1,848
Views
41
CrossRef citations to date
0
Altmetric
Research Paper

Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues

Pages 221-228 | Received 04 Oct 2012, Accepted 28 Jan 2013, Published online: 31 Jan 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Jingran Wen, Daniel R. Scoles & Julio C. Facelli. (2017) Effects of the enlargement of polyglutamine segments on the structure and folding of ataxin-2 and ataxin-3 proteins. Journal of Biomolecular Structure and Dynamics 35:3, pages 504-519.
Read now
Yixuan Zeng, Wenyuan Guo, Guangqing Xu, Qinmei Wang, Luyang Feng, Simei Long, Fengyin Liang, Yi Huang, Xilin Lu, Shichang Li, Jiebin Zhou, Jean-Marc Burgunder, Jiyan Pang & Zhong Pei. (2016) Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease. Drug Design, Development and Therapy 10, pages 1443-1451.
Read now

Articles from other publishers (39)

Yasith Indigahawela Gamage & Jianjun Pan. (2023) Elucidating the Influence of Lipid Composition on Bilayer Perturbations Induced by the N-Terminal Region of the Huntingtin Protein. Biophysica 3:4, pages 582-597.
Crossref
Pedro José Barbosa Pereira, José A. Manso & Sandra Macedo-Ribeiro. (2023) The structural plasticity of polyglutamine repeats. Current Opinion in Structural Biology 80, pages 102607.
Crossref
Mohammed Khaled, Birgit Strodel & Abdallah Sayyed-Ahmad. (2023) Comparative molecular dynamics simulations of pathogenic and non-pathogenic huntingtin protein monomers and dimers. Frontiers in Molecular Biosciences 10.
Crossref
Frank Herrmann, Manuela Hessmann, Sabine Schaertl, Karola Berg-Rosseburg, Christopher J Brown, Galina Bursow, Anass Chiki, Andreas Ebneth, Miriam Gehrmann, Nicole Hoeschen, Madlen Hotze, Stefanie Jahn, Peter D Johnson, Vinod Khetarpal, Alex Kiselyov, Karsten Kottig, Stefanie Ladewig, Hilal Lashuel, Sven Letschert, Matthew R Mills, Kathrin Petersen, Michael E Prime, Christoph Scheich, Gerhard Schmiedel, John Wityak, Longbin Liu, Celia Dominguez, Ignacio Muñoz-Sanjuán & Jonathan A Bard. (2021) Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates. Scientific Reports 11:1.
Crossref
Luciano A. Abriata & Matteo Dal Peraro. (2021) Assessment of transferable forcefields for protein simulations attests improved description of disordered states and secondary structure propensities, and hints at multi-protein systems as the next challenge for optimization. Computational and Structural Biotechnology Journal 19, pages 2626-2636.
Crossref
Meewhi Kim & Ilya Bezprozvanny. (2021) Association with proteasome determines pathogenic threshold of polyglutamine expansion diseases. Biochemical and Biophysical Research Communications 536, pages 95-99.
Crossref
Sanda Nastasia Moldovean & Vasile Chiş. (2020) Specific Key-Point Mutations along the Helical Conformation of Huntingtin-Exon 1 Protein Might Have an Antagonistic Effect on the Toxic Helical Content’s Formation. ACS Chemical Neuroscience 11:18, pages 2881-2889.
Crossref
Ester Tellone, Antonio Galtieri & Silvana Ficarra. (2020) Reviewing Biochemical Implications of Normal and Mutated Huntingtin in Huntington’s Disease. Current Medicinal Chemistry 27:31, pages 5137-5158.
Crossref
Larissa-Nele Schaffert & Wayne G. Carter. (2020) Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review. Brain Sciences 10:4, pages 232.
Crossref
Sanda Nastasia Moldovean & Vasile Chiş. (2019) Molecular Dynamics Simulations Applied to Structural and Dynamical Transitions of the Huntingtin Protein: A Review. ACS Chemical Neuroscience 11:2, pages 105-120.
