidazo[1,2-
a
]pyrazines, Imidazo[1,5-
a
]quinoxalines, and Pyrazolo[1,5-
a
]quinoxalines Series
. Journal of Medicinal Chemistry 62:15, pages 7015-7031.
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Ziwei Hu, Janardhan Banothu, Mallesh Beesu, Collin J. Gustafson, Michael J. H. Brush, Kathryn L. Trautman, Alex C. D. Salyer, Balaji Pathakumari & Sunil A. David. (2018) Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine–Quinolone Carboxamides. ACS Medicinal Chemistry Letters 10:1, pages 132-136.
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Damien Carignan, Sabine Herblot, Marie-Ève Laliberté-Gagné, Marilène Bolduc, Michel Duval, Pierre Savard & Denis Leclerc. (2018) Activation of innate immunity in primary human cells using a plant virus derived nanoparticle TLR7/8 agonist. Nanomedicine: Nanotechnology, Biology and Medicine 14:7, pages 2317-2327.
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Euna Yoo, Alex C. D. Salyer, Michael J. H. Brush, Yupeng Li, Kathryn L. Trautman, Nikunj M. Shukla, Ans De Beuckelaer, Stefan Lienenklaus, Kim Deswarte, Bart N. Lambrecht, Bruno G. De Geest & Sunil A. David. (2018) Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue. Bioconjugate Chemistry 29:8, pages 2741-2754.
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Serge Pieters, David McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Werner Embrechts, Annick Scholliers, Wendy Mostmans, Kris Van Dijck, Bertrand Van Schoubroeck, Tine Thoné, Dorien De Pooter, Gregory Fanning, Mari Luz Rosauro, Mourad Daoubi Khamlichi, Ioannis Houpis, Eric Arnoult, Tim H.M. Jonckers & Pierre Raboisson. (2018) Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists. Bioorganic & Medicinal Chemistry Letters 28:4, pages 711-719.
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Arshpreet Kaur, Poonam Poonam, Madhuri T. Patil, Surinder K. Mehta & Deepak B. Salunke. (2018)
An efficient and scalable synthesis of potent TLR2 agonistic PAM
2
CSK
4
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Mallesh Beesu, Alex C. D. Salyer, Michael J. H. Brush, Kathryn L. Trautman, Justin K. Hill & Sunil A. David. (2017) Identification of High-Potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines. Journal of Medicinal Chemistry 60:5, pages 2084-2098.
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Anissa S. H. Chan, Adria Bykowski Jonas, Xiaohong Qiu, Nadine R. Ottoson, Richard M. Walsh, Keith B Gorden, Ben Harrison, Peter J. Maimonis, Steven M. Leonardo, Kathleen E. Ertelt, Michael E. Danielson, Kyle S. Michel, Mariana Nelson, Jeremy R. Graff, Myra L. Patchen & Nandita Bose. (2016) Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation. PLOS ONE 11:11, pages e0165909.
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Mallesh Beesu, Giuseppe Caruso, Alex C. D. Salyer, Nijunj M. Shukla, Karishma K. Khetani, Luke J. Smith, Lauren M. Fox, Hiromi Tanji, Umeharu Ohto, Toshiyuki Shimizu & Sunil A. David. (2016) Identification of a Human Toll-Like Receptor (TLR) 8-Specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles. Journal of Medicinal Chemistry 59:7, pages 3311-3330.
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Mallesh Beesu, Giuseppe Caruso, Alex C. D. Salyer, Karishma K. Khetani, Diptesh Sil, Mihiri Weerasinghe, Hiromi Tanji, Umeharu Ohto, Toshiyuki Shimizu & Sunil A. David. (2015) Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. Journal of Medicinal Chemistry 58:19, pages 7833-7849.
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Dong Gao, Yuwen Diao, Wang Li, Ningning Gao, Yu Liu, Zhulin Wang, Wenqi Jiang & Guangyi Jin. (2015) Toll-Like Receptor 7 Inactive Ligands Enhanced Cytokine Induction by Conjugation to Weak Antigens. ChemMedChem 10:6, pages 977-980.
