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Review

The immuno-oncology framework

Enabling a new era of cancer therapy

&
Pages 334-339 | Published online: 01 May 2012

Keep up to date with the latest research on this topic with citation updates for this article.

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S. Harrison Farber, Aladine A. Elsamadicy, Ahmet Fatih Atik, Carter M. Suryadevara, Pakawat Chongsathidkiet, Peter E. Fecci & John H. Sampson. (2017) The Safety of available immunotherapy for the treatment of glioblastoma. Expert Opinion on Drug Safety 16:3, pages 277-287.
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Joseph M. Ryan, Jeffrey S. Wasser, Adam J. Adler & Anthony T. Vella. (2016) Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?. Expert Opinion on Biological Therapy 16:5, pages 655-674.
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Gheath Alatrash, Haroon Jakher, Patricia D Stafford & Elizabeth A Mittendorf. (2013) Cancer immunotherapies, their safety and toxicity. Expert Opinion on Drug Safety 12:5, pages 631-645.
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Axel Hoos, Sylvia Janetzki & Cedrik M. Britten. (2012) Advancing the field of cancer immunotherapy. OncoImmunology 1:9, pages 1457-1459.
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Articles from other publishers (31)

Yuying Dong, Mingming Zheng, Xiaoxuan Wang, Chenyue Yu, Tiantian Qin & Xuning Shen. (2023) High expression of CDKN2A is associated with poor prognosis in colorectal cancer and may guide PD-1-mediated immunotherapy. BMC Cancer 23:1.
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Joonatan Mattila, Silja Sormunen, Nelli Heikkilä, Ilkka P. Mattila, Jari Saramäki & T. Petteri Arstila. (2023) Analysis of thymic generation of shared T‐cell receptor α repertoire associated with recognition of tumor antigens shows no preference for neoantigens over wild‐type antigens. Cancer Medicine 12:12, pages 13486-13496.
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Olamide Tosin Olaoba, Kehinde Sulaimon Ayinde, Olubodun Michael Lateef, Michael Olawale Akintubosun, Khadijat Ayodeji Lawal & Temitope Isaac Adelusi. (2023) Is the new angel better than the old devil? Challenges and opportunities in CD47- SIRPα-based cancer therapy. Critical Reviews in Oncology/Hematology 184, pages 103939.
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M. Vindhya, M. N. Ramesh Bharadwaj, Kanthesh M. Basalingappa, T. S. Gopenath & Ashok Gnanasekaran. 2023. Targeted Cancer Therapy in Biomedical Engineering. Targeted Cancer Therapy in Biomedical Engineering 179 217 .
Yinghan Chan, Joycelin Zhu Xin Tan, Xin Wei Lim, Dinesh Kumar Chellappan & Kamal Dua. 2023. Synbiotics for the Management of Cancer. Synbiotics for the Management of Cancer 61 98 .
Rahela Zaman, Rowshan Ara Islam & Ezharul Hoque Chowdhury. (2022) Evolving therapeutic proteins to precisely kill cancer cells. Journal of Controlled Release 351, pages 779-804.
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Matthew M. Gubin & Matthew D. Vesely. (2022) Cancer Immunoediting in the Era of Immuno-oncology. Clinical Cancer Research 28:18, pages 3917-3928.
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Yuanfei Lu, Na Feng, Yongzhong Du & Risheng Yu. (2022) Nanoparticle-Based Therapeutics to Overcome Obstacles in the Tumor Microenvironment of Hepatocellular Carcinoma. Nanomaterials 12:16, pages 2832.
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Adriana Petrazzuolo, Maria Perez-Lanzon, Isabelle Martins, Peng Liu, Oliver Kepp, Véronique Minard-Colin, Maria Chiara Maiuri & Guido Kroemer. (2021) Pharmacological inhibitors of anaplastic lymphoma kinase (ALK) induce immunogenic cell death through on-target effects. Cell Death & Disease 12:8.
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Meike Kohlruss, Katja Ott, Bianca Grosser, Moritz Jesinghaus, Julia Slotta-Huspenina, Alexander Novotny, Alexander Hapfelmeier, Thomas Schmidt, Matthias M. Gaida, Wilko Weichert & Gisela Keller. (2021) Sexual Difference Matters: Females with High Microsatellite Instability Show Increased Survival after Neoadjuvant Chemotherapy in Gastric Cancer. Cancers 13:5, pages 1048.
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Carolin Haeussler & Anne Assmus. (2021) Bridging the gap between invention and innovation: Increasing success rates in publicly and industry-funded clinical trials. Research Policy 50:2, pages 104155.
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Izabela Karwacka, Łukasz Obołończyk, Sonia Kaniuka-Jakubowska & Krzysztof Sworczak. (2021) The Role of Immunotherapy in the Treatment of Adrenocortical Carcinoma. Biomedicines 9:2, pages 98.
