2,680
Views
54
CrossRef citations to date
0
Altmetric
Review

The involvement of JAK-STAT3 in cell motility, invasion, and metastasis

, &
Article: e28086 | Received 18 Nov 2013, Accepted 03 Feb 2014, Published online: 20 Feb 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Sundee Dees, Laura Pontiggia, Jean-Francois Jasmin & Isabelle Mercier. (2020) Phosphorylated STAT3 (Tyr705) as a biomarker of response to pimozide treatment in triple-negative breast cancer. Cancer Biology & Therapy 21:6, pages 506-521.
Read now
Eliza Kwiatkowska-Borowczyk, Patrycja Czerwińska, Jacek Mackiewicz, Katarzyna Gryska, Urszula Kazimierczak, Katarzyna Tomela, Anna Przybyła, Anna Karolina Kozłowska, Łukasz Galus, Łukasz Kwinta, Ewelina Dondajewska, Agnieszka Gąbka-Buszek, Monika Żakowska & Andrzej Mackiewicz. (2018) Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients. OncoImmunology 7:11.
Read now
Matteo Santoni, Francesco Massari, Marzia Del Re, Chiara Ciccarese, Francesco Piva, Giovanni Principato, Rodolfo Montironi, Daniele Santini, Romano Danesi, Giampaolo Tortora & Stefano Cascinu. (2015) Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer. Expert Opinion on Investigational Drugs 24:6, pages 809-824.
Read now

Articles from other publishers (50)

Huan Zhang, Mengxin Zhu, Anjing Zhao, Tongguo Shi & Qinhua Xi. (2024) B7-H3 regulates anti-tumor immunity and promotes tumor development in colorectal cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1879:1, pages 189031.
Crossref
Ga-Hee Ryoo, Geum Jin Kim, Ah-Reum Han, Chang Hyun Jin, Hunmin Lee, Joo-Won Nam, Hyukjae Choi & Chan-Hun Jung. (2023) Antimetastatic activity of seongsanamide B in γ-irradiated human lung cancer. Heliyon 9:9, pages e20179.
Crossref
Hehua Wang, Ziyu Dong, Jinhai Liu, Zhaoyu Zhu & Masoud Najafi. (2023) Mechanisms of Cancer-killing by Quercetin; A Review on Cell Death Mechanisms. Anti-Cancer Agents in Medicinal Chemistry 23:9, pages 999-1012.
Crossref
Qian Hu, Qihui Bian, Dingchao Rong, Leiyun Wang, Jianan Song, Hsuan-Shun Huang, Jun Zeng, Jie Mei & Peng-Yuan Wang. (2023) JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens. Frontiers in Bioengineering and Biotechnology 11.
Crossref
Mina Joo, Donghyun Kim, Myung-Won Lee, Hyo Jin Lee & Jin-Man Kim. (2023) GDF15 Promotes Cell Growth, Migration, and Invasion in Gastric Cancer by Inducing STAT3 Activation. International Journal of Molecular Sciences 24:3, pages 2925.
Crossref
Fariba Roshanzamir, Jonathan L. Robinson, Daniel Cook, Mohammad Hossein Karimi-Jafari & Jens Nielsen. (2022) Metastatic triple negative breast cancer adapts its metabolism to destination tissues while retaining key metabolic signatures. Proceedings of the National Academy of Sciences 119:35.
Crossref
Zhanzhan Li, Yanyan Li, Na Li, Liangfang Shen & Aibin Liu. (2022) Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma. Clinical Science 136:11, pages 895-909.
Crossref
Silvia Di Giacomo, Marco Gullì, Roberta Facchinetti, Marco Minacori, Romina Mancinelli, Ester Percaccio, Caterina Scuderi, Margherita Eufemi & Antonella Di Sotto. (2022) Sorafenib Chemosensitization by Caryophyllane Sesquiterpenes in Liver, Biliary, and Pancreatic Cancer Cells: The Role of STAT3/ABC Transporter Axis. Pharmaceutics 14:6, pages 1264.
Crossref
Seon-Yeong Lee, A Ram Lee, Jeong Won Choi, Chae Rim Lee, Keun-Hyung Cho, Jung Ho Lee & Mi-La Cho. (2022) IL-17 Induces Autophagy Dysfunction to Promote Inflammatory Cell Death and Fibrosis in Keloid Fibroblasts via the STAT3 and HIF-1α Dependent Signaling Pathways. Frontiers in Immunology 13.