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David J. Dowling & Ofer Levy. (2014) Ontogeny of early life immunity. Trends in Immunology 35:7, pages 299-310.
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Marco Sartor. (2014) Modulation of Sensory Nerve Activity and Pharmaceutical Treatments. Journal of Anesthesia & Critical Care: Open Access 1:2.
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Hari Prasad Kokatla, Diptesh Sil, Hiromi Tanji, Umeharu Ohto, Subbalakshmi S. Malladi, Lauren M. Fox, Toshiyoki Shimizu & Sunil A. David. (2014) Structure-Based Design of Novel Human Toll-like Receptor?8 Agonists. ChemMedChem 9:4, pages 719-723.
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Charles E. Schiaffo, Ce Shi, Zhengming Xiong, Michael Olin, John R. Ohlfest, Courtney C. Aldrich & David M. Ferguson. (2014) Structure–Activity Relationship Analysis of Imidazoquinolines with Toll-like Receptors 7 and 8 Selectivity and Enhanced Cytokine Induction. Journal of Medicinal Chemistry 57:2, pages 339-347.
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Peter Michael Moyle & Istvan Toth. (2013) Modern Subunit Vaccines: Development, Components, and Research Opportunities. ChemMedChem 8:3, pages 360-376.
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Euna Yoo, Breanna M. Crall, Rajalakshmi Balakrishna, Subbalakshmi S. Malladi, Lauren M. Fox, Alec R. Hermanson & Sunil A. David. (2013) Structure–activity relationships in Toll-like receptor 7 agonistic 1H-imidazo[4,5-c]pyridines. Organic & Biomolecular Chemistry 11:38, pages 6526.
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Hari Prasad Kokatla, Euna Yoo, Deepak B. Salunke, Diptesh Sil, Cameron F. Ng, Rajalakshmi Balakrishna, Subbalakshmi S. Malladi, Lauren M. Fox & Sunil A. David. (2013) Toll-like receptor-8 agonistic activities in C2, C4, and C8 modified thiazolo[4,5-c]quinolines. Organic & Biomolecular Chemistry 11:7, pages 1179.
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Žiga Jakopin, Martina Gobec, Irena Mlinarič-Raščan & Marija Sollner Dolenc. (2012) Immunomodulatory Properties of Novel Nucleotide Oligomerization Domain 2 (Nod2) Agonistic Desmuramyldipeptides. Journal of Medicinal Chemistry 55:14, pages 6478-6488.
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Elena Caproni, Elaine Tritto, Mario Cortese, Alessandro Muzzi, Flaviana Mosca, Elisabetta Monaci, Barbara Baudner, Anja Seubert & Ennio De Gregorio. (2012) MF59 and Pam3CSK4 Boost Adaptive Responses to Influenza Subunit Vaccine through an IFN Type I-Independent Mechanism of Action. The Journal of Immunology 188:7, pages 3088-3098.
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Rehman Ukani, Tyler C. Lewis, Timothy P. Day, Wenyan Wu, Subbalakshmi S. Malladi, Hemamali J. Warshakoon & Sunil A. David. (2012) Potent adjuvantic activity of a CCR1-agonistic bis-quinoline. Bioorganic & Medicinal Chemistry Letters 22:1, pages 293-295.
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Nikunj M. Shukla, Tyler C. Lewis, Timothy P. Day, Cole A. Mutz, Rehman Ukani, Chase D. Hamilton, Rajalakshmi Balakrishna & Sunil A. David. (2011) Toward self-adjuvanting subunit vaccines: Model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines. Bioorganic & Medicinal Chemistry Letters 21:11, pages 3232-3236.
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Nikunj M. Shukla, Subbalakshmi S. Malladi, Victor Day & Sunil A. David. (2011) Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists. Bioorganic & Medicinal Chemistry 19:12, pages 3801-3811.
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Nikunj M. Shukla, Cole A. Mutz, Rehman Ukani, Hemamali J. Warshakoon, David S. Moore & Sunil A. David. (2010) Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorganic & Medicinal Chemistry Letters 20:22, pages 6384-6386.
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