Advanced search
Publication Cover
OncoImmunology Volume 2, 2013 - Issue 4
Submit an article Journal homepage
1,327
Views
38
CrossRef citations to date
0
Altmetric
Original Research

Hepatic metastases of colorectal cancer are rather homogeneous but differ from primary lesions in terms of immune cell infiltration

Niels Halama National Center for Tumor Diseases; Medical Oncology and Internal Medicine VI; University Hospital Heidelberg; Heidelberg, Germany; Tissue Imaging and Analysis Center (TIGA); BIOQUANT; Heidelberg, Germany
,
Anna Spille National Center for Tumor Diseases; Medical Oncology and Internal Medicine VI; University Hospital Heidelberg; Heidelberg, Germany; Tissue Imaging and Analysis Center (TIGA); BIOQUANT; Heidelberg, Germany
,
Tina Lerchl National Center for Tumor Diseases; Medical Oncology and Internal Medicine VI; University Hospital Heidelberg; Heidelberg, Germany; Tissue Imaging and Analysis Center (TIGA); BIOQUANT; Heidelberg, Germany
,
Karsten Brand Institute for Pathology; University Hospital Heidelberg; Heidelberg, Germany
,
Esther Herpel Institute for Pathology; University Hospital Heidelberg; Heidelberg, Germany
,
Stefan Welte National Center for Tumor Diseases; Medical Oncology and Internal Medicine VI; University Hospital Heidelberg; Heidelberg, Germany
,
Sophia Keim National Center for Tumor Diseases; Medical Oncology and Internal Medicine VI; University Hospital Heidelberg; Heidelberg, Germany; Tissue Imaging and Analysis Center (TIGA); BIOQUANT; Heidelberg, Germany
,
Bernd Lahrmann National Center for Tumor Diseases; Medical Oncology and Internal Medicine VI; University Hospital Heidelberg; Heidelberg, Germany; Tissue Imaging and Analysis Center (TIGA); BIOQUANT; Heidelberg, Germany
,
Fee Klupp Department of Surgery; University Hospital Heidelberg; Heidelberg, Germany
,
Christoph Kahlert Department of Surgery; University Hospital Heidelberg; Heidelberg, Germany
,
Jürgen Weitz Department of Surgery; University Hospital Heidelberg; Heidelberg, Germany
,
Niels Grabe National Center for Tumor Diseases; Medical Oncology and Internal Medicine VI; University Hospital Heidelberg; Heidelberg, Germany; Tissue Imaging and Analysis Center (TIGA); BIOQUANT; Heidelberg, Germany
,
Dirk Jaeger National Center for Tumor Diseases; Medical Oncology and Internal Medicine VI; University Hospital Heidelberg; Heidelberg, Germany
&
Inka Zoernig National Center for Tumor Diseases; Medical Oncology and Internal Medicine VI; University Hospital Heidelberg; Heidelberg, GermanyCorrespondence[email protected]
 show all
Article: e24116 | Received 13 Jul 2012, Accepted 26 Feb 2013, Published online: 01 Apr 2013

Citations (38)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

David Henault, David Stephen, Pierre-Antoine St-Hilaire, Nouredin Messaoudi, Franck Vandenbroucke-Menu, Eve Simoneau, Zhixia Rong, Marylène Plasse, Richard Létourneau, André Roy, Michel Dagenais, Réal Lapointe, Bich Nguyen, Anne-Marie Mes-Masson, G. Soucy & Simon Turcotte. (2023) Homogeneity in immune features between colorectal liver metastases better identifies patients with good prognosis compared to pathological response to preoperative chemotherapy. OncoImmunology 12:1.
Read now
Azaz Ahmed, Sophia Köhler, Rosa Klotz, Nathalia Giese, Felix Lasitschka, Thilo Hackert, Christoph Springfeld, Inka Zörnig, Dirk Jäger & Niels Halama. (2021) Peripheral blood and tissue assessment highlights differential tumor-circulatory gradients of IL2 and MIF with prognostic significance in resectable pancreatic ductal adenocarcinoma. OncoImmunology 10:1.
Read now
Guoying Zhou, Lisanne Noordam, Dave Sprengers, Michail Doukas, Patrick P. C. Boor, Adriaan A. van Beek, Remco Erkens, Shanta Mancham, Dirk Grünhagen, Anand G. Menon, Johan F. Lange, Pim J. W. A. Burger, Alexandra Brandt, Boris Galjart, Cornelis Verhoef, Jaap Kwekkeboom & Marco J. Bruno. (2018) Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer. OncoImmunology 7:7.
Read now
Anna Berthel, Inka Zoernig, Nektarios A. Valous, Christoph Kahlert, Fee Klupp, Alexis Ulrich, Juergen Weitz, Dirk Jaeger & Niels Halama. (2017) Detailed resolution analysis reveals spatial T cell heterogeneity in the invasive margin of colorectal cancer liver metastases associated with improved survival. OncoImmunology 6:3.