Crossref
Lifei Liang, Xiaoqing Xu, Jiawei Li & Cheng Yang. (2022) Interaction Between microRNAs and Myeloid-Derived Suppressor Cells in Tumor Microenvironment. Frontiers in Immunology 13.
Crossref
Ameya J. Limaye, George N. Bendzunas, Matthew K. Whittaker, Timothy J. LeClair, Leah G. Helton & Eileen J. Kennedy. (2022) In Silico Optimized Stapled Peptides Targeting WASF3 in Breast Cancer . ACS Medicinal Chemistry Letters 13:4, pages 570-576.
Crossref
Ilnaz Rahimmanesh, Laleh Shariati, Nasim Dana, Yasaman Esmaeili, Golnaz Vaseghi & Shaghayegh Haghjooy Javanmard. (2022) Cancer Occurrence as the Upcoming Complications of COVID-19. Frontiers in Molecular Biosciences 8.
Crossref
Yong Teng, Reid Loveless, Elayne M Benson, Li Sun, Austin Y Shull & Chloe Shay. (2021) SHOX2 cooperates with STAT3 to promote breast cancer metastasis through the transcriptional activation of WASF3. Journal of Experimental & Clinical Cancer Research 40:1.
Crossref
Andreas Dzung, Annalisa Saltari, Natascia Tiso, Ruth Lyck, Reinhard Dummer & Mitchell P. Levesque. (2021) STK11 Prevents Invasion Through STAT3/5 and FAK Repression in Cutaneous Melanoma.. Journal of Investigative Dermatology.
Crossref
Guanghui Xu, Huiqi Wan, Litao Yi, Wei Chen, Youhua Luo, Yiqi Huang & Xiaojuan Liu. (2021) Berberine administrated with different routes attenuates inhaled LPS-induced acute respiratory distress syndrome through TLR4/NF-κB and JAK2/STAT3 inhibition. European Journal of Pharmacology 908, pages 174349.
Crossref
Zahra Memariani, Syed Qamar Abbas, Syed Shams ul Hassan, Amirhossein Ahmadi & Aroona Chabra. (2021) Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review. Pharmacological Research 171, pages 105264.
Crossref
Ahmad Othman, Marcus Winogradzki, Linus Lee, Manish Tandon, Alan Blank & Jitesh Pratap. (2021) Bone Metastatic Breast Cancer: Advances in Cell Signaling and Autophagy Related Mechanisms. Cancers 13:17, pages 4310.
Crossref
Paulina Wigner, Radosław Grębowski, Michał Bijak, Joanna Saluk-Bijak & Janusz Szemraj. (2021) The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development. International Journal of Molecular Sciences 22:9, pages 4483.
Crossref
Wanli Zhai, Xiongjun Ye, Yinyin Wang, Yarui Feng, Ying Wang, Yuting Lin, Lidan Ding, Liu Yang, Xuning Wang, Yanshen Kuang, Xinyuan Fu, Y. Eugene Chin, Baoqing Jia, Bingtao Zhu, Fangli Ren & Zhijie Chang. (2021) CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner. British Journal of Cancer 124:8, pages 1437-1448.
Crossref
Michelle Jaromy & Joshua D. Miller. (2021) Pharmacologic mechanisms underlying antidiabetic drug metformin’s chemopreventive effect against colorectal cancer. European Journal of Pharmacology 897, pages 173956.
Crossref
Anandita Basu, Anindhya Sundar Das, Pallab Kumar Borah, Raj Kumar Duary & Rupak Mukhopadhyay. (2020) Biochanin A impedes STAT3 activation by upregulating p38δ MAPK phosphorylation in IL-6-stimulated macrophages. Inflammation Research 69:11, pages 1143-1156.
Crossref
Xiwen Wang, Jun Tang, Jungang Zhao, Bin Lou & Li Li. (2020) ZFPM2-AS1 promotes the proliferation, migration, and invasion of human non-small cell lung cancer cells involving the JAK-STAT and AKT pathways. PeerJ 8, pages e10225.
Crossref
Jun-ya Han, Si Guo, Na Wei, Rui Xue, Wencai Li, Gang Dong, Jianhua Li, Xiangyu Tian, Chao Chen, Sen Qiu, Tong Wang, Qiankun Xiao, Chenguang Liu, Jingjing Xu & Kui-sheng Chen. (2020) ciRS-7 Promotes the Proliferation and Migration of Papillary Thyroid Cancer by Negatively Regulating the miR-7/Epidermal Growth Factor Receptor Axis. BioMed Research International 2020, pages 1-14.
