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Research Paper

Ceruloplasmin fragmentation is implicated in 'free' copper deregulation of Alzheimer disease

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Pages 23-27 | Received 25 Mar 2008, Accepted 14 May 2008, Published online: 15 Apr 2008

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Read on this site (5)

Zhidong Liu, Miao Wang, Chunbo Zhang, Shigao Zhou & Guang Ji. (2022) Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology. Diabetes, Metabolic Syndrome and Obesity 15, pages 695-711.
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Brian Dean, Andrew Tsatsanis, Linh Q. Lam, Elizabeth Scarr & James A. Duce. (2020) Changes in cortical protein markers of iron transport with gender, major depressive disorder and suicide. The World Journal of Biological Psychiatry 21:2, pages 119-126.
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A. V. Sokolov, V. A. Kostevich, E. T. Zakharova, V. R. Samygina, O. M. Panasenko & V. B. Vasilyev. (2015) Interaction of ceruloplasmin with eosinophil peroxidase as compared to its interplay with myeloperoxidase: Reciprocal effect on enzymatic properties. Free Radical Research 49:6, pages 800-811.
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Solange A. Pacheco, Vukosava M. Torres, Henriqueta Louro, Filomena Gomes, Carlos Lopes, Nelson Marçal, Elsa Fragoso, Carla Martins, Cátia L. Oliveira, Manuela Hagenfeldt, António Bugalho-Almeida, Deborah Penque & Tânia Simões. (2013) Effects of Occupational Exposure to Tobacco Smoke: Is There a Link Between Environmental Exposure and Disease?. Journal of Toxicology and Environmental Health, Part A 76:4-5, pages 311-327.
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Sanghamitra Bandyopadhyay, Xudong Huang, Debomoy K Lahiri & Jack T Rogers. (2010) Novel drug targets based on metallobiology of Alzheimer's disease. Expert Opinion on Therapeutic Targets 14:11, pages 1177-1197.
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Articles from other publishers (32)