Read now

Articles from other publishers (34)

Qicong Chen, Ming Cai, Xinjuan Fan, Wenbin Liu, Gang Fang, Su Yao, Yao Xu, Qian Li, Yingnan Zhao, Ke Zhao, Zaiyi Liu & Zhihua Chen. (2023) An artificial intelligence-based ecological index for prognostic evaluation of colorectal cancer. BMC Cancer 23:1.
Crossref
Marion Thibaudin, Jean-David Fumet, Benoist Chibaudel, Jaafar Bennouna, Christophe Borg, Jerome Martin-Babau, Romain Cohen, Marianne Fonck, Julien Taieb, Emeric Limagne, Julie Blanc, Elise Ballot, Léa Hampe, Marjorie Bon, Susy Daumoine, Morgane Peroz, Hugo Mananet, Valentin Derangère, Romain Boidot, Henri-Alexandre Michaud, Caroline Laheurte, Olivier Adotevi, Aurélie Bertaut, Caroline Truntzer & François Ghiringhelli. (2023) First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial. Nature Medicine 29:8, pages 2087-2098.
Crossref
Alessandro Parodi, Dmitry Kostyushev, Sergey Brezgin, Anastasiya Kostyusheva, Tatiana Borodina, Roman Akasov, Anastasia Frolova, Vladimir Chulanov & Andrey A. ZamyatninJr.Jr.. (2022) Biomimetic approaches for targeting tumor-promoting inflammation. Seminars in Cancer Biology 86, pages 555-567.
Crossref
Marion Thibaudin, Emeric Limagne, Léa Hampe, Elise Ballot, Caroline Truntzer & Francois Ghiringhelli. (2022) Targeting PD-L1 and TIGIT could restore intratumoral CD8 T cell function in human colorectal cancer. Cancer Immunology, Immunotherapy 71:10, pages 2549-2563.
Crossref
Ajaz A. Bhat, Sabah Nisar, Mayank Singh, Bazella Ashraf, Tariq Masoodi, Chandra P. Prasad, Atul Sharma, Selma Maacha, Thasni Karedath, Sheema Hashem, Syed Besina Yasin, Puneet Bagga, Ravinder Reddy, Michael P. Frennaux, Shahab Uddin, Punita Dhawan, Mohammad Haris & Muzafar A. Macha. (2022) Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy. Cancer Communications 42:8, pages 689-715.
Crossref
Marine Jary, Wen‐Wei Liu, Dongyao Yan, Isaac Bai, Andrea Muranyi, Elise Colle, Isabelle Brocheriou, Anthony Turpin, Nina Radosevic‐Robin, Pierre Bourgoin, Frédérique Penault‐Llorca, Romain Cohen, Dewi Vernerey, Thierry André, Christophe Borg, Kandavel Shanmugam & Magali Svrcek. (2022) Immune microenvironment in patients with mismatch‐repair‐proficient oligometastatic colorectal cancer exposed to chemotherapy: the randomized MIROX GERCOR cohort study. Molecular Oncology 16:11, pages 2260-2273.
Crossref
Nouredin Messaoudi, David Henault, David Stephen, Isabelle Cousineau, Eve Simoneau, Zhixia Rong, Richard Létourneau, Marylène Plasse, Michel Dagenais, André Roy, Réal Lapointe, Franck Vandenbroucke-Menu, Rastislav Kunda, Dirk Ysebaert, Geneviève Soucy, John Stagg, Peter Vermeulen & Simon Turcotte. (2022) Prognostic implications of adaptive immune features in MMR-proficient colorectal liver metastases classified by histopathological growth patterns. British Journal of Cancer 126:9, pages 1329-1338.
Crossref
Georg Martin Haag, Christoph Springfeld, Barbara Grün, Leonidas Apostolidis, Stefanie Zschäbitz, Mareike Dietrich, Anne-Katrin Berger, Tim Frederik Weber, Inka Zoernig, Marina Schaaf, Lisa Waberer, Daniel Wilhelm Müller, Salah-Eddin Al-Batran, Niels Halama & Dirk Jaeger. (2022) Pembrolizumab and maraviroc in refractory mismatch repair proficient/microsatellite-stable metastatic colorectal cancer – The PICCASSO phase I trial. European Journal of Cancer 167, pages 112-122.
Crossref
Nándor Polk, Barna Budai, Erika Hitre, Attila Patócs & Tamás Mersich. (2022) High Neutrophil-To-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammation Index (SII) Are Markers of Longer Survival After Metastasectomy of Patients With Liver-Only Metastasis of Rectal Cancer. Pathology and Oncology Research 28.
