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Special Focus Review

Therapeutic targeting of STAT pathways in CNS autoimmune diseases

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Article: e24134 | Published online: 01 Jan 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Uwe Pleyer, Engi Abdel-Hady Algharably, Eugen Feist & Reinhold Kreutz. (2017) Small molecules as therapy for uveitis: a selected perspective of new and developing agents. Expert Opinion on Pharmacotherapy 18:13, pages 1311-1323.
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Mark Plander & Bernadette Kalman. (2016) Rare autoimmune disorders with Mendelian inheritance. Autoimmunity 49:5, pages 285-297.
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Tsai-Ching Hsu, Chun-Ching Chiu, Shun-Chih Chang, Hsu-Chin Chan, Ya-Fang Shi, Tzy-Yen Chen & Bor-Show Tzang. (2016) Human parvovirus B19 VP1u Protein as inflammatory mediators induces liver injury in naïve mice. Virulence 7:2, pages 110-118.
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Mark H. Kaplan. (2013) STAT signaling in inflammation. JAK-STAT 2:1.
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Articles from other publishers (25)

Rahul Pandey, Marina Bakay & Hakon Hakonarson. (2023) SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis. Frontiers in Immunology 14.
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Aakanksha Jha, Joseph LarkinIIIIII & Erika Moore. (2023) SOCS1‐KIR Peptide in PEDGA Hydrogels Reduces Pro‐Inflammatory Macrophage Activation. Macromolecular Bioscience.
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Ioana S. Barac, Vitalie Văcăraș, Mihaela Iancu, Dafin F. Mureșanu & Lucia M. Procopciuc. (2023) Interleukins (IL-23 and IL-27) serum levels: Relationships with gene polymorphisms and disease patterns in multiple sclerosis patients under treatment with interferon and glatiramer acetate. Heliyon 9:6, pages e17427.
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Samaneh Reiszadeh-Jahromi, Mohammad Haddadi, Pegah Mousavi & Nima Sanadgol. (2022) Prophylactic effects of cucurbitacin B in the EAE Model of multiple sclerosis by adjustment of STAT3/IL-23/IL-17 axis and improvement of neuropsychological symptoms. Metabolic Brain Disease 37:8, pages 2937-2953.
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Caryn E. Plummer, Timothy Polk, Jatin Sharma, Sanghyo Sarah Bae, Olivia Barr, Amari Jones, Holly Kitchen, Michelle Wilhelmy, K. Devin, W. Clay Smith, Bryan D. Kolaczkowski & Joseph LarkinIIIIII. (2022) Open label safety and efficacy pilot to study mitigation of equine recurrent uveitis through topical suppressor of cytokine signaling-1 mimetic peptide. Scientific Reports 12:1.
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Nitish Kumar, Nidhi Sharma, Rishabh Khera, Ria Gupta & Sidharth Mehan. (2021) Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain. Metabolic Brain Disease 36:5, pages 911-925.
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Charles E. Egwuagu, Sahar A. Alhakeem & Evaristus C. Mbanefo. (2021) Uveitis: Molecular Pathogenesis and Emerging Therapies. Frontiers in Immunology 12.
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Chun Dang, Yaoheng Lu, Xingyu Chen & Qian Li. (2021) Baricitinib Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway. Frontiers in Immunology 12.
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Jatin Sharma, Teresa D. Collins, Tracoyia Roach, Shiwangi Mishra, Brandon K. Lam, Zaynab Sidi Mohamed, Antia E. Veal, Timothy B. Polk, Amari Jones, Caleb Cornaby, Mohammed I. Haider, Leilani Zeumer-Spataro, Howard M. Johnson, Laurence M. Morel & Joseph LarkinIIIIII. (2021) Suppressor of cytokine signaling-1 mimetic peptides attenuate lymphocyte activation in the MRL/lpr mouse autoimmune model. Scientific Reports 11:1.
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Kailei Guo & Xiaomin Zhang. (2021) Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis. Journal of Immunology Research 2021, pages 1-19.
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Fahad Almsned, Robert H. Lipsky & M. Saleet Jafri. (2021) Transcriptomic analysis of Multiple Sclerosis patient-derived monocytes by RNA-Sequencing for candidate gene discovery. Informatics in Medicine Unlocked 23, pages 100563.