Yan Zhang, Yu-shen Yang, Cong-mei Wang, Wei-can Chen, Xin-li Chen, Fan Wu & He-fan He. (2023) Copper metabolism-related Genes in entorhinal cortex for Alzheimer's disease. Scientific Reports 13:1.
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Min Wu, Cong Wang, Leqin Ke, Dewen Chen, Yumei Qin & Jianzhong Han. (2022) Correlation between copper speciation and transport pathway in Caco‐2 cells. Journal of the Science of Food and Agriculture 103:4, pages 1895-1900.
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Klaus T. Aspli, Trygve Holmøy, Trond Peder Flaten, Jon Elling Whist & Jan O. Aaseth. (2021) Skogholt’s disease—a tauopathy precipitated by iron and copper?. Journal of Trace Elements in Medicine and Biology, pages 126915.
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M. V. Petoukhov, A. V. Sokolov, V. A. Kostevich & V. R. Samygina. (2021) Copper-Induced Oligomerization of Ceruloplasmin. Crystallography Reports 66:5, pages 828-832.
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Xiangchao Pang & Bin Tang. (2021) Role of the copper ion in pseudoazurin during the mechanical unfolding process. International Journal of Biological Macromolecules 166, pages 213-220.
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Mukesh Kumar, Neha Sawhney & Roshan Lal. 2021. Heavy Metals in the Environment. Heavy Metals in the Environment 9 37 .
Klara Zubčić, Patrick R. Hof, Goran Šimić & Maja Jazvinšćak Jembrek. (2020) The Role of Copper in Tau-Related Pathology in Alzheimer’s Disease. Frontiers in Molecular Neuroscience 13.
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Manuel A. Treto-Suárez, Jorge Tapia, Yoan Hidalgo-Rosa, Dayan Páez-Hernández, Elies Molins, Ximena Zarate & Eduardo Schott. (2020) New Sensitive and Selective Chemical Sensors for Ni 2+ and Cu 2+ Ions: Insights into the Sensing Mechanism through DFT Methods . The Journal of Physical Chemistry A 124:32, pages 6493-6503.
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Yu-ki Tanaka & Yasumitsu Ogra. (2019) Evaluation of copper metabolism in neonatal rats by speciation analysis using liquid chromatography hyphenated to ICP mass spectrometry. Metallomics 11:10, pages 1679-1686.
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L. De Riccardis, A. Buccolieri, M. Muci, E. Pitotti, F. De Robertis, G. Trianni, D. Manno & M. Maffia. (2018) Copper and ceruloplasmin dyshomeostasis in serum and cerebrospinal fluid of multiple sclerosis subjects. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:5, pages 1828-1838.
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Alan Zanardi, Antonio Conti, Marco Cremonesi, Patrizia D'Adamo, Enrica Gilberti, Pietro Apostoli, Carlo Vittorio Cannistraci, Alberto Piperno, Samuel David & Massimo Alessio. (2017) Ceruloplasmin replacement therapy ameliorates neurological symptoms in a preclinical model of aceruloplasminemia. EMBO Molecular Medicine 10:1, pages 91-106.
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Calogero Edoardo Cicero, Giovanni Mostile, Rosario Vasta, Venerando Rapisarda, Salvatore Santo Signorelli, Margherita Ferrante, Mario Zappia & Alessandra Nicoletti. (2017) Metals and neurodegenerative diseases. A systematic review. Environmental Research 159, pages 82-94.
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Rosanna Squitti, Mariacarla Ventriglia, Mariacristina Siotto & Carlo Salustri. 2017. Biometals in Neurodegenerative Diseases. Biometals in Neurodegenerative Diseases 19 34 .
Zoe K. Mathys & Anthony R. White. 2017. Neurotoxicity of Metals. Neurotoxicity of Metals 199 216 .
Mariacristina Siotto, Ilaria Simonelli, Patrizio Pasqualetti, Stefania Mariani, Deborah Caprara, Serena Bucossi, Mariacarla Ventriglia, Rossana Molinario, Mirca Antenucci, Mauro Rongioletti, Paolo Maria Rossini & Rosanna Squitti. (2016) Association Between Serum Ceruloplasmin Specific Activity and Risk of Alzheimer’s Disease. Journal of Alzheimer's Disease 50:4, pages 1181-1189.
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Min Wu, Feifei Han, Weisha Gong, Lifang Feng & Jianzhong Han. (2016) The effect of copper from water and food: changes of serum nonceruloplasmin copper and brain's amyloid-beta in mice. Food & Function 7:9, pages 3740-3747.
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Valeria A. Kostevich, Alexey V. Sokolov, Natalia A. Grudinina, Elena T. Zakharova, Valeria R. Samygina & Vadim B. Vasilyev. (2015) Interaction of macrophage migration inhibitory factor with ceruloplasmin: role of labile copper ions. BioMetals 28:5, pages 817-826.
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Alexej V. Sokolov, Laura Acquasaliente, Valeria A. Kostevich, Roberta Frasson, Elena T. Zakharova, Giulia Pontarollo, Vadim B. Vasilyev & Vincenzo De Filippis. (2015) Thrombin inhibits the anti-myeloperoxidase and ferroxidase functions of ceruloplasmin: relevance in rheumatoid arthritis. Free Radical Biology and Medicine 86, pages 279-294.
