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Review

Evolution of the JAK-STAT pathway

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Article: e22756 | Published online: 01 Jan 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Shingo Nakayamada & Yoshiya Tanaka. (2023) Novel JAK inhibitors under investigation for systemic lupus erythematosus: - where are we now?. Expert Opinion on Investigational Drugs 32:10, pages 901-908.
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Shingo Nakayamada & Yoshiya Tanaka. (2022) Pathological relevance and treatment perspective of JAK targeting in systemic lupus erythematosus. Expert Review of Clinical Immunology 18:3, pages 245-252.
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Alexandra Gomez-Arteaga, Elizabeth Margolskee, Mike T. Wei, Koen van Besien, Giorgio Inghirami & Steven Horwitz. (2019) Combined use of tofacitinib (pan-JAK inhibitor) and ruxolitinib (a JAK1/2 inhibitor) for refractory T-cell prolymphocytic leukemia (T-PLL) with a JAK3 mutation. Leukemia & Lymphoma 60:7, pages 1626-1631.
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Articles from other publishers (33)

Wei Wang, Changkun Pan, Qingna Lai, Qian Zhang & Jianming Chen. (2024) WSV403 suppresses JAK/STAT signaling to impair antiviral resistance in Pacific white shrimp Penaeus vannamei. Aquaculture 579, pages 740139.
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Alexey Sarapultsev, Evgenii Gusev, Maria Komelkova, Irina Utepova, Shanshan Luo & Desheng Hu. (2023) JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions. Molecular Biomedicine 4:1.
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Mohamad Mahjoor, Golnaz Mahmoudvand, Simin Farokhi, Alireza Shadab, Mojtaba Kashfi & Hamed Afkhami. (2023) Double-edged sword of JAK/STAT signaling pathway in viral infections: novel insights into virotherapy. Cell Communication and Signaling 21:1.
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Oluwatobi T. Somade, Babatunji E. Oyinloye, Basiru O. Ajiboye & Olukemi A. Osukoya. (2023) Syringic acid demonstrates an anti-inflammatory effect via modulation of the NF-κB-iNOS-COX-2 and JAK-STAT signaling pathways in methyl cellosolve-induced hepato-testicular inflammation in rats. Biochemistry and Biophysics Reports 34, pages 101484.
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Ruifang Han, Yu Xiao, Qianqian Bai & Chung Hang Jonathan Choi. (2023) Self-therapeutic metal-based nanoparticles for treating inflammatory diseases. Acta Pharmaceutica Sinica B 13:5, pages 1847-1865.
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Somayyeh Heidary, Nagendra Awasthi, Nicole Page, Theo Allnutt, Rowena S. Lewis, Clifford Liongue & Alister C. Ward. (2023) A zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1). Cellular and Molecular Life Sciences 80:4.
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Seth Hilliard, Karen Mosoyan, Sergio Branciamore, Grigoriy Gogoshin, Alvin Zhang, Diana L. Simons, Russell C. Rockne, Peter P. Lee & Andrei S. Rodin. (2023) Bow-tie architectures in biological and artificial neural networks: Implications for network evolution and assay design. iScience 26:2, pages 106041.
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Mei Lan Tan, Jia Wen Yeap & Azlinah Matawali. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 32 .
Erich Loza Telleria, Daisy Aline Azevedo-Brito, Barbora Kykalová, Bruno Tinoco-Nunes, André Nóbrega Pitaluga, Petr Volf & Yara Maria Traub-Csekö. (2021) Leishmania infantum Infection Modulates the Jak-STAT Pathway in Lutzomyia longipalpis LL5 Embryonic Cells and Adult Females, and Affects Parasite Growth in the Sand Fly. Frontiers in Tropical Diseases 2.
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Muhammad Zahoor Khan, Adnan Khan, Jianxin Xiao, Yulin Ma, Jiaying Ma, Jian Gao & Zhijun Cao. (2020) Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production. Animals 10:11, pages 2107.
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Yan Shi & Hefei Ruan. (2020) Toward a Membrane-Centric Biology. Frontiers in Immunology 11.
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Sebastian Strubl, Jacob A. Torres, Alison K. Spindt, Hannah Pellegrini, Max C. Liebau & Thomas Weimbs. (2020) STAT signaling in polycystic kidney disease. Cellular Signalling 72, pages 109639.
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Matthias Kieslinger, Alexander Swoboda, Nina Kramer, Barbara Pratscher, Birgitt Wolfesberger & Iwan A. Burgener. (2019) Companion Animals as Models for Inhibition of STAT3 and STAT5. Cancers 11:12, pages 2035.
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Cuiping Fu, Liyan Jiang, Shengyu Hao, Zilong Liu, Suling Ding, Weiwei Zhang, Xiangdong Yang & Shanqun Li. (2019) Activation of the IL-4/STAT6 Signaling Pathway Promotes Lung Cancer Progression by Increasing M2 Myeloid Cells. Frontiers in Immunology 10.