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Arezoo Hosseini, Zohreh Babaloo, Tohid Gharibi, Navid Shomali, Faroogh Marofi, Vida Hashemi, Hormoz Ayromlou, Milad Asadi, Shima Rahmani, Saeed Noorolyai, Dariush Shanehbandi & Behzad Baradaran. (2020) Epigenetic mechanisms shape the underlining expression regulatory mechanisms of the STAT3 in multiple sclerosis disease. BMC Research Notes 13:1.
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Tohid Gharibi, Zohreh Babaloo, Arezoo Hosseini, Meghdad Abdollahpour-alitappeh, Vida Hashemi, Faroogh Marofi, Kazem Nejati & Behzad Baradaran. (2020) Targeting STAT3 in cancer and autoimmune diseases. European Journal of Pharmacology 878, pages 173107.
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Saba Manoochehrabadi, Shahram Arsang-Jang, Mehrdokht Mazdeh, Hidetoshi Inoko, Arezou Sayad & Mohammad Taheri. (2019) Analysis of STAT1, STAT2 and STAT3 mRNA expression levels in the blood of patients with multiple sclerosis. Human Antibodies 27:2, pages 91-98.
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Julie Schallhorn. 2019. Posterior Uveitis. Posterior Uveitis 209 225 .
Peng Xia, Xiaoting Gong, Lin Xiao, Yida Wang, Tianzhuo Zhang, Qinyuan Liao, Xiaoning Mo, Xiaoyan Qiu & Jing Huang. (2018) CCDC134 ameliorated experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells. Brain, Behavior, and Immunity 71, pages 158-168.
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Suman Acharya, Maheshwor Timilshina, Liyuan Jiang, Sabita Neupane, Dong-Young Choi, Sang Won Park, Sang Yeul Lee, Byeong-Seon Jeong, Jung-Ae Kim, Tae-gyu Nam & Jae-Hoon Chang. (2018) Amelioration of Experimental autoimmune encephalomyelitis and DSS induced colitis by NTG-A-009 through the inhibition of Th1 and Th17 cells differentiation. Scientific Reports 8:1.
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Jia-Xin Chen, Kang-Mei Huang, Meng Liu, Jin-Xiang Jiang, Jian-Peng Liu, Yu-Xiang Zhang, Chen Yang, Wen-Jun Xin & Xue-Qin Zhang. (2017) Activation of TLR4/STAT3 signaling in VTA contributes to the acquisition and maintenance of morphine-induced conditioned place preference. Behavioural Brain Research 335, pages 151-157.
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Zhiwei You, Maheshwor Timilshina, Byeong-Seon Jeong & Jae-Hoon Chang. (2017) BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway. European Journal of Immunology 47:9, pages 1488-1500.
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Maheshwor Timilshina, Youra Kang, Ishmit Dahal, Zhiwei You, Tae-gyu Nam, Keuk-Jun Kim, Byeong-Seon Jeong & Jae-Hoon Chang. (2017) BJ-3105, a 6-Alkoxypyridin-3-ol Analog, Impairs T Cell Differentiation and Prevents Experimental Autoimmune Encephalomyelitis Disease Progression. PLOS ONE 12:1, pages e0168942.
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Ke Ma, Xi Chen, Jia‐Cheng Chen, Ying Wang, Xi‐meng Zhang, Fan Huang, Jun‐Jiong Zheng, Xiong Chen, Wei Yu, Ke‐Ling Cheng, Yan‐Qing Feng & Huai‐yu Gu. (2016) Rifampicin attenuates experimental autoimmune encephalomyelitis by inhibiting pathogenic Th17 cells responses. Journal of Neurochemistry 139:6, pages 1151-1162.
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Chang He, Cheng-Rong Yu, Mary J. Mattapallil, Lin Sun, Joseph Larkin III & Charles E. Egwuagu. (2016) SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis). Mediators of Inflammation 2016, pages 1-15.
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John Fenimore & Howard A. Young. 2016. Regulation of Cytokine Gene Expression in Immunity and Diseases. Regulation of Cytokine Gene Expression in Immunity and Diseases 1 19 .
Ana I. RojoGethin McBeanMarina CindricJavier EgeaManuela G. LópezPatricia RadaNeven ZarkovicAntonio Cuadrado. (2014) Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance. Antioxidants & Redox Signaling 21:12, pages 1766-1801.
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Etty N. BenvenisteYudong LiuBraden C. McFarlandHongwei Qin. (2014) Involvement of the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway in Multiple Sclerosis and the Animal Model of Experimental Autoimmune Encephalomyelitis. Journal of Interferon & Cytokine Research 34:8, pages 577-588.
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