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Zi-Xuan Wang, Lan Tan, Hui-Fu Wang, Jing Ma, Jinyuan Liu, Meng-Shan Tan, Jia-Hao Sun, Xi-Chen Zhu, Teng Jiang & Jin-Tai Yu. (2015) Serum Iron, Zinc, and Copper Levels in Patients with Alzheimer’s Disease: A Replication Study and Meta-Analyses. Journal of Alzheimer's Disease 47:3, pages 565-581.
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Klaus Thanke Aspli, Trond Peder Flaten, Per M. Roos, Trygve Holmøy, Jon H. Skogholt & Jan Aaseth. (2015) Iron and copper in progressive demyelination – New lessons from Skogholt's disease. Journal of Trace Elements in Medicine and Biology 31, pages 183-187.
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Dominic J. Hare, James D. Doecke, Noel G. Faux, Alan Rembach, Irene Volitakis, Christopher J. Fowler, Rudolf Grimm, Philip A. Doble, Robert A. Cherny, Colin L. Masters, Ashley I. Bush & Blaine R. Roberts. (2015) Decreased Plasma Iron in Alzheimer’s Disease Is Due to Transferrin Desaturation. ACS Chemical Neuroscience 6:3, pages 398-402.
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Raúl González-Domínguez, Tamara García-Barrera & José Luis Gómez-Ariza. (2014) Homeostasis of metals in the progression of Alzheimer’s disease. BioMetals 27:3, pages 539-549.
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Raúl González-Domínguez, Tamara García-Barrera & José Luis Gómez-Ariza. (2014) Characterization of metal profiles in serum during the progression of Alzheimer's disease. Metallomics 6:2, pages 292-300.
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Alan RembachTim M Ryan, Blaine R Roberts, James D Doecke, William J Wilson, Andrew D Watt, Kevin J Barnham & Colin L Masters. (2013) Progress towards a consensus on biomarkers for Alzheimer’s disease: a review of peripheral analytes. Biomarkers in Medicine 7:4, pages 641-662.
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Jessica M. Posimo, Amanda M. Titler, Hailey J. H. Choi, Ajay S. Unnithan & Rehana K. Leak. (2013) Neocortex and Allocortex Respond Differentially to Cellular Stress In Vitro and Aging In Vivo. PLoS ONE 8:3, pages e58596.
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Anna Sieroslawska, Anna Rymuszka, Josef Velisek, Barbara Pawlik-Skowrońska, Zdenka Svobodova & Tadeusz Skowroński. (2012) Effects of microcystin-containing cyanobacterial extract on hematological and biochemical parameters of common carp (Cyprinus carpio L.). Fish Physiology and Biochemistry 38:4, pages 1159-1167.
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Rosanna Squitti. (2012) Copper dysfunction in Alzheimer's disease: From meta-analysis of biochemical studies to new insight into genetics. Journal of Trace Elements in Medicine and Biology 26:2-3, pages 93-96.
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Jae-young Joo & H. B. Lim. (2012) LA-ICP-MS with microarray chip sampling to determine holoceruloplasmin in serum. Journal of Analytical Atomic Spectrometry 27:7, pages 1069.
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Richard J. Perrin, Rebecca Craig-Schapiro, James P. Malone, Aarti R. Shah, Petra Gilmore, Alan E. Davis, Catherine M. Roe, Elaine R. Peskind, Ge Li, Douglas R. Galasko, Christopher M. Clark, Joseph F. Quinn, Jeffrey A. Kaye, John C. Morris, David M. Holtzman, R. Reid Townsend & Anne M. Fagan. (2011) Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease. PLoS ONE 6:1, pages e16032.
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Serena Bucossi, Stefania Mariani, Mariacarla Ventriglia, Renato Polimanti, Massimo Gennarelli, Cristian Bonvicini, Patrizio Pasqualetti, Federica Scrascia, Simone Migliore, Fabrizio Vernieri, Paolo M. Rossini & Rosanna Squitti. (2011) Association between the c. 2495 A>G ATP7B Polymorphism and Sporadic Alzheimer's Disease. International Journal of Alzheimer's Disease 2011, pages 1-9.
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Gudlaug Torsdottir, Jakob Kristinsson, Jón Snaedal, Sigurlaug Sveinbjörnsdóttir, Grétar Gudmundsson, Stefán Hreidarsson & Torkell Jóhannesson. (2010) Case–control studies on ceruloplasmin and superoxide dismutase (SOD1) in neurodegenerative diseases: A short review. Journal of the Neurological Sciences 299:1-2, pages 51-54.
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George J. Brewer, Steve H. Kanzer, Earl A. Zimmerman, Dzintra F. Celmins, Susan M. Heckman & Robert Dick. (2010) Copper and Ceruloplasmin Abnormalities in Alzheimer’s Disease. American Journal of Alzheimer's Disease & Other Dementiasr 25:6, pages 490-497.
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