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Maurer, Kollmann, Pickem, Hoelbl-Kovacic & Sexl. (2019) STAT5A and STAT5B—Twins with Different Personalities in Hematopoiesis and Leukemia. Cancers 11:11, pages 1726.
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Gianluca Scarno, Giuseppe Pietropaolo, Chiara Di Censo, Massimo Gadina, Angela Santoni & Giuseppe Sciumè. (2019) Transcriptional, Epigenetic and Pharmacological Control of JAK/STAT Pathway in NK Cells. Frontiers in Immunology 10.
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Esrin Aydin, Moneisha Gokhale, Serap Azizoglu & Cenk Suphioglu. (2019) To See or Not to See: A Systematic Review of the Importance of Human Ocular Surface Cytokine Biosignatures in Ocular Allergy. Cells 8:6, pages 620.
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Helena Stabile, Gianluca Scarno, Cinzia Fionda, Angela Gismondi, Angela Santoni, Massimo Gadina & Giuseppe Sciumè. (2018) JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians. Immunological Reviews 286:1, pages 148-159.
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Emira Bousoik & Hamidreza Montazeri Aliabadi. (2018) “Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway. Frontiers in Oncology 8.
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Xinyan Wang, Linyong Du, He Wei, Anying Zhang, Kun Yang & Hong Zhou. (2018) Identification of two Stat3 variants lacking a transactivation domain in grass carp: New insights into alternative splicing in the modification of teleost Stat3 signaling. Fish & Shellfish Immunology 77, pages 13-21.
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Yu Zhang, Lei Zhang, Qisheng Zuo, Yinjie Wang, Yani Zhang, Qi Xu, Bichun Li & Guohong Chen. (2017) JAK-STAT signaling regulation of chicken embryonic stem cell differentiation into male germ cells. In Vitro Cellular & Developmental Biology - Animal 53:8, pages 728-743.
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Han Xu, Sihuan Zhang, Xiaoyan Zhang, Ruihua Dang, Chuzhao Lei, Hong Chen & Xianyong Lan. (2017) Evaluation of novel SNPs and haplotypes within the <i>ATBF1</i> gene and their effects on economically important production traits in cattle. Archives Animal Breeding 60:3, pages 285-296.
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Shubhasree Banerjee, Ann Biehl, Massimo Gadina, Sarfaraz Hasni & Daniella M. Schwartz. (2017) JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects. Drugs 77:5, pages 521-546.
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Mengmeng Jiang, Wen-wen Zhang, Pengpeng Liu, Wenwen Yu, Ting Liu & Jinpu Yu. (2017) Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment. Frontiers in Immunology 8.
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Victoria L.M. Rhodes & Kristin Michel. 2017. Arthropod Vector: Controller of Disease Transmission, Volume 1. Arthropod Vector: Controller of Disease Transmission, Volume 1 59 89 .
Clifford Liongue, Robert Sertori & Alister C. Ward. (2016) Evolution of Cytokine Receptor Signaling. The Journal of Immunology 197:1, pages 11-18.
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Yongming Sang, Qinfang Liu, Jinhwa Lee, Wenjun Ma, D. Scott McVey & Frank Blecha. (2016) Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity. Scientific Reports 6:1.
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Clifford Liongue, Tarannum Taznin & Alister C. Ward. (2016) Signaling via the CytoR/JAK/STAT/SOCS pathway: Emergence during evolution. Molecular Immunology 71, pages 166-175.
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Parisa Rasighaemi, Faiza Basheer, Clifford Liongue & Alister C Ward. (2015) Zebrafish as a model for leukemia and other hematopoietic disorders. Journal of Hematology & Oncology 8:1.
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Bin Cai, Jian-ping Cai, Yu-long Luo, Cheng Chen & Sen Zhang. (2015) The Specific Roles of JAK/STAT Signaling Pathway in Sepsis. Inflammation 38:4, pages 1599-1608.
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Joseph Sinkovics. (2015) The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review). International Journal of Oncology.
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Daniela Grifoni, Manuela Sollazzo, Elisabetta Fontana, Francesca Froldi & Annalisa Pession. (2015) Multiple strategies of oxygen supply in Drosophila malignancies identify tracheogenesis as a novel cancer hallmark. Scientific Reports 5:1.
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Xianfeng Wu, Wenchao Jia, Jingjing Zhang, Xiangcheng Li, Chuanying Pan, Chuzhao Lei, Hong Chen, Ruihua Dang & Xianyong Lan. (2014) Determination of the novel genetic variants of goat STAT5A gene and their effects on body measurement traits in two Chinese native breeds. Small Ruminant Research 121:2-3, pages 232-243.
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