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Nucleus Volume 3, 2012 - Issue 5
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Research Paper

Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins

Yuexia Wang Department of Medicine; College of Physicians and Surgeons; Columbia University; New York, NY USA; Department of Pathology and Cell Biology; College of Physicians and Surgeons; Columbia University; New York, NY USA
,
Cecilia Ӧstlund Department of Medicine; College of Physicians and Surgeons; Columbia University; New York, NY USA; Department of Pathology and Cell Biology; College of Physicians and Surgeons; Columbia University; New York, NY USA
,
Jason C. Choi Department of Medicine; College of Physicians and Surgeons; Columbia University; New York, NY USA; Department of Pathology and Cell Biology; College of Physicians and Surgeons; Columbia University; New York, NY USA
,
Theresa C. Swayne Herbert Irving Comprehensive Cancer Center; College of Physicians and Surgeons; Columbia University; New York, NY USA
,
Gregg G. Gundersen Department of Pathology and Cell Biology; College of Physicians and Surgeons; Columbia University; New York, NY USA
&
Howard J. Worman Department of Medicine; College of Physicians and Surgeons; Columbia University; New York, NY USA; Department of Pathology and Cell Biology; College of Physicians and Surgeons; Columbia University; New York, NY USACorrespondence[email protected]
Pages 452-462 | Published online: 16 Aug 2012

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Andrea Casasola, David Scalzo, Vivek Nandakumar, Jessica Halow, Félix Recillas-Targa, Mark Groudine & Héctor Rincón-Arano. (2016) Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders. Nucleus 7:1, pages 84-102.
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Stephen A. Adam, Veronika Butin-Israeli, Megan M. Cleland, Takeshi Shimi & Robert D. Goldman. (2013) Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors. Nucleus 4:2, pages 142-150.
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Articles from other publishers (23)

