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Islets Volume 4, 2012 - Issue 3
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Research Paper

Diabetes reduces β-cell mitochondria and induces distinct morphological abnormalities, which are reproducible by high glucose in vitro with attendant dysfunction

Zuheng Ma Department of Molecular Medicine and Surgery; Karolinska Institutet; Stockholm, Sweden
,
Tina Wirström Department of Molecular Medicine and Surgery; Karolinska Institutet; Stockholm, Sweden
,
L.A. Håkan Borg Department of Medical Cell Biology; University of Uppsala; Uppsala, Sweden
,
Gerd Larsson-Nyrén Department of Integrative Medical Biology; Section for Histology and Cell Biology; Umeå University; Umeå, Sweden
,
Ingrid Hals Institute of Cancer Research and Molecular Medicine; The Medical Faculty; Norwegian University of Science and Technology; Trondheim, Norway
,
John Bondo-Hansen Novo Nordisk Research and Development; Målöv, Denmark
,
Valdemar Grill Department of Molecular Medicine and Surgery; Karolinska Institutet; Stockholm, Sweden; Institute of Cancer Research and Molecular Medicine; The Medical Faculty; Norwegian University of Science and Technology; Trondheim, Norway; Department of Endocrinology; St. Olav’s University Hospital; Trondheim, Norway
&
Anneli Björklund Department of Molecular Medicine and Surgery; Karolinska Institutet; Stockholm, SwedenCorrespondence[email protected]
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Pages 233-242 | Published online: 01 May 2012