Crossref
Benjamin Gabriel Poulson, Kacper Szczepski, Joanna Izabela Lachowicz, Lukasz Jaremko, Abdul-Hamid Emwas & Mariusz Jaremko. (2020) Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations. RSC Advances 10:1, pages 215-227.
Crossref
Irina Matlahov & Patrick CA van der Wel. (2019) Conformational studies of pathogenic expanded polyglutamine protein deposits from Huntington’s disease. Experimental Biology and Medicine 244:17, pages 1584-1595.
Crossref
Huiling Hong, Alex Chun Koon, Zhefan Stephen Chen, Yuming Wei, Ying An, Wen Li, Matthew Ho Yan Lau, Kwok-Fai Lau, Jacky Chi Ki Ngo, Chun-Ho Wong, Ho Yu Au-Yeung, Steven C. Zimmerman & Ho Yin Edwin Chan. (2019) AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models. Journal of Biological Chemistry 294:8, pages 2757-5526.
Crossref
Jose M. Bravo-Arredondo, Natalie C. Kegulian, Thomas Schmidt, Nitin K. Pandey, Alan J. Situ, Tobias S. Ulmer & Ralf Langen. (2018) The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract. Journal of Biological Chemistry 293:51, pages 19613-19623.
Crossref
Hongsuk Kang, Binquan Luan & Ruhong Zhou. (2018) Glassy dynamics in mutant huntingtin proteins. The Journal of Chemical Physics 149:7.
Crossref
Bor Luen Tang. (2018) Unconventional Secretion and Intercellular Transfer of Mutant Huntingtin. Cells 7:6, pages 59.
Crossref
Xinran Feng, Shouqing Luo & Boxun Lu. (2018) Conformation Polymorphism of Polyglutamine Proteins. Trends in Biochemical Sciences 43:6, pages 424-435.
Crossref
Debasish Kumar Ghosh, Ajit Roy & Akash Ranjan. (2018) Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation. Biochemistry 57:13, pages 2009-2023.
Crossref
Tetyana Yushchenko, Elke Deuerling & Karin Hauser. (2018) Insights into the Aggregation Mechanism of PolyQ Proteins with Different Glutamine Repeat Lengths. Biophysical Journal 114:8, pages 1847-1857.
Crossref
Cristina Dezi, Celic N. Ortíz Balderas & Patrizia Calaminici. (2017) A theoretical study of monomeric polyglutamine chains from molecular dynamics simulations with explicit water. Theoretical Chemistry Accounts 137:1.
Crossref
Ana Luisa Carvalho, Alexandra Silva & Sandra Macedo-Ribeiro. 2018. Polyglutamine Disorders. Polyglutamine Disorders 275 288 .
Wen-Tian He, Wei Xue, Yong-Guang Gao, Jun-Ye Hong, Hong-Wei Yue, Lei-Lei Jiang & Hong-Yu Hu. (2017) HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19. Scientific Reports 7:1.
Crossref
Hongsuk Kang, Francisco X. Vázquez, Leili Zhang, Payel Das, Leticia Toledo-Sherman, Binquan Luan, Michael Levitt & Ruhong Zhou. (2017) Emerging β-Sheet Rich Conformations in Supercompact Huntingtin Exon-1 Mutant Structures. Journal of the American Chemical Society 139:26, pages 8820-8827.
Crossref
Coral Y. Zhou, Caitlin I. Stoddard, Jonathan B. Johnston, Michael J. Trnka, Ignacia Echeverria, Eugene Palovcak, Andrej Sali, Alma L. Burlingame, Yifan Cheng & Geeta J. Narlikar. (2017) Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones. Cell Reports 19:10, pages 2033-2044.
Crossref
Leili Zhang, Hongsuk Kang, Francisco X. Vázquez, Leticia Toledo-Sherman, Binquan Luan & Ruhong Zhou. (2017) Molecular Mechanism of Stabilizing the Helical Structure of Huntingtin N17 in a Micellar Environment. The Journal of Physical Chemistry B 121:18, pages 4713-4721.