Ramona Hartinger, Eva-Maria Lederer, Elisa Schena, Giovanna Lattanzi & Karima Djabali. (2023) Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson–Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies. Cells 12:10, pages 1350.
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Noelle J. Batista, Sanket G. Desai, Alexis M. Perez, Alexa Finkelstein, Rachel Radigan, Manrose Singh, Aaron Landman, Brian Drittel, Daniella Abramov, Mina Ahsan, Samantha Cornwell & Dong Zhang. (2023) The Molecular and Cellular Basis of Hutchinson–Gilford Progeria Syndrome and Potential Treatments. Genes 14:3, pages 602.
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Mattia La Torre, Chiara Merigliano, Klizia Maccaroni, Alexandre Chojnowski, Wah Ing Goh, Maria Giubettini, Fiammetta Vernì, Cristina Capanni, Daniela Rhodes, Graham Wright, Brian Burke, Silvia Soddu, Romina Burla & Isabella Saggio. (2022) Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP. Journal of Experimental & Clinical Cancer Research 41:1.
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Rouven Arnold, Elena Vehns, Hannah Randl & Karima Djabali. (2021) Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells. International Journal of Molecular Sciences 22:14, pages 7474.
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Manuel Hernández Sigüenza. (2021) Descubrimiento de varios fragmentos de una biblia hebrea (Calahorra, s. XIV). Sefarad 81:1, pages 89-106.
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Halida P. Widyastuti, Trina M. Norden-Krichmar, Anna Grosberg & Michael V. Zaragoza. (2020) Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis. BMC Medical Genetics 21:1.
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Benjamin Cogné, Jamal-Eddine Bouameur, Gaëlle Hayot, Xenia Latypova, Sundararaghavan Pattabiraman, Amandine Caillaud, Karim Si-Tayeb, Thomas Besnard, Sébastien Küry, Caroline Chariau, Anne Gaignerie, Laurent David, Philippe Bordure, Daniel Kaganovich, Stéphane Bézieau, Christelle Golzio, Thomas M. Magin & Bertrand Isidor. (2020) A dominant vimentin variant causes a rare syndrome with premature aging. European Journal of Human Genetics 28:9, pages 1218-1230.
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Kang So-mi, Kim Minju & Park Bum-Joon. (2020) Development of a new drug for progeria syndrome; Past, Present and Future. Archive of Gerontology and Geriatrics Research 5:1, pages 022-025.
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Daniel Scherman & Christine Fetro. (2020) Drug repositioning for rare diseases: Knowledge-based success stories. Therapies 75:2, pages 161-167.
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Yuexia Wang, Ji-Yeon Shin, Koki Nakanishi, Shunichi Homma, Grace J Kim, Kurenai Tanji, Leroy C Joseph, John P Morrow, Colin L Stewart, Willian T Dauer & Howard J Worman. (2019) Postnatal development of mice with combined genetic depletions of lamin A/C, emerin and lamina-associated polypeptide 1. Human Molecular Genetics 28:15, pages 2486-2500.
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Craig S. Clements, Mehmet U. Bikkul, Wendy Ofosu, Christopher Eskiw, David Tree, Evgeny Makarov, Ian R. Kill & Joanna M. Bridger. (2019) Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways. Biogerontology 20:3, pages 337-358.
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Wakam ChangYuexia Wang, G. W. Gant LuxtonCecilia Östlund, Howard J. Worman & Gregg G. Gundersen. (2019) Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging. Proceedings of the National Academy of Sciences 116:9, pages 3578-3583.
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Hsiang-Jung Chen, Chee Ying Chew, En-Hao Chang, Yu-Wei Tu, Li-Yu Wei, Bo-Han Wu, Chien-Hung ChenYa-Ting YangSu-Chin HuangJen-Kun ChenI-Chia Chen & Kui-Thong Tan. (2018) S - Cis Diene Conformation: A New Bathochromic Shift Strategy for Near-Infrared Fluorescence Switchable Dye and the Imaging Applications . Journal of the American Chemical Society 140:15, pages 5224-5234.
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Yi-Ru HongChak Hin LamKui-Thong Tan. (2017) Fluorogenic Protein Labeling Probes to Study the Morphological Interplay between PreLamin and Mature Lamin. Bioconjugate Chemistry 28:11, pages 2895-2902.
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Svatava Snopková. (2017) HIV infection - a new disease of internal medicine. Vnitřní lékařství 63:7-8, pages 502-506.
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Andrew M. Cobb, Delphine Larrieu, Derek T. Warren, Yiwen Liu, Sonal Srivastava, Andrew J. O. Smith, Richard P. Bowater, Stephen P. Jackson & Catherine M. Shanahan. (2016) Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient. Aging Cell 15:6, pages 1039-1050.
Crossref
Yuexia Wang, Uta Lichter-Konecki, Kwame Anyane-Yeboa, Jessica E. Shaw, Jonathan T. Lu, Cecilia Östlund, Ji-Yeon Shin, Lorraine N. Clark, Gregg G. Gundersen, Peter L. Nagy & Howard J. Worman. (2016) A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder. Journal of Cell Science 129:10, pages 1975-1980.
Crossref
Veronika Eisch, Xiang Lu, Diana Gabriel & Karima Djabali. (2016) Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts. Oncotarget 7:17, pages 24700-24718.
Crossref
Diana Gabriel, Daniela Roedl, Leslie B. Gordon & Karima Djabali. (2015) Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts. Aging Cell 14:1, pages 78-91.
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Laurin Marie Pacheco, Lourdes Adriana Gomez, Janice Dias, Noel M Ziebarth, Guy A Howard & Paul C Schiller. (2014) Progerin expression disrupts critical adult stem cell functions involved in tissue repair. Aging 6:12, pages 1049-1063.
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María Genoveva González Morán. (2014) Síndrome de Progeria de Hutchinson-Gilford. Causas, investigación y tratamientos farmacológicos. Educación Química 25:4, pages 432-439.
Crossref
Delphine LarrieuSébastien BrittonMukerrem DemirRaphaël RodriguezStephen P. Jackson. (2014) Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells. Science 344:6183, pages 527-532.
Crossref
Rebecca A Torres & William Lewis. (2014) Aging and HIV/AIDS: pathogenetic role of therapeutic side effects. Laboratory Investigation 94:2, pages 120-128.
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