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Research Paper

Altering β-cell number through stable alteration of miR-21 and miR-34a expression

Marie Balslev Backe Section of Endocrinological Research; Department of Biomedical Sciences; Faculty of Health Sciences; University of Copenhagen; Copenhagen, Denmark
,
Guy Wayne Novotny Section of Endocrinological Research; Department of Biomedical Sciences; Faculty of Health Sciences; University of Copenhagen; Copenhagen, Denmark
,
Dan Ploug Christensen Section of Endocrinological Research; Department of Biomedical Sciences; Faculty of Health Sciences; University of Copenhagen; Copenhagen, Denmark
,
Lars Groth Grunnet Section of Endocrinological Research; Department of Biomedical Sciences; Faculty of Health Sciences; University of Copenhagen; Copenhagen, Denmark; Novo Nordisk; Department of Islet Biology; Måløv, Denmark
&
Thomas Mandrup-Poulsen Section of Endocrinological Research; Department of Biomedical Sciences; Faculty of Health Sciences; University of Copenhagen; Copenhagen, Denmark; Department of Molecular Medicine and Surgery; Karolinska Institutet; Stockholm, SwedenCorrespondence[email protected]
Article: e27754 | Received 07 Aug 2013, Accepted 07 Jan 2014, Published online: 26 Feb 2014

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Kiyonori Ito, Susumu Ookawara, Kenichi Ishibashi & Yoshiyuki Morishita. (2017) Transgene and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus. Nano Reviews & Experiments 8:1.
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Brian D. Adams, Christine Parsons & Frank J. Slack. (2016) The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas. Expert Opinion on Therapeutic Targets 20:6, pages 737-753.
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Articles from other publishers (31)