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Justin J. Crowder, Ziqian Zeng, Alissa N. Novak, Nathan J. Alves & Amelia K. Linnemann. (2022) Stabilization protects islet integrity during respirometry in the Oroboros Oxygraph-2K analyzer. Islets 14:1, pages 128-138.
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Roberta Scrimieri, Laura Locatelli, Alessandra Cazzaniga, Roberta Cazzola, Emil Malucelli, Andrea Sorrentino, Stefano Iotti & Jeanette A. Maier. (2023) Ultrastructural features mirror metabolic derangement in human endothelial cells exposed to high glucose. Scientific Reports 13:1.
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Rong Wu, Sheng Huang, Jin-feng Xie, Nian-lian Wen, Min Wen & Su-e Zhong. (2023) CircRNA SCAR Improves High-Glucose-Induced Mitochondrial Dysfunction and Permeability Damage in Retinal Microvascular Endothelial Cells. Hormone and Metabolic Research 55:08, pages 555-562.
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Mohammad Tariq, Arnaldo H. de Souza, Mohammed Bensellam, Heeyoung Chae, Manon Jaffredo, Anne-Françoise Close, Jean-Philippe Deglasse, Laila R. B. Santos, Antoine Buemi, Nizar I. Mourad, Anne Wojtusciszyn, Matthieu Raoux, Patrick Gilon, Christophe Broca & Jean-Christophe Jonas. (2022) Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped. Diabetologia 66:4, pages 709-723.
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Maša Skelin Klemen, Jurij Dolenšek, Ismael Valladolid-Acebes, Andraž Stožer & Saška Lipovšek. 2022. Electron Microscopy. Electron Microscopy.
Aranzazu M. de Marañón, Pedro Díaz-Pozo, Francisco Canet, Noelia Díaz-Morales, Zaida Abad-Jiménez, Sandra López-Domènech, Teresa Vezza, Nadezda Apostolova, Carlos Morillas, Milagros Rocha & Víctor M. Víctor. (2022) Metformin modulates mitochondrial function and mitophagy in peripheral blood mononuclear cells from type 2 diabetic patients. Redox Biology 53, pages 102342.
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Abhijit Paul, Salman Azhar, Phonindra Nath Das, Nandadulal Bairagi & Samrat Chatterjee. (2022) Elucidating the metabolic characteristics of pancreatic β-cells from patients with type 2 diabetes (T2D) using a genome-scale metabolic modeling. Computers in Biology and Medicine 144, pages 105365.
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Sebastian Friedrich Petry, Axel Römer, Divya Rawat, Lara Brunner, Nina Lerch, Mengmeng Zhou, Rekha Grewal, Fatemeh Sharifpanah, Heinrich Sauer, Gunter Peter Eckert & Thomas Linn. (2022) Loss and Recovery of Glutaredoxin 5 Is Inducible by Diet in a Murine Model of Diabesity and Mediated by Free Fatty Acids In Vitro. Antioxidants 11:4, pages 788.
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Meng-Yuan Zhang, Lingpeng Zhu, Xinhua Zheng, Tian-Hua Xie, Wenjuan Wang, Jian Zou, Yan Li, Hong-Ying Li, Jiping Cai, Shun Gu, Yong Yao & Ting-Ting Wei. (2022) TGR5 Activation Ameliorates Mitochondrial Homeostasis via Regulating the PKCδ/Drp1-HK2 Signaling in Diabetic Retinopathy. Frontiers in Cell and Developmental Biology 9.
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Isabelle Chareyron, Stefan Christen, Sofia Moco, Armand Valsesia, Steve Lassueur, Loïc Dayon, Claes B. Wollheim, Jaime Santo Domingo & Andreas Wiederkehr. (2020) Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells. Diabetologia 63:12, pages 2628-2640.
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In O Sun, Long Jin, Jian Jin, Sun Woo Lim, Byung Ha Chung & Chul Woo Yang. (2019) The effects of addition of coenzyme Q10 to metformin on sirolimus-induced diabetes mellitus. The Korean Journal of Internal Medicine 34:2, pages 365-374.
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Chiara Mandò, Gaia Maria Anelli, Chiara Novielli, Paola Panina-Bordignon, Maddalena Massari, Martina Ilaria Mazzocco & Irene Cetin. (2018) Impact of Obesity and Hyperglycemia on Placental Mitochondria. Oxidative Medicine and Cellular Longevity 2018, pages 1-10.
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F. Haczeyni, K. S. Bell-Anderson & G. C. Farrell. (2018) Causes and mechanisms of adipocyte enlargement and adipose expansion. Obesity Reviews 19:3, pages 406-420.
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Wenjing Pan, Linghong Miao, Yan Lin, Xin Huang, Xianping Ge, Silli Laban Moosa, Bo Liu, Mingchun Ren, Qunlan Zhou, Hualiang Liang, Wuxiao Zhang & Liangkun Pan. (2017) Regulation mechanism of oxidative stress induced by high glucose through PI3K/Akt/Nrf2 pathway in juvenile blunt snout bream (Megalobrama amblycephala). Fish & Shellfish Immunology 70, pages 66-75.
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Merrick S. Reynolds, Chad R. Hancock, Jason D. Ray, Kyle B. Kener, Carrie Draney, Kevin Garland, Jeremy Hardman, Benjamin T. Bikman & Jeffery S. Tessem. (2016) β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. American Journal of Physiology-Endocrinology and Metabolism 311:1, pages E186-E201.
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Antonino De Lorenzo. (2016) New obesity classification criteria as a tool for bariatric surgery indication. World Journal of Gastroenterology 22:2, pages 681.
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Carla Beatriz Collares-Buzato. 2016. Molecular Nutrition and Diabetes. Molecular Nutrition and Diabetes 115 130 .
Natasha Machado, Silvio Eduardo Duailibi, Jennifer Adriane dos Santos, Vanessa Penna, Lydia Masako Ferreira & Monica Talarico Duailibi. (2014) Effects of glucose and glutamine concentrations in human dental pulp stem cells viability. An approach for cell transplantation. Acta Cirurgica Brasileira 29:10, pages 658-666.
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Christopher Lipina, Andrew J. Irving & Harinder S. Hundal. (2014) Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?. American Journal of Physiology-Endocrinology and Metabolism 307:1, pages E1-E13.
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Hironori Chiba, Koji Ataka, Kousuke Iba, Kanna Nagaishi, Toshihiko Yamashita & Mineko Fujimiya. (2013) Diabetes impairs the interactions between long-term hematopoietic stem cells and osteopontin-positive cells in the endosteal niche of mouse bone marrow. American Journal of Physiology-Cell Physiology 305:7, pages C693-C703.
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