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AnjumMehmood Dhamani, HardikSanjeev Sheth, Susrita Bhattacharyya & ImranNisar Shaikh. (2021) Paradigm shift from palliation to cure in metastatic microsatellite high colorectal carcinoma with immune checkpoint inhibitors. Journal of Cancer Research and Therapeutics 17:6, pages 1552.
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Salonee Martins, Purva Salvi, Sai Tejaswi Lavuri, Manjita Srivastava, Shalini Sakthivel, Muneesh Kumar Barman, Kailash Chand, Meenakshi Singh, Subash C. Sonkar & Prudhvilal Bhukya. 2021. Handbook of Research on Advancements in Cancer Therapeutics. Handbook of Research on Advancements in Cancer Therapeutics 42 88 .
Fatemeh Sadeghi, Ali Sanjari Moghaddam & Saeed Soleyman-Jahi. 2021. Cancer Immunology. Cancer Immunology 597 635 .
François-Emery Cotté, Paméla Voillot, Bryan Bennett, Bruno Falissard, Christophe Tzourio, Pierre Foulquié, Anne-Françoise Gaudin, Hervé Lemasson, Valentine Grumberg, Laura McDonald, Carole Faviez & Stéphane Schück. (2020) Exploring the Health-Related Quality of Life of Patients Treated With Immune Checkpoint Inhibitors: Social Media Study. Journal of Medical Internet Research 22:9, pages e19694.
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Yuanyuan Zhang & Zemin Zhang. (2020) The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Cellular & Molecular Immunology 17:8, pages 807-821.
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Marc Buyse, Everardo D. Saad, Tomasz Burzykowski & Julien Péron. (2020) Assessing Treatment Benefit in Immuno-oncology. Statistics in Biosciences 12:2, pages 83-103.
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Chang Hoon Lee, Jungsook Cho & Kyeong Lee. (2020) Tumour Regression via Integrative Regulation of Neurological, Inflammatory, and Hypoxic Tumour Microenvironment. Biomolecules & Therapeutics 28:2, pages 119-130.
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Beth L Nordstrom, Mustafa Oguz, Bong Chul Chu, Mario Ouwens, Henrik-Tobias Arkenau & Alyssa B Klein. (2020) Effectiveness of durvalumab versus chemotherapy in metastatic urothelial cancer: an observational, indirect comparison. Journal of Comparative Effectiveness Research 9:3, pages 191-199.
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M. Provencio, E. Carcereny & Á. Artal. (2019) Consensus on the use of immune-related response criteria to evaluate the efficacy of immunotherapy in non-small cell lung cancer. Clinical and Translational Oncology 21:11, pages 1464-1471.
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Quoc-Viet Le, Geon Yang, Yina Wu, Ho Won Jang, Mohammadreza Shokouhimehr & Yu-Kyoung Oh. (2019) Nanomaterials for modulating innate immune cells in cancer immunotherapy. Asian Journal of Pharmaceutical Sciences 14:1, pages 16-29.
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Antje Hoering, Brian Durie, Hongwei Wang & John Crowley. (2017) End points and statistical considerations in immuno-oncology trials: impact on multiple myeloma. Future Oncology 13:13, pages 1181-1193.
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Axel Hoos. (2016) Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations. Nature Reviews Drug Discovery 15:4, pages 235-247.
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Sangeetha De & Linda Meredith. (2016) A unique multiattribute method to predict success of emerging drug targets. Drug Discovery Today 21:3, pages 385-394.
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Pankita H. Pandya, Mary E. Murray, Karen E. Pollok & Jamie L. Renbarger. (2016) The Immune System in Cancer Pathogenesis: Potential Therapeutic Approaches. Journal of Immunology Research 2016, pages 1-13.
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Litao Zhang & Carl Decicco. 2014. Collaborative Innovation in Drug Discovery. Collaborative Innovation in Drug Discovery 31 56 .
Cristina Suárez, Rafael Morales-Barrera, Victor Ramos, Isaac Núñez, Claudia Valverde, Jacques Planas, Juan Morote, Xavier Maldonado & Joan Carles. (2014) Role of Immunotherapy in Castration-Resistant Prostate Cancer (CRPC). BJU International 113:3, pages 367-375.
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Jessica Marshall. (2014) Identification of differences in immunotherapy knowledge and practice patterns among oncologists from six European countries. Molecular and Clinical Oncology.
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Francesca Kalli, Rodolfo Machiorlatti, Florinda Battaglia, Alessia Parodi, Giuseppina Conteduca, Francesca Ferrera, Michele Proietti, Samuele Tardito, Marina Sanguineti, Enrico Millo, Daniela Fenoglio, Raffaele De Palma, Giorgio Inghirami & Gilberto Filaci. (2013) Comparative analysis of cancer vaccine settings for the selection of an effective protocol in mice. Journal of Translational Medicine 11:1.
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