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Organogenesis Forum

Applications of Metabolomics for Kidney Disease Research

From biomarkers to therapeutic targets

&
Pages 11-18 | Received 14 Mar 2013, Accepted 14 Mar 2013, Published online: 01 Jan 2013

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S Abdelsattar, ZA Kasemy, M Elsayed, TA Elrahem & SK Zewain. (2021) Targeted metabolomics as a tool for the diagnosis of kidney disease in Type II diabetes mellitus. British Journal of Biomedical Science 78:4, pages 184-190.
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Nimisha Gupta, Sreelakshmi Ramakrishnan & Saima Wajid. (2021) Emerging role of metabolomics in protein conformational disorders. Expert Review of Proteomics 18:5, pages 395-410.
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Yanqing Song, Jie Ma, Huan Gao, Jinghui Zhai, Yueming Zhang, Jiawei Gong, Xiaoyu Qu & Tingting Hu. (2023) The identification of key metabolites and mechanisms during isoniazid/rifampicin-induced neurotoxicity and hepatotoxicity in a mouse model by HPLC-TOF/MS-based untargeted urine metabolomics. Journal of Pharmaceutical and Biomedical Analysis 236, pages 115709.
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Dan Cai, Biao Hou & Song Lin Xie. (2023) Amino acid analysis as a method of discovering biomarkers for diagnosis of diabetes and its complications. Amino Acids 55:5, pages 563-578.
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Hiba S Al-Amodi, Shimaa Abdelsattar, Zeinab A. Kasemy, Hanan M. Bedair, Hany S. Elbarbary & Hala F. M. Kamel. (2021) Potential Value of TNF-α (–376 G/A) Polymorphism and Cystatin C (CysC) in the Diagnosis of Sepsis Associated Acute Kidney Injury (S-AK I) and Prediction of Mortality in Critically Ill patients. Frontiers in Molecular Biosciences 8.
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Jesse A. Davidson, Benjamin S. Frank, Tracy T. Urban, Mark Twite, James Jaggers, Ludmila Khailova & Jelena Klawitter. (2021) Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass. Pediatric Nephrology 36:10, pages 3259-3269.
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Yao Tan, Liming Wang, Jian Gao, Junhong Ma, Haiyang Yu, Yi Zhang, Tao Wang & Lifeng Han. (2020) Multiomics Integrative Analysis for Discovering the Potential Mechanism of Dioscin against Hyperuricemia Mice. Journal of Proteome Research 20:1, pages 645-660.
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Yanqing Song, Tingting Hu, Huan Gao, Jinghui Zhai, Jiawei Gong, Yueming Zhang, Lina Tao, Jingmeng Sun, Zhiyuan Li & Xiaoyu Qu. (2021) Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study. Biochemical Pharmacology 183, pages 114299.
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Shosha E. I. Dekker, Aswin Verhoeven, Darius Soonawala, Dorien J. M. Peters, Johan W. de Fijter & Oleg A. Mayboroda. (2020) Urinary metabolites associate with the rate of kidney function decline in patients with autosomal dominant polycystic kidney disease. PLOS ONE 15:5, pages e0233213.
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Xiaoyu Qu, Huan Gao, Jingmeng Sun, Lina Tao, Yueming Zhang, Jinghui Zhai, Yanqing Song, Tingting Hu & Zhiyuan Li. (2020) Identification of key metabolites during cisplatin-induced acute kidney injury using an HPLC-TOF/MS-based non-targeted urine and kidney metabolomics approach in rats. Toxicology 431, pages 152366.
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R Vairakkani, MEdwin Fernando & TYashwanth Raj. (2020) Metabolome and microbiome in kidney diseases. Saudi Journal of Kidney Diseases and Transplantation 31:1, pages 1.