Jenner Chrystian Veríssimo de Azevedo, Thales Allyrio Araújo de Medeiros Fernandes, Gilson Aquino Cavalcante, Iluska Almeida Carneiro Martins de Medeiros, Daniel Carlos Ferreira Lanza, Joselio Maria Galvão de Araújo, Fabiana Lima Bezerra & José Veríssimo Fernandes. (2023) Biology and Natural History of Type 1 Diabetes Mellitus. Current Pediatric Reviews 19:3, pages 253-275.
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Mirjana T Macvanin, Zoran Gluvic, Vladan Bajic & Esma R Isenovic. (2023) Novel insights regarding the role of noncoding RNAs in diabetes. World Journal of Diabetes 14:7, pages 958-976.
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Mirjana T. MacvaninEsma R. Isenovic. (2023) Diabetes and associated cardiovascular complications: The role of microRNAs. Cardiology Plus 8:3, pages 167-183.
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Raúl Barzalobre-Geronimo, Alejandra Contreras-Ramos, Aaron I. Cervantes-Cruz, Miguel Cruz, Fernando Suárez-Sánchez, Jaime Goméz-Zamudio, Guadalupe Diaz-Rosas, Alejandro Ávalos-Rodríguez, Margarita Díaz-Flores & Clara Ortega-Camarillo. (2023) Pancreatic β-Cell Apoptosis in Normoglycemic Rats is Due to Mitochondrial Translocation of p53-Induced by the Consumption of Sugar-Sweetened Beverages. Cell Biochemistry and Biophysics.
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Yueyang Yu, Mengyin Li, Yuxuan Zhao, Fangzhou Fan, Wenxiang Wu, Yuhua Gao & Chunyu Bai. (2022) Immune cell-derived extracellular vesicular microRNAs induce pancreatic beta cell apoptosis. Heliyon 8:12, pages e11995.
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Yiru Wang, Feiye Zhou, Mingzhu Li, Yumei Zhang, Na Li & Li Shao. (2022) MiR-34a-5p promotes hepatic gluconeogenesis by suppressing SIRT1 expression. Experimental Cell Research 420:1, pages 113336.
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Bodo C. Melnik & Gerd Schmitz. (2022) Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life. International Journal of Molecular Sciences 23:19, pages 11503.
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Angel Mendonca, Prabu Thandapani, Priyashree Nagarajan, Sanjana Venkatesh & Sujatha Sundaresan. (2022) Role of microRNAs in regulation of insulin secretion and insulin signaling involved in type 2 diabetes mellitus. Journal of Biosciences 47:4.
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Christian Prinz, Leonard Fehring & Robin Frese. (2022) MicroRNAs as Indicators of Malignancy in Pancreatic Ductal Adenocarcinoma (PDAC) and Cystic Pancreatic Lesions. Cells 11:15, pages 2374.
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Helaleh Vaezi Heris & Zohreh Zahraei. (2022) miRNAs: Regulators of immune system in diabetes. Mutation Research/Reviews in Mutation Research 790, pages 108442.
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Farbod Bahreini, Elham Rayzan & Nima Rezaei. (2022) MicroRNAs and Diabetes Mellitus Type 1. Current Diabetes Reviews 18:2.
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Stanislovas S. Jankauskas, Jessica Gambardella, Urna Kansakar, Scott Wilson, Pasquale Mone, Fahimeh Varzideh, Kwame Donkor, Michael Eacobacci, Ayobami Adebayo, Marco Morelli, John Ferrara, Xujun Wang, Angela Lombardi & Gaetano Santulli. 2022. MicroRNA. MicroRNA 373 400 .
Anna Sałówka & Aida Martinez-Sanchez. (2021) Molecular Mechanisms of Nutrient-Mediated Regulation of MicroRNAs in Pancreatic β-cells. Frontiers in Endocrinology 12.
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Sara Ibrahim, Macey Johnson, Clarissa Hernandez Stephens, Jerry Xu, Rachel Moore, Andrea Mariani, Christopher Contreras, Farooq Syed, Raghavendra G. Mirmira, Ryan M. Anderson & Emily K. Sims. (2021) β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs. Molecular Metabolism 53, pages 101289.
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Jamie M.R. Tarlton, Richard J. Lightbody, Steven Patterson & Annette Graham. (2021) Protection against Glucolipotoxicity by High Density Lipoprotein in Human PANC-1 Hybrid 1.1B4 Pancreatic Beta Cells: The Role of microRNA. Biology 10:3, pages 218.
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Paul HolvoetPaul Holvoet. 2021. Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer. Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer 53 72 .
Mohammad Reza Alipour, Roya Naderi, Alireza Alihemmati, Roghayeh Sheervalilou & Rafighe Ghiasi. (2020) Swimming training attenuates pancreatic apoptosis through miR-34a/Sirtu in1/P53 Axis in high-fat diet and Streptozotocin-induced Type-2 diabetic rats. Journal of Diabetes & Metabolic Disorders 19:2, pages 1439-1446.
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Claudiane Guay, Cécile Jacovetti, Mustafa Bilal Bayazit, Flora Brozzi, Adriana Rodriguez‐Trejo, Kejing Wu & Romano Regazzi. 2011. Comprehensive Physiology. Comprehensive Physiology 893 932 .
Adele Soltani, Arefeh Jafarian & Abdolamir Allameh. (2020) The Predominant microRNAs in β-cell Clusters for Insulin Regulation and Diabetic Control. Current Drug Targets 21:7, pages 722-734.
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Sergey A. Solodskikh, Vladimir M. Dudenkov, Viktor Yu. Glanz, Anna V. Panevina, Vasily N. Popov & Alexey S. Velikorodny. 2020. Obesity and Diabetes. Obesity and Diabetes 893 906 .
Nicola Jeffery & Lorna W. Harries. (2019) miRNAs responsive to the diabetic microenvironment in the human beta cell line EndoC-βH1 may target genes in the FOXO, HIPPO and Lysine degradation pathways. Experimental Cell Research 384:1, pages 111559.
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Mohsen Mohammady, Seyed I. Ghetmiri, Mahtab Baharizade, Mohammad H. Morowvat & Susan Torabi. (2019) Expanding the Biotherapeutics Realm via miR-34a: “Potent Clever Little” Agent in Breast Cancer Therapy. Current Pharmaceutical Biotechnology 20:8, pages 665-673.
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Dan Jiao, Huan Zhang, Ziping Jiang, Wenlin Huang, Zhuo Liu, Zhaohui Wang, Yonggang Wang & Hao Wu. (2018) MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death. Journal of Molecular Medicine 96:9, pages 939-949.
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Mary P. LaPierre & Markus Stoffel. (2017) MicroRNAs as stress regulators in pancreatic beta cells and diabetes. Molecular Metabolism 6:9, pages 1010-1023.
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Louise Torp Dalgaard & Lena Eliasson. (2017) An ‘alpha-beta’ of pancreatic islet microribonucleotides. The International Journal of Biochemistry & Cell Biology 88, pages 208-219.
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Emily K. Sims, Alexander J. Lakhter, Emily Anderson-Baucum, Tatsuyoshi Kono, Xin Tong & Carmella Evans-Molina. (2017) MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells. Diabetologia 60:6, pages 1057-1065.
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Anna Vestergaard, Maaike Blankestijn, Jonathan Stahl, Emil Pallesen, Claus Bang-Berthelsen, Flemming Pociot, Guy Novotny, Morten Lundh & Thomas Mandrup-Poulsen. (2016) A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells. International Journal of Molecular Sciences 17:6, pages 896.
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Shaowen Wang, Xiaochun Wan & Qingguo Ruan. (2016) The MicroRNA-21 in Autoimmune Diseases. International Journal of Molecular Sciences 17:6, pages 864.
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Durairaj Sekar, Basam Venugopal, Punitha Sekar & Krishnan Ramalingam. (2016) Role of microRNA 21 in diabetes and associated/related diseases. Gene 582:1, pages 14-18.
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Mirwais Osmai, Yama Osmai, Claus H. Bang-Berthelsen, Emil M. H. Pallesen, Anna L. Vestergaard, Guy W. Novotny, Flemming Pociot & Thomas Mandrup-Poulsen. (2016) MicroRNAs as regulators of beta-cell function and dysfunction. Diabetes/Metabolism Research and Reviews 32:4, pages 334-349.
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Stephen R. Filios & Anath Shalev. (2015) β-Cell MicroRNAs: Small but Powerful. Diabetes 64:11, pages 3631-3644.
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