Crossref
Steffen Büning, Abhishek Sharma, Shivang Vachharajani, Estella Newcombe, Angelique Ormsby, Mimi Gao, David Gnutt, Tobias Vöpel, Danny M. Hatters & Simon Ebbinghaus. (2017) Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells. Physical Chemistry Chemical Physics 19:17, pages 10738-10747.
Crossref
Christopher A. Ross, Martin Kronenbuerger, Wenzhen Duan & Russell L. Margolis. 2017. Huntington Disease. Huntington Disease 15 28 .
Vladimir A. Zhemkov, Anna A. Kulminskaya, Ilya B. Bezprozvanny & Meewhi Kim. (2016) The 2.2‐Angstrom resolution crystal structure of the carboxy‐terminal region of ataxin‐3. FEBS Open Bio 6:3, pages 168-178.
Crossref
Clinton Rice, Danielle Beekman, Liping Liu & Albert Erives. (2015) The Nature, Extent, and Consequences of Genetic Variation in the opa Repeats of Notch in Drosophila . G3 Genes|Genomes|Genetics 5:11, pages 2405-2419.
Crossref
Vladimir Egorov, Natalia Grudinina, Andrey Vasin & Dmitry Lebedev. (2015) Peptide-Induced Amyloid-Like Conformational Transitions in Proteins. International Journal of Peptides 2015, pages 1-5.
Crossref
Jiang Hong, Lila M. Gierasch & Zhicheng Liu. (2015) Its Preferential Interactions with Biopolymers Account for Diverse Observed Effects of Trehalose. Biophysical Journal 109:1, pages 144-153.
Crossref
James R. Arndt, Maxmore Chaibva & Justin Legleiter. (2015) The emerging role of the first 17 amino acids of huntingtin in Huntington’s disease. Biomolecular Concepts 6:1, pages 33-46.
Crossref
Valentina Fodale, Natalie C. Kegulian, Margherita Verani, Cristina Cariulo, Lucia Azzollini, Lara Petricca, Manuel Daldin, Roberto Boggio, Alessandro Padova, Rainer Kuhn, Robert Pacifici, Douglas Macdonald, Ryan C. Schoenfeld, Hyunsun Park, J. Mario Isas, Ralf Langen, Andreas Weiss & Andrea Caricasole. (2014) Polyglutamine- and Temperature-Dependent Conformational Rigidity in Mutant Huntingtin Revealed by Immunoassays and Circular Dichroism Spectroscopy. PLoS ONE 9:12, pages e112262.
Crossref
Shounak Baksi, Sreetama Basu & Debashis Mukhopadhyay. (2014) Mutant huntingtin replaces Gab1 and interacts with C-terminal SH3 domain of growth factor receptor binding protein 2 (Grb2). Neuroscience Research 87, pages 77-83.
Crossref
Michael W. Beck, Amit S. Pithadia, Alaina S. DeToma, Kyle J. Korshavn & Mi Hee Lim. 2014. Ligand Design in Medicinal Inorganic Chemistry. Ligand Design in Medicinal Inorganic Chemistry 257 286 .
Jingran Wen, Daniel R Scoles & Julio C Facelli. (2014) Structure prediction of polyglutamine disease proteins: comparison of methods. BMC Bioinformatics 15:S7.
Crossref
Christopher A. Ross, Elizabeth H. Aylward, Edward J. Wild, Douglas R. Langbehn, Jeffrey D. Long, John H. Warner, Rachael I. Scahill, Blair R. Leavitt, Julie C. Stout, Jane S. Paulsen, Ralf Reilmann, Paul G. Unschuld, Alice Wexler, Russell L. Margolis & Sarah J. Tabrizi. (2014) Huntington disease: natural history, biomarkers and prospects for therapeutics. Nature Reviews Neurology 10:4, pages 204-216.
Crossref
Andrew C. Gill. (2014) β-Hairpin-Mediated Formation of Structurally Distinct Multimers of Neurotoxic Prion Peptides. PLoS ONE 9:1, pages e87354.
Crossref
Meewhi Kim. (2014) Pathogenic polyglutamine expansion length correlates with polarity of the flanking sequences. Molecular Neurodegeneration 9:1, pages 45.
Crossref