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NITI MADAN & ROBERT H. WEISS. 2020. Onco-Nephrology. Onco-Nephrology 229 243.e4 .
Kyoungmi Kim, Josephine F. Trott, Guimin Gao, Arlene Chapman & Robert H. Weiss. (2019) Plasma metabolites and lipids associate with kidney function and kidney volume in hypertensive ADPKD patients early in the disease course. BMC Nephrology 20:1.
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Yang Wang, Cong-Hui Wang, Yu-Fei Zhang, Liang Zhu, Hui-Min Lei & Ya-Bin Tang. (2019) UPLC-MS-based metabolomics reveals metabolic dysregulation in ALDH1A1-overexpressed lung adenocarcinoma cells. Metabolomics 15:4.
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Igor Maksimovic, Song Zhang, Ivan Vuckovic & Maria V. Irazabal. 2019. Methods in Kidney Cell Biology - Part B. Methods in Kidney Cell Biology - Part B 15 29 .
Ryan B Gil, Alberto Ortiz, Maria D Sanchez-Niño, Katerina Markoska, Eva Schepers, Raymond Vanholder, Griet Glorieux, Philippe Schmitt-Kopplin & Silke S Heinzmann. (2018) Increased urinary osmolyte excretion indicates chronic kidney disease severity and progression rate. Nephrology Dialysis Transplantation 33:12, pages 2156-2164.
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Feng Zhang, Qinghua Wang, Tianyi Xia, Shangxi Fu, Xia Tao, Yan Wen, Shen’an Chan, Shouhong Gao, Xiaojuan Xiong & Wansheng Chen. (2018) Diagnostic value of plasma tryptophan and symmetric dimethylarginine levels for acute kidney injury among tacrolimus-treated kidney transplant patients by targeted metabolomics analysis. Scientific Reports 8:1.
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Tianyi Xia, Shangxi Fu, Qinghua Wang, Yan Wen, Shen-an Chan, Sang Zhu, Shouhong Gao, Xia Tao, Feng Zhang & Wansheng Chen. (2018) Targeted metabolomic analysis of 33 amino acids and biogenic amines in human urine by ion-pairing HPLC-MS/MS: Biomarkers for tacrolimus nephrotoxicity after renal transplantation. Biomedical Chromatography 32:7, pages e4198.
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Han-Qing Pang, Shi-Jun Yue, Yu-Ping Tang, Yan-Yan Chen, Ya-Jie Tan, Yu-Jie Cao, Xu-Qin Shi, Gui-Sheng Zhou, An Kang, Sheng-Liang Huang, Ya-Jun Shi, Jing Sun, Zhi-Shu Tang & Jin-Ao Duan. (2018) Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia. Frontiers in Pharmacology 9.
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Chien‐An Chou, Chia‐Ni Lin, Daniel Tsun‐Yee Chiu, I‐Wen Chen & Szu‐Tah Chen. (2017) Tryptophan as a surrogate prognostic marker for diabetic nephropathy. Journal of Diabetes Investigation 9:2, pages 366-374.
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Ryan B. Gil & Silke Heinzmann. 2018. Integration of Omics Approaches and Systems Biology for Clinical Applications. Integration of Omics Approaches and Systems Biology for Clinical Applications 173 195 .
Ryan B. Gil, Rainer Lehmann, Philippe Schmitt-Kopplin & Silke S. Heinzmann. (2016) 1H NMR-based metabolite profiling workflow to reduce inter-sample chemical shift variations in urine samples for improved biomarker discovery. Analytical and Bioanalytical Chemistry 408:17, pages 4683-4691.
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Libing Ye & Wei Mao. (2016) Metabonomic biomarkers for risk factors of chronic kidney disease. International Urology and Nephrology 48:4, pages 547-552.
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Iole Maria Di Gangi, Urska Vrhovsek, Valerio Pazienza & Fulvio Mattivi. (2014) Analytical metabolomics-based approaches to pancreatic cancer. TrAC Trends in Analytical Chemistry 55, pages 94-116.
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