Crossref
Hui Zhou, Zhongtao Liu, Yongxiang Wang, Xiaoyong Wen, Eric H. Amador, Liqin Yuan, Xin Ran, Li Xiong, Yuping Ran, Wei Chen & Yu Wen. (2022) Colorectal liver metastasis: molecular mechanism and interventional therapy. Signal Transduction and Targeted Therapy 7:1.
Crossref
Violaine Randrian, Amandine Desette, Sheik Emambux, Valentin Derangere, Pauline Roussille, Eric Frouin, Julie Godet, Lucie Karayan-Tapon, François Ghiringhelli & David Tougeron. (2021) New Artificial Intelligence Score and Immune Infiltrates as Prognostic Factors in Colorectal Cancer With Brain Metastases. Frontiers in Immunology 12.
Crossref
Meggy Suarez-Carmona, Anja Williams, Jutta Schreiber, Nicolas Hohmann, Ulrike Pruefer, Jürgen Krauss, Dirk Jäger, Anna Frömming, Diana Beyer, Dirk Eulberg, Jarf Ulf Jungelius, Matthias Baumann, Aram Mangasarian & Niels Halama. (2021) Combined inhibition of CXCL12 and PD-1 in MSS colorectal and pancreatic cancer: modulation of the microenvironment and clinical effects. Journal for ImmunoTherapy of Cancer 9:10, pages e002505.
Crossref
Vegar Johansen Dagenborg, Serena Elizabeth Marshall, Krzysztof Grzyb, Åsmund Avdem Fretland, Marius Lund-Iversen, Gunhild Mari Mælandsmo, Anne Hansen Ree, Bjørn Edwin, Sheraz Yaqub & Kjersti Flatmark. (2021) Low Concordance Between T-Cell Densities in Matched Primary Tumors and Liver Metastases in Microsatellite Stable Colorectal Cancer. Frontiers in Oncology 11.
Crossref
Elodie Pramil, Clémentine Dillard & Alexandre E. Escargueil. (2021) Colorectal Cancer and Immunity: From the Wet Lab to Individuals. Cancers 13:7, pages 1713.
Crossref
Maarit Ahtiainen, Hanna Elomaa, Juha P. Väyrynen, Erkki-Ville Wirta, Teijo Kuopio, Olli Helminen, Toni T. Seppälä, Ilmo Kellokumpu & Jukka-Pekka Mecklin. (2021) Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases. Cancers 13:7, pages 1530.
Crossref
Alessandra Rigamonti, Friedrich Feuerhake, Matteo Donadon, Massimo Locati & Federica Marchesi. (2021) Histopathological and Immune Prognostic Factors in Colo-Rectal Liver Metastases. Cancers 13:5, pages 1075.
Crossref
Niels Halama & Uwe Haberkorn. (2020) The Unmet Needs of the Diagnosis, Staging, and Treatment of Gastrointestinal Tumors. Seminars in Nuclear Medicine 50:5, pages 389-398.
Crossref
Elisabeth S. Gruber, Georg Oberhuber, Dietmar Pils, Theresa Stork, Katharina Sinn, Sylvia Gruber, Robert Nica, Dan Kolmer, Suzanne D. Turner, Michaela Schlederer, Joachim Widder, Wolfgang Doerr, Béla Teleky & Lukas Kenner. (2020) The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray. Cancers 12:3, pages 563.
Crossref
Anita Sveen, Scott Kopetz & Ragnhild A. Lothe. (2019) Biomarker-guided therapy for colorectal cancer: strength in complexity. Nature Reviews Clinical Oncology 17:1, pages 11-32.
Crossref
Luca Vigano, Cristiana Soldani, Barbara Franceschini, Matteo Cimino, Ana Lleo, Matteo Donadon, Massimo Roncalli, Alessio Aghemo, Luca Di Tommaso & Guido Torzilli. (2019) Tumor-Infiltrating Lymphocytes and Macrophages in Intrahepatic Cholangiocellular Carcinoma. Impact on Prognosis after Complete Surgery. Journal of Gastrointestinal Surgery 23:11, pages 2216-2224.
Crossref
Guoying Zhou, Dave Sprengers, Shanta Mancham, Remco Erkens, Patrick P.C. Boor, Adriaan A. van Beek, Michail Doukas, Lisanne Noordam, Lucia Campos Carrascosa, Valeska de Ruiter, Roelof W.F. van Leeuwen, Wojciech G. Polak, Jeroen de Jonge, Bas Groot Koerkamp, Belle van Rosmalen, Thomas M. van Gulik, Joanne Verheij, Jan N.M. IJzermans, Marco J. Bruno & Jaap Kwekkeboom. (2019) Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex vivo targeting immune checkpoint molecules. Journal of Hepatology 71:4, pages 753-762.