Crossref
Jingyu Song, Xintao Gao, Zhe Tang, Hao Li, Yajun Ruan, Zhuo Liu, Tao Wang, Shaogang Wang, Jihong Liu & Hongyang Jiang. (2020) Protective effect of Berberine on reproductive function and spermatogenesis in diabetic rats via inhibition of ROS/JAK2/NFκB pathway. Andrology 8:3, pages 793-806.
Crossref
Magnolia Muk-Lan Lee, Brandon Dow Chan, Wing-Yan Wong, Zhao Qu, Man-Sum Chan, Tsz-Wing Leung, Yushan Lin, Daniel Kam-Wah Mok, Sibao Chen & William Chi-Shing Tai. (2020) Anti-cancer Activity of Centipeda minima Extract in Triple Negative Breast Cancer via Inhibition of AKT, NF-κB, and STAT3 Signaling Pathways. Frontiers in Oncology 10.
Crossref
Chandan Kanta Das, Bikash Chandra Jena, Ranabir Majumder, Himadri Tanaya Panda & Mahitosh Mandal. 2020. Autophagy in tumor and tumor microenvironment. Autophagy in tumor and tumor microenvironment 183 202 .
Guan-Min Jiang, Yuan Tan, Hao Wang, Liang Peng, Hong-Tao Chen, Xiao-Jun Meng, Ling-Ling Li, Yan Liu, Wen-Fang Li & Hong Shan. (2019) The relationship between autophagy and the immune system and its applications for tumor immunotherapy. Molecular Cancer 18:1.
Crossref
Shengli Pan, Yingying Deng, Jun Fu, Yuhao Zhang, Zhijin Zhang, Xiaokun Ru & Xianju Qin. (2019) TRIM52 promotes colorectal cancer cell proliferation through the STAT3 signaling. Cancer Cell International 19:1.
Crossref
Min Jee Jo, Soyeon Jeong, Hye Kyeong Yun, Dae Yeong Kim, Bo Ram Kim, Jung Lim Kim, Yoo Jin Na, Seong Hye Park, Yoon A. Jeong, Bu Gyeom Kim, Hassan Ashktorab, Duane T. Smoot, Jun Young Heo, Jeongsu Han, Dae-Hee Lee & Sang Cheul Oh. (2019) Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer. BMC Cancer 19:1.
Crossref
Pantipa Tonsawan, James Dylewski, Linda Lewis & Judith Blaine. (2019) Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton. American Journal of Physiology-Cell Physiology 317:5, pages C1048-C1060.
Crossref
Yael Belo, Zachery Mielko, Hila Nudelman, Ariel Afek, Oshrit Ben-David, Anat Shahar, Raz Zarivach, Raluca Gordan & Eyal Arbely. (2019) Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine. Biochimica et Biophysica Acta (BBA) - General Subjects 1863:9, pages 1343-1350.
Crossref
Gatta, Melocchi, Bugatti, Missale, Lonardi, Zanetti, Cristinelli, Belotti, Simeone, Ronca, Grillo, Licini, Bresciani, Tardanico, Chan, Giurisato, Calza & Vermi. (2019) Hyper-Activation of STAT3 Sustains Progression of Non-Papillary Basal-Type Bladder Cancer via FOSL1 Regulome. Cancers 11:9, pages 1219.
Crossref
Senthilnath Lakshmanachetty, Velmurugan Balaiya, Whitney A. High & Maranke I. Koster. (2019) Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling. Molecular Cancer Research 17:6, pages 1279-1293.
Crossref
Ahmad Ghasemi, Jafar Saeidi, Mohsen Azimi-Nejad & Seyed Isaac Hashemy. (2019) Leptin-induced signaling pathways in cancer cell migration and invasion. Cellular Oncology 42:3, pages 243-260.
Crossref
Meiying Li, Guangsheng Wan, Hongjie Yu & Wei Xiong. (2019) Retracted: High‐intensity focused ultrasound inhibits invasion and metastasis of colon cancer cells by enhancing microRNA‐124‐mediated suppression of STAT3 . FEBS Open Bio 9:6, pages 1128-1136.