Crossref
Jakob Nikolas Kather & Niels Halama. (2019) Harnessing the innate immune system and local immunological microenvironment to treat colorectal cancer. British Journal of Cancer 120:9, pages 871-882.
Crossref
Fanny Ledys, Quentin Klopfenstein, Caroline Truntzer, Laurent Arnould, Julie Vincent, Leila Bengrine, Romain Remark, Romain Boidot, Sylvain Ladoire, Francois Ghiringhelli & Valentin Derangere. (2018) RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer. Journal for ImmunoTherapy of Cancer 6:1.
Crossref
Valentin Barsan & Paul C. Tumeh. 2018. Early Phase Cancer Immunotherapy. Early Phase Cancer Immunotherapy 1 28 .
Niels Halama. 2018. Oncoimmunology. Oncoimmunology 621 639 .
Jessica Roelands, Peter Kuppen, Louis Vermeulen, Cristina Maccalli, Julie Decock, Ena Wang, Francesco Marincola, Davide Bedognetti & Wouter Hendrickx. (2017) Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications. International Journal of Molecular Sciences 18:10, pages 2229.
Crossref
Mehmet Asim Bilen, Kenneth R. Hess, Sumit K. Subudhi, Ana Aparicio, Jeri Kim, Amado J. Zurita-Saavedra, John C. Araujo, Paul G. Corn, Jessica Stover, Sue-Hwa Lin, Christopher J. Logothetis & Shi-Ming Tu. (2017) Clinical predictors of survival in patients with castration-resistant prostate cancer receiving sipuleucel-T cellular immunotherapy. Cancer Chemotherapy and Pharmacology 80:3, pages 583-589.
Crossref
Jakob Nikolas Kather, Frank Gerrit Zöllner, Lothar R. Schad, Susanne Maria Melchers, Hans-Peter Sinn, Alexander Marx, Timo Gaiser & Cleo-Aron Weis. (2017) Identification of a characteristic vascular belt zone in human colorectal cancer. PLOS ONE 12:3, pages e0171378.
Crossref
Thomas Schweiger, Anna Sophie Berghoff, Christoph Glogner, Olaf Glueck, Orsolya Rajky, Denise Traxler, Peter Birner, Matthias Preusser, Walter Klepetko & Konrad Hoetzenecker. (2016) Tumor-infiltrating lymphocyte subsets and tertiary lymphoid structures in pulmonary metastases from colorectal cancer. Clinical & Experimental Metastasis 33:7, pages 727-739.
Crossref
Priti S. Hegde, Vaios Karanikas & Stefan Evers. (2016) The Where, the When, and the How of Immune Monitoring for Cancer Immunotherapies in the Era of Checkpoint Inhibition. Clinical Cancer Research 22:8, pages 1865-1874.
Crossref
Niels Halama, Inka Zoernig, Anna Berthel, Christoph Kahlert, Fee Klupp, Meggy Suarez-Carmona, Thomas Suetterlin, Karsten Brand, Juergen Krauss, Felix Lasitschka, Tina Lerchl, Claudia Luckner-Minden, Alexis Ulrich, Moritz Koch, Juergen Weitz, Martin Schneider, Markus W. Buechler, Laurence Zitvogel, Thomas Herrmann, Axel Benner, Christina Kunz, Stephan Luecke, Christoph Springfeld, Niels Grabe, Christine S. Falk & Dirk Jaeger. (2016) Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients. Cancer Cell 29:4, pages 587-601.
Crossref
Jannemarie A. M. de Ridder, Nikki Knijn, Bastiaan Wiering, Johannes H. W. de Wilt & Iris D. Nagtegaal. (2015) Lymphatic Invasion is an Independent Adverse Prognostic Factor in Patients with Colorectal Liver Metastasis. Annals of Surgical Oncology 22:S3, pages 638-645.
Crossref
Anastasia Meshcheryakova, Dietmar Tamandl, Erika Bajna, Judith Stift, Martina Mittlboeck, Martin Svoboda, Denise Heiden, Stefan Stremitzer, Erika Jensen-Jarolim, Thomas Grünberger, Michael Bergmann & Diana Mechtcheriakova. (2014) B Cells and Ectopic Follicular Structures: Novel Players in Anti-Tumor Programming with Prognostic Power for Patients with Metastatic Colorectal Cancer. PLoS ONE 9:6, pages e99008.
Crossref
Qicong Chen, Ming Cai, Xinjuan Fan, Wenbin Liu, Gang Fang, Su Yao, Yao Xu, Qian Li, Yingnan Zhao, Ke Zhao, Zaiyi Liu & Zhihua Chen. (2022) An Artificial Intelligence-Based Ecological Index for Prognostic Evaluation of Colorectal Cancer. SSRN Electronic Journal.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.