Crossref
Nele Van Der Steen, Alessandro Leonetti, Kaylee Keller, Henk Dekker, Niccola Funel, Filip Lardon, Rob Ruijtenbeek, Marcello Tiseo, Christian Rolfo, Patrick Pauwels, Godefridus J. Peters & Elisa Giovannetti. (2019) Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line. Biochemical Pharmacology.
Crossref
Narjes Babchia, Solange Landreville, Bruno Clément, Cédric Coulouarn & Frédéric Mouriaux. (2019) The bidirectional crosstalk between metastatic uveal melanoma cells and hepatic stellate cells engenders an inflammatory microenvironment. Experimental Eye Research 181, pages 213-222.
Crossref
Nicole Pinto, Stephenie D. Prokopec, Frederick Vizeacoumar, Karlee Searle, Matthew Lowerison, Kara M. Ruicci, John Yoo, Kevin Fung, Danielle MacNeil, Jim C. Lacefield, Hon S. Leong, Joe S. Mymryk, John W. Barrett, Alessandro Datti, Paul C. Boutros & Anthony C. Nichols. (2018) Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models. PLOS ONE 13:11, pages e0207152.
Crossref
Shen Sun, Yue Wang, Yue Wu, Yue Gao, Qi Li, Ayanlaja Abdulrahman, Xin‑Feng Liu, Guang‑Quan Ji, Jin Gao, Li Li, Fa‑Ping Wan, Yun‑Qing Li & Dian‑Shuai Gao. (2018) Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma. International Journal of Oncology.
Crossref
Jun Lv, Yongkui Kong, Zhiqiang Gao, Yanmin Liu, Pengfei Zhu & Zujiang Yu. (2018) LncRNA TUG1 interacting with miR-144 contributes to proliferation, migration and tumorigenesis through activating the JAK2/STAT3 pathway in hepatocellular carcinoma. The International Journal of Biochemistry & Cell Biology 101, pages 19-28.
Crossref
Ruben Jansen, Birte Moehlendick, Christoph Bartenhagen, Csaba Tóth, Nadja Lehwald, Nikolas H. Stoecklein, Wolfram T. Knoefel & Anja Lachenmayer. (2018) ACGH detects distinct genomic alterations of primary intrahepatic cholangiocarcinomas and matched lymph node metastases and identifies a poor prognosis subclass. Scientific Reports 8:1.
Crossref
Puja Khanna, Joan Shuying Lee, Amornpun Sereemaspun, Haeryun Lee & Gyeong Hun Baeg. (2018) GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling. Scientific Reports 8:1.
Crossref
Bassam Janji, Guy Berchem & Salem Chouaib. (2018) Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity. Frontiers in Immunology 9.
Crossref
Mohammad W. Khan, Abdulrahman Saadalla, Ahmed H. Ewida, Khalid Al-Katranji, Ghadier Al-Saoudi, Zachary T. Giaccone, Fotini Gounari, Ming Zhang, David A. Frank & Khashayarsha Khazaie. (2017) The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer. Cancer Immunology, Immunotherapy 67:1, pages 13-23.
Crossref
Rong Lu, Yong-guo Zhang & Jun Sun. (2017) STAT3 activation in infection and infection-associated cancer. Molecular and Cellular Endocrinology 451, pages 80-87.
Crossref
Hasini Jayatilaka, Pranay Tyle, Jonathan J. Chen, Minsuk Kwak, Julia Ju, Hyun Ji Kim, Jerry S. H. Lee, Pei-Hsun Wu, Daniele M. Gilkes, Rong Fan & Denis Wirtz. (2017) Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration. Nature Communications 8:1.
Crossref
Gang Xu, Lihua Zhu, Yan Wang, Yawei Shi, Aihua Gong & Chaoyang Wu. (2017) Stattic Enhances Radiosensitivity and Reduces Radio-Induced Migration and Invasion in HCC Cell Lines through an Apoptosis Pathway. BioMed Research International 2017, pages 1-9.
Crossref
Cong Guo, Wei-Dong Chen & Yan-Dong Wang. (2016) TGR5, Not Only a Metabolic Regulator. Frontiers in Physiology 7.
Crossref
PUJA KHANNA, PEI JOU CHUA, BOON HUAT BAY & GYEONG HUN BAEG. (2015) The JAK/STAT signaling cascade in gastric carcinoma (Review). International Journal of Oncology 47:5, pages 1617-1626.
Crossref
Ting Zhang. (2015) Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. World Journal of Gastroenterology 21:6, pages 1804.
Crossref